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Protein

Protein O-mannosyl-transferase 1

Gene

Pomt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.By similarity

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.109 5301
ReactomeiR-RNO-5173105 O-linked glycosylation
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT39 Glycosyltransferase Family 39

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 1 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Gene namesi
Name:Pomt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620078 Pomt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Transmembranei660 – 680HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214861 – 747Protein O-mannosyl-transferase 1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi539N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99PR0
PRIDEiQ99PR0

PTM databases

UniCarbKBiQ99PR0

Expressioni

Gene expression databases

BgeeiENSRNOG00000010477
ExpressionAtlasiQ99PR0 baseline and differential
GenevisibleiQ99PR0 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015214

Structurei

3D structure databases

ProteinModelPortaliQ99PR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 381MIR 1PROSITE-ProRule annotationAdd BLAST64
Domaini392 – 449MIR 2PROSITE-ProRule annotationAdd BLAST58
Domaini453 – 513MIR 3PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3359 Eukaryota
COG1928 LUCA
GeneTreeiENSGT00910000144161
HOGENOMiHOG000157526
HOVERGENiHBG053637
InParanoidiQ99PR0
KOiK00728
OMAiWWIVKDP
OrthoDBiEOG091G02QX
PhylomeDBiQ99PR0
TreeFamiTF300552

Family and domain databases

InterProiView protein in InterPro
IPR027005 GlyclTrfase_39-like
IPR003342 Glyco_trans_39/83
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR032421 PMT_4TMC
PANTHERiPTHR10050 PTHR10050, 1 hit
PfamiView protein in Pfam
PF02815 MIR, 1 hit
PF02366 PMT, 1 hit
PF16192 PMT_4TMC, 1 hit
SMARTiView protein in SMART
SM00472 MIR, 3 hits
SUPFAMiSSF82109 SSF82109, 1 hit
PROSITEiView protein in PROSITE
PS50919 MIR, 3 hits

Sequencei

Sequence statusi: Complete.

Q99PR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNRSMGRED TLGVLPSLLF CKMLRFLKRP LVVTIDINLN LVALTVLGLL
60 70 80 90 100
TRLWQLSYPR AVVFDEVYYG QYISFYMKRV FFLDDSGPPF GHMLLALGGW
110 120 130 140 150
LGGFDGNFLW NRIGAEYSSN VPVWSLRLLP ALAGALSVPM AYQIVLELHF
160 170 180 190 200
SHCTAMGAAL LMLIENALIT QSRLMLLESI LIFFNLLAVL SYLKFFNSQT
210 220 230 240 250
HSPFSVHWWL WLMLTGVSCS CAVGIKYMGI FTYLLVLSIA AVHAWHLIGD
260 270 280 290 300
QTLSNICVLS HLLARAVALL VVPVFLYLLF FYVHLMLLYR SGPHDQIMSS
310 320 330 340 350
AFQASLEGGL ARITQGQPLE VAFGSQVTLK SVSGKPLPCW LHSHKNTYPM
360 370 380 390 400
IYENGRGSSH QQQVTCYPFK DINNWWIVKD PGRHQLVVNN PPRPVRHGDI
410 420 430 440 450
VQLVHGMTTR LLNTHDVAAP LSPHSQEVSC YIDYNISMPA QNLWKLDIVN
460 470 480 490 500
RESNQDTWKT ILSEVRFVHV NTSAILKLSG AHLPDWGFRQ LEVVGEKLSL
510 520 530 540 550
GPHESMVWNV EEHRYGRGHE QKERELELHS PTQHDISRNL SFMARFSELQ
560 570 580 590 600
WKMLTLKNED LEHQYSSTPL EWLTLDTNIA YWLHPRTSAQ IHLLGNIVIW
610 620 630 640 650
TSASLATVAY TLLFFWYLLR RRRNICDLPE DAWSHWVLAG ALCIGGWALN
660 670 680 690 700
YLPFFLMERM LFLYHYLPAL TFQILLLPIV MQHASDHLCR SQLQRNVFSA
710 720 730 740
LVVAWYSSAC HVSNMLRPLT YGDTSLSPGE LRALRWKDSW DILIRKY
Length:747
Mass (Da):85,496
Last modified:June 1, 2001 - v1
Checksum:i7ECE8F752E7FFA89
GO

Sequence cautioni

The sequence AAH70912 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192388 mRNA Translation: AAG53461.1
BC070912 mRNA Translation: AAH70912.1 Sequence problems.
RefSeqiNP_445858.1, NM_053406.2
UniGeneiRn.162659

Genome annotation databases

EnsembliENSRNOT00000015214; ENSRNOP00000015214; ENSRNOG00000010477
GeneIDi84430
KEGGirno:84430
UCSCiRGD:620078 rat

Similar proteinsi

Entry informationi

Entry nameiPOMT1_RAT
AccessioniPrimary (citable) accession number: Q99PR0
Secondary accession number(s): Q6IRI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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