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Q99PV3 (MKLN1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Muskelin
Gene names
Name:Mkln1
Synonyms:Msk
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length735 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 By similarity.

Subunit structure

Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8 By similarity. Interacts with the C-terminal tail of the prostaglandin EP3 receptor alpha isoform. Ref.1

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 CTLH domain.

Contains 6 Kelch repeats.

Contains 1 LisH domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainKelch repeat
Repeat
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 735734Muskelin
PRO_0000119140

Regions

Domain172 – 20433LisH
Domain206 – 25853CTLH
Repeat284 – 33047Kelch 1
Repeat339 – 39153Kelch 2
Repeat400 – 45859Kelch 3
Repeat469 – 51547Kelch 4
Repeat526 – 57853Kelch 5
Repeat597 – 65155Kelch 6

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99PV3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 79BD0BBF74419E76

FASTA73584,834
        10         20         30         40         50         60 
MAAGGAVAAA PECRLLPYAL HKWSSFSSTY LPENILVDKP NDQSSRWSSE SNYPPQYLIL 

        70         80         90        100        110        120 
KLERPAIVQN ITFGKYEKTH VCNLKKFKVF GGMNEENMTE LLSSGLKNDY NKETFTLKHK 

       130        140        150        160        170        180 
IDEQMFPCRF IKIVPLLSWG PSFNFSIWYV ELSGIDDPDI VQPCLNWYSK YREQEAIRLC 

       190        200        210        220        230        240 
LKHFRQHNYT EAFESLQKKT KIALEHPMLT DMHDKLVLKG DFDACEELIE KAVNDGLFNQ 

       250        260        270        280        290        300 
YISQQEYKPR WSQIIPKSTK GDGEDNRPGM RGGHQMVIDV QTETVYLFGG WDGTQDLADF 

       310        320        330        340        350        360 
WAYSVKENQW TCISRDTEKE NGPSARSCHK MCIDIQRRQI YTLGRYLDSS VRNSKSLKSD 

       370        380        390        400        410        420 
FYRYDIDTNT WMLLSEDTAA DGGPKLVFDH QMCMDSEKHM IYTFGGRILT CNGSVDDSRA 

       430        440        450        460        470        480 
SEPQFSGLFA FNCQCQTWKL LREDSCNAGP EDIQSRIGHC MLFHSKNRCL YVFGGQRSKT 

       490        500        510        520        530        540 
YLNDFFSYDV DSDHVDIISD GTKKDSGMVP MTGFTQRATI DPELNEIHVL SGLSKDKEKR 

       550        560        570        580        590        600 
EENVRNSFWI YDIVRNSWSC VYKNDQAAKE NLSKSLQEEE PCPRFAHQLV YDELHKVHYL 

       610        620        630        640        650        660 
FGGNPGKSCS PKMRLDDFWS LKLCRPSKDY LLRHCKYLIR KHRFEEKAQM DPLSALKYLQ 

       670        680        690        700        710        720 
NDLYITVDHS DPEETKEFQL LASALFKSGS DFTALGFSDV DHTYAQRTQL FDTLVNFFPD 

       730 
SMTPPKGNLV DLITL 

« Hide

References

[1]"Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin."
Hasegawa H., Katoh H., Fujita H., Mori K., Negishi M.
Biochem. Biophys. Res. Commun. 276:350-354(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EP3-ALPHA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB046442 mRNA. Translation: BAB21439.1.
RefSeqNP_112649.1. NM_031359.1.
UniGeneRn.6383.

3D structure databases

ProteinModelPortalQ99PV3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016633.

Proteomic databases

PaxDbQ99PV3.
PRIDEQ99PV3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016633; ENSRNOP00000016633; ENSRNOG00000011524.
GeneID83536.
KEGGrno:83536.
UCSCRGD:620076. rat.

Organism-specific databases

CTD4289.
RGD620076. Mkln1.

Phylogenomic databases

eggNOGNOG290166.
GeneTreeENSGT00390000001702.
HOGENOMHOG000047912.
HOVERGENHBG052481.
InParanoidQ99PV3.
OMAWIYDIAR.
OrthoDBEOG7CNZFQ.
PhylomeDBQ99PV3.
TreeFamTF323659.

Gene expression databases

GenevestigatorQ99PV3.

Family and domain databases

Gene3D2.120.10.80. 1 hit.
2.60.120.260. 1 hit.
InterProIPR006595. CTLH_C.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR008979. Galactose-bd-like.
IPR015915. Kelch-typ_b-propeller.
IPR006594. LisH_dimerisation.
IPR010565. Muskelin_N.
[Graphical view]
PfamPF06588. Muskelin_N. 1 hit.
[Graphical view]
SMARTSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF50965. SSF50965. 1 hit.
PROSITEPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616045.
PROQ99PV3.

Entry information

Entry nameMKLN1_RAT
AccessionPrimary (citable) accession number: Q99PV3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families