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Q99PP0 (WISP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WNT1-inducible-signaling pathway protein 1

Short name=WISP-1
Alternative name(s):
CCN family member 4
ELM-1
Gene names
Name:Wisp1
Synonyms:Ccn4, Elm1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Downstream regulator in the Wnt/Frizzled-signaling pathway By similarity. Associated with cell survival. Adheres to skin and melanoma fibroblasts By similarity. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
Wnt signaling pathway
   Cellular componentSecreted
   DiseaseProto-oncogene
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 367345WNT1-inducible-signaling pathway protein 1
PRO_0000014408

Regions

Domain45 – 11874IGFBP N-terminal
Domain121 – 18666VWFC
Domain215 – 26046TSP type-1
Domain273 – 34775CTCK

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Potential
Disulfide bond273 ↔ 310 By similarity
Disulfide bond290 ↔ 324 By similarity
Disulfide bond301 ↔ 340 By similarity
Disulfide bond304 ↔ 342 By similarity
Disulfide bond309 ↔ 346 By similarity

Experimental info

Sequence conflict171V → L in CAB41995. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99PP0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 8A4A34C69D3243D2

FASTA36740,614
        10         20         30         40         50         60 
MRWLLPWTLA AVAVLMVGNI LATALSPTPT TMTFTPAPLE ETITRPEFCK WPCECPQAPP 

        70         80         90        100        110        120 
RCPLGVSLIT DGCECCKICA QQLGDNCTEA AVCDPHRGLY CDYSGDRPRY AIGVCAQVVG 

       130        140        150        160        170        180 
VGCVLDGVRY TNGESFQPNC RYNCTCIDGT VGCTPLCLSP RPPRLWCRQP RHVRVPGQCC 

       190        200        210        220        230        240 
EQWVCDDDAR RPRQTALLDT RAFAASGAVE QRYENCIAYT SPWSPCSTTC GLGISTRISN 

       250        260        270        280        290        300 
VNARCWPEQE SRLCNLRPCD VDIRPHIKAG KKCLAVYQPE EATNFTLAGC VSTRTYRPKY 

       310        320        330        340        350        360 
CGVCTDNRCC IPYKSKTISV DFQCPEGPGF SRQVLWINAC FCNLSCRNPN DIFADLESYP 


DFAEIAN 

« Hide

References

[1]"Gene expression in rat dermal papilla cells: analysis of 2529 ESTs."
Sleeman M.A., Murison J.G., Strachan L., Kumble K.D., Glenn M.P., McGrath A., Bickerstaff P., Grierson A., Havukkala I., Tan P., Watson J.D.
Genomics 69:214-224(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hair follicle dermal papilla.
[2]"Partial cDNA-sequence of rat ELM1."
Jia J.D., Bauer M., Schuppan D.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-74.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF228049 mRNA. Translation: AAK00729.1.
AJ236871 mRNA. Translation: CAB41995.1.
RefSeqNP_113904.1. NM_031716.1.
UniGeneRn.63486.

3D structure databases

ProteinModelPortalQ99PP0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009673.

Proteomic databases

PaxDbQ99PP0.
PRIDEQ99PP0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65154.
KEGGrno:65154.
UCSCRGD:69431. rat.

Organism-specific databases

CTD8840.
RGD69431. Wisp1.

Phylogenomic databases

eggNOGNOG76761.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidQ99PP0.
PhylomeDBQ99PP0.

Gene expression databases

GenevestigatorQ99PP0.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613997.
PROQ99PP0.

Entry information

Entry nameWISP1_RAT
AccessionPrimary (citable) accession number: Q99PP0
Secondary accession number(s): Q9WUW4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families