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Q99PP2

- ZN318_MOUSE

UniProt

Q99PP2 - ZN318_MOUSE

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Protein
Zinc finger protein 318
Gene
Znf318, Tzf, Zfp318
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri912 – 94635Matrin-type 1
Add
BLAST
Zinc fingeri985 – 100723Matrin-type 2
Add
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Meiosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 318
Alternative name(s):
Testicular zinc finger protein
Gene namesi
Name:Znf318
Synonyms:Tzf, Zfp318
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1889348. Zfp318.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 2064›2064Zinc finger protein 318
PRO_0000191808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321Phosphoserine By similarity
Modified residuei73 – 731Phosphoserine By similarity
Modified residuei324 – 3241Phosphoserine By similarity
Modified residuei384 – 3841Phosphoserine By similarity
Modified residuei886 – 8861Phosphoserine By similarity
Modified residuei1272 – 12721Phosphoserine By similarity
Modified residuei1735 – 17351Phosphoserine By similarity
Modified residuei1881 – 18811Phosphoserine By similarity
Modified residuei1967 – 19671Phosphoserine By similarity
Modified residuei1970 – 19701Phosphoserine By similarity
Modified residuei2021 – 20211Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99PP2.
PRIDEiQ99PP2.

PTM databases

PhosphoSiteiQ99PP2.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are highly expressed in testis, moderately expressed in adrenal gland and uterus and faintly expressed in brain, kidney and liver. Isoform 1 is expressed more in adrenal gland, uterus and liver than isoform 2 is. Expression during testicular development of isoform 1 and isoform 2 is restricted to spermatocytes at the pachytene stage of meiotic prophase and to round and elongated spermatids.2 Publications

Gene expression databases

CleanExiMM_ZFP318.
GenevestigatoriQ99PP2.

Interactioni

Subunit structurei

Interacts with the N-terminal domain of AR.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ99PP2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili175 – 20329 Reviewed prediction
Add
BLAST
Coiled coili731 – 830100 Reviewed prediction
Add
BLAST
Coiled coili1625 – 165430 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1297 – 132630Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG87509.
HOGENOMiHOG000043103.
HOVERGENiHBG107139.
InParanoidiQ99PP2.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Fragment.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99PP2-1) [UniParc]FASTAAdd to Basket

Also known as: TZF-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

SLEESLRITV GNDHFCVSTP ERRRLSDRLG ISPVDGLQDM DRDDLTDDSD     50
FTRSSQCSRG LERYISREEG PLSPFLGQLD EDYRTRETFL HRPEFSPQSS 100
CHDELLRGTE RNRDKLKSSS YSIRSEERSR EAKRPRYDDT EKVHSSGGDH 150
SSFTSGTRNY RQRRSSPSPR FLDPEFRELD LARRKREEEE EQSRSLSQEL 200
VGVGDDQIGC SIPGLAGVLT TSEPGYSLQR PEEVPMMPKK SILKKRIEAD 250
MKPSLQLESF SSGASSGEDH PLYSEHSPLP LSGAIAAFTS EIENKGTTVE 300
ADLKEPQSNL YQWGPLREIP KDNSEKFDSF LGFKERLDLK AEGLEQQTDN 350
LLPHERASQD GSGFSRILSM LADPTITQEK RRRSFPDIED EEKFLYGDEE 400
EDIKSESPLK SLEDPESAGT RQKANSLPST PAVKLESLEE SNPEYAKIHN 450
LLKTIGLDIG VAEIGKLAAR TQERLHGKKP SSRPSADRRL SADRHLSGDR 500
HFSADRCSSV EHSFTADWRS SDPHRPESRE THHSNTQSPE VSHPHPASPV 550
DPYLRTKNSP PFLKSDHPVC HVSGPEVVGS GFQSSVAVRC MLPSAPSTPI 600
RLPHSAALSQ FHIPGASQFA AARIPPNYQG SVIPSASFDA YRHYMAYAAS 650
RWPMYPASQP PSHPLSDPHR LLPVTKQAAR SRPNLRVIPT VTPAKPKQEI 700
PVLGSISVKR IPVRVSIPSL IKYNPKKISD EKNRASQKQK VIEEREKLKT 750
EQEARQKKMF YLTTELERLH KQQGEMLRKK RREKDGHKDP LLMEVSRLQD 800
SIMKDIAELH KETEEAEKKQ SELDKVAQIL GIDIFDKSLK SSNDSKESTE 850
KPEKEKSKSP EKELSPSNSS SSNKESKMNE KSCIKSPSST ESLQPTVKQS 900
DQPVAAYEYY DAGSHWCKDC NTTCGTMFDF FTHMHNKKHT QTLDPYNRPW 950
ASKTQSEAKQ DTVKRTDKIT VPAKGSEFLI PVTGFYCQLC EEFLGDPISG 1000
EQHVKGHQHN ENYKKYVEEN PLYEERRNLD RQAGLAVVLE TERRRQNELK 1050
RKLNEKPKEE KIEKKARIVR EVKEDDKAPG ELEEQLSEDG SAPEKGEVKG 1100
NASLRPQVKE EVKKEPSVAS IAASFGKFSW KKPEKEEEKG SVVTPGAPKE 1150
DTVETSKDRD DGKAEVGKAK PIKIKLSGKT VIAHTSPWTP VVTTSTQTKI 1200
RPNLPIPSTV LRKSGSATVS KPAPLNTFLS IKSSGTSTKP LPVVKESSSD 1250
LLLPPDIISK AFGGEEVVLK GSPEEKVELA EKNEPSQVPE QMLALLPPPP 1300
PPPPPPPPPP PPPPPQAVPQ LSAPSPAQAN VVLTPVKSNS VISQTFSLGF 1350
QGPNILNPGL PVAFMASEQP TVIPSDETAP GVSESDWDQT LISMLVRPPP 1400
PLSSVFSEQA KKLEKRNSCL ATANAKDLYD IFYSSGGKGA HETKLSSSTL 1450
ANGESSSLPR TESSDFSSTC TLNSSMSSED LPQCSALVTA TEISNLENPI 1500
SKGMESTGKW SVVDQIDPKS RDSTYSFLQP LTRLYQNKPY EIVSPKTDTL 1550
VMWTSGSSQN DTHKDRPPEG KIRFDLGEPG PPGTDSTSHL SDTHCQTNGP 1600
QKLIEINLID NQNKNQEVYQ SEGCRESEMK RKTELKGKVA TEEEEEEEEE 1650
GANSIEDSNS NHGNRNTWEG EIGQPKLSTV DKKGEQSSKL MTGHENTSKV 1700
VIELSPSLPS KRTKIDLFPS LLQNPKSMPE LLLLSPAGSG LCLKRQEIWE 1750
RPEKPGLEDV ELQGTRPELT VTIESKVLEN FDTTHLEVEG FASLRNLGDM 1800
HANFHNSQTE QTRRSPTALS EKMSEEISVS SVMCNPSSSS DIEPVPSFSG 1850
FPLESPKTLV LNFETEGAHS SSNSRNGRIT SNSLETGHPV ENVGHDLGGE 1900
RTHQALDLLA GGMLSEDVKE TSPLQKDLLR MESTTVSPSG LGPSPCLPDL 1950
VDFVTRTPGV PKQKPCSPLS EPDAFLKCSS LEMGSPPPEI LSVSVSEVAV 2000
PQVSEDNDSA LNLVKTPPSG SPSRDQVVGG NVSPREMPEQ EAAVDVIPDH 2050
TRSNVYNSQD YLNG 2064
Length:2,064
Mass (Da):228,220
Last modified:January 15, 2008 - v2
Checksum:iCA64069FFA9D269B
GO
Isoform 2 (identifier: Q99PP2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     942-981: TLDPYNRPWA...PAKGSEFLIP → GQFQKSSHFQ...YGNNVRPCGQ
     982-2064: Missing.

Show »
Length:981
Mass (Da):110,832
Checksum:i8CCE812CE531C1F6
GO

Sequence cautioni

The sequence AAF61636.1 differs from that shown. Reason: Frameshift at positions 13 and 32.
The sequence AAK00650.1 differs from that shown. Reason: Frameshift at positions 13 and 32.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei942 – 98140TLDPY…EFLIP → GQFQKSSHFQTEGLKQMFLL QECRDRNHRDYGNNVRPCGQ in isoform 2.
VSP_016594Add
BLAST
Alternative sequencei982 – 20641083Missing in isoform 2.
VSP_016595Add
BLAST

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159455 mRNA. Translation: AAF61636.1. Frameshift.
AF227194 mRNA. Translation: AAK00650.1. Frameshift.
AK011661 mRNA. Translation: BAC25342.1.
AK157779 mRNA. Translation: BAE34193.1.
PIRiJC7316.
RefSeqiNP_997554.2. NM_207671.4.
UniGeneiMm.439916.

Genome annotation databases

GeneIDi57908.
KEGGimmu:57908.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159455 mRNA. Translation: AAF61636.1 . Frameshift.
AF227194 mRNA. Translation: AAK00650.1 . Frameshift.
AK011661 mRNA. Translation: BAC25342.1 .
AK157779 mRNA. Translation: BAE34193.1 .
PIRi JC7316.
RefSeqi NP_997554.2. NM_207671.4.
UniGenei Mm.439916.

3D structure databases

ProteinModelPortali Q99PP2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99PP2.

Proteomic databases

PaxDbi Q99PP2.
PRIDEi Q99PP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 57908.
KEGGi mmu:57908.

Organism-specific databases

CTDi 57908.
MGIi MGI:1889348. Zfp318.

Phylogenomic databases

eggNOGi NOG87509.
HOGENOMi HOG000043103.
HOVERGENi HBG107139.
InParanoidi Q99PP2.

Miscellaneous databases

ChiTaRSi ZNF318. mouse.
NextBioi 314073.
PROi Q99PP2.
SOURCEi Search...

Gene expression databases

CleanExi MM_ZFP318.
Genevestigatori Q99PP2.

Family and domain databases

InterProi IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis."
    Inoue A., Ishiji A., Kasagi S., Ishizuka M., Hirose S., Baba T., Hagiwara H.
    Biochem. Biophys. Res. Commun. 273:398-403(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: ddY.
    Tissue: Testis.
  2. "Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis."
    Ishizuka M., Ohshima H., Tamura N., Nakada T., Inoue A., Hirose S., Hagiwara H.
    Biochem. Biophys. Res. Commun. 301:1079-1085(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: ddY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 393-1057 AND 1999-2064 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. Cited for: FUNCTION, INTERACTION WITH AR.

Entry informationi

Entry nameiZN318_MOUSE
AccessioniPrimary (citable) accession number: Q99PP2
Secondary accession number(s): Q3TZL5, Q8BMX9, Q9JJ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi