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Protein

TOX high mobility group box family member 4

Gene

Tox4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi223 – 29169HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 4
Alternative name(s):
Epidermal Langerhans cell protein LCP1
Gene namesi
Name:Tox4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708449. Tox4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

  • Note: Associated with chromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619TOX high mobility group box family member 4PRO_0000048570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphoserineCombined sources
Modified residuei182 – 1821PhosphoserineCombined sources
Modified residuei313 – 3131PhosphothreonineBy similarity
Modified residuei315 – 3151PhosphoserineBy similarity
Modified residuei531 – 5311PhosphoserineBy similarity
Modified residuei548 – 5481PhosphoserineBy similarity
Modified residuei550 – 5501PhosphoserineBy similarity
Modified residuei558 – 5581PhosphoserineBy similarity
Modified residuei560 – 5601PhosphoserineBy similarity
Modified residuei565 – 5651PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99PM1.
PRIDEiQ99PM1.

PTM databases

iPTMnetiQ99PM1.
PhosphoSiteiQ99PM1.

Interactioni

Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017476.

Structurei

3D structure databases

ProteinModelPortaliQ99PM1.
SMRiQ99PM1. Positions 219-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi213 – 2186Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi401 – 522122Gln/Pro-richAdd
BLAST
Compositional biasi426 – 4327Poly-Ala

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
HOGENOMiHOG000230949.
HOVERGENiHBG051013.
InParanoidiQ99PM1.
PhylomeDBiQ99PM1.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL
60 70 80 90 100
AVSDVVAHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL
110 120 130 140 150
SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS
160 170 180 190 200
SQLGLSLGGG TILPPAQSPE DRLSTTPSPT NSLHEDGVDD FRRQLPAQKT
210 220 230 240 250
VVVETGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF
260 270 280 290 300
GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
310 320 330 340 350
ETVELDPVPQ SQTPSPPPVT TADPASPAPA STESPALSPC IVVNSTLSSY
360 370 380 390 400
VANQAFSGPG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL
410 420 430 440 450
QLGQTSTATI QPSQQAQIAT RSVLQAAAAA AASMQLPPPR LQPPPLQQMP
460 470 480 490 500
QPPTQQQVTI LQQPPPLQAM QQPPPQKVRI NLQQQPPPLQ SKIVPPPALK
510 520 530 540 550
MQATVLPPTV ESSPEQPMNS SPEAHTVEAT SPETICEMIA DVVPEVESPS
560 570 580 590 600
QMDVELVSGS PVTLSPQPRC VRSGCENPPV ISKDWDNEYC SNECVVKHCR
610
DVFLAWVASR NPNSVVLVK
Length:619
Mass (Da):66,010
Last modified:June 1, 2001 - v1
Checksum:iEAC7B6C775B2D203
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267197 mRNA. Translation: AAK00807.1.
UniGeneiRn.22195.

Genome annotation databases

UCSCiRGD:708449. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267197 mRNA. Translation: AAK00807.1.
UniGeneiRn.22195.

3D structure databases

ProteinModelPortaliQ99PM1.
SMRiQ99PM1. Positions 219-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017476.

PTM databases

iPTMnetiQ99PM1.
PhosphoSiteiQ99PM1.

Proteomic databases

PaxDbiQ99PM1.
PRIDEiQ99PM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:708449. rat.

Organism-specific databases

RGDi708449. Tox4.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
HOGENOMiHOG000230949.
HOVERGENiHBG051013.
InParanoidiQ99PM1.
PhylomeDBiQ99PM1.

Miscellaneous databases

PROiQ99PM1.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel gene expressed differentially in maturing epidermal Langerhans cells."
    Luy M.A., Koehler B.F., Demleitner K., Reske K.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LEW.AVN.
    Tissue: Bone marrow macrophage.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOX4_RAT
AccessioniPrimary (citable) accession number: Q99PM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2001
Last modified: February 17, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.