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Q99RD4

- GTAB_STAAM

UniProt

Q99RD4 - GTAB_STAAM

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

gtaB

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.By similarity

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. enterobacterial common antigen biosynthetic process Source: UniProtKB-UniPathway
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-2568-MONOMER.
    UniPathwayiUPA00894.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Uridine diphosphoglucose pyrophosphorylase
    Gene namesi
    Name:gtaB
    Ordered Locus Names:SAV2500
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288UTP--glucose-1-phosphate uridylyltransferasePRO_0000308305Add
    BLAST

    Proteomic databases

    PRIDEiQ99RD4.

    2D gel databases

    World-2DPAGE0002:Q99RD4.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV2500.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99RD4.
    SMRiQ99RD4. Positions 1-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG1210.
    HOGENOMiHOG000283477.
    KOiK00963.
    OMAiKLIDECS.
    OrthoDBiEOG6Z9B3V.
    PhylomeDBiQ99RD4.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01099. galU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99RD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI    50
    EDIIIVTGRH KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF 100
    YVRQKEQKGL GHAISSARQF IGNEPFAVLL GDDIVESEVP AVKQLIDVYE 150
    ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG RQYEVKKFVE KPAQGTAPSN 200
    LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND NQVYAYDFEG 250
    ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKALGL 288
    Length:288
    Mass (Da):32,451
    Last modified:June 1, 2001 - v1
    Checksum:i126BF005599D4418
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58662.1.
    RefSeqiNP_373024.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB58662; BAB58662; SAV2500.
    GeneIDi1122525.
    KEGGisav:SAV2500.
    PATRICi19565928. VBIStaAur52173_2590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB58662.1 .
    RefSeqi NP_373024.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali Q99RD4.
    SMRi Q99RD4. Positions 1-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV2500.

    2D gel databases

    World-2DPAGE 0002:Q99RD4.

    Proteomic databases

    PRIDEi Q99RD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB58662 ; BAB58662 ; SAV2500 .
    GeneIDi 1122525.
    KEGGi sav:SAV2500.
    PATRICi 19565928. VBIStaAur52173_2590.

    Phylogenomic databases

    eggNOGi COG1210.
    HOGENOMi HOG000283477.
    KOi K00963.
    OMAi KLIDECS.
    OrthoDBi EOG6Z9B3V.
    PhylomeDBi Q99RD4.

    Enzyme and pathway databases

    UniPathwayi UPA00894 .
    BioCyci SAUR158878:GJJ5-2568-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01099. galU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiGTAB_STAAM
    AccessioniPrimary (citable) accession number: Q99RD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3