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Q99PW5

- NEUR3_RAT

UniProt

Q99PW5 - NEUR3_RAT

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Protein

Sialidase-3

Gene
Neu3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Substrate By similarity
Binding sitei45 – 451Substrate By similarity
Active sitei50 – 501Proton acceptor By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei181 – 1811Substrate By similarity
Binding sitei223 – 2231Substrate By similarity
Binding sitei243 – 2431Substrate Reviewed prediction
Binding sitei339 – 3391Substrate By similarity
Active sitei369 – 3691Nucleophile By similarity
Active sitei386 – 3861 Reviewed prediction

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB

GO - Biological processi

  1. ganglioside catabolic process Source: UniProtKB
  2. oligosaccharide catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_198596. Glycosphingolipid metabolism.
REACT_213723. Sialic acid metabolism.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-3 (EC:3.2.1.18)
Alternative name(s):
Ganglioside sialidase
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
Gene namesi
Name:Neu3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi619881. Neu3.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Sialidase-3PRO_0000208905Add
BLAST

Proteomic databases

PaxDbiQ99PW5.
PRIDEiQ99PW5.

PTM databases

PhosphoSiteiQ99PW5.

Expressioni

Tissue specificityi

Expressed in brain, cardiac muscle and weakly in liver.

Gene expression databases

GenevestigatoriQ99PW5.

Structurei

3D structure databases

ProteinModelPortaliQ99PW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati129 – 14012BNR 1Add
BLAST
Repeati201 – 21212BNR 2Add
BLAST
Repeati252 – 26312BNR 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 274FRIP motif

Sequence similaritiesi

Contains 3 BNR repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG4409.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiQ99PW5.
KOiK12357.
OMAiVYLFFIC.
OrthoDBiEOG7MSMNP.
PhylomeDBiQ99PW5.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMiSSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Q99PW5-1 [UniParc]FASTAAdd to Basket

« Hide

MEEVSSCSLR STLFQQEEQN RITYRIPALL YIPPTHTFLA FAEMRTSSRD    50
EDAVYLVFRR GVMKGCSVEW GPQQPLMEAT LPGHRTMSPC PVWEKNTGRV 100
YLFFICVQGH VSERWQLLWG RNAARLCFLY SEDSGCSWGE VKDLTEEVVG 150
SEMKHWATFA VGPGHGIQLQ SGRLLIPAYA YLISCWFLCF PCSVKPHSLM 200
FYSDDLGVTW HCGKFIKPQV TGECQVAEVP GKAGNLVLYC SARTPNKFRA 250
EAFSTDSGDC FQKPTLNQQL CEPRGGCQGS VVSTRPLKMP YTCQDSSGKD 300
VPSTQKCPLM DRSLEVEEGA GAPSGTWLLY SHPTNKKKRM NLGIYYNQNP 350
LEVNYWSRPW ILNRGPSGYS DLAVVEGQGL FACLFECGER HEDEKIDFCL 400
FSDQEVLSCD DCTSPSSN 418
Length:418
Mass (Da):46,980
Last modified:June 1, 2001 - v1
Checksum:i7CC46F2E5952E240
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026841 mRNA. Translation: BAB32440.1.
BC100625 mRNA. Translation: AAI00626.1.
PIRiJC7588.
RefSeqiNP_446462.1. NM_054010.1.
UniGeneiRn.67067.

Genome annotation databases

EnsembliENSRNOT00000024420; ENSRNOP00000024420; ENSRNOG00000018106.
GeneIDi117185.
KEGGirno:117185.
UCSCiRGD:619881. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026841 mRNA. Translation: BAB32440.1 .
BC100625 mRNA. Translation: AAI00626.1 .
PIRi JC7588.
RefSeqi NP_446462.1. NM_054010.1.
UniGenei Rn.67067.

3D structure databases

ProteinModelPortali Q99PW5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

PTM databases

PhosphoSitei Q99PW5.

Proteomic databases

PaxDbi Q99PW5.
PRIDEi Q99PW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024420 ; ENSRNOP00000024420 ; ENSRNOG00000018106 .
GeneIDi 117185.
KEGGi rno:117185.
UCSCi RGD:619881. rat.

Organism-specific databases

CTDi 10825.
RGDi 619881. Neu3.

Phylogenomic databases

eggNOGi COG4409.
GeneTreei ENSGT00390000011171.
HOGENOMi HOG000233778.
HOVERGENi HBG052608.
InParanoidi Q99PW5.
KOi K12357.
OMAi VYLFFIC.
OrthoDBi EOG7MSMNP.
PhylomeDBi Q99PW5.
TreeFami TF331063.

Enzyme and pathway databases

Reactomei REACT_198596. Glycosphingolipid metabolism.
REACT_213723. Sialic acid metabolism.

Miscellaneous databases

NextBioi 620050.
PROi Q99PW5.

Gene expression databases

Genevestigatori Q99PW5.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMi SSF50939. SSF50939. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of three sialidase genes in rat development."
    Hasegawa T., Feijoo Carnero C., Wada T., Itoyama Y., Miyagi T.
    Biochem. Biophys. Res. Commun. 280:726-732(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiNEUR3_RAT
AccessioniPrimary (citable) accession number: Q99PW5
Secondary accession number(s): Q497C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi