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Protein

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates iodide uptake in the thyroid gland.

GO - Molecular functioni

  • iodide transmembrane transporter activity Source: MGI
  • sodium:iodide symporter activity Source: MGI
  • symporter activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene namesi
Name:Slc5a5
Synonyms:Nis
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2149330. Slc5a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 53CytoplasmicSequence analysisAdd BLAST16
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 88ExtracellularSequence analysisAdd BLAST14
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 136CytoplasmicSequence analysisAdd BLAST27
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 163ExtracellularSequence analysis6
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 186CytoplasmicSequence analysis2
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 241ExtracellularSequence analysisAdd BLAST34
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 286CytoplasmicSequence analysisAdd BLAST24
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326ExtracellularSequence analysisAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 391CytoplasmicSequence analysisAdd BLAST44
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 416ExtracellularSequence analysis4
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 444CytoplasmicSequence analysis7
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 520ExtracellularSequence analysisAdd BLAST55
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 618CytoplasmicSequence analysisAdd BLAST77

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053841 – 618Sodium/iodide cotransporterAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Modified residuei551Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99PN0.
PRIDEiQ99PN0.

PTM databases

PhosphoSitePlusiQ99PN0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000809.

Structurei

3D structure databases

ProteinModelPortaliQ99PN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ99PN0.
PhylomeDBiQ99PN0.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL
110 120 130 140 150
TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG
260 270 280 290 300
GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR
510 520 530 540 550
GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR
610
PEAETHPLYL GHDVETNL
Length:618
Mass (Da):65,568
Last modified:June 1, 2001 - v1
Checksum:i448AC5FE9AB5118E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235001 mRNA. Translation: AAK00232.1.
AF380353 mRNA. Translation: AAK59274.1.
BC137650 mRNA. Translation: AAI37651.1.
BC137651 mRNA. Translation: AAI37652.1.
CCDSiCCDS22385.1.
UniGeneiMm.172923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235001 mRNA. Translation: AAK00232.1.
AF380353 mRNA. Translation: AAK59274.1.
BC137650 mRNA. Translation: AAI37651.1.
BC137651 mRNA. Translation: AAI37652.1.
CCDSiCCDS22385.1.
UniGeneiMm.172923.

3D structure databases

ProteinModelPortaliQ99PN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000809.

PTM databases

PhosphoSitePlusiQ99PN0.

Proteomic databases

PaxDbiQ99PN0.
PRIDEiQ99PN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2149330. Slc5a5.

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ99PN0.
PhylomeDBiQ99PN0.

Miscellaneous databases

PROiQ99PN0.
SOURCEiSearch...

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A5_MOUSE
AccessioniPrimary (citable) accession number: Q99PN0
Secondary accession number(s): B2RPX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.