UniProtKB - Q99PP2 (ZN318_MOUSE)
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Protein
Zinc finger protein 318
Gene
Znf318
Organism
Mus musculus (Mouse)
Status
Functioni
Isoform 2: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division.3 Publications
Isoform 1: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1085 – 1119 | Matrin-type 1Add BLAST | 35 | |
Zinc fingeri | 1158 – 1180 | Matrin-type 2Add BLAST | 23 |
GO - Molecular functioni
- nucleic acid binding Source: InterPro
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- meiotic cell cycle Source: UniProtKB-KW
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Meiosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 318Alternative name(s): Testicular zinc finger protein |
Gene namesi | Name:Znf318 Synonyms:Tzf, Zfp318 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1889348 Zfp318 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191808 | 1 – 2237 | Zinc finger protein 318Add BLAST | 2237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | PhosphoserineBy similarity | 1 | |
Modified residuei | 109 | PhosphoserineBy similarity | 1 | |
Modified residuei | 111 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Modified residuei | 205 | PhosphoserineBy similarity | 1 | |
Modified residuei | 237 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 239 | PhosphoserineCombined sources | 1 | |
Modified residuei | 246 | PhosphoserineCombined sources | 1 | |
Modified residuei | 497 | PhosphoserineBy similarity | 1 | |
Modified residuei | 502 | PhosphoserineBy similarity | 1 | |
Modified residuei | 531 | PhosphoserineBy similarity | 1 | |
Modified residuei | 557 | PhosphoserineBy similarity | 1 | |
Cross-linki | 577 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 583 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 596 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 607 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 865 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1032 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1059 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1445 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1878 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1908 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1988 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2044 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2054 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2140 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2194 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2206 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q99PP2 |
PaxDbi | Q99PP2 |
PeptideAtlasi | Q99PP2 |
PRIDEi | Q99PP2 |
PTM databases
iPTMneti | Q99PP2 |
PhosphoSitePlusi | Q99PP2 |
Expressioni
Tissue specificityi
Isoform 1 and isoform 2 are highly expressed in testis, moderately expressed in adrenal gland and uterus and faintly expressed in brain, kidney and liver. Isoform 1 is expressed more in adrenal gland, uterus and liver than isoform 2 is. Expression during testicular development of isoform 1 and isoform 2 is restricted to spermatocytes at the pachytene stage of meiotic prophase and to round and elongated spermatids.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000015597 |
CleanExi | MM_ZFP318 |
ExpressionAtlasi | B0V2M3 baseline and differential |
Genevisiblei | B0V2M3 MM |
Interactioni
Subunit structurei
Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR.2 Publications
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 2083601 interactor. |
IntActi | Q99PP2 1 interactor. |
STRINGi | 10090.ENSMUSP00000109109 |
Structurei
3D structure databases
ProteinModelPortali | Q99PP2 |
SMRi | Q99PP2 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 1114 | Interaction with AR1 PublicationAdd BLAST | 1114 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 348 – 376 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 904 – 1003 | Sequence analysisAdd BLAST | 100 | |
Coiled coili | 1798 – 1827 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1470 – 1499 | Pro-richAdd BLAST | 30 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1085 – 1119 | Matrin-type 1Add BLAST | 35 | |
Zinc fingeri | 1158 – 1180 | Matrin-type 2Add BLAST | 23 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG410IHGT Eukaryota ENOG4111IJJ LUCA |
GeneTreei | ENSGT00390000000614 |
HOGENOMi | HOG000043103 |
HOVERGENi | HBG107139 |
InParanoidi | Q99PP2 |
OMAi | QHNEKYK |
OrthoDBi | EOG091G00B9 |
TreeFami | TF350583 |
Family and domain databases
InterProi | View protein in InterPro IPR003604 Matrin/U1-like-C_Znf_C2H2 |
SMARTi | View protein in SMART SM00451 ZnF_U1, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q99PP2-1) [UniParc]FASTAAdd to basket
Also known as: TZF-L
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MYRSGSRSSV SSHRSKDGSA SGPPPGRPVG ASSGPTRRPS SPPPPSCSSL
60 70 80 90 100
RLPARRHRSP SGHRGRWASP SPPRGRRGSP SPPRGRRASP SPTRGRRASP
110 120 130 140 150
SPPRGRRGSP SPPRARRGSP SPPRSRRHYP PGLGGFRGSI RGESRADFAR
160 170 180 190 200
DGRGDHPGGG GGSRRRSPGL CSDSSLEESL RITVGNDHFC VSTPERRRLS
210 220 230 240 250
DRLGSPVDGL QDMDRDDLTD DSVFTRSSQC SRGLERYISR EEGPLSPFLG
260 270 280 290 300
QLDEDYRTRE TFLHRPEFSP QSSCHDELLR GTERNRDKLK SSSYSIRSEE
310 320 330 340 350
RSREAKRPRY DDTEKVHSSG GDHSSFTSGT RNYRQRRSSP SPRFLDPEFR
360 370 380 390 400
ELDLARRKRE EEEEQSRSLS QELVGVGDDQ IGCSIPGLAG VLTTSEPGYS
410 420 430 440 450
LQRPEEVPMM PKKSILKKRI EADMKPSLQL ESFSSGASSG EDHPLYSEHS
460 470 480 490 500
PLPLSGAIAA FTSEIENKGT TVEADLKEPQ SNLYQWGPLR EIPKDNSEKF
510 520 530 540 550
DSFLGFKEKL DLKAEGLEQQ TDFLLPHERA SQDGSGFSRI LSMLADPTIT
560 570 580 590 600
QEKRRRSFPD IEDEEKFLYG DEEEDIKSES PLKSLEDPES AGTRQKANSL
610 620 630 640 650
PSTPAVKLES LEESNPEYAK IHNLLKTIGL DIGVAEIGKL AARTQERLHG
660 670 680 690 700
KKPSSRPSAD RRLSADRHLS GDRHFSADRC SSVEHSFTAD WRSSDPHRPE
710 720 730 740 750
SRETHHSNTQ SPEVSHPHPA SPVDPYLRTK NSPPFLKSDH PVCHVSGPEV
760 770 780 790 800
VGSGFQSSVA VRCMLPSAPS TPIRLPHSAA LSQFHIPGAS QFAAARIPPN
810 820 830 840 850
YQGSVIPSAS FDAYRHYMAY AASRWPMYPA SQPPSHPLSD PHRLLPVTKQ
860 870 880 890 900
AARSRPNLRV IPTVTPAKPK QEIPVLGSIS VKRIPVRVSI PSLIKYNPKK
910 920 930 940 950
ISDEKNRASQ KQKVIEEREK LKTEQEARQK KMFYLTTELE RLHKQQGEML
960 970 980 990 1000
RKKRREKDGH KDPLLMEVSR LQDSIMKDIA ELHKETEEAE KKQSELDKVA
1010 1020 1030 1040 1050
QILGIDIFDK SLKSSNDSKE STEKPEKEKS KSPEKELSPS NSSSSNKESK
1060 1070 1080 1090 1100
MNEKSCIKSP SSTESLQPTV KQSDQPVAAY EYYDAGSHWC KDCNTTCGTM
1110 1120 1130 1140 1150
FDFFTHMHNK KHTQTLDPYN RPWASKTQSE AKQDTVKRTD KITVPAKGSE
1160 1170 1180 1190 1200
FLIPVTGFYC QLCEEFLGDP ISGEQHVKGH QHNENYKKYV EENPLYEERR
1210 1220 1230 1240 1250
NLDRQAGLAV VLETERRRQN ELKRKLNEKP KEEKIEKKAR IVREVKEDDK
1260 1270 1280 1290 1300
APGELEEQLS EDGSAPEKGE VKGNASLRPQ VKEEVKKEPS VASIAASFGK
1310 1320 1330 1340 1350
FSWKKPEKEE EKGSVVTPGA PKEDTVETSK DRDDGKAEVG KAKPIKIKLS
1360 1370 1380 1390 1400
GKTVIAHTSP WTPVVTTSTQ TKIRPNLPIP STVLRKSGSA TVSKPAPLNT
1410 1420 1430 1440 1450
FLSIKSSGTS TKPLPVVKES SSDLLLPPDI ISKAFGGEEV VLKGSPEEKV
1460 1470 1480 1490 1500
ELAEKNEPSQ VPEQMLALLP PPPPPPPPPP PPPPPPPPQA VPQLSAPSPA
1510 1520 1530 1540 1550
QANVVLTPVK SNSVISQTFS LGFQGPNILN PGLPVAFMAS EQPTVIPSDE
1560 1570 1580 1590 1600
TAPGVSESDW DQTLISMLVR PPPPLSSVFS EQAKKLEKRN SCLATANAKD
1610 1620 1630 1640 1650
LYDIFYSSGG KGAHETKLSS STLANGESSS LPRTESSDFS STCTLNSSMS
1660 1670 1680 1690 1700
SEDLPQCSAL VTATEISNLE NPISKGMEST GKWSVVDQID PKSRDSTYSF
1710 1720 1730 1740 1750
LQPLTRLYQN KPYEIVSPKT DTLVMWTSGS SQNDTHKDRP PEGKIRFDLG
1760 1770 1780 1790 1800
EPGPPGTDST SHLSDTHCQT NGPQKLIEIN LIDNQNKNQE VYQSEGCRES
1810 1820 1830 1840 1850
EMKRKTELKG KVATEEEEEE EEEGANSIED SNSNHGNRNT WEGEIGQPKL
1860 1870 1880 1890 1900
STVDKKGEQS SKLMTGHENT SKVVIELSPS LPSKRTKIDL FPSLLQNPKS
1910 1920 1930 1940 1950
MPELLLLSPA GSGLCLKRQE IWERPEKPGL EDVELQGTRP ELTVTIESKV
1960 1970 1980 1990 2000
LENFDTTHLE VEGFASLRNL GDMHANFHNS QTEQTRRSPT ALSEKMSEEI
2010 2020 2030 2040 2050
SVSSVMCNPS SSSDIEPVPS FSGFPLESPK TLVLNFETEG AHSSSNSRNG
2060 2070 2080 2090 2100
RITSNSLETG HPVENVGHDL GGERTHQALD LLAGGMLSED VKETSPLQKD
2110 2120 2130 2140 2150
LLRMESTTVS PSGLGPSPCL PDLVDFVTRT PGVPKQKPCS PLSEPDAFLK
2160 2170 2180 2190 2200
CSSLEMGSPP PEILSVSVSE VAVPQVSEDN DSALNLVKTP PSGSPSRDQV
2210 2220 2230
VGGNVSPREM PEQEAAVDVI PDHTRSNVYN SQDYLNG
Sequence cautioni
The sequence AAF61636 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI50731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK00650 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 223 | V → D in AAF61636 (PubMed:10873617).Curated | 1 | |
Sequence conflicti | 223 | V → D in AAK00650 (PubMed:12589823).Curated | 1 | |
Sequence conflicti | 295 | S → F in AAI50731 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 509 | K → R in AAF61636 (PubMed:10873617).Curated | 1 | |
Sequence conflicti | 509 | K → R in AAK00650 (PubMed:12589823).Curated | 1 | |
Sequence conflicti | 523 | F → N in AAF61636 (PubMed:10873617).Curated | 1 | |
Sequence conflicti | 523 | F → N in AAK00650 (PubMed:12589823).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016594 | 1115 – 1154 | TLDPY…EFLIP → GQFQKSSHFQTEGLKQMFLL QECRDRNHRDYGNNVRPCGQ in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_016595 | 1155 – 2237 | Missing in isoform 2. 1 PublicationAdd BLAST | 1083 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC151275 Genomic DNA No translation available. CT009572 Genomic DNA No translation available. AF159455 mRNA Translation: AAF61636.1 Sequence problems. AF227194 mRNA Translation: AAK00650.1 Sequence problems. BC150730 mRNA Translation: AAI50731.1 Sequence problems. AK011661 mRNA Translation: BAC25342.1 AK157779 mRNA Translation: BAE34193.1 |
CCDSi | CCDS28826.2 [Q99PP2-2] CCDS28827.2 [Q99PP2-1] |
PIRi | JC7316 |
RefSeqi | NP_067321.2, NM_021346.2 [Q99PP2-2] NP_997554.2, NM_207671.4 [Q99PP2-1] |
UniGenei | Mm.439916 |
Genome annotation databases
Ensembli | ENSMUST00000113481; ENSMUSP00000109109; ENSMUSG00000015597 [Q99PP2-1] ENSMUST00000138127; ENSMUSP00000116544; ENSMUSG00000015597 [Q99PP2-2] |
GeneIDi | 57908 |
KEGGi | mmu:57908 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | ZN318_MOUSE | |
Accessioni | Q99PP2Primary (citable) accession number: Q99PP2 Secondary accession number(s): B0V2M3 Q9JJ01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | January 31, 2018 | |
Last modified: | April 25, 2018 | |
This is version 119 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |