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Protein

Protein O-mannosyl-transferase 1

Gene

Pomt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.By similarity

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.109. 5301.
ReactomeiR-RNO-5173105. O-linked glycosylation.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 1 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Gene namesi
Name:Pomt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620078. Pomt1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Transmembranei660 – 680HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214861 – 747Protein O-mannosyl-transferase 1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi539N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99PR0.
PRIDEiQ99PR0.

PTM databases

UniCarbKBiQ99PR0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010477.
ExpressionAtlasiQ99PR0. differential.
GenevisibleiQ99PR0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015214.

Structurei

3D structure databases

ProteinModelPortaliQ99PR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 381MIR 1PROSITE-ProRule annotationAdd BLAST64
Domaini392 – 449MIR 2PROSITE-ProRule annotationAdd BLAST58
Domaini453 – 513MIR 3PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3359. Eukaryota.
COG1928. LUCA.
GeneTreeiENSGT00860000133866.
HOGENOMiHOG000157526.
HOVERGENiHBG053637.
InParanoidiQ99PR0.
KOiK00728.
OMAiFFYVHLI.
OrthoDBiEOG091G02QX.
PhylomeDBiQ99PR0.
TreeFamiTF300552.

Family and domain databases

InterProiIPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
IPR032421. PMT_4TMC.
[Graphical view]
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
PF16192. PMT_4TMC. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNRSMGRED TLGVLPSLLF CKMLRFLKRP LVVTIDINLN LVALTVLGLL
60 70 80 90 100
TRLWQLSYPR AVVFDEVYYG QYISFYMKRV FFLDDSGPPF GHMLLALGGW
110 120 130 140 150
LGGFDGNFLW NRIGAEYSSN VPVWSLRLLP ALAGALSVPM AYQIVLELHF
160 170 180 190 200
SHCTAMGAAL LMLIENALIT QSRLMLLESI LIFFNLLAVL SYLKFFNSQT
210 220 230 240 250
HSPFSVHWWL WLMLTGVSCS CAVGIKYMGI FTYLLVLSIA AVHAWHLIGD
260 270 280 290 300
QTLSNICVLS HLLARAVALL VVPVFLYLLF FYVHLMLLYR SGPHDQIMSS
310 320 330 340 350
AFQASLEGGL ARITQGQPLE VAFGSQVTLK SVSGKPLPCW LHSHKNTYPM
360 370 380 390 400
IYENGRGSSH QQQVTCYPFK DINNWWIVKD PGRHQLVVNN PPRPVRHGDI
410 420 430 440 450
VQLVHGMTTR LLNTHDVAAP LSPHSQEVSC YIDYNISMPA QNLWKLDIVN
460 470 480 490 500
RESNQDTWKT ILSEVRFVHV NTSAILKLSG AHLPDWGFRQ LEVVGEKLSL
510 520 530 540 550
GPHESMVWNV EEHRYGRGHE QKERELELHS PTQHDISRNL SFMARFSELQ
560 570 580 590 600
WKMLTLKNED LEHQYSSTPL EWLTLDTNIA YWLHPRTSAQ IHLLGNIVIW
610 620 630 640 650
TSASLATVAY TLLFFWYLLR RRRNICDLPE DAWSHWVLAG ALCIGGWALN
660 670 680 690 700
YLPFFLMERM LFLYHYLPAL TFQILLLPIV MQHASDHLCR SQLQRNVFSA
710 720 730 740
LVVAWYSSAC HVSNMLRPLT YGDTSLSPGE LRALRWKDSW DILIRKY
Length:747
Mass (Da):85,496
Last modified:June 1, 2001 - v1
Checksum:i7ECE8F752E7FFA89
GO

Sequence cautioni

The sequence AAH70912 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192388 mRNA. Translation: AAG53461.1.
BC070912 mRNA. Translation: AAH70912.1. Sequence problems.
RefSeqiNP_445858.1. NM_053406.2.
UniGeneiRn.162659.

Genome annotation databases

EnsembliENSRNOT00000015214; ENSRNOP00000015214; ENSRNOG00000010477.
GeneIDi84430.
KEGGirno:84430.
UCSCiRGD:620078. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192388 mRNA. Translation: AAG53461.1.
BC070912 mRNA. Translation: AAH70912.1. Sequence problems.
RefSeqiNP_445858.1. NM_053406.2.
UniGeneiRn.162659.

3D structure databases

ProteinModelPortaliQ99PR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015214.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

PTM databases

UniCarbKBiQ99PR0.

Proteomic databases

PaxDbiQ99PR0.
PRIDEiQ99PR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015214; ENSRNOP00000015214; ENSRNOG00000010477.
GeneIDi84430.
KEGGirno:84430.
UCSCiRGD:620078. rat.

Organism-specific databases

CTDi10585.
RGDi620078. Pomt1.

Phylogenomic databases

eggNOGiKOG3359. Eukaryota.
COG1928. LUCA.
GeneTreeiENSGT00860000133866.
HOGENOMiHOG000157526.
HOVERGENiHBG053637.
InParanoidiQ99PR0.
KOiK00728.
OMAiFFYVHLI.
OrthoDBiEOG091G02QX.
PhylomeDBiQ99PR0.
TreeFamiTF300552.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.109. 5301.
ReactomeiR-RNO-5173105. O-linked glycosylation.

Miscellaneous databases

PROiQ99PR0.

Gene expression databases

BgeeiENSRNOG00000010477.
ExpressionAtlasiQ99PR0. differential.
GenevisibleiQ99PR0. RN.

Family and domain databases

InterProiIPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
IPR032421. PMT_4TMC.
[Graphical view]
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
PF16192. PMT_4TMC. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOMT1_RAT
AccessioniPrimary (citable) accession number: Q99PR0
Secondary accession number(s): Q6IRI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.