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Q99PN0

- SC5A5_MOUSE

UniProt

Q99PN0 - SC5A5_MOUSE

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Protein
Sodium/iodide cotransporter
Gene
Slc5a5, Nis
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates iodide uptake in the thyroid gland.

GO - Molecular functioni

  1. sodium:iodide symporter activity Source: MGI
  2. symporter activity Source: MGI

GO - Biological processi

  1. anion transport Source: GOC
  2. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene namesi
Name:Slc5a5
Synonyms:Nis
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2149330. Slc5a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Extracellular Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Topological domaini38 – 5316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei54 – 7421Helical; Reviewed prediction
Add
BLAST
Topological domaini75 – 8814Extracellular Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Topological domaini110 – 13627Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 1636Extracellular Reviewed prediction
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Topological domaini185 – 1862Cytoplasmic Reviewed prediction
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Topological domaini208 – 24134Extracellular Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Topological domaini263 – 28624Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei287 – 30721Helical; Reviewed prediction
Add
BLAST
Topological domaini308 – 32619Extracellular Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Topological domaini348 – 39144Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei392 – 41221Helical; Reviewed prediction
Add
BLAST
Topological domaini413 – 4164Extracellular Reviewed prediction
Transmembranei417 – 43721Helical; Reviewed prediction
Add
BLAST
Topological domaini438 – 4447Cytoplasmic Reviewed prediction
Transmembranei445 – 46521Helical; Reviewed prediction
Add
BLAST
Topological domaini466 – 52055Extracellular Reviewed prediction
Add
BLAST
Transmembranei521 – 54121Helical; Reviewed prediction
Add
BLAST
Topological domaini542 – 61877Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Sodium/iodide cotransporter
PRO_0000105384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi497 – 4971N-linked (GlcNAc...) Reviewed prediction
Modified residuei551 – 5511Phosphoserine; by PKA Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ99PN0.

PTM databases

PhosphoSiteiQ99PN0.

Expressioni

Gene expression databases

GenevestigatoriQ99PN0.

Structurei

3D structure databases

ProteinModelPortaliQ99PN0.
SMRiQ99PN0. Positions 16-476.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiB2RPX6.
PhylomeDBiQ99PN0.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PN0-1 [UniParc]FASTAAdd to Basket

« Hide

MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG    50
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL 100
TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY 150
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV 200
GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG 250
GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG 300
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG 350
TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT 400
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT 450
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR 500
GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR 550
SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR 600
PEAETHPLYL GHDVETNL 618
Length:618
Mass (Da):65,568
Last modified:June 1, 2001 - v1
Checksum:i448AC5FE9AB5118E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235001 mRNA. Translation: AAK00232.1.
AF380353 mRNA. Translation: AAK59274.1.
BC137650 mRNA. Translation: AAI37651.1.
BC137651 mRNA. Translation: AAI37652.1.
CCDSiCCDS22385.1.
UniGeneiMm.172923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235001 mRNA. Translation: AAK00232.1 .
AF380353 mRNA. Translation: AAK59274.1 .
BC137650 mRNA. Translation: AAI37651.1 .
BC137651 mRNA. Translation: AAI37652.1 .
CCDSi CCDS22385.1.
UniGenei Mm.172923.

3D structure databases

ProteinModelPortali Q99PN0.
SMRi Q99PN0. Positions 16-476.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99PN0.

Proteomic databases

PRIDEi Q99PN0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2149330. Slc5a5.

Phylogenomic databases

eggNOGi COG0591.
HOGENOMi HOG000261662.
HOVERGENi HBG057280.
InParanoidi B2RPX6.
PhylomeDBi Q99PN0.

Miscellaneous databases

PROi Q99PN0.
SOURCEi Search...

Gene expression databases

Genevestigatori Q99PN0.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse sodium iodide symporter (mNIS) and its expression in the mammary gland."
    Perron B., Rodriguez A.-M., Leblanc G., Pourcher T.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSC5A5_MOUSE
AccessioniPrimary (citable) accession number: Q99PN0
Secondary accession number(s): B2RPX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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