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Q99SD6

- ALD1_STAAM

UniProt

Q99SD6 - ALD1_STAAM

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Protein

Putative aldehyde dehydrogenase SAV2122

Gene

SAV2122

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei245 – 2451By similarity
Active sitei279 – 2791By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2077NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase SAV2122 (EC:1.2.1.3)
Gene namesi
Ordered Locus Names:SAV2122
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Putative aldehyde dehydrogenase SAV2122PRO_0000293556Add
BLAST

Proteomic databases

PRIDEiQ99SD6.

2D gel databases

World-2DPAGE0002:Q99SD6.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2122.

Structurei

Secondary structure

1
475
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94
Beta strandi12 – 154
Beta strandi17 – 193
Beta strandi21 – 255
Turni27 – 293
Beta strandi32 – 376
Helixi41 – 5919
Helixi63 – 7917
Helixi81 – 9212
Helixi96 – 1016
Helixi103 – 12018
Beta strandi123 – 1275
Beta strandi130 – 1367
Beta strandi140 – 1434
Beta strandi146 – 1483
Helixi151 – 16313
Beta strandi167 – 1704
Helixi177 – 18913
Turni193 – 1953
Beta strandi196 – 1983
Turni203 – 2064
Helixi207 – 2126
Beta strandi218 – 2214
Helixi225 – 2284
Turni235 – 2395
Beta strandi241 – 2433
Beta strandi251 – 2544
Helixi260 – 27213
Helixi273 – 2764
Beta strandi284 – 2885
Turni289 – 2913
Helixi292 – 30413
Helixi324 – 34017
Beta strandi343 – 3464
Beta strandi364 – 3685
Helixi374 – 3774
Beta strandi382 – 39211
Helixi393 – 4008
Beta strandi407 – 4126
Helixi416 – 42510
Beta strandi428 – 4336
Helixi462 – 4643
Beta strandi465 – 4717

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TY7X-ray2.40A/B1-475[»]
ProteinModelPortaliQ99SD6.
SMRiQ99SD6. Positions 1-475.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99SD6.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiIDENRAA.
OrthoDBiEOG6BS8QW.
PhylomeDBiQ99SD6.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99SD6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA
60 70 80 90 100
ADDVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE
110 120 130 140 150
RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPNK IKDAFLAELK
310 320 330 340 350
EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS
460 470
GLGREWGDYG IEEFLEVKSI AGYFK
Length:475
Mass (Da):51,969
Last modified:June 1, 2001 - v1
Checksum:i03C66ED0B87BC09A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58284.1.
RefSeqiNP_372646.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58284; BAB58284; SAV2122.
GeneIDi1122138.
KEGGisav:SAV2122.
PATRICi19565122. VBIStaAur52173_2196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58284.1 .
RefSeqi NP_372646.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TY7 X-ray 2.40 A/B 1-475 [» ]
ProteinModelPortali Q99SD6.
SMRi Q99SD6. Positions 1-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV2122.

2D gel databases

World-2DPAGE 0002:Q99SD6.

Proteomic databases

PRIDEi Q99SD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB58284 ; BAB58284 ; SAV2122 .
GeneIDi 1122138.
KEGGi sav:SAV2122.
PATRICi 19565122. VBIStaAur52173_2196.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00128.
OMAi IDENRAA.
OrthoDBi EOG6BS8QW.
PhylomeDBi Q99SD6.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-2181-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q99SD6.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiALD1_STAAM
AccessioniPrimary (citable) accession number: Q99SD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3