Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99PR0

- POMT1_RAT

UniProt

Q99PR0 - POMT1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein O-mannosyl-transferase 1

Gene

Pomt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.By similarity

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Cofactori

Magnesium.By similarity

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.109. 5301.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 1 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Gene namesi
Name:Pomt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi620078. Pomt1.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Protein O-mannosyl-transferase 1PRO_0000121486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ99PR0.

Expressioni

Gene expression databases

GenevestigatoriQ99PR0.

Structurei

3D structure databases

ProteinModelPortaliQ99PR0.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei597 – 61721HelicalSequence AnalysisAdd
BLAST
Transmembranei636 – 65621HelicalSequence AnalysisAdd
BLAST
Transmembranei660 – 68021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini318 – 38164MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 44958MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 51361MIR 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
GeneTreeiENSGT00740000115531.
HOGENOMiHOG000157526.
HOVERGENiHBG053637.
InParanoidiQ99PR0.
KOiK00728.
OMAiLLFFYVH.
OrthoDBiEOG79KPDP.
PhylomeDBiQ99PR0.
TreeFamiTF300552.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PR0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNRSMGRED TLGVLPSLLF CKMLRFLKRP LVVTIDINLN LVALTVLGLL
60 70 80 90 100
TRLWQLSYPR AVVFDEVYYG QYISFYMKRV FFLDDSGPPF GHMLLALGGW
110 120 130 140 150
LGGFDGNFLW NRIGAEYSSN VPVWSLRLLP ALAGALSVPM AYQIVLELHF
160 170 180 190 200
SHCTAMGAAL LMLIENALIT QSRLMLLESI LIFFNLLAVL SYLKFFNSQT
210 220 230 240 250
HSPFSVHWWL WLMLTGVSCS CAVGIKYMGI FTYLLVLSIA AVHAWHLIGD
260 270 280 290 300
QTLSNICVLS HLLARAVALL VVPVFLYLLF FYVHLMLLYR SGPHDQIMSS
310 320 330 340 350
AFQASLEGGL ARITQGQPLE VAFGSQVTLK SVSGKPLPCW LHSHKNTYPM
360 370 380 390 400
IYENGRGSSH QQQVTCYPFK DINNWWIVKD PGRHQLVVNN PPRPVRHGDI
410 420 430 440 450
VQLVHGMTTR LLNTHDVAAP LSPHSQEVSC YIDYNISMPA QNLWKLDIVN
460 470 480 490 500
RESNQDTWKT ILSEVRFVHV NTSAILKLSG AHLPDWGFRQ LEVVGEKLSL
510 520 530 540 550
GPHESMVWNV EEHRYGRGHE QKERELELHS PTQHDISRNL SFMARFSELQ
560 570 580 590 600
WKMLTLKNED LEHQYSSTPL EWLTLDTNIA YWLHPRTSAQ IHLLGNIVIW
610 620 630 640 650
TSASLATVAY TLLFFWYLLR RRRNICDLPE DAWSHWVLAG ALCIGGWALN
660 670 680 690 700
YLPFFLMERM LFLYHYLPAL TFQILLLPIV MQHASDHLCR SQLQRNVFSA
710 720 730 740
LVVAWYSSAC HVSNMLRPLT YGDTSLSPGE LRALRWKDSW DILIRKY
Length:747
Mass (Da):85,496
Last modified:June 1, 2001 - v1
Checksum:i7ECE8F752E7FFA89
GO

Sequence cautioni

The sequence AAH70912.1 differs from that shown. Reason: Intron retention.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192388 mRNA. Translation: AAG53461.1.
BC070912 mRNA. Translation: AAH70912.1. Sequence problems.
RefSeqiNP_445858.1. NM_053406.2.
XP_006234063.1. XM_006234001.2.
UniGeneiRn.162659.

Genome annotation databases

EnsembliENSRNOT00000015214; ENSRNOP00000015214; ENSRNOG00000010477.
GeneIDi84430.
KEGGirno:84430.
UCSCiRGD:620078. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192388 mRNA. Translation: AAG53461.1 .
BC070912 mRNA. Translation: AAH70912.1 . Sequence problems.
RefSeqi NP_445858.1. NM_053406.2.
XP_006234063.1. XM_006234001.2.
UniGenei Rn.162659.

3D structure databases

ProteinModelPortali Q99PR0.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

Proteomic databases

PRIDEi Q99PR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015214 ; ENSRNOP00000015214 ; ENSRNOG00000010477 .
GeneIDi 84430.
KEGGi rno:84430.
UCSCi RGD:620078. rat.

Organism-specific databases

CTDi 10585.
RGDi 620078. Pomt1.

Phylogenomic databases

eggNOGi COG1928.
GeneTreei ENSGT00740000115531.
HOGENOMi HOG000157526.
HOVERGENi HBG053637.
InParanoidi Q99PR0.
KOi K00728.
OMAi LLFFYVH.
OrthoDBi EOG79KPDP.
PhylomeDBi Q99PR0.
TreeFami TF300552.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.1.109. 5301.

Miscellaneous databases

NextBioi 616936.
PROi Q99PR0.

Gene expression databases

Genevestigatori Q99PR0.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a rat homologue of the Saccharomyces protein O-mannosyltransferase gene."
    Chiba A., Ronca F., Popp S., Margolis R.U.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiPOMT1_RAT
AccessioniPrimary (citable) accession number: Q99PR0
Secondary accession number(s): Q6IRI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3