Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Follistatin-related protein 3

Gene

Fstl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processOsteogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-2473224 Antagonism of Activin by Follistatin
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI01.968

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 3
Alternative name(s):
Follistatin-like protein 3
Follistatin-related gene protein
Gene namesi
Name:Fstl3
Synonyms:Flrg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621811 Fstl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001011724 – 256Follistatin-related protein 3Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 59PROSITE-ProRule annotation
Disulfide bondi46 ↔ 90PROSITE-ProRule annotation
Disulfide bondi60 ↔ 93PROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi119 ↔ 151PROSITE-ProRule annotation
Disulfide bondi123 ↔ 144PROSITE-ProRule annotation
Disulfide bondi133 ↔ 165PROSITE-ProRule annotation
Disulfide bondi193 ↔ 227PROSITE-ProRule annotation
Disulfide bondi198 ↔ 220PROSITE-ProRule annotation
Disulfide bondi209 ↔ 241PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99PW7

PTM databases

PhosphoSitePlusiQ99PW7

Expressioni

Gene expression databases

BgeeiENSRNOG00000009311
GenevisibleiQ99PW7 RN

Interactioni

Subunit structurei

Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012578

Structurei

3D structure databases

ProteinModelPortaliQ99PW7
SMRiQ99PW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 105TBPROSITE-ProRule annotationAdd BLAST72
Domaini97 – 117Follistatin-like 1Add BLAST21
Domaini111 – 167Kazal-like 1PROSITE-ProRule annotationAdd BLAST57
Domaini168 – 191Follistatin-like 2Add BLAST24
Domaini187 – 243Kazal-like 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiQ99PW7
OMAiHCLPCKD
OrthoDBiEOG091G09I0
PhylomeDBiQ99PW7
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00274 FOLN, 2 hits
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 2 hits
PS51364 TB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPGALWPLL WGALVWAVGS VGAVMGSGDS VPGGVCWLQQ GKEATCSLVL
60 70 80 90 100
KTQVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV
110 120 130 140 150
ECGPGKACRM LGGRPHCECV SNCEGVPAGF QVCGSDGATY RDECELRTAR
160 170 180 190 200
CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPV
210 220 230 240 250
PPNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAE

EEENFV
Length:256
Mass (Da):27,109
Last modified:June 1, 2001 - v1
Checksum:iC8464166C0A1D56F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021295 mRNA Translation: BAB32664.1
AB071603 mRNA Translation: BAC16229.1
RefSeqiNP_446081.1, NM_053629.3
UniGeneiRn.48835

Genome annotation databases

EnsembliENSRNOT00000012578; ENSRNOP00000012578; ENSRNOG00000009311
GeneIDi114031
KEGGirno:114031
UCSCiRGD:621811 rat

Similar proteinsi

Entry informationi

Entry nameiFSTL3_RAT
AccessioniPrimary (citable) accession number: Q99PW7
Secondary accession number(s): Q54A93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health