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Q99PP0

- WISP1_RAT

UniProt

Q99PP0 - WISP1_RAT

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Protein

WNT1-inducible-signaling pathway protein 1

Gene
Wisp1, Ccn4, Elm1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Downstream regulator in the Wnt/Frizzled-signaling pathway By similarity. Associated with cell survival. Adheres to skin and melanoma fibroblasts By similarity. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. regulation of cell growth Source: InterPro
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 1
Short name:
WISP-1
Alternative name(s):
CCN family member 4
ELM-1
Gene namesi
Name:Wisp1
Synonyms:Ccn4, Elm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69431. Wisp1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 367345WNT1-inducible-signaling pathway protein 1PRO_0000014408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi273 ↔ 310 By similarity
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi290 ↔ 324 By similarity
Disulfide bondi301 ↔ 340 By similarity
Disulfide bondi304 ↔ 342 By similarity
Disulfide bondi309 ↔ 346 By similarity
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99PP0.
PRIDEiQ99PP0.

Expressioni

Gene expression databases

GenevestigatoriQ99PP0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009673.

Structurei

3D structure databases

ProteinModelPortaliQ99PP0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 11874IGFBP N-terminalAdd
BLAST
Domaini121 – 18666VWFCAdd
BLAST
Domaini215 – 26046TSP type-1Add
BLAST
Domaini273 – 34775CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG76761.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ99PP0.
PhylomeDBiQ99PP0.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PP0-1 [UniParc]FASTAAdd to Basket

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MRWLLPWTLA AVAVLMVGNI LATALSPTPT TMTFTPAPLE ETITRPEFCK    50
WPCECPQAPP RCPLGVSLIT DGCECCKICA QQLGDNCTEA AVCDPHRGLY 100
CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY TNGESFQPNC RYNCTCIDGT 150
VGCTPLCLSP RPPRLWCRQP RHVRVPGQCC EQWVCDDDAR RPRQTALLDT 200
RAFAASGAVE QRYENCIAYT SPWSPCSTTC GLGISTRISN VNARCWPEQE 250
SRLCNLRPCD VDIRPHIKAG KKCLAVYQPE EATNFTLAGC VSTRTYRPKY 300
CGVCTDNRCC IPYKSKTISV DFQCPEGPGF SRQVLWINAC FCNLSCRNPN 350
DIFADLESYP DFAEIAN 367
Length:367
Mass (Da):40,614
Last modified:June 1, 2001 - v1
Checksum:i8A4A34C69D3243D2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171V → L in CAB41995. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228049 mRNA. Translation: AAK00729.1.
AJ236871 mRNA. Translation: CAB41995.1.
RefSeqiNP_113904.1. NM_031716.1.
UniGeneiRn.63486.

Genome annotation databases

GeneIDi65154.
KEGGirno:65154.
UCSCiRGD:69431. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228049 mRNA. Translation: AAK00729.1 .
AJ236871 mRNA. Translation: CAB41995.1 .
RefSeqi NP_113904.1. NM_031716.1.
UniGenei Rn.63486.

3D structure databases

ProteinModelPortali Q99PP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009673.

Proteomic databases

PaxDbi Q99PP0.
PRIDEi Q99PP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 65154.
KEGGi rno:65154.
UCSCi RGD:69431. rat.

Organism-specific databases

CTDi 8840.
RGDi 69431. Wisp1.

Phylogenomic databases

eggNOGi NOG76761.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi Q99PP0.
PhylomeDBi Q99PP0.

Miscellaneous databases

NextBioi 613997.
PROi Q99PP0.

Gene expression databases

Genevestigatori Q99PP0.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair follicle dermal papilla.
  2. "Partial cDNA-sequence of rat ELM1."
    Jia J.D., Bauer M., Schuppan D.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-74.

Entry informationi

Entry nameiWISP1_RAT
AccessioniPrimary (citable) accession number: Q99PP0
Secondary accession number(s): Q9WUW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi