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Q99R06 (ARCR_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional regulator ArcR
Gene names
Name:arcR
Ordered Locus Names:SAV2631
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   LigandcAMP
cAMP-binding
DNA-binding
Nucleotide-binding
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

cAMP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234HTH-type transcriptional regulator ArcR
PRO_0000349411

Regions

Domain155 – 22874HTH crp-type
Nucleotide binding40 – 12990cNMP
DNA binding188 – 20720H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99R06 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A63E59D8A1ED4E1E

FASTA23427,428
        10         20         30         40         50         60 
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY 

        70         80         90        100        110        120 
FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM 

       130        140        150        160        170        180 
AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLLCHLCQ TVGYDQDEFY 

       190        200        210        220        230 
EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000017 Genomic DNA. Translation: BAB58793.1.
RefSeqNP_373155.1. NC_002758.2.

3D structure databases

ProteinModelPortalQ99R06.
SMRQ99R06. Positions 31-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158878.SAV2631.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB58793; BAB58793; SAV2631.
GeneID1122656.
KEGGsav:SAV2631.
PATRIC19566202. VBIStaAur52173_2727.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000022896.
OMAERVNQNG.
OrthoDBEOG6QRWC5.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-2699-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARCR_STAAM
AccessionPrimary (citable) accession number: Q99R06
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families