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Q99PS0 (K1C23_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name=CK-23
Keratin-23
Short name=K23
Gene names
Name:Krt23
Synonyms:Haik1, Krt1-23
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins By similarity.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Keratin, type I cytoskeletal 23
PRO_0000063678

Regions

Region1 – 7171Head
Region72 – 378307Rod
Region72 – 10736Coil 1A
Region108 – 12518Linker 1
Region126 – 21792Coil 1B
Region218 – 24023Linker 12
Region241 – 378138Coil 2
Region379 – 42244Rod-like helical tail

Sequences

Sequence LengthMass (Da)Tools
Q99PS0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: BD49C5215B5BB61E

FASTA42248,027
        10         20         30         40         50         60 
MNSSHSFNQT YSASVHSLGS TRGRQGSCHR APSVHGGAGG VRISLSFTTP GCLPPGGSWG 

        70         80         90        100        110        120 
SGRSSPLLGG NGKATMQNLN DRLATYLEKV RALEEANSKL ETRILRWHQE REPSHRKDYS 

       130        140        150        160        170        180 
QYEENISRLQ EQIVDGKMAN AHIVVLIDNA RMAVDDFNLK FENEHSLKKD LEIEVEGLRK 

       190        200        210        220        230        240 
TLDDLTIVTT DLEQEVEGMR KELILMKKRH EQEMEENHLP SDFKVSVKVD TTPGEDLIKV 

       250        260        270        280        290        300 
LEDMRQEYEL IIKKKHQELD TWFREQSAAM AQEVASPAPV QGNQSDIHEL RRTFQALEID 

       310        320        330        340        350        360 
LQAQHSRKTA LENMLTETRA RYSCRLQDMQ QIISHYEEEL IQLRQDLERQ NNEHKVLLGI 

       370        380        390        400        410        420 
KTHLEKEIAT YRRLLEGDTE GTMDGSESRL KGSEASTIKA ITQESVNGRI VLSQVNEIQK 


HI 

« Hide

References

« Hide 'large scale' references
[1]"Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells."
Zhang J.-S., Wang L., Huang H., Nelson M., Smith D.I.
Genes Chromosomes Cancer 30:123-135(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF102849 mRNA. Translation: AAK00051.1.
BC019972 mRNA. Translation: AAH19972.1.
RefSeqNP_203537.1. NM_033373.1.
UniGeneMm.290657.

3D structure databases

ProteinModelPortalQ99PS0.
SMRQ99PS0. Positions 70-220, 236-377.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000006969.

PTM databases

PhosphoSiteQ99PS0.

Proteomic databases

PaxDbQ99PS0.
PRIDEQ99PS0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006969; ENSMUSP00000006969; ENSMUSG00000006777.
GeneID94179.
KEGGmmu:94179.
UCSCuc007liv.1. mouse.

Organism-specific databases

CTD25984.
MGIMGI:2148866. Krt23.

Phylogenomic databases

eggNOGNOG145955.
GeneTreeENSGT00740000115042.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ99PS0.
KOK07604.
OMAKAITQES.
OrthoDBEOG7FV3Q8.
PhylomeDBQ99PS0.
TreeFamTF332742.

Gene expression databases

ArrayExpressQ99PS0.
BgeeQ99PS0.
CleanExMM_KRT23.
GenevestigatorQ99PS0.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio352129.
PROQ99PS0.
SOURCESearch...

Entry information

Entry nameK1C23_MOUSE
AccessionPrimary (citable) accession number: Q99PS0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot