Q99SG2 (SCED_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable transglycosylase sceD
EC=3.2.-.-

Gene names

Name:	sceD
Ordered Locus Names:	SAV2095

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Is able to cleave peptidoglycan and affects clumping and separation of bacterial cells By similarity.
Subcellular location	Secreted By similarity.
Induction	Positively regulated by sigma B factor By similarity.
Sequence similarities	Belongs to the transglycosylase family. SceD subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity, acting on glycosyl bonds Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	By similarity
	Chain	28 – 231	204	Probable transglycosylase sceD		PRO_0000320313

Sequences

	Sequence		Length	Mass (Da)
	Q99SG2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D30E43170FE65583	FASTA	231	24,077
	10 20 30 40 50 60 MKKTLLASSL AVGLGIVAGN AGHEAHASEA DLNKASLAQM AQSNDQTLNQ KPIEAGAYNY 70 80 90 100 110 120 TFDYEGFTYH FESDGTHFAW NYHATGANGA NMSAQAPATN NVEPSAVQAN QVQSQEVEAP 130 140 150 160 170 180 QNAQTQQPQA STSNNSQVTA TPTESKASEG SSVNVNAHLK QIAQRESGGN IHAVNPTSGA 190 200 210 220 230 AGKYQFLQST WDSVAPAKYK GVSPANAPES VQDAAAVKLY NTGGAGHWVT A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.
[2]	"Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains." Drummelsmith J., Winstall E., Bergeron M.G., Poirier G.G., Ouellette M. J. Proteome Res. 6:4690-4702(2007) [PubMed: 17997515] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, MRNA EXPRESSION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB58257.1.
RefSeq	NP_372619.1. NC_002758.2.
3D structure databases
ProteinModelPortal	Q99SG2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q99SG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000007778; EBSTAP00000007596; EBSTAG00000007777.
GeneID	1122112.
GenomeReviews	Gene locus SAV2095 in contig BA000017_GR.
KEGG	sav:SAV2095.
PATRIC	19565070. VBIStaAur52173_2170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG144953.
GeneTree	EBGT00050000023704.
HOGENOM	HBG693910.
OMA	QSTTQEQ.
ProtClustDB	CLSK885764.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV2095-MONOMER.
Family and domain databases
InterPro	IPR010618. Transglycosylas. [Graphical view]
Pfam	PF06737. Transglycosylas. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCED_STAAM

Accession

Primary (citable) accession number: Q99SG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program