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Protein

Putative aldehyde dehydrogenase SAV2122

Gene

SAV2122

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei245By similarity1
Active sitei279By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 207NADBy similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase SAV2122 (EC:1.2.1.3)
Gene namesi
Ordered Locus Names:SAV2122
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002935561 – 475Putative aldehyde dehydrogenase SAV2122Add BLAST475

Proteomic databases

PaxDbiQ99SD6.
PRIDEiQ99SD6.

2D gel databases

World-2DPAGE0002:Q99SD6.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2122.

Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi12 – 15Combined sources4
Beta strandi17 – 19Combined sources3
Beta strandi21 – 25Combined sources5
Turni27 – 29Combined sources3
Beta strandi32 – 37Combined sources6
Helixi41 – 59Combined sources19
Helixi63 – 79Combined sources17
Helixi81 – 92Combined sources12
Helixi96 – 101Combined sources6
Helixi103 – 120Combined sources18
Beta strandi123 – 127Combined sources5
Beta strandi130 – 136Combined sources7
Beta strandi140 – 143Combined sources4
Beta strandi146 – 148Combined sources3
Helixi151 – 163Combined sources13
Beta strandi167 – 170Combined sources4
Helixi177 – 189Combined sources13
Turni193 – 195Combined sources3
Beta strandi196 – 198Combined sources3
Turni203 – 206Combined sources4
Helixi207 – 212Combined sources6
Beta strandi218 – 221Combined sources4
Helixi225 – 228Combined sources4
Turni235 – 239Combined sources5
Beta strandi241 – 243Combined sources3
Beta strandi251 – 254Combined sources4
Helixi260 – 272Combined sources13
Helixi273 – 276Combined sources4
Beta strandi284 – 288Combined sources5
Turni289 – 291Combined sources3
Helixi292 – 304Combined sources13
Helixi324 – 340Combined sources17
Beta strandi343 – 346Combined sources4
Beta strandi364 – 368Combined sources5
Helixi374 – 377Combined sources4
Beta strandi382 – 392Combined sources11
Helixi393 – 400Combined sources8
Beta strandi407 – 412Combined sources6
Helixi416 – 425Combined sources10
Beta strandi428 – 433Combined sources6
Helixi462 – 464Combined sources3
Beta strandi465 – 471Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TY7X-ray2.40A/B1-475[»]
ProteinModelPortaliQ99SD6.
SMRiQ99SD6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99SD6.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271505.
KOiK00128.
OMAiINEDHNA.
PhylomeDBiQ99SD6.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99SD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA
60 70 80 90 100
ADDVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE
110 120 130 140 150
RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPNK IKDAFLAELK
310 320 330 340 350
EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS
460 470
GLGREWGDYG IEEFLEVKSI AGYFK
Length:475
Mass (Da):51,969
Last modified:June 1, 2001 - v1
Checksum:i03C66ED0B87BC09A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58284.1.
RefSeqiWP_001206093.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58284; BAB58284; SAV2122.
GeneIDi28380292.
KEGGisav:SAV2122.
PATRICi19565122. VBIStaAur52173_2196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58284.1.
RefSeqiWP_001206093.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TY7X-ray2.40A/B1-475[»]
ProteinModelPortaliQ99SD6.
SMRiQ99SD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2122.

2D gel databases

World-2DPAGE0002:Q99SD6.

Proteomic databases

PaxDbiQ99SD6.
PRIDEiQ99SD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58284; BAB58284; SAV2122.
GeneIDi28380292.
KEGGisav:SAV2122.
PATRICi19565122. VBIStaAur52173_2196.

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271505.
KOiK00128.
OMAiINEDHNA.
PhylomeDBiQ99SD6.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2170-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ99SD6.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALD1_STAAM
AccessioniPrimary (citable) accession number: Q99SD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.