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UniProtKB - Q99PP2 (ZN318_MOUSE)

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Protein

Zinc finger protein 318

Gene

Znf318

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri912 – 946Matrin-type 1Add BLAST35
Zinc fingeri985 – 1007Matrin-type 2Add BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionRepressor
Biological processMeiosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 318
Alternative name(s):
Testicular zinc finger protein
Gene namesi
Name:Znf318
Synonyms:Tzf, Zfp318
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1889348. Zfp318.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000191808‹1 – 2064Zinc finger protein 318Add BLAST›2064

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei64PhosphotyrosineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei324PhosphoserineBy similarity1
Modified residuei329PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Cross-linki434Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei692PhosphothreonineBy similarity1
Modified residuei859PhosphoserineBy similarity1
Modified residuei886PhosphoserineBy similarity1
Modified residuei1272PhosphoserineBy similarity1
Modified residuei1705PhosphoserineBy similarity1
Modified residuei1735PhosphoserineBy similarity1
Modified residuei1815PhosphoserineBy similarity1
Modified residuei1871PhosphoserineBy similarity1
Modified residuei1881PhosphoserineBy similarity1
Modified residuei1967PhosphoserineBy similarity1
Modified residuei1970PhosphoserineBy similarity1
Modified residuei2021PhosphoserineBy similarity1
Modified residuei2033PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ99PP2.
PeptideAtlasiQ99PP2.
PRIDEiQ99PP2.

PTM databases

iPTMnetiQ99PP2.
PhosphoSitePlusiQ99PP2.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are highly expressed in testis, moderately expressed in adrenal gland and uterus and faintly expressed in brain, kidney and liver. Isoform 1 is expressed more in adrenal gland, uterus and liver than isoform 2 is. Expression during testicular development of isoform 1 and isoform 2 is restricted to spermatocytes at the pachytene stage of meiotic prophase and to round and elongated spermatids.2 Publications

Gene expression databases

CleanExiMM_ZFP318.

Interactioni

Subunit structurei

Interacts with the N-terminal domain of AR.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109109.

Structurei

3D structure databases

ProteinModelPortaliQ99PP2.
SMRiQ99PP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 203Sequence analysisAdd BLAST29
Coiled coili731 – 830Sequence analysisAdd BLAST100
Coiled coili1625 – 1654Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1297 – 1326Pro-richAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri912 – 946Matrin-type 1Add BLAST35
Zinc fingeri985 – 1007Matrin-type 2Add BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHGT. Eukaryota.
ENOG4111IJJ. LUCA.
HOGENOMiHOG000043103.
HOVERGENiHBG107139.
InParanoidiQ99PP2.

Family and domain databases

InterProiView protein in InterPro
IPR003604. Matrin/U1-like-C_Znf_C2H2.
SMARTiView protein in SMART
SM00451. ZnF_U1. 2 hits.

Sequences (2)i

Sequence statusi: Fragment.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99PP2-1) [UniParc]FASTAAdd to basket
Also known as: TZF-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
SLEESLRITV GNDHFCVSTP ERRRLSDRLG ISPVDGLQDM DRDDLTDDSD 
        60         70         80         90        100
FTRSSQCSRG LERYISREEG PLSPFLGQLD EDYRTRETFL HRPEFSPQSS 
       110        120        130        140        150
CHDELLRGTE RNRDKLKSSS YSIRSEERSR EAKRPRYDDT EKVHSSGGDH 
       160        170        180        190        200
SSFTSGTRNY RQRRSSPSPR FLDPEFRELD LARRKREEEE EQSRSLSQEL 
       210        220        230        240        250
VGVGDDQIGC SIPGLAGVLT TSEPGYSLQR PEEVPMMPKK SILKKRIEAD 
       260        270        280        290        300
MKPSLQLESF SSGASSGEDH PLYSEHSPLP LSGAIAAFTS EIENKGTTVE 
       310        320        330        340        350
ADLKEPQSNL YQWGPLREIP KDNSEKFDSF LGFKERLDLK AEGLEQQTDN 
       360        370        380        390        400
LLPHERASQD GSGFSRILSM LADPTITQEK RRRSFPDIED EEKFLYGDEE 
       410        420        430        440        450
EDIKSESPLK SLEDPESAGT RQKANSLPST PAVKLESLEE SNPEYAKIHN 
       460        470        480        490        500
LLKTIGLDIG VAEIGKLAAR TQERLHGKKP SSRPSADRRL SADRHLSGDR 
       510        520        530        540        550
HFSADRCSSV EHSFTADWRS SDPHRPESRE THHSNTQSPE VSHPHPASPV 
       560        570        580        590        600
DPYLRTKNSP PFLKSDHPVC HVSGPEVVGS GFQSSVAVRC MLPSAPSTPI 
       610        620        630        640        650
RLPHSAALSQ FHIPGASQFA AARIPPNYQG SVIPSASFDA YRHYMAYAAS 
       660        670        680        690        700
RWPMYPASQP PSHPLSDPHR LLPVTKQAAR SRPNLRVIPT VTPAKPKQEI 
       710        720        730        740        750
PVLGSISVKR IPVRVSIPSL IKYNPKKISD EKNRASQKQK VIEEREKLKT 
       760        770        780        790        800
EQEARQKKMF YLTTELERLH KQQGEMLRKK RREKDGHKDP LLMEVSRLQD 
       810        820        830        840        850
SIMKDIAELH KETEEAEKKQ SELDKVAQIL GIDIFDKSLK SSNDSKESTE 
       860        870        880        890        900
KPEKEKSKSP EKELSPSNSS SSNKESKMNE KSCIKSPSST ESLQPTVKQS 
       910        920        930        940        950
DQPVAAYEYY DAGSHWCKDC NTTCGTMFDF FTHMHNKKHT QTLDPYNRPW 
       960        970        980        990       1000
ASKTQSEAKQ DTVKRTDKIT VPAKGSEFLI PVTGFYCQLC EEFLGDPISG 
      1010       1020       1030       1040       1050
EQHVKGHQHN ENYKKYVEEN PLYEERRNLD RQAGLAVVLE TERRRQNELK 
      1060       1070       1080       1090       1100
RKLNEKPKEE KIEKKARIVR EVKEDDKAPG ELEEQLSEDG SAPEKGEVKG 
      1110       1120       1130       1140       1150
NASLRPQVKE EVKKEPSVAS IAASFGKFSW KKPEKEEEKG SVVTPGAPKE 
      1160       1170       1180       1190       1200
DTVETSKDRD DGKAEVGKAK PIKIKLSGKT VIAHTSPWTP VVTTSTQTKI 
      1210       1220       1230       1240       1250
RPNLPIPSTV LRKSGSATVS KPAPLNTFLS IKSSGTSTKP LPVVKESSSD 
      1260       1270       1280       1290       1300
LLLPPDIISK AFGGEEVVLK GSPEEKVELA EKNEPSQVPE QMLALLPPPP 
      1310       1320       1330       1340       1350
PPPPPPPPPP PPPPPQAVPQ LSAPSPAQAN VVLTPVKSNS VISQTFSLGF 
      1360       1370       1380       1390       1400
QGPNILNPGL PVAFMASEQP TVIPSDETAP GVSESDWDQT LISMLVRPPP 
      1410       1420       1430       1440       1450
PLSSVFSEQA KKLEKRNSCL ATANAKDLYD IFYSSGGKGA HETKLSSSTL 
      1460       1470       1480       1490       1500
ANGESSSLPR TESSDFSSTC TLNSSMSSED LPQCSALVTA TEISNLENPI 
      1510       1520       1530       1540       1550
SKGMESTGKW SVVDQIDPKS RDSTYSFLQP LTRLYQNKPY EIVSPKTDTL 
      1560       1570       1580       1590       1600
VMWTSGSSQN DTHKDRPPEG KIRFDLGEPG PPGTDSTSHL SDTHCQTNGP 
      1610       1620       1630       1640       1650
QKLIEINLID NQNKNQEVYQ SEGCRESEMK RKTELKGKVA TEEEEEEEEE 
      1660       1670       1680       1690       1700
GANSIEDSNS NHGNRNTWEG EIGQPKLSTV DKKGEQSSKL MTGHENTSKV 
      1710       1720       1730       1740       1750
VIELSPSLPS KRTKIDLFPS LLQNPKSMPE LLLLSPAGSG LCLKRQEIWE 
      1760       1770       1780       1790       1800
RPEKPGLEDV ELQGTRPELT VTIESKVLEN FDTTHLEVEG FASLRNLGDM 
      1810       1820       1830       1840       1850
HANFHNSQTE QTRRSPTALS EKMSEEISVS SVMCNPSSSS DIEPVPSFSG 
      1860       1870       1880       1890       1900
FPLESPKTLV LNFETEGAHS SSNSRNGRIT SNSLETGHPV ENVGHDLGGE 
      1910       1920       1930       1940       1950
RTHQALDLLA GGMLSEDVKE TSPLQKDLLR MESTTVSPSG LGPSPCLPDL 
      1960       1970       1980       1990       2000
VDFVTRTPGV PKQKPCSPLS EPDAFLKCSS LEMGSPPPEI LSVSVSEVAV 
      2010       2020       2030       2040       2050
PQVSEDNDSA LNLVKTPPSG SPSRDQVVGG NVSPREMPEQ EAAVDVIPDH 
      2060 
TRSNVYNSQD YLNG
Length:2,064
Mass (Da):228,220
Last modified:January 15, 2008 - v2
Checksum:iCA64069FFA9D269B
GO
Isoform 2 (identifier: Q99PP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     942-981: TLDPYNRPWA...PAKGSEFLIP → GQFQKSSHFQ...YGNNVRPCGQ
     982-2064: Missing.

Show »
Length:981
Mass (Da):110,832
Checksum:i8CCE812CE531C1F6
GO

Sequence cautioni

The sequence AAF61636 differs from that shown. Reason: Frameshift at positions 13 and 32.Curated
The sequence AAK00650 differs from that shown. Reason: Frameshift at positions 13 and 32.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016594942 – 981TLDPY…EFLIP → GQFQKSSHFQTEGLKQMFLL QECRDRNHRDYGNNVRPCGQ in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_016595982 – 2064Missing in isoform 2. 1 PublicationAdd BLAST1083

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159455 mRNA. Translation: AAF61636.1. Frameshift.
AF227194 mRNA. Translation: AAK00650.1. Frameshift.
AK011661 mRNA. Translation: BAC25342.1.
AK157779 mRNA. Translation: BAE34193.1.
PIRiJC7316.
RefSeqiNP_997554.2. NM_207671.4.
UniGeneiMm.439916.

Genome annotation databases

GeneIDi57908.
KEGGimmu:57908.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN318_MOUSE
AccessioniPrimary (citable) accession number: Q99PP2
Secondary accession number(s): Q3TZL5, Q8BMX9, Q9JJ01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: May 10, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot