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Q99R06

- ARCR_STAAM

UniProt

Q99R06 - ARCR_STAAM

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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 12990cNMPAdd
BLAST
DNA bindingi188 – 20720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SAV2631
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234HTH-type transcriptional regulator ArcRPRO_0000349411Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2631.

Structurei

3D structure databases

ProteinModelPortaliQ99R06.
SMRiQ99R06. Positions 31-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 22874HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000022896.
OMAiERVNQNG.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99R06 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY
60 70 80 90 100
FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV
110 120 130 140 150
NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM
160 170 180 190 200
ALTSKFAKDR IIKLLCHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE
210 220 230
TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
Length:234
Mass (Da):27,428
Last modified:June 1, 2001 - v1
Checksum:iA63E59D8A1ED4E1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58793.1.
RefSeqiNP_373155.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58793; BAB58793; SAV2631.
GeneIDi1122656.
KEGGisav:SAV2631.
PATRICi19566202. VBIStaAur52173_2727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58793.1 .
RefSeqi NP_373155.1. NC_002758.2.

3D structure databases

ProteinModelPortali Q99R06.
SMRi Q99R06. Positions 31-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV2631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB58793 ; BAB58793 ; SAV2631 .
GeneIDi 1122656.
KEGGi sav:SAV2631.
PATRICi 19566202. VBIStaAur52173_2727.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000022896.
OMAi ERVNQNG.
OrthoDBi EOG6QRWC5.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-2699-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiARCR_STAAM
AccessioniPrimary (citable) accession number: Q99R06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3