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Q99T60 (SPLA_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine protease SplA
EC=3.4.21.-
Gene names
Name:splA
Ordered Locus Names:SAV1813
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peptidase S1B family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 By similarity
Chain36 – 235200Serine protease SplA
PRO_0000359530

Sites

Active site741Charge relay system By similarity
Active site1131Charge relay system By similarity
Active site1891Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99T60 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DE576B839B4A8682

FASTA23525,441
        10         20         30         40         50         60 
MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKAPY NSVVAFAGGT 

        70         80         90        100        110        120 
GVVVGKNTIV TNKHIAKSND IFKNRVAAHY SSKGKGGGNY DVKDIVEYPG KEDLAIVHVH 

       130        140        150        160        170        180 
ETSTEGLNFN KNVSYTKFAE GAKAKDRISV IGYPKGAQTK YKMFESTGTI NHISGTFIEF 

       190        200        210        220        230 
DAYAQPGNSG SPVLNSKHEL IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB57975.1.
RefSeqNP_372337.1. NC_002758.2.

3D structure databases

HSSPHSSP built from PDB template 2AS9 based on UniProtKB Q53782.
ProteinModelPortalQ99T60.
SMRQ99T60. Positions 36-235.
ModBaseSearch...

Protein-protein interaction databases

STRING158878.SAV1813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB57975; BAB57975; SAV1813.
GeneID1121787.
KEGGsav:SAV1813.
PATRIC19564384. VBIStaAur52173_1870.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3591.
OMATINHING.
ProtClustDBCLSK885576.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-1829-MONOMER.

Family and domain databases

InterProIPR000126. Pept_S1B_AS.
IPR001254. Peptidase_S1.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS00672. V8_HIS. 1 hit.
PS00673. V8_SER. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPLA_STAAM
AccessionPrimary (citable) accession number: Q99T60
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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