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Protein

Chemotaxis inhibitory protein

Gene

chp

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1872-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis inhibitory protein
Alternative name(s):
CHIPS
Gene namesi
Name:chp
Ordered Locus Names:SA1755
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 149121Chemotaxis inhibitory proteinPRO_0000319606Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ99SU8.
SMRiQ99SU8. Positions 59-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 346FPR-blocking activityBy similarity
Regioni59 – 14991C5aR-blocking activityBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CHIPS/FLIPr family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232728.

Family and domain databases

InterProiIPR020986. CHIPS.
IPR023253. FLIPR/CHIPS.
[Graphical view]
PfamiPF11434. CHIPS. 1 hit.
[Graphical view]
PRINTSiPR02036. CHEMOTAXISIP.
PR02035. FLIPRCHIPS.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99SU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKLATTVL ALSFLTAGIS THHHSAKAFT FEPFPTNEEI ESNKKMLEKE
60 70 80 90 100
KAYKESFKNS GLPTTLGKLD ERLRNYLEKG TKNTAQFEKM VILTENKGYY
110 120 130 140
TVYLNTPLAE DRKNVELLGK MYKTYFFKKG ESKSSYVING PGKTNEYAY
Length:149
Mass (Da):17,073
Last modified:June 1, 2001 - v1
Checksum:i54EEDE97E9CF26A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43029.1.
PIRiE89983.
RefSeqiWP_000727645.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43029; BAB43029; BAB43029.
PATRICi19575932. VBIStaAur116463_1898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43029.1.
PIRiE89983.
RefSeqiWP_000727645.1. NC_002745.2.

3D structure databases

ProteinModelPortaliQ99SU8.
SMRiQ99SU8. Positions 59-149.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB43029; BAB43029; BAB43029.
PATRICi19575932. VBIStaAur116463_1898.

Phylogenomic databases

HOGENOMiHOG000232728.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1872-MONOMER.

Miscellaneous databases

PROiQ99SU8.

Family and domain databases

InterProiIPR020986. CHIPS.
IPR023253. FLIPR/CHIPS.
[Graphical view]
PfamiPF11434. CHIPS. 1 hit.
[Graphical view]
PRINTSiPR02036. CHEMOTAXISIP.
PR02035. FLIPRCHIPS.
ProtoNetiSearch...

Entry informationi

Entry nameiCHIPS_STAAN
AccessioniPrimary (citable) accession number: Q99SU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.