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Q99SG3 (TENA_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative thiaminase-2
EC=3.5.99.2
Alternative name(s):
Thiaminase II
Gene names
Name:tenA
Ordered Locus Names:SAV2094
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.

Pathway

Cofactor metabolism; thiamine degradation; 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1.

Sequence similarities

Belongs to the thiaminase-2 family.

Ontologies

Keywords
   Biological processThiamine catabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthiamine catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionthiaminase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Putative thiaminase-2
PRO_0000293609

Sites

Active site1371Nucleophile By similarity
Binding site441Thiamine By similarity
Binding site1411Thiamine By similarity
Binding site1671Thiamine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99SG3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3D013A7D04082701

FASTA22926,729
        10         20         30         40         50         60 
MEFSQKLYQA AKPIINDIYE DDFIQKMLSG DIGADALRHY LKADAAYLKE FTNLYALLIP 

        70         80         90        100        110        120 
KMNSMNDVKF LVEQIEFMVE GEVLAHDILA QIVGESYEEI IKTKVWPPSG DHYIKHMYFQ 

       130        140        150        160        170        180 
AHSRENAIYT IAAMAPCPYI YAELAKRSQS DHKLNREKDT AKWFDFYSTE MDDIINVFEA 

       190        200        210        220 
LMNKLAESMS DKELEQVKQV FLESCIHERR FFNMAMTLEQ WEFGGKVND

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB58256.1.
RefSeqNP_372618.1. NC_002758.2.

3D structure databases

ProteinModelPortalQ99SG3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ99SG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000006416; EBSTAP00000006234; EBSTAG00000006415.
GeneID1122111.
GenomeReviewsGene locus SAV2094 in contig BA000017_GR.
KEGGsav:SAV2094.
PATRIC19565066. VBIStaAur52173_2168.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0819.
GeneTreeEBGT00050000025505.
HOGENOMHBG535447.
OMALLPCPWT.
PhylomeDBQ99SG3.
ProtClustDBCLSK885763.

Enzyme and pathway databases

BioCycSAUR158878:SAV2094-MONOMER.

Family and domain databases

InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. TENA/THI4/PQQ_synthPqqC_dom.
[Graphical view]
Gene3DG3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
KOK03707.
PfamPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMSSF48613. Heme_oxygenase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTENA_STAAM
AccessionPrimary (citable) accession number: Q99SG3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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