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Q99PN0

- SC5A5_MOUSE

UniProt

Q99PN0 - SC5A5_MOUSE

Protein

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Mediates iodide uptake in the thyroid gland.

    GO - Molecular functioni

    1. sodium:iodide symporter activity Source: MGI
    2. symporter activity Source: MGI

    GO - Biological processi

    1. anion transport Source: GOC
    2. sodium ion transmembrane transport Source: GOC

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/iodide cotransporter
    Short name:
    Na(+)/I(-) cotransporter
    Alternative name(s):
    Sodium-iodide symporter
    Short name:
    Na(+)/I(-) symporter
    Solute carrier family 5 member 5
    Gene namesi
    Name:Slc5a5
    Synonyms:Nis
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2149330. Slc5a5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Sodium/iodide cotransporterPRO_0000105384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
    Modified residuei551 – 5511Phosphoserine; by PKASequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ99PN0.

    PTM databases

    PhosphoSiteiQ99PN0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99PN0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PN0.
    SMRiQ99PN0. Positions 16-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini38 – 5316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini75 – 8814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 13627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 1636ExtracellularSequence Analysis
    Topological domaini185 – 1862CytoplasmicSequence Analysis
    Topological domaini208 – 24134ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 32619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini348 – 39144CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini413 – 4164ExtracellularSequence Analysis
    Topological domaini438 – 4447CytoplasmicSequence Analysis
    Topological domaini466 – 52055ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini542 – 61877CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei445 – 46521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0591.
    HOGENOMiHOG000261662.
    HOVERGENiHBG057280.
    InParanoidiB2RPX6.
    PhylomeDBiQ99PN0.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99PN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG    50
    GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL 100
    TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY 150
    APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV 200
    GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG 250
    GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG 300
    IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG 350
    TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT 400
    VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT 450
    AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR 500
    GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR 550
    SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR 600
    PEAETHPLYL GHDVETNL 618
    Length:618
    Mass (Da):65,568
    Last modified:June 1, 2001 - v1
    Checksum:i448AC5FE9AB5118E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235001 mRNA. Translation: AAK00232.1.
    AF380353 mRNA. Translation: AAK59274.1.
    BC137650 mRNA. Translation: AAI37651.1.
    BC137651 mRNA. Translation: AAI37652.1.
    CCDSiCCDS22385.1.
    UniGeneiMm.172923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235001 mRNA. Translation: AAK00232.1 .
    AF380353 mRNA. Translation: AAK59274.1 .
    BC137650 mRNA. Translation: AAI37651.1 .
    BC137651 mRNA. Translation: AAI37652.1 .
    CCDSi CCDS22385.1.
    UniGenei Mm.172923.

    3D structure databases

    ProteinModelPortali Q99PN0.
    SMRi Q99PN0. Positions 16-476.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q99PN0.

    Proteomic databases

    PRIDEi Q99PN0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:2149330. Slc5a5.

    Phylogenomic databases

    eggNOGi COG0591.
    HOGENOMi HOG000261662.
    HOVERGENi HBG057280.
    InParanoidi B2RPX6.
    PhylomeDBi Q99PN0.

    Miscellaneous databases

    PROi Q99PN0.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q99PN0.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse sodium iodide symporter (mNIS) and its expression in the mammary gland."
      Perron B., Rodriguez A.-M., Leblanc G., Pourcher T.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X DBA/2.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiSC5A5_MOUSE
    AccessioniPrimary (citable) accession number: Q99PN0
    Secondary accession number(s): B2RPX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3