SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99PV3

- MKLN1_RAT

UniProt

Q99PV3 - MKLN1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Muskelin

Gene
Mkln1, Msk
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Muskelin
Gene namesi
Name:Mkln1
Synonyms:Msk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi620076. Mkln1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 735734MuskelinPRO_0000119140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ99PV3.
PRIDEiQ99PV3.

Expressioni

Gene expression databases

GenevestigatoriQ99PV3.

Interactioni

Subunit structurei

Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8 By similarity. Interacts with the C-terminal tail of the prostaglandin EP3 receptor alpha isoform.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016633.

Structurei

3D structure databases

ProteinModelPortaliQ99PV3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 20433LisHAdd
BLAST
Domaini206 – 25853CTLHAdd
BLAST
Repeati284 – 33047Kelch 1Add
BLAST
Repeati339 – 39153Kelch 2Add
BLAST
Repeati400 – 45859Kelch 3Add
BLAST
Repeati469 – 51547Kelch 4Add
BLAST
Repeati526 – 57853Kelch 5Add
BLAST
Repeati597 – 65155Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.
Contains 6 Kelch repeats.
Contains 1 LisH domain.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG290166.
GeneTreeiENSGT00390000001702.
HOGENOMiHOG000047912.
HOVERGENiHBG052481.
InParanoidiQ99PV3.
OMAiWIYDIAR.
OrthoDBiEOG7CNZFQ.
PhylomeDBiQ99PV3.
TreeFamiTF323659.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR006595. CTLH_C.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR008979. Galactose-bd-like.
IPR015915. Kelch-typ_b-propeller.
IPR006594. LisH_dimerisation.
IPR010565. Muskelin_N.
[Graphical view]
PfamiPF06588. Muskelin_N. 1 hit.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50965. SSF50965. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PV3-1 [UniParc]FASTAAdd to Basket

« Hide

MAAGGAVAAA PECRLLPYAL HKWSSFSSTY LPENILVDKP NDQSSRWSSE    50
SNYPPQYLIL KLERPAIVQN ITFGKYEKTH VCNLKKFKVF GGMNEENMTE 100
LLSSGLKNDY NKETFTLKHK IDEQMFPCRF IKIVPLLSWG PSFNFSIWYV 150
ELSGIDDPDI VQPCLNWYSK YREQEAIRLC LKHFRQHNYT EAFESLQKKT 200
KIALEHPMLT DMHDKLVLKG DFDACEELIE KAVNDGLFNQ YISQQEYKPR 250
WSQIIPKSTK GDGEDNRPGM RGGHQMVIDV QTETVYLFGG WDGTQDLADF 300
WAYSVKENQW TCISRDTEKE NGPSARSCHK MCIDIQRRQI YTLGRYLDSS 350
VRNSKSLKSD FYRYDIDTNT WMLLSEDTAA DGGPKLVFDH QMCMDSEKHM 400
IYTFGGRILT CNGSVDDSRA SEPQFSGLFA FNCQCQTWKL LREDSCNAGP 450
EDIQSRIGHC MLFHSKNRCL YVFGGQRSKT YLNDFFSYDV DSDHVDIISD 500
GTKKDSGMVP MTGFTQRATI DPELNEIHVL SGLSKDKEKR EENVRNSFWI 550
YDIVRNSWSC VYKNDQAAKE NLSKSLQEEE PCPRFAHQLV YDELHKVHYL 600
FGGNPGKSCS PKMRLDDFWS LKLCRPSKDY LLRHCKYLIR KHRFEEKAQM 650
DPLSALKYLQ NDLYITVDHS DPEETKEFQL LASALFKSGS DFTALGFSDV 700
DHTYAQRTQL FDTLVNFFPD SMTPPKGNLV DLITL 735
Length:735
Mass (Da):84,834
Last modified:June 1, 2001 - v1
Checksum:i79BD0BBF74419E76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046442 mRNA. Translation: BAB21439.1.
RefSeqiNP_112649.1. NM_031359.1.
UniGeneiRn.6383.

Genome annotation databases

EnsembliENSRNOT00000016633; ENSRNOP00000016633; ENSRNOG00000011524.
GeneIDi83536.
KEGGirno:83536.
UCSCiRGD:620076. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046442 mRNA. Translation: BAB21439.1 .
RefSeqi NP_112649.1. NM_031359.1.
UniGenei Rn.6383.

3D structure databases

ProteinModelPortali Q99PV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016633.

Proteomic databases

PaxDbi Q99PV3.
PRIDEi Q99PV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016633 ; ENSRNOP00000016633 ; ENSRNOG00000011524 .
GeneIDi 83536.
KEGGi rno:83536.
UCSCi RGD:620076. rat.

Organism-specific databases

CTDi 4289.
RGDi 620076. Mkln1.

Phylogenomic databases

eggNOGi NOG290166.
GeneTreei ENSGT00390000001702.
HOGENOMi HOG000047912.
HOVERGENi HBG052481.
InParanoidi Q99PV3.
OMAi WIYDIAR.
OrthoDBi EOG7CNZFQ.
PhylomeDBi Q99PV3.
TreeFami TF323659.

Miscellaneous databases

NextBioi 616045.
PROi Q99PV3.

Gene expression databases

Genevestigatori Q99PV3.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
2.60.120.260. 1 hit.
InterProi IPR006595. CTLH_C.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR008979. Galactose-bd-like.
IPR015915. Kelch-typ_b-propeller.
IPR006594. LisH_dimerisation.
IPR010565. Muskelin_N.
[Graphical view ]
Pfami PF06588. Muskelin_N. 1 hit.
[Graphical view ]
SMARTi SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50965. SSF50965. 1 hit.
PROSITEi PS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin."
    Hasegawa H., Katoh H., Fujita H., Mori K., Negishi M.
    Biochem. Biophys. Res. Commun. 276:350-354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EP3-ALPHA.

Entry informationi

Entry nameiMKLN1_RAT
AccessioniPrimary (citable) accession number: Q99PV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi