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Q99PV8

- BC11B_MOUSE

UniProt

Q99PV8 - BC11B_MOUSE

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Protein
B-cell lymphoma/leukemia 11B
Gene
Bcl11b, Ctip2, Rit1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri221 – 25131C2H2-type 1
Add
BLAST
Zinc fingeri426 – 45328C2H2-type 2
Add
BLAST
Zinc fingeri454 – 48128C2H2-type 3
Add
BLAST
Zinc fingeri786 – 81328C2H2-type 4
Add
BLAST
Zinc fingeri814 – 84330C2H2-type 5
Add
BLAST
Zinc fingeri844 – 87431C2H2-type 6
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: MGI
  5. sequence-specific DNA binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. T cell differentiation in thymus Source: MGI
  2. T cell receptor V(D)J recombination Source: MGI
  3. alpha-beta T cell differentiation Source: MGI
  4. axonogenesis Source: MGI
  5. central nervous system neuron differentiation Source: MGI
  6. epithelial cell morphogenesis Source: MGI
  7. keratinocyte development Source: MGI
  8. negative regulation of apoptotic process Source: MGI
  9. negative regulation of cell proliferation Source: MGI
  10. odontogenesis of dentin-containing tooth Source: MGI
  11. olfactory bulb axon guidance Source: MGI
  12. positive T cell selection Source: MGI
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. post-embryonic camera-type eye development Source: MGI
  15. post-embryonic development Source: MGI
  16. regulation of gene expression Source: MGI
  17. regulation of keratinocyte proliferation Source: MGI
  18. regulation of lipid metabolic process Source: MGI
  19. regulation of neuron differentiation Source: MGI
  20. skin development Source: MGI
  21. striatal medium spiny neuron differentiation Source: MGI
  22. thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma/leukemia 11B
Short name:
BCL-11B
Alternative name(s):
B-cell CLL/lymphoma 11B
COUP-TF-interacting protein 2
Radiation-induced tumor suppressor gene 1 protein
Short name:
mRit1
Gene namesi
Name:Bcl11b
Synonyms:Ctip2, Rit1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1929913. Bcl11b.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884B-cell lymphoma/leukemia 11B
PRO_0000047105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961Phosphoserine By similarity
Modified residuei119 – 1191Phosphothreonine By similarity
Modified residuei256 – 2561Phosphoserine By similarity
Modified residuei260 – 2601Phosphothreonine By similarity
Modified residuei277 – 2771Phosphoserine By similarity
Modified residuei358 – 3581Phosphoserine By similarity
Modified residuei376 – 3761Phosphothreonine By similarity
Modified residuei381 – 3811Phosphoserine By similarity
Modified residuei398 – 3981Phosphoserine By similarity
Modified residuei416 – 4161Phosphothreonine By similarity
Modified residuei482 – 4821Phosphoserine By similarity
Modified residuei487 – 4871Phosphoserine By similarity
Modified residuei495 – 4951Phosphoserine By similarity
Modified residuei496 – 4961Phosphoserine By similarity
Modified residuei664 – 6641Phosphoserine By similarity
Modified residuei755 – 7551Phosphoserine By similarity
Modified residuei841 – 8411N6-acetyllysine By similarity

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ99PV8.
PRIDEiQ99PV8.

PTM databases

PhosphoSiteiQ99PV8.

Expressioni

Tissue specificityi

Expressed in brain and thymus.

Developmental stagei

Highly expressed in the developing embryo.

Gene expression databases

ArrayExpressiQ99PV8.
BgeeiQ99PV8.
CleanExiMM_BCL11B.
MM_RIT1.
GenevestigatoriQ99PV8.

Interactioni

Subunit structurei

Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.2 Publications

Protein-protein interaction databases

BioGridi208391. 3 interactions.
STRINGi10090.ENSMUSP00000068258.

Structurei

3D structure databases

ProteinModelPortaliQ99PV8.
SMRiQ99PV8. Positions 219-252, 423-506, 750-871.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi560 – 64788Gly-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG271772.
GeneTreeiENSGT00530000063542.
HOGENOMiHOG000015256.
HOVERGENiHBG050673.
InParanoidiQ99PV8.
OMAiDDAGGCG.
OrthoDBiEOG7MH0XP.
PhylomeDBiQ99PV8.
TreeFamiTF318131.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99PV8-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRRKQGNPQ HLSQRELITP EADHVEATIL EEDEGLEIEE PSSLGLMVGG    50
PDPDLLTCGQ CQMNFPLGDI LVFIEHKKKQ CGGLGPCYDK VLDKSSPPPS 100
SRSELRRVSE PVEIGIQVTP DEDDHLLSPT KGICPKQENI AGPCRPAQLP 150
SMAPIAASSS HPPTSVITSP LRALGVLPPC FPLPCCGARP ISGDGTQGEG 200
QMEAPFGCQC ELSGKDEPSS YICTTCKQPF NSAWFLLQHA QNTHGFRIYL 250
EPGPASTSLT PRLTIPPPLG PETVAQSPLM NFLGDSNPFN LLRMTGPILR 300
DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR 350
LNPMAIDSPA MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK 400
SPFLSTPPLP PMPAGTPPPQ PPAKSKSCEF CGKTFKFQSN LIVHRRSHTG 450
EKPYKCQLCD HACSQASKLK RHMKTHMHKA GSLAGRSDDG LSAASSPEPG 500
TSELPGDLKA ADGDFRHHES DPSLGPEPED DEDEEEEEEE LLLENESRPE 550
SSFSMDSELG RGRENGGGVP PGVAGAGAAA AALADEKALA LGKVMEDAGL 600
GALPQYGEKR GAFLKRAGDT GDAGAVGCGD AGAPGAVNGR GGAFAPGAEP 650
FPALFPRKPA PLPSPGLGGP ALHAAKRIKV EKDLELPPAA LIPSENVYSQ 700
WLVGYAASRH FMKDPFLGFT DARQSPFATS SEHSSENGSL RFSTPPGDLL 750
DGGLSGRSGT ASGGSTPHLG GPGPGRPSSK EGRRSDTCEY CGKVFKNCSN 800
LTVHRRSHTG ERPYKCELCN YACAQSSKLT RHMKTHGQIG KEVYRCDICQ 850
MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS 884
Length:884
Mass (Da):94,566
Last modified:June 1, 2001 - v1
Checksum:i9A86B7E34450B2F2
GO
Isoform 2 (identifier: Q99PV8-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     142-213: Missing.

Note: May be due to exon skipping.

Show »
Length:812
Mass (Da):87,336
Checksum:i4924D623215C11AB
GO
Isoform 3 (identifier: Q99PV8-3) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     21-214: Missing.

Note: May be due to exon skipping.

Show »
Length:690
Mass (Da):74,174
Checksum:iE031A3FD8BD307F9
GO

Sequence cautioni

The sequence AAF63683.1 differs from that shown. Reason: Frameshift at positions 135, 221, 227, 252, 259 and 264.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti676 – 6761K → T in gamma induced thymic lymphomas. 1 Publication
Natural varianti783 – 7831R → C in gamma induced thymic lymphomas. 1 Publication
Natural varianti849 – 8491C → S in gamma induced thymic lymphomas. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei21 – 214194Missing in isoform 3.
VSP_009566Add
BLAST
Alternative sequencei142 – 21372Missing in isoform 2.
VSP_009568Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201P → R in BAB32730. 1 Publication
Sequence conflicti379 – 3791P → S in AAF63683. 1 Publication
Sequence conflicti806 – 8072RS → KN in AAF63683. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043551 mRNA. Translation: BAB32728.1.
AB043553 mRNA. Translation: BAB32729.1.
AB043583 mRNA. Translation: BAB32730.1.
AF186019 mRNA. Translation: AAF63683.1. Frameshift.
BC019503 mRNA. Translation: AAH19503.1.
AK088588 mRNA. Translation: BAC40438.1.
CCDSiCCDS36552.1. [Q99PV8-2]
CCDS36553.1. [Q99PV8-1]
CCDS70419.1. [Q99PV8-3]
RefSeqiNP_001073352.1. NM_001079883.1. [Q99PV8-1]
NP_001273272.1. NM_001286343.1.
NP_067374.2. NM_021399.2. [Q99PV8-2]
UniGeneiMm.392694.

Genome annotation databases

EnsembliENSMUST00000066060; ENSMUSP00000068258; ENSMUSG00000048251. [Q99PV8-1]
ENSMUST00000109887; ENSMUSP00000105513; ENSMUSG00000048251.
ENSMUST00000109891; ENSMUSP00000105517; ENSMUSG00000048251. [Q99PV8-2]
GeneIDi58208.
KEGGimmu:58208.
UCSCiuc007ozh.1. mouse. [Q99PV8-1]
uc007ozi.1. mouse. [Q99PV8-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043551 mRNA. Translation: BAB32728.1 .
AB043553 mRNA. Translation: BAB32729.1 .
AB043583 mRNA. Translation: BAB32730.1 .
AF186019 mRNA. Translation: AAF63683.1 . Frameshift.
BC019503 mRNA. Translation: AAH19503.1 .
AK088588 mRNA. Translation: BAC40438.1 .
CCDSi CCDS36552.1. [Q99PV8-2 ]
CCDS36553.1. [Q99PV8-1 ]
CCDS70419.1. [Q99PV8-3 ]
RefSeqi NP_001073352.1. NM_001079883.1. [Q99PV8-1 ]
NP_001273272.1. NM_001286343.1.
NP_067374.2. NM_021399.2. [Q99PV8-2 ]
UniGenei Mm.392694.

3D structure databases

ProteinModelPortali Q99PV8.
SMRi Q99PV8. Positions 219-252, 423-506, 750-871.
ModBasei Search...

Protein-protein interaction databases

BioGridi 208391. 3 interactions.
STRINGi 10090.ENSMUSP00000068258.

PTM databases

PhosphoSitei Q99PV8.

Proteomic databases

PaxDbi Q99PV8.
PRIDEi Q99PV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066060 ; ENSMUSP00000068258 ; ENSMUSG00000048251 . [Q99PV8-1 ]
ENSMUST00000109887 ; ENSMUSP00000105513 ; ENSMUSG00000048251 .
ENSMUST00000109891 ; ENSMUSP00000105517 ; ENSMUSG00000048251 . [Q99PV8-2 ]
GeneIDi 58208.
KEGGi mmu:58208.
UCSCi uc007ozh.1. mouse. [Q99PV8-1 ]
uc007ozi.1. mouse. [Q99PV8-2 ]

Organism-specific databases

CTDi 64919.
MGIi MGI:1929913. Bcl11b.

Phylogenomic databases

eggNOGi NOG271772.
GeneTreei ENSGT00530000063542.
HOGENOMi HOG000015256.
HOVERGENi HBG050673.
InParanoidi Q99PV8.
OMAi DDAGGCG.
OrthoDBi EOG7MH0XP.
PhylomeDBi Q99PV8.
TreeFami TF318131.

Miscellaneous databases

NextBioi 314201.
PROi Q99PV8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99PV8.
Bgeei Q99PV8.
CleanExi MM_BCL11B.
MM_RIT1.
Genevestigatori Q99PV8.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas."
    Wakabayashi Y., Inoue J., Takahashi Y., Matsuki A., Kosugi-Okano H., Shinbo T., Mishima Y., Niwa O., Kominami R.
    Biochem. Biophys. Res. Commun. 301:598-603(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANTS THR-676; CYS-783 AND SER-849.
  2. "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors."
    Avram D., Fields A., Pretty On Top K., Nevrivy D.J., Ishmael J.E., Leid M.
    J. Biol. Chem. 275:10315-10322(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH TFCOUP1; EAR2 AND ARP1.
    Strain: BALB/c.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-884.
    Strain: NOD.
    Tissue: Thymus.
  5. Cited for: FUNCTION.
  6. "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression."
    Senawong T., Peterson V.J., Avram D., Shepherd D.M., Frye R.A., Minucci S., Leid M.
    J. Biol. Chem. 278:43041-43050(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIRT1.
  7. "In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice."
    Tirard M., Hsiao H.H., Nikolov M., Urlaub H., Melchior F., Brose N.
    Proc. Natl. Acad. Sci. U.S.A. 109:21122-21127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION WITH SUMO1.

Entry informationi

Entry nameiBC11B_MOUSE
AccessioniPrimary (citable) accession number: Q99PV8
Secondary accession number(s): Q8C2I1
, Q99PV6, Q99PV7, Q9JLF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi