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Protein

B-cell lymphoma/leukemia 11B

Gene

Bcl11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri221 – 251C2H2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri426 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri454 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri786 – 813C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri814 – 843C2H2-type 5PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri844 – 874C2H2-type 6PROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

  • alpha-beta T cell differentiation Source: MGI
  • axonogenesis Source: MGI
  • central nervous system neuron differentiation Source: MGI
  • commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  • epithelial cell morphogenesis Source: MGI
  • keratinocyte development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • olfactory bulb axon guidance Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive T cell selection Source: MGI
  • post-embryonic camera-type eye development Source: MGI
  • post-embryonic development Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of keratinocyte proliferation Source: MGI
  • regulation of lipid metabolic process Source: MGI
  • regulation of neuron differentiation Source: MGI
  • signal transduction Source: GO_Central
  • skin development Source: MGI
  • striatal medium spiny neuron differentiation Source: MGI
  • T cell differentiation in thymus Source: MGI
  • T cell receptor V(D)J recombination Source: MGI
  • thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma/leukemia 11B
Short name:
BCL-11B
Alternative name(s):
B-cell CLL/lymphoma 11B
COUP-TF-interacting protein 2
Radiation-induced tumor suppressor gene 1 protein
Short name:
mRit1
Gene namesi
Name:Bcl11b
Synonyms:Ctip2, Rit1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1929913. Bcl11b.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: MGI
  • neuron projection Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471051 – 884B-cell lymphoma/leukemia 11BAdd BLAST884

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei128PhosphoserineCombined sources1
Modified residuei256PhosphoserineBy similarity1
Modified residuei260PhosphothreonineCombined sources1
Modified residuei277PhosphoserineBy similarity1
Modified residuei293Omega-N-methylarginineCombined sources1
Modified residuei322Asymmetric dimethylarginineCombined sources1
Modified residuei358PhosphoserineBy similarity1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei398PhosphoserineBy similarity1
Modified residuei401PhosphoserineCombined sources1
Modified residuei406PhosphothreonineCombined sources1
Modified residuei416PhosphothreonineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei487PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Cross-linki587Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei664PhosphoserineBy similarity1
Modified residuei744PhosphothreonineCombined sources1
Modified residuei755PhosphoserineBy similarity1
Modified residuei762PhosphoserineCombined sources1
Modified residuei841N6-acetyllysineBy similarity1
Cross-linki877Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ99PV8.
PeptideAtlasiQ99PV8.
PRIDEiQ99PV8.

PTM databases

iPTMnetiQ99PV8.
PhosphoSitePlusiQ99PV8.

Expressioni

Tissue specificityi

Expressed in brain and thymus.

Developmental stagei

Highly expressed in the developing embryo.

Gene expression databases

BgeeiENSMUSG00000048251.
CleanExiMM_BCL11B.
MM_RIT1.
ExpressionAtlasiQ99PV8. baseline and differential.
GenevisibleiQ99PV8. MM.

Interactioni

Subunit structurei

Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.2 Publications

Protein-protein interaction databases

BioGridi208391. 3 interactors.
STRINGi10090.ENSMUSP00000068258.

Structurei

3D structure databases

ProteinModelPortaliQ99PV8.
SMRiQ99PV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi560 – 647Gly-richAdd BLAST88

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri221 – 251C2H2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri426 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri454 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri786 – 813C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri814 – 843C2H2-type 5PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri844 – 874C2H2-type 6PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063542.
HOGENOMiHOG000015256.
HOVERGENiHBG050673.
InParanoidiQ99PV8.
OMAiDDAGGCG.
OrthoDBiEOG091G160N.
PhylomeDBiQ99PV8.
TreeFamiTF318131.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99PV8-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRKQGNPQ HLSQRELITP EADHVEATIL EEDEGLEIEE PSSLGLMVGG
60 70 80 90 100
PDPDLLTCGQ CQMNFPLGDI LVFIEHKKKQ CGGLGPCYDK VLDKSSPPPS
110 120 130 140 150
SRSELRRVSE PVEIGIQVTP DEDDHLLSPT KGICPKQENI AGPCRPAQLP
160 170 180 190 200
SMAPIAASSS HPPTSVITSP LRALGVLPPC FPLPCCGARP ISGDGTQGEG
210 220 230 240 250
QMEAPFGCQC ELSGKDEPSS YICTTCKQPF NSAWFLLQHA QNTHGFRIYL
260 270 280 290 300
EPGPASTSLT PRLTIPPPLG PETVAQSPLM NFLGDSNPFN LLRMTGPILR
310 320 330 340 350
DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR
360 370 380 390 400
LNPMAIDSPA MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK
410 420 430 440 450
SPFLSTPPLP PMPAGTPPPQ PPAKSKSCEF CGKTFKFQSN LIVHRRSHTG
460 470 480 490 500
EKPYKCQLCD HACSQASKLK RHMKTHMHKA GSLAGRSDDG LSAASSPEPG
510 520 530 540 550
TSELPGDLKA ADGDFRHHES DPSLGPEPED DEDEEEEEEE LLLENESRPE
560 570 580 590 600
SSFSMDSELG RGRENGGGVP PGVAGAGAAA AALADEKALA LGKVMEDAGL
610 620 630 640 650
GALPQYGEKR GAFLKRAGDT GDAGAVGCGD AGAPGAVNGR GGAFAPGAEP
660 670 680 690 700
FPALFPRKPA PLPSPGLGGP ALHAAKRIKV EKDLELPPAA LIPSENVYSQ
710 720 730 740 750
WLVGYAASRH FMKDPFLGFT DARQSPFATS SEHSSENGSL RFSTPPGDLL
760 770 780 790 800
DGGLSGRSGT ASGGSTPHLG GPGPGRPSSK EGRRSDTCEY CGKVFKNCSN
810 820 830 840 850
LTVHRRSHTG ERPYKCELCN YACAQSSKLT RHMKTHGQIG KEVYRCDICQ
860 870 880
MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS
Length:884
Mass (Da):94,566
Last modified:June 1, 2001 - v1
Checksum:i9A86B7E34450B2F2
GO
Isoform 2 (identifier: Q99PV8-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     142-213: Missing.

Note: May be due to exon skipping.
Show »
Length:812
Mass (Da):87,336
Checksum:i4924D623215C11AB
GO
Isoform 3 (identifier: Q99PV8-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     21-214: Missing.

Note: May be due to exon skipping.
Show »
Length:690
Mass (Da):74,174
Checksum:iE031A3FD8BD307F9
GO

Sequence cautioni

The sequence AAF63683 differs from that shown. Reason: Frameshift at positions 135, 221, 227, 252, 259 and 264.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → R in BAB32730 (PubMed:12565905).Curated1
Sequence conflicti379P → S in AAF63683 (PubMed:10744719).Curated1
Sequence conflicti806 – 807RS → KN in AAF63683 (PubMed:10744719).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti676K → T in gamma induced thymic lymphomas. 1 Publication1
Natural varianti783R → C in gamma induced thymic lymphomas. 1 Publication1
Natural varianti849C → S in gamma induced thymic lymphomas. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00956621 – 214Missing in isoform 3. 1 PublicationAdd BLAST194
Alternative sequenceiVSP_009568142 – 213Missing in isoform 2. 3 PublicationsAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043551 mRNA. Translation: BAB32728.1.
AB043553 mRNA. Translation: BAB32729.1.
AB043583 mRNA. Translation: BAB32730.1.
AF186019 mRNA. Translation: AAF63683.1. Frameshift.
BC019503 mRNA. Translation: AAH19503.1.
AK088588 mRNA. Translation: BAC40438.1.
CCDSiCCDS36552.1. [Q99PV8-2]
CCDS36553.1. [Q99PV8-1]
CCDS70419.1. [Q99PV8-3]
RefSeqiNP_001073352.1. NM_001079883.1. [Q99PV8-1]
NP_001273272.1. NM_001286343.1.
NP_067374.2. NM_021399.2. [Q99PV8-2]
UniGeneiMm.392694.

Genome annotation databases

EnsembliENSMUST00000066060; ENSMUSP00000068258; ENSMUSG00000048251. [Q99PV8-1]
ENSMUST00000109891; ENSMUSP00000105517; ENSMUSG00000048251. [Q99PV8-2]
GeneIDi58208.
KEGGimmu:58208.
UCSCiuc007ozh.1. mouse. [Q99PV8-1]
uc007ozi.1. mouse. [Q99PV8-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043551 mRNA. Translation: BAB32728.1.
AB043553 mRNA. Translation: BAB32729.1.
AB043583 mRNA. Translation: BAB32730.1.
AF186019 mRNA. Translation: AAF63683.1. Frameshift.
BC019503 mRNA. Translation: AAH19503.1.
AK088588 mRNA. Translation: BAC40438.1.
CCDSiCCDS36552.1. [Q99PV8-2]
CCDS36553.1. [Q99PV8-1]
CCDS70419.1. [Q99PV8-3]
RefSeqiNP_001073352.1. NM_001079883.1. [Q99PV8-1]
NP_001273272.1. NM_001286343.1.
NP_067374.2. NM_021399.2. [Q99PV8-2]
UniGeneiMm.392694.

3D structure databases

ProteinModelPortaliQ99PV8.
SMRiQ99PV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208391. 3 interactors.
STRINGi10090.ENSMUSP00000068258.

PTM databases

iPTMnetiQ99PV8.
PhosphoSitePlusiQ99PV8.

Proteomic databases

PaxDbiQ99PV8.
PeptideAtlasiQ99PV8.
PRIDEiQ99PV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066060; ENSMUSP00000068258; ENSMUSG00000048251. [Q99PV8-1]
ENSMUST00000109891; ENSMUSP00000105517; ENSMUSG00000048251. [Q99PV8-2]
GeneIDi58208.
KEGGimmu:58208.
UCSCiuc007ozh.1. mouse. [Q99PV8-1]
uc007ozi.1. mouse. [Q99PV8-2]

Organism-specific databases

CTDi64919.
MGIiMGI:1929913. Bcl11b.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063542.
HOGENOMiHOG000015256.
HOVERGENiHBG050673.
InParanoidiQ99PV8.
OMAiDDAGGCG.
OrthoDBiEOG091G160N.
PhylomeDBiQ99PV8.
TreeFamiTF318131.

Miscellaneous databases

PROiQ99PV8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048251.
CleanExiMM_BCL11B.
MM_RIT1.
ExpressionAtlasiQ99PV8. baseline and differential.
GenevisibleiQ99PV8. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBC11B_MOUSE
AccessioniPrimary (citable) accession number: Q99PV8
Secondary accession number(s): Q8C2I1
, Q99PV6, Q99PV7, Q9JLF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.