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Q99PS0

- K1C23_MOUSE

UniProt

Q99PS0 - K1C23_MOUSE

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Protein

Keratin, type I cytoskeletal 23

Gene
Krt23, Haik1, Krt1-23
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name:
CK-23
Keratin-23
Short name:
K23
Gene namesi
Name:Krt23
Synonyms:Haik1, Krt1-23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2148866. Krt23.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Keratin, type I cytoskeletal 23PRO_0000063678Add
BLAST

Proteomic databases

MaxQBiQ99PS0.
PaxDbiQ99PS0.
PRIDEiQ99PS0.

PTM databases

PhosphoSiteiQ99PS0.

Expressioni

Gene expression databases

ArrayExpressiQ99PS0.
BgeeiQ99PS0.
CleanExiMM_KRT23.
GenevestigatoriQ99PS0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006969.

Structurei

3D structure databases

ProteinModelPortaliQ99PS0.
SMRiQ99PS0. Positions 289-377.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7171HeadAdd
BLAST
Regioni72 – 378307RodAdd
BLAST
Regioni72 – 10736Coil 1AAdd
BLAST
Regioni108 – 12518Linker 1Add
BLAST
Regioni126 – 21792Coil 1BAdd
BLAST
Regioni218 – 24023Linker 12Add
BLAST
Regioni241 – 378138Coil 2Add
BLAST
Regioni379 – 42244Rod-like helical tailAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145955.
GeneTreeiENSGT00740000115042.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ99PS0.
KOiK07604.
OMAiKAITQES.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ99PS0.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PS0-1 [UniParc]FASTAAdd to Basket

« Hide

MNSSHSFNQT YSASVHSLGS TRGRQGSCHR APSVHGGAGG VRISLSFTTP    50
GCLPPGGSWG SGRSSPLLGG NGKATMQNLN DRLATYLEKV RALEEANSKL 100
ETRILRWHQE REPSHRKDYS QYEENISRLQ EQIVDGKMAN AHIVVLIDNA 150
RMAVDDFNLK FENEHSLKKD LEIEVEGLRK TLDDLTIVTT DLEQEVEGMR 200
KELILMKKRH EQEMEENHLP SDFKVSVKVD TTPGEDLIKV LEDMRQEYEL 250
IIKKKHQELD TWFREQSAAM AQEVASPAPV QGNQSDIHEL RRTFQALEID 300
LQAQHSRKTA LENMLTETRA RYSCRLQDMQ QIISHYEEEL IQLRQDLERQ 350
NNEHKVLLGI KTHLEKEIAT YRRLLEGDTE GTMDGSESRL KGSEASTIKA 400
ITQESVNGRI VLSQVNEIQK HI 422
Length:422
Mass (Da):48,027
Last modified:June 1, 2001 - v1
Checksum:iBD49C5215B5BB61E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102849 mRNA. Translation: AAK00051.1.
BC019972 mRNA. Translation: AAH19972.1.
CCDSiCCDS25382.1.
RefSeqiNP_203537.1. NM_033373.1.
UniGeneiMm.290657.

Genome annotation databases

EnsembliENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777.
GeneIDi94179.
KEGGimmu:94179.
UCSCiuc007liv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102849 mRNA. Translation: AAK00051.1 .
BC019972 mRNA. Translation: AAH19972.1 .
CCDSi CCDS25382.1.
RefSeqi NP_203537.1. NM_033373.1.
UniGenei Mm.290657.

3D structure databases

ProteinModelPortali Q99PS0.
SMRi Q99PS0. Positions 289-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000006969.

PTM databases

PhosphoSitei Q99PS0.

Proteomic databases

MaxQBi Q99PS0.
PaxDbi Q99PS0.
PRIDEi Q99PS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006969 ; ENSMUSP00000006969 ; ENSMUSG00000006777 .
GeneIDi 94179.
KEGGi mmu:94179.
UCSCi uc007liv.1. mouse.

Organism-specific databases

CTDi 25984.
MGIi MGI:2148866. Krt23.

Phylogenomic databases

eggNOGi NOG145955.
GeneTreei ENSGT00740000115042.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q99PS0.
KOi K07604.
OMAi KAITQES.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q99PS0.
TreeFami TF332742.

Miscellaneous databases

NextBioi 352129.
PROi Q99PS0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99PS0.
Bgeei Q99PS0.
CleanExi MM_KRT23.
Genevestigatori Q99PS0.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells."
    Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I.
    Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiK1C23_MOUSE
AccessioniPrimary (citable) accession number: Q99PS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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