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Protein

Probable ATP-dependent RNA helicase DDX52

Gene

Ddx52

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 217ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • poly(A) RNA binding Source: Ensembl
  • RNA helicase activity Source: RGD

GO - Biological processi

  • RNA secondary structure unwinding Source: GO_Central
  • rRNA processing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX52 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase ROK1-like
Short name:
rROK1L
DEAD box protein 52
Gene namesi
Name:Ddx52
Synonyms:Rok1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621743. Ddx52.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550621 – 598Probable ATP-dependent RNA helicase DDX52Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei39PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99PT0.
PRIDEiQ99PT0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002612.
GenevisibleiQ99PT0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003600.

Structurei

3D structure databases

ProteinModelPortaliQ99PT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 375Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST179
Domaini386 – 547Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi166 – 194Q motifAdd BLAST29
Motifi319 – 322DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 92Poly-Lys7

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0344. Eukaryota.
ENOG410XQS8. LUCA.
GeneTreeiENSGT00550000074863.
HOGENOMiHOG000242486.
HOVERGENiHBG051332.
InParanoidiQ99PT0.
KOiK14779.
OMAiTKCVAFF.
OrthoDBiEOG091G06V2.
PhylomeDBiQ99PT0.
TreeFamiTF314448.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSYDLFRRL GAGAKFDVKR FSADATRFQV GKRKFGSDSS ETVKGLDFFG
60 70 80 90 100
NKKSVSDECG GLQTQQELQN EETTEGGLLE RSKEPKKKKR KKMTADVPAQ
110 120 130 140 150
EDLDGTIQWT SSVEAKLQDK KANGEKKLTS EKLEHLRKEK INFFRNKHKI
160 170 180 190 200
HVQGTDLPDP IATFQQLDQE YKISPRLLQN ILDAGFQVPT PIQMQAIPVM
210 220 230 240 250
LHGRELLASA PTGSGKTLAF SIPILMQLKQ PTNKGFRALV ISPTRELASQ
260 270 280 290 300
IHRELIKISE GTGFRIHMIH KAAIAAKKFG PKSSKKFDIL VTTPNRLIYL
310 320 330 340 350
LKQEPPGIDL TSVEWLVVDE SDKLFEDGKT GFRDQLASIF LACTSPKVRR
360 370 380 390 400
AMFSATFAYD VEQWCKLNLD NIVSVSIGAR NSAVETVEQE LLFVGSETGK
410 420 430 440 450
LLAMRELVKK GFNPPVLVFV QSIERAKELF HELIYEGINV DVIHAERTQQ
460 470 480 490 500
QRDNTVHSFR AGKIWVLICT ALLARGIDFK GVNLVINYDF PTSSVEYIHR
510 520 530 540 550
IGRTGRAGNR GKAVTFFTED DKPLLRSVAN VIQQAGCPVP EYIKGFQKLL
560 570 580 590
SKQKKKMIKK PLERESISTT PKYFLEQAKQ KKVAGQNSKK KETLKGKS
Length:598
Mass (Da):67,240
Last modified:June 1, 2001 - v1
Checksum:iB9E818EA6B144425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055628 mRNA. Translation: BAB32441.1.
RefSeqiNP_445977.1. NM_053525.1.
UniGeneiRn.18605.

Genome annotation databases

EnsembliENSRNOT00000003600; ENSRNOP00000003600; ENSRNOG00000002612.
GeneIDi85432.
KEGGirno:85432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055628 mRNA. Translation: BAB32441.1.
RefSeqiNP_445977.1. NM_053525.1.
UniGeneiRn.18605.

3D structure databases

ProteinModelPortaliQ99PT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003600.

Proteomic databases

PaxDbiQ99PT0.
PRIDEiQ99PT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003600; ENSRNOP00000003600; ENSRNOG00000002612.
GeneIDi85432.
KEGGirno:85432.

Organism-specific databases

CTDi11056.
RGDi621743. Ddx52.

Phylogenomic databases

eggNOGiKOG0344. Eukaryota.
ENOG410XQS8. LUCA.
GeneTreeiENSGT00550000074863.
HOGENOMiHOG000242486.
HOVERGENiHBG051332.
InParanoidiQ99PT0.
KOiK14779.
OMAiTKCVAFF.
OrthoDBiEOG091G06V2.
PhylomeDBiQ99PT0.
TreeFamiTF314448.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ99PT0.

Gene expression databases

BgeeiENSRNOG00000002612.
GenevisibleiQ99PT0. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX52_RAT
AccessioniPrimary (citable) accession number: Q99PT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2001
Last modified: October 5, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.