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Protein

Keratin, type I cytoskeletal 23

Gene

Krt23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name:
CK-23
Keratin-23
Short name:
K23
Gene namesi
Name:Krt23
Synonyms:Haik1, Krt1-23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2148866 Krt23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636781 – 422Keratin, type I cytoskeletal 23Add BLAST422

Proteomic databases

PaxDbiQ99PS0
PRIDEiQ99PS0

PTM databases

iPTMnetiQ99PS0
PhosphoSitePlusiQ99PS0

Expressioni

Gene expression databases

BgeeiENSMUSG00000006777
CleanExiMM_KRT23
ExpressionAtlasiQ99PS0 baseline and differential
GenevisibleiQ99PS0 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99PS0
SMRiQ99PS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 382IF rodPROSITE-ProRule annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71HeadAdd BLAST71
Regioni72 – 107Coil 1AAdd BLAST36
Regioni108 – 125Linker 1Add BLAST18
Regioni126 – 217Coil 1BAdd BLAST92
Regioni218 – 240Linker 12Add BLAST23
Regioni241 – 378Coil 2Add BLAST138
Regioni379 – 422Rod-like helical tailAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK9C Eukaryota
ENOG4111DWD LUCA
GeneTreeiENSGT00910000144130
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ99PS0
KOiK07604
OMAiYSQYEEN
OrthoDBiEOG091G087I
PhylomeDBiQ99PS0
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99PS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSHSFNQT YSASVHSLGS TRGRQGSCHR APSVHGGAGG VRISLSFTTP
60 70 80 90 100
GCLPPGGSWG SGRSSPLLGG NGKATMQNLN DRLATYLEKV RALEEANSKL
110 120 130 140 150
ETRILRWHQE REPSHRKDYS QYEENISRLQ EQIVDGKMAN AHIVVLIDNA
160 170 180 190 200
RMAVDDFNLK FENEHSLKKD LEIEVEGLRK TLDDLTIVTT DLEQEVEGMR
210 220 230 240 250
KELILMKKRH EQEMEENHLP SDFKVSVKVD TTPGEDLIKV LEDMRQEYEL
260 270 280 290 300
IIKKKHQELD TWFREQSAAM AQEVASPAPV QGNQSDIHEL RRTFQALEID
310 320 330 340 350
LQAQHSRKTA LENMLTETRA RYSCRLQDMQ QIISHYEEEL IQLRQDLERQ
360 370 380 390 400
NNEHKVLLGI KTHLEKEIAT YRRLLEGDTE GTMDGSESRL KGSEASTIKA
410 420
ITQESVNGRI VLSQVNEIQK HI
Length:422
Mass (Da):48,027
Last modified:June 1, 2001 - v1
Checksum:iBD49C5215B5BB61E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102849 mRNA Translation: AAK00051.1
BC019972 mRNA Translation: AAH19972.1
CCDSiCCDS25382.1
RefSeqiNP_203537.1, NM_033373.1
UniGeneiMm.290657

Genome annotation databases

EnsembliENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777
GeneIDi94179
KEGGimmu:94179
UCSCiuc007liv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1C23_MOUSE
AccessioniPrimary (citable) accession number: Q99PS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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