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Q99TW7

- Q99TW7_STAAM

UniProt

Q99TW7 - Q99TW7_STAAM

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Protein
Submitted name:

Acetyl-CoA carboxylase

Gene

accC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151ATPanalogImported
Binding sitei157 – 1571ATPanalogImported
Binding sitei164 – 1641ATPanalog; via amide nitrogenImported
Binding sitei231 – 2311ATPanalogImported
Metal bindingi274 – 2741MagnesiumImported
Binding sitei274 – 2741ATPanalogImported
Metal bindingi288 – 2881MagnesiumImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2024ATPanalogImported
Nucleotide bindingi288 – 2903ATPanalogImported

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. biotin carboxylase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

MagnesiumImported, Metal-bindingImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1542-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Acetyl-CoA carboxylaseImported
Gene namesi
Name:accCImported
Ordered Locus Names:SAV1526Imported
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

2D gel databases

World-2DPAGE0002:Q99TW7.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1526.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VPQX-ray2.10A/B1-451[»]
ProteinModelPortaliQ99TW7.
SMRiQ99TW7. Positions 2-449.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99TW7.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0439.
KOiK01961.
OMAiENIRHEM.
OrthoDBiEOG6CVV6Z.
PhylomeDBiQ99TW7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00514. accC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99TW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVLIANRG EIAVRIIRAC RDLGIQTVAI YSEGDKDALH TQIADEAYCV
60 70 80 90 100
GPTLSKDSYL NIPNILSIAT STGCDGVHPG YGFLAENADF AELCEACQLK
110 120 130 140 150
FIGPSYQSIQ KMGIKDVAKA EMIKANVPVV PGSDGLMKDV SEAKKIAKKI
160 170 180 190 200
GYPVIIKATA GGGGKGIRVA RDEKELETGF RMTEQEAQTA FGNGGLYMEK
210 220 230 240 250
FIENFRHIEI QIVGDSYGNV IHLGERDCTI QRRMQKLVEE APSPILDDET
260 270 280 290 300
RREMGNAAVR AAKAVNYENA GTIEFIYDLN DNKFYFMEMN TRIQVEHPVT
310 320 330 340 350
EMVTGIDLVK LQLQVAMGDV LPYKQEDIKL TGHAIEFRIN AENPYKNFMP
360 370 380 390 400
SPGKIEQYLA PGGYGVRIES ACYTNYTIPP YYDSMVAKLI IHEPTRDEAI
410 420 430 440 450
MAGIRALSEF VVLGIDTTIP FHIKLLNNDI FRSGKFNTNF LEQNSIMNDE

G
Length:451
Mass (Da):50,049
Last modified:June 1, 2001 - v1
Checksum:i8E8ED63980022092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57688.1.
PIRiF89932.
RefSeqiNP_372050.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57688; BAB57688; SAV1526.
GeneIDi1121501.
KEGGisav:SAV1526.
PATRICi19563792. VBIStaAur52173_1573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57688.1 .
PIRi F89932.
RefSeqi NP_372050.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VPQ X-ray 2.10 A/B 1-451 [» ]
ProteinModelPortali Q99TW7.
SMRi Q99TW7. Positions 2-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV1526.

2D gel databases

World-2DPAGE 0002:Q99TW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB57688 ; BAB57688 ; SAV1526 .
GeneIDi 1121501.
KEGGi sav:SAV1526.
PATRICi 19563792. VBIStaAur52173_1573.

Phylogenomic databases

eggNOGi COG0439.
KOi K01961.
OMAi ENIRHEM.
OrthoDBi EOG6CVV6Z.
PhylomeDBi Q99TW7.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-1542-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q99TW7.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00514. accC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699Imported.
  2. "Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase."
    Mochalkin I., Miller J.R., Evdokimov A., Lightle S., Yan C., Stover C.K., Waldrop G.L.
    Protein Sci. 17:1706-1718(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH ATPANALOG AND MAGNESIUM.

Entry informationi

Entry nameiQ99TW7_STAAM
AccessioniPrimary (citable) accession number: Q99TW7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3