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Q99PN0

- SC5A5_MOUSE

UniProt

Q99PN0 - SC5A5_MOUSE

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Protein

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates iodide uptake in the thyroid gland.

GO - Molecular functioni

  1. sodium:iodide symporter activity Source: MGI
  2. symporter activity Source: MGI

GO - Biological processi

  1. anion transport Source: GOC
  2. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene namesi
Name:Slc5a5
Synonyms:Nis
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2149330. Slc5a5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Sodium/iodide cotransporterPRO_0000105384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
Modified residuei551 – 5511Phosphoserine; by PKASequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ99PN0.

PTM databases

PhosphoSiteiQ99PN0.

Expressioni

Gene expression databases

GenevestigatoriQ99PN0.

Structurei

3D structure databases

ProteinModelPortaliQ99PN0.
SMRiQ99PN0. Positions 16-476.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
BLAST
Topological domaini38 – 5316CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini75 – 8814ExtracellularSequence AnalysisAdd
BLAST
Topological domaini110 – 13627CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini158 – 1636ExtracellularSequence Analysis
Topological domaini185 – 1862CytoplasmicSequence Analysis
Topological domaini208 – 24134ExtracellularSequence AnalysisAdd
BLAST
Topological domaini263 – 28624CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini308 – 32619ExtracellularSequence AnalysisAdd
BLAST
Topological domaini348 – 39144CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini413 – 4164ExtracellularSequence Analysis
Topological domaini438 – 4447CytoplasmicSequence Analysis
Topological domaini466 – 52055ExtracellularSequence AnalysisAdd
BLAST
Topological domaini542 – 61877CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei445 – 46521HelicalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ99PN0.
PhylomeDBiQ99PN0.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL
110 120 130 140 150
TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG
260 270 280 290 300
GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR
510 520 530 540 550
GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR
610
PEAETHPLYL GHDVETNL
Length:618
Mass (Da):65,568
Last modified:June 1, 2001 - v1
Checksum:i448AC5FE9AB5118E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235001 mRNA. Translation: AAK00232.1.
AF380353 mRNA. Translation: AAK59274.1.
BC137650 mRNA. Translation: AAI37651.1.
BC137651 mRNA. Translation: AAI37652.1.
CCDSiCCDS22385.1.
UniGeneiMm.172923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235001 mRNA. Translation: AAK00232.1 .
AF380353 mRNA. Translation: AAK59274.1 .
BC137650 mRNA. Translation: AAI37651.1 .
BC137651 mRNA. Translation: AAI37652.1 .
CCDSi CCDS22385.1.
UniGenei Mm.172923.

3D structure databases

ProteinModelPortali Q99PN0.
SMRi Q99PN0. Positions 16-476.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99PN0.

Proteomic databases

PRIDEi Q99PN0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2149330. Slc5a5.

Phylogenomic databases

eggNOGi COG0591.
HOGENOMi HOG000261662.
HOVERGENi HBG057280.
InParanoidi Q99PN0.
PhylomeDBi Q99PN0.

Miscellaneous databases

PROi Q99PN0.
SOURCEi Search...

Gene expression databases

Genevestigatori Q99PN0.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse sodium iodide symporter (mNIS) and its expression in the mammary gland."
    Perron B., Rodriguez A.-M., Leblanc G., Pourcher T.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSC5A5_MOUSE
AccessioniPrimary (citable) accession number: Q99PN0
Secondary accession number(s): B2RPX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3