Q99PS0 (K1C23_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cytoskeletal 23

Alternative name(s):
Cytokeratin-23
Short name=CK-23
Keratin-23
Short name=K23

Gene names

Name:	Krt23
Synonyms:	Haik1, Krt1-23

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins By similarity.
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Keratin, type I cytoskeletal 23		PRO_0000063678
Regions
	Region	1 – 71	71	Head
	Region	72 – 378	307	Rod
	Region	72 – 107	36	Coil 1A
	Region	108 – 125	18	Linker 1
	Region	126 – 217	92	Coil 1B
	Region	218 – 240	23	Linker 12
	Region	241 – 378	138	Coil 2
	Region	379 – 422	44	Rod-like helical tail

Sequences

	Sequence		Length	Mass (Da)
	Q99PS0 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: BD49C5215B5BB61E	FASTA	422	48,027
	10 20 30 40 50 60 MNSSHSFNQT YSASVHSLGS TRGRQGSCHR APSVHGGAGG VRISLSFTTP GCLPPGGSWG 70 80 90 100 110 120 SGRSSPLLGG NGKATMQNLN DRLATYLEKV RALEEANSKL ETRILRWHQE REPSHRKDYS 130 140 150 160 170 180 QYEENISRLQ EQIVDGKMAN AHIVVLIDNA RMAVDDFNLK FENEHSLKKD LEIEVEGLRK 190 200 210 220 230 240 TLDDLTIVTT DLEQEVEGMR KELILMKKRH EQEMEENHLP SDFKVSVKVD TTPGEDLIKV 250 260 270 280 290 300 LEDMRQEYEL IIKKKHQELD TWFREQSAAM AQEVASPAPV QGNQSDIHEL RRTFQALEID 310 320 330 340 350 360 LQAQHSRKTA LENMLTETRA RYSCRLQDMQ QIISHYEEEL IQLRQDLERQ NNEHKVLLGI 370 380 390 400 410 420 KTHLEKEIAT YRRLLEGDTE GTMDGSESRL KGSEASTIKA ITQESVNGRI VLSQVNEIQK HI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells." Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I. Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF102849 mRNA. Translation: AAK00051.1. BC019972 mRNA. Translation: AAH19972.1.
IPI	IPI00121462.
RefSeq	NP_203537.1. NM_033373.1.
UniGene	Mm.290657.
3D structure databases
ProteinModelPortal	Q99PS0.
SMR	Q99PS0. Positions 289-377.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000006969.
PTM databases
PhosphoSite	Q99PS0.
Proteomic databases
PaxDb	Q99PS0.
PRIDE	Q99PS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777.
GeneID	94179.
KEGG	mmu:94179.
Organism-specific databases
CTD	25984.
MGI	MGI:2148866. Krt23.
Phylogenomic databases
eggNOG	NOG145955.
GeneTree	ENSGT00560000076905.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	Q99PS0.
KO	K07604.
OMA	LILMKKH.
OrthoDB	EOG4001JS.
Gene expression databases
ArrayExpress	Q99PS0.
Bgee	Q99PS0.
CleanEx	MM_KRT23.
Genevestigator	Q99PS0.
GermOnline	ENSMUSG00000006777. Mus musculus.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	352129.
SOURCE	Search...

Entry information

Entry name

K1C23_MOUSE

Accession

Primary (citable) accession number: Q99PS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program