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Q99T00

- PTPA_STAAM

UniProt

Q99T00 - PTPA_STAAM

Protein

Low molecular weight protein-tyrosine-phosphatase PtpA

Gene

ptpA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Dephosphorylates the phosphotyrosine-containing proteins.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81NucleophileBy similarity
    Active sitei14 – 141By similarity
    Active sitei120 – 1201Proton donorBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-1936-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight protein-tyrosine-phosphatase PtpA (EC:3.1.3.48)
    Alternative name(s):
    Phosphotyrosine phosphatase A
    Short name:
    PTPase A
    Gene namesi
    Name:ptpA
    Ordered Locus Names:SAV1881
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154Low molecular weight protein-tyrosine-phosphatase PtpAPRO_0000300661Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV1881.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99T00.
    SMRiQ99T00. Positions 1-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273094.
    KOiK01104.
    OMAiDSAGTHD.
    OrthoDBiEOG6MH5JB.
    PhylomeDBiQ99T00.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99T00-1 [UniParc]FASTAAdd to Basket

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    MVDVAFVCLG NICRSPMAEA IMRQRLKDRN IHDIKVHSRG TGSWNLGEPP    50
    HEGTQKILNK HNIPFDGMIS ELFEATDDFD YIVAMDQSNV DNIKSINPNL 100
    KGQLFKLLEF SNMEESDVPD PYYTNNFEGV YDMVLSSCDN LIDYIVKDAN 150
    LKEG 154
    Length:154
    Mass (Da):17,491
    Last modified:June 1, 2001 - v1
    Checksum:i67E81E0B8125B1E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58043.1.
    RefSeqiNP_372405.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB58043; BAB58043; SAV1881.
    GeneIDi1121894.
    KEGGisav:SAV1881.
    PATRICi19564608. VBIStaAur52173_1943.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58043.1 .
    RefSeqi NP_372405.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali Q99T00.
    SMRi Q99T00. Positions 1-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV1881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB58043 ; BAB58043 ; SAV1881 .
    GeneIDi 1121894.
    KEGGi sav:SAV1881.
    PATRICi 19564608. VBIStaAur52173_1943.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273094.
    KOi K01104.
    OMAi DSAGTHD.
    OrthoDBi EOG6MH5JB.
    PhylomeDBi Q99T00.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-1936-MONOMER.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiPTPA_STAAM
    AccessioniPrimary (citable) accession number: Q99T00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3