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Q99SD6

- ALD1_STAAM

UniProt

Q99SD6 - ALD1_STAAM

Protein

Putative aldehyde dehydrogenase SAV2122

Gene

SAV2122

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei245 – 2451By similarity
    Active sitei279 – 2791By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2077NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-2181-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aldehyde dehydrogenase SAV2122 (EC:1.2.1.3)
    Gene namesi
    Ordered Locus Names:SAV2122
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Putative aldehyde dehydrogenase SAV2122PRO_0000293556Add
    BLAST

    Proteomic databases

    PRIDEiQ99SD6.

    2D gel databases

    World-2DPAGE0002:Q99SD6.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV2122.

    Structurei

    Secondary structure

    1
    475
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 94
    Beta strandi12 – 154
    Beta strandi17 – 193
    Beta strandi21 – 255
    Turni27 – 293
    Beta strandi32 – 376
    Helixi41 – 5919
    Helixi63 – 7917
    Helixi81 – 9212
    Helixi96 – 1016
    Helixi103 – 12018
    Beta strandi123 – 1275
    Beta strandi130 – 1367
    Beta strandi140 – 1434
    Beta strandi146 – 1483
    Helixi151 – 16313
    Beta strandi167 – 1704
    Helixi177 – 18913
    Turni193 – 1953
    Beta strandi196 – 1983
    Turni203 – 2064
    Helixi207 – 2126
    Beta strandi218 – 2214
    Helixi225 – 2284
    Turni235 – 2395
    Beta strandi241 – 2433
    Beta strandi251 – 2544
    Helixi260 – 27213
    Helixi273 – 2764
    Beta strandi284 – 2885
    Turni289 – 2913
    Helixi292 – 30413
    Helixi324 – 34017
    Beta strandi343 – 3464
    Beta strandi364 – 3685
    Helixi374 – 3774
    Beta strandi382 – 39211
    Helixi393 – 4008
    Beta strandi407 – 4126
    Helixi416 – 42510
    Beta strandi428 – 4336
    Helixi462 – 4643
    Beta strandi465 – 4717

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TY7X-ray2.40A/B1-475[»]
    ProteinModelPortaliQ99SD6.
    SMRiQ99SD6. Positions 1-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99SD6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.
    OMAiIDENRAA.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiQ99SD6.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99SD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA    50
    ADDVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE 100
    RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT 150
    NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN 200
    GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS 250
    PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPNK IKDAFLAELK 300
    EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG 350
    KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA 400
    NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS 450
    GLGREWGDYG IEEFLEVKSI AGYFK 475
    Length:475
    Mass (Da):51,969
    Last modified:June 1, 2001 - v1
    Checksum:i03C66ED0B87BC09A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58284.1.
    RefSeqiNP_372646.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB58284; BAB58284; SAV2122.
    GeneIDi1122138.
    KEGGisav:SAV2122.
    PATRICi19565122. VBIStaAur52173_2196.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58284.1 .
    RefSeqi NP_372646.1. NC_002758.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TY7 X-ray 2.40 A/B 1-475 [» ]
    ProteinModelPortali Q99SD6.
    SMRi Q99SD6. Positions 1-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV2122.

    2D gel databases

    World-2DPAGE 0002:Q99SD6.

    Proteomic databases

    PRIDEi Q99SD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB58284 ; BAB58284 ; SAV2122 .
    GeneIDi 1122138.
    KEGGi sav:SAV2122.
    PATRICi 19565122. VBIStaAur52173_2196.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.
    OMAi IDENRAA.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi Q99SD6.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-2181-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q99SD6.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiALD1_STAAM
    AccessioniPrimary (citable) accession number: Q99SD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3