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Protein

Kinesin-like protein KIF17

Gene

Kif17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 98ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cell projection organization Source: GO_Central
  • intraciliary transport Source: MGI
  • microtubule-based movement Source: GO_Central
  • microtubule-based process Source: MGI
  • neurogenesis Source: GO_Central
  • protein complex localization Source: MGI
  • vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF17
Short name:
MmKIF17
Gene namesi
Name:Kif17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098229. Kif17.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: MGI
  • ciliary basal body Source: MGI
  • cilium Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • intraciliary transport particle B Source: MGI
  • kinesin complex Source: MGI
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: MGI
  • periciliary membrane compartment Source: MGI
  • photoreceptor connecting cilium Source: MGI
  • photoreceptor inner segment Source: GOC-OWL
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254511 – 1038Kinesin-like protein KIF17Add BLAST1038

Proteomic databases

MaxQBiQ99PW8.
PaxDbiQ99PW8.
PRIDEiQ99PW8.

PTM databases

iPTMnetiQ99PW8.
PhosphoSitePlusiQ99PW8.

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiENSMUSG00000028758.
CleanExiMM_KIF17.
ExpressionAtlasiQ99PW8. baseline and differential.
GenevisibleiQ99PW8. MM.

Interactioni

Subunit structurei

Interacts with LIN-10 PDZ domain. Interacts with PIWIL1. Interacts with TBATA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnd2Q9Z0V23EBI-959754,EBI-959779

Protein-protein interaction databases

BioGridi200934. 1 interactor.
DIPiDIP-36586N.
IntActiQ99PW8. 2 interactors.
MINTiMINT-134710.
STRINGi10090.ENSMUSP00000030539.

Structurei

3D structure databases

ProteinModelPortaliQ99PW8.
SMRiQ99PW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 335Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 470Sequence analysisAdd BLAST125
Coiled coili748 – 855Sequence analysisAdd BLAST108

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiQ99PW8.
KOiK20198.
OMAiILAQQMG.
OrthoDBiEOG091G03RO.
PhylomeDBiQ99PW8.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASESVKVVV RCRPMNKRER ELSCQSVVTV DSARGQCFIQ NPGAADEPPK
60 70 80 90 100
QFTFDGAYYI EHFTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT
110 120 130 140 150
MQGLPDPPCQ RGIIPRAFEH VFESVQCAEN TKFLVRASYL EIYNEDVHDL
160 170 180 190 200
LGADTKQRLE LKEHPEKGVY VKGLSMHTVH NVAQCERVME TGWKNRAVGY
210 220 230 240 250
TLMNKDSSRS HSIFTINIEI YAVDERGKDH LRAGKLNLVD LAGSERQSKT
260 270 280 290 300
GATGERLKEA TKINLSLSAL GNVISALVDG RCKHIPYRDS KLTRLLQDSL
310 320 330 340 350
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIKNKPR INEDPKDALL
360 370 380 390 400
REYQEEIKRL KAILAQQMGP GNLSALLSTQ TPPGPVQSEE KLLSPTTVQQ
410 420 430 440 450
DTEAEKQLIR EEYEERLARL KADYEAEQES RVRLQEDITA MRNSYDVKLS
460 470 480 490 500
TLQENLRKEK ETEAILKAEV LCKTEVMSRA ELASGPEYSP PLQYETAVKP
510 520 530 540 550
TILSMPDMPP SGKVTKSQAP LAFEEPHGET SRSEFSFESN ECSTLEDSAT
560 570 580 590 600
SEAFPGPEEF SNMEFSMAAA LTESRYLPEE YLGGQEAAAS PLEAERYVQE
610 620 630 640 650
NEPSLEPLRI LASLQDPFAE VEAKLARLSS TVAMSDSSQT VVPQIPKQPS
660 670 680 690 700
SADLLEPSDT KSEADVAVAD NVVLGTEPDV NLRVAEEVVS EAETGVWMES
710 720 730 740 750
EAQVAHVAQV SEEAQPQPLL AMVSVRRESV GVEVAVLTEE ELQPVDQQQV
760 770 780 790 800
LARLQLLEQQ VVGGEQAKNK DLREKHKRRK RYADERKKQL VAALQNSDED
810 820 830 840 850
GGDWVLLNVY DSIQEEVRAK SKLLEKMQRK LRAAEVEIKD LQSEFQLEKI
860 870 880 890 900
DYLATIRRQE RDSMLFQQLL EQVQPLIRRD CNYSNLEKIR RESSWDEDNG
910 920 930 940 950
FWKIPDPIIL KTSLPVVPTG TQNKPARKTS AVDSGEPHMQ EEDRYKLMLS
960 970 980 990 1000
RSDSENIASN YFRSKRASQI LSTDPMKSLT YHNSPPGLNS SLSNNSALPP
1010 1020 1030
TQTPEMPQPR PFRLESLDIP FSKAKRKKSK NSFGGEPL
Length:1,038
Mass (Da):116,373
Last modified:June 1, 2001 - v1
Checksum:i2BED852A3AFDBD46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008867 mRNA. Translation: BAB21099.1.
AL807249 Genomic DNA. Translation: CAM18869.1.
CCDSiCCDS18823.1.
RefSeqiNP_034753.1. NM_010623.4.
UniGeneiMm.271936.

Genome annotation databases

EnsembliENSMUST00000030539; ENSMUSP00000030539; ENSMUSG00000028758.
GeneIDi16559.
KEGGimmu:16559.
UCSCiuc008vkq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008867 mRNA. Translation: BAB21099.1.
AL807249 Genomic DNA. Translation: CAM18869.1.
CCDSiCCDS18823.1.
RefSeqiNP_034753.1. NM_010623.4.
UniGeneiMm.271936.

3D structure databases

ProteinModelPortaliQ99PW8.
SMRiQ99PW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200934. 1 interactor.
DIPiDIP-36586N.
IntActiQ99PW8. 2 interactors.
MINTiMINT-134710.
STRINGi10090.ENSMUSP00000030539.

PTM databases

iPTMnetiQ99PW8.
PhosphoSitePlusiQ99PW8.

Proteomic databases

MaxQBiQ99PW8.
PaxDbiQ99PW8.
PRIDEiQ99PW8.

Protocols and materials databases

DNASUi16559.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030539; ENSMUSP00000030539; ENSMUSG00000028758.
GeneIDi16559.
KEGGimmu:16559.
UCSCiuc008vkq.2. mouse.

Organism-specific databases

CTDi57576.
MGIiMGI:1098229. Kif17.

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiQ99PW8.
KOiK20198.
OMAiILAQQMG.
OrthoDBiEOG091G03RO.
PhylomeDBiQ99PW8.
TreeFamiTF105223.

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ99PW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028758.
CleanExiMM_KIF17.
ExpressionAtlasiQ99PW8. baseline and differential.
GenevisibleiQ99PW8. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF17_MOUSE
AccessioniPrimary (citable) accession number: Q99PW8
Secondary accession number(s): A2AM73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.