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Protein

Keratin, type I cytoskeletal 23

Gene

Krt23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name:
CK-23
Keratin-23
Short name:
K23
Gene namesi
Name:Krt23
Synonyms:Haik1, Krt1-23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2148866. Krt23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636781 – 422Keratin, type I cytoskeletal 23Add BLAST422

Proteomic databases

PaxDbiQ99PS0.
PRIDEiQ99PS0.

PTM databases

iPTMnetiQ99PS0.
PhosphoSitePlusiQ99PS0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006777.
CleanExiMM_KRT23.
ExpressionAtlasiQ99PS0. baseline and differential.
GenevisibleiQ99PS0. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99PS0.
SMRiQ99PS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71HeadAdd BLAST71
Regioni72 – 378RodAdd BLAST307
Regioni72 – 107Coil 1AAdd BLAST36
Regioni108 – 125Linker 1Add BLAST18
Regioni126 – 217Coil 1BAdd BLAST92
Regioni218 – 240Linker 12Add BLAST23
Regioni241 – 378Coil 2Add BLAST138
Regioni379 – 422Rod-like helical tailAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK9C. Eukaryota.
ENOG4111DWD. LUCA.
GeneTreeiENSGT00760000119046.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ99PS0.
KOiK07604.
OMAiDTWYKEQ.
OrthoDBiEOG091G087I.
PhylomeDBiQ99PS0.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSHSFNQT YSASVHSLGS TRGRQGSCHR APSVHGGAGG VRISLSFTTP
60 70 80 90 100
GCLPPGGSWG SGRSSPLLGG NGKATMQNLN DRLATYLEKV RALEEANSKL
110 120 130 140 150
ETRILRWHQE REPSHRKDYS QYEENISRLQ EQIVDGKMAN AHIVVLIDNA
160 170 180 190 200
RMAVDDFNLK FENEHSLKKD LEIEVEGLRK TLDDLTIVTT DLEQEVEGMR
210 220 230 240 250
KELILMKKRH EQEMEENHLP SDFKVSVKVD TTPGEDLIKV LEDMRQEYEL
260 270 280 290 300
IIKKKHQELD TWFREQSAAM AQEVASPAPV QGNQSDIHEL RRTFQALEID
310 320 330 340 350
LQAQHSRKTA LENMLTETRA RYSCRLQDMQ QIISHYEEEL IQLRQDLERQ
360 370 380 390 400
NNEHKVLLGI KTHLEKEIAT YRRLLEGDTE GTMDGSESRL KGSEASTIKA
410 420
ITQESVNGRI VLSQVNEIQK HI
Length:422
Mass (Da):48,027
Last modified:June 1, 2001 - v1
Checksum:iBD49C5215B5BB61E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102849 mRNA. Translation: AAK00051.1.
BC019972 mRNA. Translation: AAH19972.1.
CCDSiCCDS25382.1.
RefSeqiNP_203537.1. NM_033373.1.
UniGeneiMm.290657.

Genome annotation databases

EnsembliENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777.
GeneIDi94179.
KEGGimmu:94179.
UCSCiuc007liv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102849 mRNA. Translation: AAK00051.1.
BC019972 mRNA. Translation: AAH19972.1.
CCDSiCCDS25382.1.
RefSeqiNP_203537.1. NM_033373.1.
UniGeneiMm.290657.

3D structure databases

ProteinModelPortaliQ99PS0.
SMRiQ99PS0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ99PS0.
PhosphoSitePlusiQ99PS0.

Proteomic databases

PaxDbiQ99PS0.
PRIDEiQ99PS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777.
GeneIDi94179.
KEGGimmu:94179.
UCSCiuc007liv.1. mouse.

Organism-specific databases

CTDi25984.
MGIiMGI:2148866. Krt23.

Phylogenomic databases

eggNOGiENOG410IK9C. Eukaryota.
ENOG4111DWD. LUCA.
GeneTreeiENSGT00760000119046.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ99PS0.
KOiK07604.
OMAiDTWYKEQ.
OrthoDBiEOG091G087I.
PhylomeDBiQ99PS0.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ99PS0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006777.
CleanExiMM_KRT23.
ExpressionAtlasiQ99PS0. baseline and differential.
GenevisibleiQ99PS0. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C23_MOUSE
AccessioniPrimary (citable) accession number: Q99PS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.