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Protein

Oxygen regulatory protein NreC

Gene

nreC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi172 – 191H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen regulatory protein NreC
Alternative name(s):
Nitrogen regulation protein C
Gene namesi
Name:nreC
Ordered Locus Names:SAV2391
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

Q99RN8:

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493491 – 217Oxygen regulatory protein NreCAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by NreB.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99RN8.
PRIDEiQ99RN8.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2391.

Structurei

3D structure databases

ProteinModelPortaliQ99RN8.
SMRiQ99RN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini148 – 213HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
HOGENOMiHOG000034813.
KOiK07696.
OMAiSHKTRIM.
PhylomeDBiQ99RN8.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
cd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99RN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL
60 70 80 90 100
LMDLSMPPGE SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG
110 120 130 140 150
YILKNAPDEQ LLLAIRTVYK GETYVDMKLT TSLVNEFVSN SNQDTANTTD
160 170 180 190 200
PFKILSKREL EILPLIAKGY GNKEIAEKLF VSVKTVEAHK THIMTKLGLK
210
SKPELVEYAL KKKLLEF
Length:217
Mass (Da):24,368
Last modified:June 1, 2001 - v1
Checksum:iDDF2969C5B277320
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58553.1.
RefSeqiWP_000706315.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58553; BAB58553; SAV2391.
KEGGisav:SAV2391.

Similar proteinsi

Entry informationi

Entry nameiNREC_STAAM
AccessioniPrimary (citable) accession number: Q99RN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome