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Protein

4,4'-diaponeurosporen-aldehyde dehydrogenase

Gene

aldH

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'-diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid.By similarity

Catalytic activityi

4,4'-diaponeurosporenal + NAD+ + H2O = 4,4'-diaponeurosporenoate + NADH.By similarity

Pathwayi: staphyloxanthin biosynthesis

This protein is involved in the subpathway that synthesizes staphyloxanthin from farnesyl diphosphate.By similarity This subpathway is part of the pathway staphyloxanthin biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway staphyloxanthin biosynthesis and in Carotenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei245Proton acceptorBy similarity1
Binding sitei246NAD; via carbonyl oxygenBy similarity1
Active sitei279NucleophileBy similarity1
Binding sitei379NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi146 – 147NADBy similarity2
Nucleotide bindingi223 – 224NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarotenoid biosynthesis, Virulence
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
4,4'-diaponeurosporen-aldehyde dehydrogenaseBy similarity (EC:1.2.1.-By similarity)
Alternative name(s):
4,4'-diaponeurosporenal dehydrogenaseBy similarity
Gene namesi
Name:aldHBy similarity
Ordered Locus Names:SAV2122
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002935561 – 4754,4'-diaponeurosporen-aldehyde dehydrogenaseAdd BLAST475

Proteomic databases

PaxDbiQ99SD6

2D gel databases

World-2DPAGEi0002:Q99SD6

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi158878.SAV2122

Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi12 – 15Combined sources4
Beta strandi17 – 19Combined sources3
Beta strandi21 – 25Combined sources5
Turni27 – 29Combined sources3
Beta strandi32 – 37Combined sources6
Helixi41 – 59Combined sources19
Helixi63 – 79Combined sources17
Helixi81 – 92Combined sources12
Helixi96 – 101Combined sources6
Helixi103 – 120Combined sources18
Beta strandi123 – 127Combined sources5
Beta strandi130 – 136Combined sources7
Beta strandi140 – 143Combined sources4
Beta strandi146 – 148Combined sources3
Helixi151 – 163Combined sources13
Beta strandi167 – 170Combined sources4
Helixi177 – 189Combined sources13
Turni193 – 195Combined sources3
Beta strandi196 – 198Combined sources3
Turni203 – 206Combined sources4
Helixi207 – 212Combined sources6
Beta strandi218 – 221Combined sources4
Helixi225 – 228Combined sources4
Turni235 – 239Combined sources5
Beta strandi241 – 243Combined sources3
Beta strandi251 – 254Combined sources4
Helixi260 – 272Combined sources13
Helixi273 – 276Combined sources4
Beta strandi284 – 288Combined sources5
Turni289 – 291Combined sources3
Helixi292 – 304Combined sources13
Helixi324 – 340Combined sources17
Beta strandi343 – 346Combined sources4
Beta strandi364 – 368Combined sources5
Helixi374 – 377Combined sources4
Beta strandi382 – 392Combined sources11
Helixi393 – 400Combined sources8
Beta strandi407 – 412Combined sources6
Helixi416 – 425Combined sources10
Beta strandi428 – 433Combined sources6
Helixi462 – 464Combined sources3
Beta strandi465 – 471Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TY7X-ray2.40A/B1-475[»]
ProteinModelPortaliQ99SD6
SMRiQ99SD6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99SD6

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00128
OMAiRHVMIKH
PhylomeDBiQ99SD6

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q99SD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA
60 70 80 90 100
ADDVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE
110 120 130 140 150
RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPNK IKDAFLAELK
310 320 330 340 350
EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS
460 470
GLGREWGDYG IEEFLEVKSI AGYFK
Length:475
Mass (Da):51,969
Last modified:June 1, 2001 - v1
Checksum:i03C66ED0B87BC09A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58284.1
RefSeqiWP_001206093.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB58284; BAB58284; SAV2122
KEGGisav:SAV2122

Similar proteinsi

Entry informationi

Entry nameiALDH_STAAM
AccessioniPrimary (citable) accession number: Q99SD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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