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Q99TW7

- Q99TW7_STAAM

UniProt

Q99TW7 - Q99TW7_STAAM

Protein
Submitted name:

Acetyl-CoA carboxylase

Gene

accC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei115 – 1151ATPanalogImported
    Binding sitei157 – 1571ATPanalogImported
    Binding sitei164 – 1641ATPanalog; via amide nitrogenImported
    Binding sitei231 – 2311ATPanalogImported
    Metal bindingi274 – 2741MagnesiumImported
    Binding sitei274 – 2741ATPanalogImported
    Metal bindingi288 – 2881MagnesiumImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi199 – 2024ATPanalogImported
    Nucleotide bindingi288 – 2903ATPanalogImported

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. biotin carboxylase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    MagnesiumImported, Metal-bindingImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-1542-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Acetyl-CoA carboxylaseImported
    Gene namesi
    Name:accCImported
    Ordered Locus Names:SAV1526Imported
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    2D gel databases

    World-2DPAGE0002:Q99TW7.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV1526.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VPQX-ray2.10A/B1-451[»]
    ProteinModelPortaliQ99TW7.
    SMRiQ99TW7. Positions 2-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99TW7.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0439.
    KOiK01961.
    OMAiENIRHEM.
    OrthoDBiEOG6CVV6Z.
    PhylomeDBiQ99TW7.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF02785. Biotin_carb_C. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR00514. accC. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99TW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVLIANRG EIAVRIIRAC RDLGIQTVAI YSEGDKDALH TQIADEAYCV    50
    GPTLSKDSYL NIPNILSIAT STGCDGVHPG YGFLAENADF AELCEACQLK 100
    FIGPSYQSIQ KMGIKDVAKA EMIKANVPVV PGSDGLMKDV SEAKKIAKKI 150
    GYPVIIKATA GGGGKGIRVA RDEKELETGF RMTEQEAQTA FGNGGLYMEK 200
    FIENFRHIEI QIVGDSYGNV IHLGERDCTI QRRMQKLVEE APSPILDDET 250
    RREMGNAAVR AAKAVNYENA GTIEFIYDLN DNKFYFMEMN TRIQVEHPVT 300
    EMVTGIDLVK LQLQVAMGDV LPYKQEDIKL TGHAIEFRIN AENPYKNFMP 350
    SPGKIEQYLA PGGYGVRIES ACYTNYTIPP YYDSMVAKLI IHEPTRDEAI 400
    MAGIRALSEF VVLGIDTTIP FHIKLLNNDI FRSGKFNTNF LEQNSIMNDE 450
    G 451
    Length:451
    Mass (Da):50,049
    Last modified:June 1, 2001 - v1
    Checksum:i8E8ED63980022092
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57688.1.
    PIRiF89932.
    RefSeqiNP_372050.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB57688; BAB57688; SAV1526.
    GeneIDi1121501.
    KEGGisav:SAV1526.
    PATRICi19563792. VBIStaAur52173_1573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57688.1 .
    PIRi F89932.
    RefSeqi NP_372050.1. NC_002758.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VPQ X-ray 2.10 A/B 1-451 [» ]
    ProteinModelPortali Q99TW7.
    SMRi Q99TW7. Positions 2-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV1526.

    2D gel databases

    World-2DPAGE 0002:Q99TW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB57688 ; BAB57688 ; SAV1526 .
    GeneIDi 1121501.
    KEGGi sav:SAV1526.
    PATRICi 19563792. VBIStaAur52173_1573.

    Phylogenomic databases

    eggNOGi COG0439.
    KOi K01961.
    OMAi ENIRHEM.
    OrthoDBi EOG6CVV6Z.
    PhylomeDBi Q99TW7.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-1542-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q99TW7.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF02785. Biotin_carb_C. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR00514. accC. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699Imported.
    2. "Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase."
      Mochalkin I., Miller J.R., Evdokimov A., Lightle S., Yan C., Stover C.K., Waldrop G.L.
      Protein Sci. 17:1706-1718(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH ATPANALOG AND MAGNESIUM.

    Entry informationi

    Entry nameiQ99TW7_STAAM
    AccessioniPrimary (citable) accession number: Q99TW7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3