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Q99PN0 (SC5A5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/iodide cotransporter

Short name=Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name=Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene names
Name:Slc5a5
Synonyms:Nis
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates iodide uptake in the thyroid gland.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618Sodium/iodide cotransporter
PRO_0000105384

Regions

Topological domain1 – 1616Extracellular Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 5316Cytoplasmic Potential
Transmembrane54 – 7421Helical; Potential
Topological domain75 – 8814Extracellular Potential
Transmembrane89 – 10921Helical; Potential
Topological domain110 – 13627Cytoplasmic Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 1636Extracellular Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 1862Cytoplasmic Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 24134Extracellular Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 28624Cytoplasmic Potential
Transmembrane287 – 30721Helical; Potential
Topological domain308 – 32619Extracellular Potential
Transmembrane327 – 34721Helical; Potential
Topological domain348 – 39144Cytoplasmic Potential
Transmembrane392 – 41221Helical; Potential
Topological domain413 – 4164Extracellular Potential
Transmembrane417 – 43721Helical; Potential
Topological domain438 – 4447Cytoplasmic Potential
Transmembrane445 – 46521Helical; Potential
Topological domain466 – 52055Extracellular Potential
Transmembrane521 – 54121Helical; Potential
Topological domain542 – 61877Cytoplasmic Potential

Amino acid modifications

Modified residue5511Phosphoserine; by PKA Potential
Glycosylation4851N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q99PN0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 448AC5FE9AB5118E

FASTA61865,568
        10         20         30         40         50         60 
MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG GRQLAAVPVG 

        70         80         90        100        110        120 
LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL TALLFLPIFY RLGLTSTYQY 

       130        140        150        160        170        180 
LELRFSRAVR LCGTLQYLVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTLYTT 

       190        200        210        220        230        240 
VGGMKAVVWT DVFQVVVMLV GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS 

       250        260        270        280        290        300 
RYTFWTFVVG GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG 

       310        320        330        340        350        360 
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN 

       370        380        390        400        410        420 
AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT VAALSSLLGG GVLQGSFTVM 

       430        440        450        460        470        480 
GVISGPLLGA FTLGMLLPAC NTPGVLSGLT AGLAVSLWVA VGATLYPPGE QTMGVLPTSA 

       490        500        510        520        530        540 
AGCTNASVLP SPPGAANTSR GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL 

       550        560        570        580        590        600 
ISYLTGPTKR SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR 

       610 
PEAETHPLYL GHDVETNL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the mouse sodium iodide symporter (mNIS) and its expression in the mammary gland."
Perron B., Rodriguez A.-M., Leblanc G., Pourcher T.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X DBA/2.
[2]"Cloning of the mouse sodium iodide symporter."
Pinke L.A., Dean D.S., Bergert E.R., Spitzweg C., Dutton C.M., Morris J.C.
Thyroid 11:935-939(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF235001 mRNA. Translation: AAK00232.1.
AF380353 mRNA. Translation: AAK59274.1.
BC137650 mRNA. Translation: AAI37651.1.
BC137651 mRNA. Translation: AAI37652.1.
CCDSCCDS22385.1.
UniGeneMm.172923.

3D structure databases

ProteinModelPortalQ99PN0.
SMRQ99PN0. Positions 16-476.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ99PN0.

Proteomic databases

PRIDEQ99PN0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:2149330. Slc5a5.

Phylogenomic databases

eggNOGCOG0591.
HOGENOMHOG000261662.
HOVERGENHBG057280.
InParanoidB2RPX6.
PhylomeDBQ99PN0.

Gene expression databases

GenevestigatorQ99PN0.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ99PN0.
SOURCESearch...

Entry information

Entry nameSC5A5_MOUSE
AccessionPrimary (citable) accession number: Q99PN0
Secondary accession number(s): B2RPX6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot