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Q99SE3

- PTPB_STAAM

UniProt

Q99SE3 - PTPB_STAAM

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Protein
Low molecular weight protein-tyrosine-phosphatase PtpB
Gene
ptpB, SAV2115
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Dephosphorylates the phosphotyrosine-containing proteins By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei7 – 71Nucleophile By similarity
Active sitei13 – 131 By similarity
Active sitei111 – 1111Proton donor By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-2174-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight protein-tyrosine-phosphatase PtpB (EC:3.1.3.48)
    Alternative name(s):
    Phosphotyrosine phosphatase B
    Short name:
    PTPase B
    Gene namesi
    Name:ptpB
    Ordered Locus Names:SAV2115
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Low molecular weight protein-tyrosine-phosphatase PtpB
    PRO_0000300675Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV2115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99SE3.
    SMRiQ99SE3. Positions 1-134.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273091.
    KOiK01104.
    OMAiPMAMALL.
    OrthoDBiEOG6MH5JB.
    PhylomeDBiQ99SE3.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99SE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILFVCTGN TCRSPLAESI AKEVMPNHQF ESRGIFAVNN QGVSNYVEDL    50
    VEEHHLAETT LSQQFTEADL KADIILTMSY SHKELIEAHF GLQNHVFTLH 100
    EYVKEAGEVI DPYGGTKEMY VHTYEELVSL ILKLKDIIC 139
    Length:139
    Mass (Da):15,788
    Last modified:June 1, 2001 - v1
    Checksum:i63EB2C0E2A53EA5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58277.1.
    RefSeqiNP_372639.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB58277; BAB58277; SAV2115.
    GeneIDi1122131.
    KEGGisav:SAV2115.
    PATRICi19565108. VBIStaAur52173_2189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58277.1 .
    RefSeqi NP_372639.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali Q99SE3.
    SMRi Q99SE3. Positions 1-134.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV2115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB58277 ; BAB58277 ; SAV2115 .
    GeneIDi 1122131.
    KEGGi sav:SAV2115.
    PATRICi 19565108. VBIStaAur52173_2189.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273091.
    KOi K01104.
    OMAi PMAMALL.
    OrthoDBi EOG6MH5JB.
    PhylomeDBi Q99SE3.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-2174-MONOMER.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiPTPB_STAAM
    AccessioniPrimary (citable) accession number: Q99SE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 1, 2001
    Last modified: July 9, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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