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Protein

Monofunctional glycosyltransferase

Gene

mgt

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of cell wall peptidoglycan. Responsible for the elongation of the glycan strands using lipid-linked disaccharide-pentapeptide as the substrate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1929-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Monofunctional glycosyltransferaseUniRule annotation (EC:2.4.-.-UniRule annotation)
Short name:
MGTUniRule annotation
Alternative name(s):
Peptidoglycan TGaseUniRule annotation
Gene namesi
Name:mgtUniRule annotation
Ordered Locus Names:SAV1874
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Monofunctional glycosyltransferasePRO_0000083154Add
BLAST

Proteomic databases

PaxDbiQ99T05.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1874.

Structurei

Secondary structure

1
269
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 6521Combined sources
Helixi70 – 789Combined sources
Helixi85 – 873Combined sources
Helixi90 – 10011Combined sources
Turni102 – 1065Combined sources
Beta strandi107 – 1093Combined sources
Helixi112 – 1165Combined sources
Turni117 – 1204Combined sources
Helixi134 – 14310Combined sources
Helixi151 – 16616Combined sources
Helixi169 – 1779Combined sources
Beta strandi183 – 1853Combined sources
Helixi189 – 1979Combined sources
Beta strandi206 – 2083Combined sources
Helixi213 – 22210Combined sources
Helixi236 – 25116Combined sources
Helixi257 – 26610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VMQX-ray2.52A/B28-269[»]
3VMRX-ray3.69A28-269[»]
3VMSX-ray3.20A/B28-269[»]
3VMTX-ray2.30A/B28-269[»]
ProteinModelPortaliQ99T05.
SMRiQ99T05. Positions 61-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288116.
KOiK04478.
OMAiGSDQYTI.
PhylomeDBiQ99T05.

Family and domain databases

HAMAPiMF_01434. MGT. 1 hit.
InterProiIPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR022978. Monofunct_glyco_trans.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99T05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSDRYSNS NEHFEHMKHE PHYNTYYQPV GKPPKKKKSK RILLKILLTI
60 70 80 90 100
LIIIALFIGI MYFLSTRDNV DELRKIENKS SFVSADNMPE YVKGAFISME
110 120 130 140 150
DERFYNHHGF DLKGTTRALF STISDRDVQG GSTITQQVVK NYFYDNDRSF
160 170 180 190 200
TRKVKELFVA HRVEKQYNKN EILSFYLNNI YFGDNQYTLE GAANHYFGTT
210 220 230 240 250
VNKNSTTMSH ITVLQSAILA SKVNAPSVYN INNMSENFTQ RVSTNLEKMK
260
QQNYINETQY QQAMSQLNR
Length:269
Mass (Da):31,460
Last modified:June 1, 2001 - v1
Checksum:iC0F65B9F5CAB8761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58036.1.
RefSeqiWP_000830380.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58036; BAB58036; SAV1874.
KEGGisav:SAV1874.
PATRICi19564594. VBIStaAur52173_1936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58036.1.
RefSeqiWP_000830380.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VMQX-ray2.52A/B28-269[»]
3VMRX-ray3.69A28-269[»]
3VMSX-ray3.20A/B28-269[»]
3VMTX-ray2.30A/B28-269[»]
ProteinModelPortaliQ99T05.
SMRiQ99T05. Positions 61-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1874.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Proteomic databases

PaxDbiQ99T05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58036; BAB58036; SAV1874.
KEGGisav:SAV1874.
PATRICi19564594. VBIStaAur52173_1936.

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288116.
KOiK04478.
OMAiGSDQYTI.
PhylomeDBiQ99T05.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSAUR158878:GJJ5-1929-MONOMER.

Family and domain databases

HAMAPiMF_01434. MGT. 1 hit.
InterProiIPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR022978. Monofunct_glyco_trans.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMGT_STAAM
AccessioniPrimary (citable) accession number: Q99T05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.