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Q99PP0

- WISP1_RAT

UniProt

Q99PP0 - WISP1_RAT

Protein

WNT1-inducible-signaling pathway protein 1

Gene

Wisp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Downstream regulator in the Wnt/Frizzled-signaling pathway By similarity. Associated with cell survival. Adheres to skin and melanoma fibroblasts By similarity. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. regulation of cell growth Source: InterPro
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WNT1-inducible-signaling pathway protein 1
    Short name:
    WISP-1
    Alternative name(s):
    CCN family member 4
    ELM-1
    Gene namesi
    Name:Wisp1
    Synonyms:Ccn4, Elm1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69431. Wisp1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 367345WNT1-inducible-signaling pathway protein 1PRO_0000014408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi273 ↔ 310By similarity
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 324By similarity
    Disulfide bondi301 ↔ 340By similarity
    Disulfide bondi304 ↔ 342By similarity
    Disulfide bondi309 ↔ 346By similarity
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ99PP0.
    PRIDEiQ99PP0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99PP0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 11874IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini121 – 18666VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 26046TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini273 – 34775CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG76761.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiQ99PP0.
    PhylomeDBiQ99PP0.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99PP0-1 [UniParc]FASTAAdd to Basket

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    MRWLLPWTLA AVAVLMVGNI LATALSPTPT TMTFTPAPLE ETITRPEFCK    50
    WPCECPQAPP RCPLGVSLIT DGCECCKICA QQLGDNCTEA AVCDPHRGLY 100
    CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY TNGESFQPNC RYNCTCIDGT 150
    VGCTPLCLSP RPPRLWCRQP RHVRVPGQCC EQWVCDDDAR RPRQTALLDT 200
    RAFAASGAVE QRYENCIAYT SPWSPCSTTC GLGISTRISN VNARCWPEQE 250
    SRLCNLRPCD VDIRPHIKAG KKCLAVYQPE EATNFTLAGC VSTRTYRPKY 300
    CGVCTDNRCC IPYKSKTISV DFQCPEGPGF SRQVLWINAC FCNLSCRNPN 350
    DIFADLESYP DFAEIAN 367
    Length:367
    Mass (Da):40,614
    Last modified:June 1, 2001 - v1
    Checksum:i8A4A34C69D3243D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171V → L in CAB41995. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228049 mRNA. Translation: AAK00729.1.
    AJ236871 mRNA. Translation: CAB41995.1.
    RefSeqiNP_113904.1. NM_031716.1.
    UniGeneiRn.63486.

    Genome annotation databases

    GeneIDi65154.
    KEGGirno:65154.
    UCSCiRGD:69431. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228049 mRNA. Translation: AAK00729.1 .
    AJ236871 mRNA. Translation: CAB41995.1 .
    RefSeqi NP_113904.1. NM_031716.1.
    UniGenei Rn.63486.

    3D structure databases

    ProteinModelPortali Q99PP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009673.

    Proteomic databases

    PaxDbi Q99PP0.
    PRIDEi Q99PP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 65154.
    KEGGi rno:65154.
    UCSCi RGD:69431. rat.

    Organism-specific databases

    CTDi 8840.
    RGDi 69431. Wisp1.

    Phylogenomic databases

    eggNOGi NOG76761.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi Q99PP0.
    PhylomeDBi Q99PP0.

    Miscellaneous databases

    NextBioi 613997.
    PROi Q99PP0.

    Gene expression databases

    Genevestigatori Q99PP0.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hair follicle dermal papilla.
    2. "Partial cDNA-sequence of rat ELM1."
      Jia J.D., Bauer M., Schuppan D.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-74.

    Entry informationi

    Entry nameiWISP1_RAT
    AccessioniPrimary (citable) accession number: Q99PP0
    Secondary accession number(s): Q9WUW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3