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Protein
Submitted name:

3-hydroxy-3-methylglutaryl CoA synthase

Gene

mvaS

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA synthase activity Source: InterPro

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2614-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl CoA synthaseImported
Gene namesi
Name:mvaSImported
Ordered Locus Names:SAV2546Imported
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481 Componenti: Chromosome

PTM / Processingi

2D gel databases

World-2DPAGE0002:Q99R90.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2546.

Structurei

3D structure databases

ProteinModelPortaliQ99R90.
SMRiQ99R90. Positions 2-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG3425.
KOiK01641.
OMAiACFGLTA.
OrthoDBiEOG6HXJ54.
PhylomeDBiQ99R90.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR011554. HMG_CoA_synthase_prok.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 2 hits.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01835. HMG-CoA-S_prok. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99R90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIGIDKINF YVPKYYVDMA KLAEARQVDP NKFLIGIGQT EMAVSPVNQD
60 70 80 90 100
IVSMGANAAK DIITDEDKKK IGMVIVATES AVDAAKAAAV QIHNLLGIQP
110 120 130 140 150
FARCFEMKEA CYAATPAIQL AKDYLATRPN EKVLVIATDT ARYGLNSGGE
160 170 180 190 200
PTQGAGAVAM VIAHNPSILA LNEDAVAYTE DVYDFWRPTG HKYPLVDGAL
210 220 230 240 250
SKDAYIRSFQ QSWNEYAKRQ GKSLADFASL CFHVPFTKMG KKALESIIDN
260 270 280 290 300
ADETTQERLR SGYEDAVDYN RYVGNIYTGS LYLSLISLLE NRDLQAGETI
310 320 330 340 350
GLFSYGSGSV GEFYSATLVE GYKDHLDQAA HKALLNNRTE VSVDAYETFF
360 370 380
KRFDDVEFDE EQDAVHEDRH IFYLSNIENN VREYHRPE
Length:388
Mass (Da):43,206
Last modified:June 1, 2001 - v1
Checksum:iDB97F07344F353FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58708.1.
PIRiC90059.
RefSeqiNP_373070.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58708; BAB58708; SAV2546.
KEGGisav:SAV2546.
PATRICi19566024. VBIStaAur52173_2638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58708.1.
PIRiC90059.
RefSeqiNP_373070.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ99R90.
SMRiQ99R90. Positions 2-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2546.

2D gel databases

World-2DPAGE0002:Q99R90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58708; BAB58708; SAV2546.
KEGGisav:SAV2546.
PATRICi19566024. VBIStaAur52173_2638.

Phylogenomic databases

eggNOGiCOG3425.
KOiK01641.
OMAiACFGLTA.
OrthoDBiEOG6HXJ54.
PhylomeDBiQ99R90.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2614-MONOMER.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR011554. HMG_CoA_synthase_prok.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 2 hits.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01835. HMG-CoA-S_prok. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699Imported.

Entry informationi

Entry nameiQ99R90_STAAM
AccessioniPrimary (citable) accession number: Q99R90
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.