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Q99PV3

- MKLN1_RAT

UniProt

Q99PV3 - MKLN1_RAT

Protein

Muskelin

Gene

Mkln1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Muskelin
    Gene namesi
    Name:Mkln1
    Synonyms:Msk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi620076. Mkln1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 735734MuskelinPRO_0000119140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ99PV3.
    PRIDEiQ99PV3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99PV3.

    Interactioni

    Subunit structurei

    Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8 By similarity. Interacts with the C-terminal tail of the prostaglandin EP3 receptor alpha isoform.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016633.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 20433LisHPROSITE-ProRule annotationAdd
    BLAST
    Domaini206 – 25853CTLHPROSITE-ProRule annotationAdd
    BLAST
    Repeati284 – 33047Kelch 1Add
    BLAST
    Repeati339 – 39153Kelch 2Add
    BLAST
    Repeati400 – 45859Kelch 3Add
    BLAST
    Repeati469 – 51547Kelch 4Add
    BLAST
    Repeati526 – 57853Kelch 5Add
    BLAST
    Repeati597 – 65155Kelch 6Add
    BLAST

    Sequence similaritiesi

    Contains 1 CTLH domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated
    Contains 1 LisH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG290166.
    GeneTreeiENSGT00390000001702.
    HOGENOMiHOG000047912.
    HOVERGENiHBG052481.
    InParanoidiQ99PV3.
    OMAiWIYDIAR.
    OrthoDBiEOG7CNZFQ.
    PhylomeDBiQ99PV3.
    TreeFamiTF323659.

    Family and domain databases

    Gene3Di2.120.10.80. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR006595. CTLH_C.
    IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR008979. Galactose-bd-like.
    IPR015915. Kelch-typ_b-propeller.
    IPR006594. LisH_dimerisation.
    IPR010565. Muskelin_N.
    [Graphical view]
    PfamiPF06588. Muskelin_N. 1 hit.
    [Graphical view]
    SMARTiSM00668. CTLH. 1 hit.
    SM00667. LisH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF50965. SSF50965. 1 hit.
    PROSITEiPS50897. CTLH. 1 hit.
    PS50896. LISH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99PV3-1 [UniParc]FASTAAdd to Basket

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    MAAGGAVAAA PECRLLPYAL HKWSSFSSTY LPENILVDKP NDQSSRWSSE    50
    SNYPPQYLIL KLERPAIVQN ITFGKYEKTH VCNLKKFKVF GGMNEENMTE 100
    LLSSGLKNDY NKETFTLKHK IDEQMFPCRF IKIVPLLSWG PSFNFSIWYV 150
    ELSGIDDPDI VQPCLNWYSK YREQEAIRLC LKHFRQHNYT EAFESLQKKT 200
    KIALEHPMLT DMHDKLVLKG DFDACEELIE KAVNDGLFNQ YISQQEYKPR 250
    WSQIIPKSTK GDGEDNRPGM RGGHQMVIDV QTETVYLFGG WDGTQDLADF 300
    WAYSVKENQW TCISRDTEKE NGPSARSCHK MCIDIQRRQI YTLGRYLDSS 350
    VRNSKSLKSD FYRYDIDTNT WMLLSEDTAA DGGPKLVFDH QMCMDSEKHM 400
    IYTFGGRILT CNGSVDDSRA SEPQFSGLFA FNCQCQTWKL LREDSCNAGP 450
    EDIQSRIGHC MLFHSKNRCL YVFGGQRSKT YLNDFFSYDV DSDHVDIISD 500
    GTKKDSGMVP MTGFTQRATI DPELNEIHVL SGLSKDKEKR EENVRNSFWI 550
    YDIVRNSWSC VYKNDQAAKE NLSKSLQEEE PCPRFAHQLV YDELHKVHYL 600
    FGGNPGKSCS PKMRLDDFWS LKLCRPSKDY LLRHCKYLIR KHRFEEKAQM 650
    DPLSALKYLQ NDLYITVDHS DPEETKEFQL LASALFKSGS DFTALGFSDV 700
    DHTYAQRTQL FDTLVNFFPD SMTPPKGNLV DLITL 735
    Length:735
    Mass (Da):84,834
    Last modified:June 1, 2001 - v1
    Checksum:i79BD0BBF74419E76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046442 mRNA. Translation: BAB21439.1.
    RefSeqiNP_112649.1. NM_031359.1.
    UniGeneiRn.6383.

    Genome annotation databases

    EnsembliENSRNOT00000016633; ENSRNOP00000016633; ENSRNOG00000011524.
    GeneIDi83536.
    KEGGirno:83536.
    UCSCiRGD:620076. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046442 mRNA. Translation: BAB21439.1 .
    RefSeqi NP_112649.1. NM_031359.1.
    UniGenei Rn.6383.

    3D structure databases

    ProteinModelPortali Q99PV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016633.

    Proteomic databases

    PaxDbi Q99PV3.
    PRIDEi Q99PV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016633 ; ENSRNOP00000016633 ; ENSRNOG00000011524 .
    GeneIDi 83536.
    KEGGi rno:83536.
    UCSCi RGD:620076. rat.

    Organism-specific databases

    CTDi 4289.
    RGDi 620076. Mkln1.

    Phylogenomic databases

    eggNOGi NOG290166.
    GeneTreei ENSGT00390000001702.
    HOGENOMi HOG000047912.
    HOVERGENi HBG052481.
    InParanoidi Q99PV3.
    OMAi WIYDIAR.
    OrthoDBi EOG7CNZFQ.
    PhylomeDBi Q99PV3.
    TreeFami TF323659.

    Miscellaneous databases

    NextBioi 616045.
    PROi Q99PV3.

    Gene expression databases

    Genevestigatori Q99PV3.

    Family and domain databases

    Gene3Di 2.120.10.80. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR006595. CTLH_C.
    IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR008979. Galactose-bd-like.
    IPR015915. Kelch-typ_b-propeller.
    IPR006594. LisH_dimerisation.
    IPR010565. Muskelin_N.
    [Graphical view ]
    Pfami PF06588. Muskelin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00668. CTLH. 1 hit.
    SM00667. LisH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF50965. SSF50965. 1 hit.
    PROSITEi PS50897. CTLH. 1 hit.
    PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin."
      Hasegawa H., Katoh H., Fujita H., Mori K., Negishi M.
      Biochem. Biophys. Res. Commun. 276:350-354(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EP3-ALPHA.

    Entry informationi

    Entry nameiMKLN1_RAT
    AccessioniPrimary (citable) accession number: Q99PV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3