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Protein

Follistatin-related protein 3

Gene

Fstl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Osteogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-2473224. Antagonism of Activin by Follistatin.

Protein family/group databases

MEROPSiI01.968.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 3
Alternative name(s):
Follistatin-like protein 3
Follistatin-related gene protein
Gene namesi
Name:Fstl3
Synonyms:Flrg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621811. Fstl3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • Golgi apparatus Source: RGD
  • neuron projection terminus Source: RGD
  • nucleoplasm Source: Ensembl
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001011724 – 256Follistatin-related protein 3Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 59PROSITE-ProRule annotation
Disulfide bondi46 ↔ 90PROSITE-ProRule annotation
Disulfide bondi60 ↔ 93PROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi119 ↔ 151PROSITE-ProRule annotation
Disulfide bondi123 ↔ 144PROSITE-ProRule annotation
Disulfide bondi133 ↔ 165PROSITE-ProRule annotation
Disulfide bondi193 ↔ 227PROSITE-ProRule annotation
Disulfide bondi198 ↔ 220PROSITE-ProRule annotation
Disulfide bondi209 ↔ 241PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99PW7.

PTM databases

PhosphoSitePlusiQ99PW7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009311.
GenevisibleiQ99PW7. RN.

Interactioni

Subunit structurei

Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012578.

Structurei

3D structure databases

ProteinModelPortaliQ99PW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 105TBPROSITE-ProRule annotationAdd BLAST72
Domaini97 – 117Follistatin-like 1Add BLAST21
Domaini111 – 167Kazal-like 1PROSITE-ProRule annotationAdd BLAST57
Domaini168 – 191Follistatin-like 2Add BLAST24
Domaini187 – 243Kazal-like 2PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Contains 2 follistatin-like domains.Curated
Contains 2 Kazal-like domains.PROSITE-ProRule annotation
Contains 1 TB (TGF-beta binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00440000033501.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiQ99PW7.
OMAiLPCKDSC.
OrthoDBiEOG091G09I0.
PhylomeDBiQ99PW7.
TreeFamiTF106409.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00274. FOLN. 2 hits.
SM00280. KAZAL. 2 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 2 hits.
PS51364. TB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPGALWPLL WGALVWAVGS VGAVMGSGDS VPGGVCWLQQ GKEATCSLVL
60 70 80 90 100
KTQVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV
110 120 130 140 150
ECGPGKACRM LGGRPHCECV SNCEGVPAGF QVCGSDGATY RDECELRTAR
160 170 180 190 200
CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPV
210 220 230 240 250
PPNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAE

EEENFV
Length:256
Mass (Da):27,109
Last modified:June 1, 2001 - v1
Checksum:iC8464166C0A1D56F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021295 mRNA. Translation: BAB32664.1.
AB071603 mRNA. Translation: BAC16229.1.
RefSeqiNP_446081.1. NM_053629.3.
UniGeneiRn.48835.

Genome annotation databases

EnsembliENSRNOT00000012578; ENSRNOP00000012578; ENSRNOG00000009311.
GeneIDi114031.
KEGGirno:114031.
UCSCiRGD:621811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021295 mRNA. Translation: BAB32664.1.
AB071603 mRNA. Translation: BAC16229.1.
RefSeqiNP_446081.1. NM_053629.3.
UniGeneiRn.48835.

3D structure databases

ProteinModelPortaliQ99PW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012578.

Protein family/group databases

MEROPSiI01.968.

PTM databases

PhosphoSitePlusiQ99PW7.

Proteomic databases

PaxDbiQ99PW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012578; ENSRNOP00000012578; ENSRNOG00000009311.
GeneIDi114031.
KEGGirno:114031.
UCSCiRGD:621811. rat.

Organism-specific databases

CTDi10272.
RGDi621811. Fstl3.

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00440000033501.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiQ99PW7.
OMAiLPCKDSC.
OrthoDBiEOG091G09I0.
PhylomeDBiQ99PW7.
TreeFamiTF106409.

Enzyme and pathway databases

ReactomeiR-RNO-2473224. Antagonism of Activin by Follistatin.

Miscellaneous databases

PROiQ99PW7.

Gene expression databases

BgeeiENSRNOG00000009311.
GenevisibleiQ99PW7. RN.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00274. FOLN. 2 hits.
SM00280. KAZAL. 2 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 2 hits.
PS51364. TB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSTL3_RAT
AccessioniPrimary (citable) accession number: Q99PW7
Secondary accession number(s): Q54A93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.