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Protein

Sialidase-3

Gene

Neu3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstrateBy similarity1
Binding sitei45SubstrateBy similarity1
Active sitei50Proton acceptorBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei243SubstrateSequence analysis1
Binding sitei339SubstrateBy similarity1
Active sitei369NucleophileBy similarity1
Active sitei386Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
R-RNO-4085001 Sialic acid metabolism

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-3 (EC:3.2.1.18)
Alternative name(s):
Ganglioside sialidase
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
Gene namesi
Name:Neu3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619881 Neu3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089051 – 418Sialidase-3Add BLAST418

Proteomic databases

PaxDbiQ99PW5
PRIDEiQ99PW5

PTM databases

PhosphoSitePlusiQ99PW5

Expressioni

Tissue specificityi

Expressed in brain, cardiac muscle and weakly in liver.

Gene expression databases

BgeeiENSRNOG00000018106
GenevisibleiQ99PW5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024420

Structurei

3D structure databases

ProteinModelPortaliQ99PW5
SMRiQ99PW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati129 – 140BNR 1Add BLAST12
Repeati201 – 212BNR 2Add BLAST12
Repeati252 – 263BNR 3Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 27FRIP motif4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFVF Eukaryota
ENOG410Y74Z LUCA
GeneTreeiENSGT00390000011171
HOGENOMiHOG000233778
HOVERGENiHBG052608
InParanoidiQ99PW5
KOiK12357
OMAiHSLMIYS
OrthoDBiEOG091G08BI
PhylomeDBiQ99PW5
TreeFamiTF331063

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026944 Sialidase-3
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PTHR10628:SF23 PTHR10628:SF23, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
SUPFAMiSSF50939 SSF50939, 2 hits

Sequencei

Sequence statusi: Complete.

Q99PW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVSSCSLR STLFQQEEQN RITYRIPALL YIPPTHTFLA FAEMRTSSRD
60 70 80 90 100
EDAVYLVFRR GVMKGCSVEW GPQQPLMEAT LPGHRTMSPC PVWEKNTGRV
110 120 130 140 150
YLFFICVQGH VSERWQLLWG RNAARLCFLY SEDSGCSWGE VKDLTEEVVG
160 170 180 190 200
SEMKHWATFA VGPGHGIQLQ SGRLLIPAYA YLISCWFLCF PCSVKPHSLM
210 220 230 240 250
FYSDDLGVTW HCGKFIKPQV TGECQVAEVP GKAGNLVLYC SARTPNKFRA
260 270 280 290 300
EAFSTDSGDC FQKPTLNQQL CEPRGGCQGS VVSTRPLKMP YTCQDSSGKD
310 320 330 340 350
VPSTQKCPLM DRSLEVEEGA GAPSGTWLLY SHPTNKKKRM NLGIYYNQNP
360 370 380 390 400
LEVNYWSRPW ILNRGPSGYS DLAVVEGQGL FACLFECGER HEDEKIDFCL
410
FSDQEVLSCD DCTSPSSN
Length:418
Mass (Da):46,980
Last modified:June 1, 2001 - v1
Checksum:i7CC46F2E5952E240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026841 mRNA Translation: BAB32440.1
BC100625 mRNA Translation: AAI00626.1
PIRiJC7588
RefSeqiNP_446462.1, NM_054010.1
XP_008757887.1, XM_008759665.2
UniGeneiRn.67067

Genome annotation databases

EnsembliENSRNOT00000024420; ENSRNOP00000024420; ENSRNOG00000018106
GeneIDi117185
KEGGirno:117185
UCSCiRGD:619881 rat

Similar proteinsi

Entry informationi

Entry nameiNEUR3_RAT
AccessioniPrimary (citable) accession number: Q99PW5
Secondary accession number(s): Q497C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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