Zinc finger protein 318

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• nucleic acid binding Source: InterPro
• protein heterodimerization activity Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 16446156
• protein homodimerization activity Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 16446156
• zinc ion binding Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• meiotic cell cycle Source: UniProtKB-KW
• negative regulation of transcription, DNA-templated Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 16446156
• positive regulation of transcription, DNA-templated Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 16446156
• transcription, DNA-templated Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein heterodimerization activity Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 16446156
• protein homodimerization activity Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 16446156

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Coiled coil

Compositional bias

Zinc finger

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MYRSGSRSSV SSHRSKDGSA SGPPPGRPVG ASSGPTRRPS SPPPPSCSSL 
        60         70         80         90        100
RLPARRHRSP SGHRGRWASP SPPRGRRGSP SPPRGRRASP SPTRGRRASP 
       110        120        130        140        150
SPPRGRRGSP SPPRARRGSP SPPRSRRHYP PGLGGFRGSI RGESRADFAR 
       160        170        180        190        200
DGRGDHPGGG GGSRRRSPGL CSDSSLEESL RITVGNDHFC VSTPERRRLS 
       210        220        230        240        250
DRLGSPVDGL QDMDRDDLTD DSVFTRSSQC SRGLERYISR EEGPLSPFLG 
       260        270        280        290        300
QLDEDYRTRE TFLHRPEFSP QSSCHDELLR GTERNRDKLK SSSYSIRSEE 
       310        320        330        340        350
RSREAKRPRY DDTEKVHSSG GDHSSFTSGT RNYRQRRSSP SPRFLDPEFR 
       360        370        380        390        400
ELDLARRKRE EEEEQSRSLS QELVGVGDDQ IGCSIPGLAG VLTTSEPGYS 
       410        420        430        440        450
LQRPEEVPMM PKKSILKKRI EADMKPSLQL ESFSSGASSG EDHPLYSEHS 
       460        470        480        490        500
PLPLSGAIAA FTSEIENKGT TVEADLKEPQ SNLYQWGPLR EIPKDNSEKF 
       510        520        530        540        550
DSFLGFKEKL DLKAEGLEQQ TDFLLPHERA SQDGSGFSRI LSMLADPTIT 
       560        570        580        590        600
QEKRRRSFPD IEDEEKFLYG DEEEDIKSES PLKSLEDPES AGTRQKANSL 
       610        620        630        640        650
PSTPAVKLES LEESNPEYAK IHNLLKTIGL DIGVAEIGKL AARTQERLHG 
       660        670        680        690        700
KKPSSRPSAD RRLSADRHLS GDRHFSADRC SSVEHSFTAD WRSSDPHRPE 
       710        720        730        740        750
SRETHHSNTQ SPEVSHPHPA SPVDPYLRTK NSPPFLKSDH PVCHVSGPEV 
       760        770        780        790        800
VGSGFQSSVA VRCMLPSAPS TPIRLPHSAA LSQFHIPGAS QFAAARIPPN 
       810        820        830        840        850
YQGSVIPSAS FDAYRHYMAY AASRWPMYPA SQPPSHPLSD PHRLLPVTKQ 
       860        870        880        890        900
AARSRPNLRV IPTVTPAKPK QEIPVLGSIS VKRIPVRVSI PSLIKYNPKK 
       910        920        930        940        950
ISDEKNRASQ KQKVIEEREK LKTEQEARQK KMFYLTTELE RLHKQQGEML 
       960        970        980        990       1000
RKKRREKDGH KDPLLMEVSR LQDSIMKDIA ELHKETEEAE KKQSELDKVA 
      1010       1020       1030       1040       1050
QILGIDIFDK SLKSSNDSKE STEKPEKEKS KSPEKELSPS NSSSSNKESK 
      1060       1070       1080       1090       1100
MNEKSCIKSP SSTESLQPTV KQSDQPVAAY EYYDAGSHWC KDCNTTCGTM 
      1110       1120       1130       1140       1150
FDFFTHMHNK KHTQTLDPYN RPWASKTQSE AKQDTVKRTD KITVPAKGSE 
      1160       1170       1180       1190       1200
FLIPVTGFYC QLCEEFLGDP ISGEQHVKGH QHNENYKKYV EENPLYEERR 
      1210       1220       1230       1240       1250
NLDRQAGLAV VLETERRRQN ELKRKLNEKP KEEKIEKKAR IVREVKEDDK 
      1260       1270       1280       1290       1300
APGELEEQLS EDGSAPEKGE VKGNASLRPQ VKEEVKKEPS VASIAASFGK 
      1310       1320       1330       1340       1350
FSWKKPEKEE EKGSVVTPGA PKEDTVETSK DRDDGKAEVG KAKPIKIKLS 
      1360       1370       1380       1390       1400
GKTVIAHTSP WTPVVTTSTQ TKIRPNLPIP STVLRKSGSA TVSKPAPLNT 
      1410       1420       1430       1440       1450
FLSIKSSGTS TKPLPVVKES SSDLLLPPDI ISKAFGGEEV VLKGSPEEKV 
      1460       1470       1480       1490       1500
ELAEKNEPSQ VPEQMLALLP PPPPPPPPPP PPPPPPPPQA VPQLSAPSPA 
      1510       1520       1530       1540       1550
QANVVLTPVK SNSVISQTFS LGFQGPNILN PGLPVAFMAS EQPTVIPSDE 
      1560       1570       1580       1590       1600
TAPGVSESDW DQTLISMLVR PPPPLSSVFS EQAKKLEKRN SCLATANAKD 
      1610       1620       1630       1640       1650
LYDIFYSSGG KGAHETKLSS STLANGESSS LPRTESSDFS STCTLNSSMS 
      1660       1670       1680       1690       1700
SEDLPQCSAL VTATEISNLE NPISKGMEST GKWSVVDQID PKSRDSTYSF 
      1710       1720       1730       1740       1750
LQPLTRLYQN KPYEIVSPKT DTLVMWTSGS SQNDTHKDRP PEGKIRFDLG 
      1760       1770       1780       1790       1800
EPGPPGTDST SHLSDTHCQT NGPQKLIEIN LIDNQNKNQE VYQSEGCRES 
      1810       1820       1830       1840       1850
EMKRKTELKG KVATEEEEEE EEEGANSIED SNSNHGNRNT WEGEIGQPKL 
      1860       1870       1880       1890       1900
STVDKKGEQS SKLMTGHENT SKVVIELSPS LPSKRTKIDL FPSLLQNPKS 
      1910       1920       1930       1940       1950
MPELLLLSPA GSGLCLKRQE IWERPEKPGL EDVELQGTRP ELTVTIESKV 
      1960       1970       1980       1990       2000
LENFDTTHLE VEGFASLRNL GDMHANFHNS QTEQTRRSPT ALSEKMSEEI 
      2010       2020       2030       2040       2050
SVSSVMCNPS SSSDIEPVPS FSGFPLESPK TLVLNFETEG AHSSSNSRNG 
      2060       2070       2080       2090       2100
RITSNSLETG HPVENVGHDL GGERTHQALD LLAGGMLSED VKETSPLQKD 
      2110       2120       2130       2140       2150
LLRMESTTVS PSGLGPSPCL PDLVDFVTRT PGVPKQKPCS PLSEPDAFLK 
      2160       2170       2180       2190       2200
CSSLEMGSPP PEILSVSVSE VAVPQVSEDN DSALNLVKTP PSGSPSRDQV 
      2210       2220       2230 
VGGNVSPREM PEQEAAVDVI PDHTRSNVYN SQDYLNG               

        10         20         30         40         50
MYRSGSRSSV SSHRSKDGSA SGPPPGRPVG ASSGPTRRPS SPPPPSCSSL 
        60         70         80         90        100
RLPARRHRSP SGHRGRWASP SPPRGRRGSP SPPRGRRASP SPTRGRRASP 
       110        120        130        140        150
SPPRGRRGSP SPPRARRGSP SPPRSRRHYP PGLGGFRGSI RGESRADFAR 
       160        170        180        190        200
DGRGDHPGGG GGSRRRSPGL CSDSSLEESL RITVGNDHFC VSTPERRRLS 
       210        220        230        240        250
DRLGSPVDGL QDMDRDDLTD DSVFTRSSQC SRGLERYISR EEGPLSPFLG 
       260        270        280        290        300
QLDEDYRTRE TFLHRPEFSP QSSCHDELLR GTERNRDKLK SSSYSIRSEE 
       310        320        330        340        350
RSREAKRPRY DDTEKVHSSG GDHSSFTSGT RNYRQRRSSP SPRFLDPEFR 
       360        370        380        390        400
ELDLARRKRE EEEEQSRSLS QELVGVGDDQ IGCSIPGLAG VLTTSEPGYS 
       410        420        430        440        450
LQRPEEVPMM PKKSILKKRI EADMKPSLQL ESFSSGASSG EDHPLYSEHS 
       460        470        480        490        500
PLPLSGAIAA FTSEIENKGT TVEADLKEPQ SNLYQWGPLR EIPKDNSEKF 
       510        520        530        540        550
DSFLGFKEKL DLKAEGLEQQ TDFLLPHERA SQDGSGFSRI LSMLADPTIT 
       560        570        580        590        600
QEKRRRSFPD IEDEEKFLYG DEEEDIKSES PLKSLEDPES AGTRQKANSL 
       610        620        630        640        650
PSTPAVKLES LEESNPEYAK IHNLLKTIGL DIGVAEIGKL AARTQERLHG 
       660        670        680        690        700
KKPSSRPSAD RRLSADRHLS GDRHFSADRC SSVEHSFTAD WRSSDPHRPE 
       710        720        730        740        750
SRETHHSNTQ SPEVSHPHPA SPVDPYLRTK NSPPFLKSDH PVCHVSGPEV 
       760        770        780        790        800
VGSGFQSSVA VRCMLPSAPS TPIRLPHSAA LSQFHIPGAS QFAAARIPPN 
       810        820        830        840        850
YQGSVIPSAS FDAYRHYMAY AASRWPMYPA SQPPSHPLSD PHRLLPVTKQ 
       860        870        880        890        900
AARSRPNLRV IPTVTPAKPK QEIPVLGSIS VKRIPVRVSI PSLIKYNPKK 
       910        920        930        940        950
ISDEKNRASQ KQKVIEEREK LKTEQEARQK KMFYLTTELE RLHKQQGEML 
       960        970        980        990       1000
RKKRREKDGH KDPLLMEVSR LQDSIMKDIA ELHKETEEAE KKQSELDKVA 
      1010       1020       1030       1040       1050
QILGIDIFDK SLKSSNDSKE STEKPEKEKS KSPEKELSPS NSSSSNKESK 
      1060       1070       1080       1090       1100
MNEKSCIKSP SSTESLQPTV KQSDQPVAAY EYYDAGSHWC KDCNTTCGTM 
      1110       1120       1130       1140       1150
FDFFTHMHNK KHTQGQFQKS SHFQTEGLKQ MFLLQECRDR NHRDYGNNVR 

PCGQ                                                   

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ