ID   ARCR_STAAM              Reviewed;         234 AA.
AC   Q99R06;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 134.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SAV2631;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BA000017; BAB58793.1; -; Genomic_DNA.
DR   RefSeq; WP_000138218.1; NC_002758.2.
DR   AlphaFoldDB; Q99R06; -.
DR   SMR; Q99R06; -.
DR   KEGG; sav:SAV2631; -.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   PhylomeDB; Q99R06; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   3: Inferred from homology;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349411"
FT   DOMAIN          155..228
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        188..207
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   BINDING         40..129
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   234 AA;  27428 MW;  A63E59D8A1ED4E1E CRC64;
     MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY
     FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM
     AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLLCHLCQ TVGYDQDEFY
     EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
//