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Q99PS0

- K1C23_MOUSE

UniProt

Q99PS0 - K1C23_MOUSE

Protein

Keratin, type I cytoskeletal 23

Gene

Krt23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 23
    Alternative name(s):
    Cytokeratin-23
    Short name:
    CK-23
    Keratin-23
    Short name:
    K23
    Gene namesi
    Name:Krt23
    Synonyms:Haik1, Krt1-23
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2148866. Krt23.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Keratin, type I cytoskeletal 23PRO_0000063678Add
    BLAST

    Proteomic databases

    MaxQBiQ99PS0.
    PaxDbiQ99PS0.
    PRIDEiQ99PS0.

    PTM databases

    PhosphoSiteiQ99PS0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99PS0.
    BgeeiQ99PS0.
    CleanExiMM_KRT23.
    GenevestigatoriQ99PS0.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000006969.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PS0.
    SMRiQ99PS0. Positions 289-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7171HeadAdd
    BLAST
    Regioni72 – 378307RodAdd
    BLAST
    Regioni72 – 10736Coil 1AAdd
    BLAST
    Regioni108 – 12518Linker 1Add
    BLAST
    Regioni126 – 21792Coil 1BAdd
    BLAST
    Regioni218 – 24023Linker 12Add
    BLAST
    Regioni241 – 378138Coil 2Add
    BLAST
    Regioni379 – 42244Rod-like helical tailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG145955.
    GeneTreeiENSGT00740000115042.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ99PS0.
    KOiK07604.
    OMAiKAITQES.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ99PS0.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99PS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSSHSFNQT YSASVHSLGS TRGRQGSCHR APSVHGGAGG VRISLSFTTP    50
    GCLPPGGSWG SGRSSPLLGG NGKATMQNLN DRLATYLEKV RALEEANSKL 100
    ETRILRWHQE REPSHRKDYS QYEENISRLQ EQIVDGKMAN AHIVVLIDNA 150
    RMAVDDFNLK FENEHSLKKD LEIEVEGLRK TLDDLTIVTT DLEQEVEGMR 200
    KELILMKKRH EQEMEENHLP SDFKVSVKVD TTPGEDLIKV LEDMRQEYEL 250
    IIKKKHQELD TWFREQSAAM AQEVASPAPV QGNQSDIHEL RRTFQALEID 300
    LQAQHSRKTA LENMLTETRA RYSCRLQDMQ QIISHYEEEL IQLRQDLERQ 350
    NNEHKVLLGI KTHLEKEIAT YRRLLEGDTE GTMDGSESRL KGSEASTIKA 400
    ITQESVNGRI VLSQVNEIQK HI 422
    Length:422
    Mass (Da):48,027
    Last modified:June 1, 2001 - v1
    Checksum:iBD49C5215B5BB61E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102849 mRNA. Translation: AAK00051.1.
    BC019972 mRNA. Translation: AAH19972.1.
    CCDSiCCDS25382.1.
    RefSeqiNP_203537.1. NM_033373.1.
    UniGeneiMm.290657.

    Genome annotation databases

    EnsembliENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777.
    GeneIDi94179.
    KEGGimmu:94179.
    UCSCiuc007liv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102849 mRNA. Translation: AAK00051.1 .
    BC019972 mRNA. Translation: AAH19972.1 .
    CCDSi CCDS25382.1.
    RefSeqi NP_203537.1. NM_033373.1.
    UniGenei Mm.290657.

    3D structure databases

    ProteinModelPortali Q99PS0.
    SMRi Q99PS0. Positions 289-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000006969.

    PTM databases

    PhosphoSitei Q99PS0.

    Proteomic databases

    MaxQBi Q99PS0.
    PaxDbi Q99PS0.
    PRIDEi Q99PS0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006969 ; ENSMUSP00000006969 ; ENSMUSG00000006777 .
    GeneIDi 94179.
    KEGGi mmu:94179.
    UCSCi uc007liv.1. mouse.

    Organism-specific databases

    CTDi 25984.
    MGIi MGI:2148866. Krt23.

    Phylogenomic databases

    eggNOGi NOG145955.
    GeneTreei ENSGT00740000115042.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q99PS0.
    KOi K07604.
    OMAi KAITQES.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q99PS0.
    TreeFami TF332742.

    Miscellaneous databases

    NextBioi 352129.
    PROi Q99PS0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99PS0.
    Bgeei Q99PS0.
    CleanExi MM_KRT23.
    Genevestigatori Q99PS0.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells."
      Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I.
      Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiK1C23_MOUSE
    AccessioniPrimary (citable) accession number: Q99PS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3