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Protein

DNA-binding protein HU

Gene

hup

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein HU
Gene namesi
Name:hup
Ordered Locus Names:SAV1473
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002233761 – 90DNA-binding protein HUAdd BLAST90

Proteomic databases

PaxDbiQ99U17.
PRIDEiQ99U17.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi158878.SAV1473.

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Helixi18 – 37Combined sources20
Beta strandi42 – 44Combined sources3
Turni45 – 47Combined sources3
Beta strandi48 – 55Combined sources8
Beta strandi58 – 61Combined sources4
Turni63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi74 – 81Combined sources8
Helixi83 – 89Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QJNX-ray2.61A/B/C/D1-90[»]
4QJUX-ray2.16A/B1-90[»]
ProteinModelPortaliQ99U17.
SMRiQ99U17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
HOGENOMiHOG000043829.
KOiK03530.
OMAiGSWSVSK.
PhylomeDBiQ99U17.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99U17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTDLINAV AEQADLTKKE AGSAVDAVFE SIQNSLAKGE KVQLIGFGNF
60 70 80 90
EVRERAARKG RNPQTGKEID IPASKVPAFK AGKALKDAVK
Length:90
Mass (Da):9,626
Last modified:June 1, 2001 - v1
Checksum:i554F2EF88514060F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57635.1.
RefSeqiWP_001043863.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57635; BAB57635; SAV1473.
GeneIDi28380945.
KEGGisav:SAV1473.
PATRICi19563678. VBIStaAur52173_1516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57635.1.
RefSeqiWP_001043863.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QJNX-ray2.61A/B/C/D1-90[»]
4QJUX-ray2.16A/B1-90[»]
ProteinModelPortaliQ99U17.
SMRiQ99U17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1473.

Proteomic databases

PaxDbiQ99U17.
PRIDEiQ99U17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB57635; BAB57635; SAV1473.
GeneIDi28380945.
KEGGisav:SAV1473.
PATRICi19563678. VBIStaAur52173_1516.

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
HOGENOMiHOG000043829.
KOiK03530.
OMAiGSWSVSK.
PhylomeDBiQ99U17.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBH_STAAM
AccessioniPrimary (citable) accession number: Q99U17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.