Q99TW7 (Q99TW7_STAAM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Acetyl-CoA carboxylase EMBL BAB57688.1

Gene names

Name:	accC EMBL BAB57688.1
Ordered Locus Names:	SAV1526 EMBL BAB57688.1

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP] EMBL BAB57688.1

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 2VPQ Metal-binding PDB 2VPQ
Technical term	3D-structure PDB 2VPQ Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro biotin carboxylase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	274	1	Magnesium PDB 2VPQ
	Metal binding	288	1	Magnesium PDB 2VPQ

Sequences

	Sequence		Length	Mass (Da)
	Q99TW7 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 8E8ED63980022092	FASTA	451	50,049
	10 20 30 40 50 60 MKKVLIANRG EIAVRIIRAC RDLGIQTVAI YSEGDKDALH TQIADEAYCV GPTLSKDSYL 70 80 90 100 110 120 NIPNILSIAT STGCDGVHPG YGFLAENADF AELCEACQLK FIGPSYQSIQ KMGIKDVAKA 130 140 150 160 170 180 EMIKANVPVV PGSDGLMKDV SEAKKIAKKI GYPVIIKATA GGGGKGIRVA RDEKELETGF 190 200 210 220 230 240 RMTEQEAQTA FGNGGLYMEK FIENFRHIEI QIVGDSYGNV IHLGERDCTI QRRMQKLVEE 250 260 270 280 290 300 APSPILDDET RREMGNAAVR AAKAVNYENA GTIEFIYDLN DNKFYFMEMN TRIQVEHPVT 310 320 330 340 350 360 EMVTGIDLVK LQLQVAMGDV LPYKQEDIKL TGHAIEFRIN AENPYKNFMP SPGKIEQYLA 370 380 390 400 410 420 PGGYGVRIES ACYTNYTIPP YYDSMVAKLI IHEPTRDEAI MAGIRALSEF VVLGIDTTIP 430 440 450 FHIKLLNNDI FRSGKFNTNF LEQNSIMNDE G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.
[2]	"Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase." Mochalkin I., Miller J.R., Evdokimov A., Lightle S., Yan C., Stover C.K., Waldrop G.L. Protein Sci. 17:1706-1718(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000017 Genomic DNA. Translation: BAB57688.1.

PIR

F89932.

RefSeq

NP_372050.1. NC_002758.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VPQ	X-ray	2.10	A/B	1-451	[»]

ProteinModelPortal

Q99TW7.

SMR

Q99TW7. Positions 2-449.

ModBase

Search...

Protein-protein interaction databases

STRING

158878.SAV1526.

2D gel databases

World-2DPAGE

0002:Q99TW7.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

BAB57688; BAB57688; SAV1526.

GeneID

1121501.

KEGG

sav:SAV1526.

PATRIC

19563792. VBIStaAur52173_1573.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG0439.

KO

K01961.

OMA

IEKFVDN.

ProtClustDB

PRK08591.

Enzyme and pathway databases

BioCyc

SAUR158878:GJJ5-1542-MONOMER.

Family and domain databases

Gene3D

3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.

InterPro

IPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]

Pfam

PF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]

SMART

SM00878. Biotin_carb_C. 1 hit.
[Graphical view]

SUPFAM

SSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.

TIGRFAMs

TIGR00514. accC. 1 hit.

PROSITE

PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q99TW7.

Entry information

Entry name

Q99TW7_STAAM

Accession

Primary (citable) accession number: Q99TW7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)