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Protein

Thiamine transporter 2

Gene

Slc19a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity (By similarity).By similarity

GO - Molecular functioni

  • thiamine transmembrane transporter activity Source: MGI
  • thiamine uptake transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-196819. Vitamin B1 (thiamin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transporter 2
Short name:
ThTr-2
Short name:
ThTr2
Alternative name(s):
Solute carrier family 19 member 3
Gene namesi
Name:Slc19a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1931307. Slc19a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 54ExtracellularSequence analysisAdd BLAST25
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 82CytoplasmicSequence analysis7
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 111ExtracellularSequence analysis8
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 145CytoplasmicSequence analysisAdd BLAST13
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 172ExtracellularSequence analysis6
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 276CytoplasmicSequence analysisAdd BLAST83
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 310ExtracellularSequence analysisAdd BLAST13
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 335CytoplasmicSequence analysis4
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 369ExtracellularSequence analysisAdd BLAST13
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 399CytoplasmicSequence analysis9
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 428ExtracellularSequence analysis8
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 488CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326581 – 488Thiamine transporter 2Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi358N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99PL8.
PRIDEiQ99PL8.

PTM databases

iPTMnetiQ99PL8.
PhosphoSitePlusiQ99PL8.

Expressioni

Tissue specificityi

High expression in kidney, brain, lung and small intestine.

Gene expression databases

BgeeiENSMUSG00000038496.
GenevisibleiQ99PL8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041683.

Structurei

3D structure databases

ProteinModelPortaliQ99PL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3810. Eukaryota.
ENOG410XT34. LUCA.
GeneTreeiENSGT00510000046382.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiQ99PL8.
KOiK14610.
OMAiMYIIYST.
OrthoDBiEOG091G0BSJ.
PhylomeDBiQ99PL8.
TreeFamiTF313684.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002666. Folate_carrier.
IPR020846. MFS_dom.
IPR028337. ThTr-2.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500795. Thiamine_transporter_2. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00806. rfc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99PL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSCRTPPS NSWVYPTVIL CLFGFFSMFR PSEAFLIPFL SEPSKNLTSP
60 70 80 90 100
EMTNEILPVW TYSYLATLPP VFVLTDYLRY KPVIMLHVVA FATSYLFLLF
110 120 130 140 150
GQGVMLMQTA EFFFGVVSAT EIAYFAYIYS MVSPEHYQKV SSYCRSITLV
160 170 180 190 200
AYTAGSVLAQ LLVSLTNLPY SSLFYISLAC VSVAFFFSLF LPMPKKSMFF
210 220 230 240 250
HAKSDRDDCP KPLEQCTVPK EAQSNRTHSE LFANSKNLED REMSNPDPEN
260 270 280 290 300
SALRHFAHWF QDLKECYSSK HLVYWSLWWA FATAGYNQIL NYVQVLWEHK
310 320 330 340 350
APSQDSSIYN GAVEAIATFG GALASFSVGY LKVNWDLLGE LGLAVFSAVI
360 370 380 390 400
AGSLFLMNYS RSIWVCYAGY LLVKSSYSFL ITIAVFQIAV NLSLERYALV
410 420 430 440 450
FGIDTFIALV IQTIMTMIVV DQRGLQLPVT TQFLVYGSYF AVIAGVFLMR
460 470 480
SIYILCSAKC RKEVQNLATT RSPNEPHPQE PSNVSTKF
Length:488
Mass (Da):55,073
Last modified:April 18, 2006 - v2
Checksum:iB078ECED31936B1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129Y → H in AAG53880 (PubMed:11136550).Curated1
Sequence conflicti183V → G in AAG53880 (PubMed:11136550).Curated1
Sequence conflicti218V → G in AAG53880 (PubMed:11136550).Curated1
Sequence conflicti232F → V in AAG53880 (PubMed:11136550).Curated1
Sequence conflicti357M → K in AAG53880 (PubMed:11136550).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271634 mRNA. Translation: AAG53880.1.
BC109154 mRNA. Translation: AAI09155.1.
BC109155 mRNA. Translation: AAI09156.1.
CCDSiCCDS15101.1.
RefSeqiNP_085033.2. NM_030556.2.
XP_006496642.1. XM_006496579.3.
XP_006496643.1. XM_006496580.3.
XP_011237017.1. XM_011238715.2.
XP_011237018.1. XM_011238716.2.
UniGeneiMm.261542.

Genome annotation databases

EnsembliENSMUST00000045560; ENSMUSP00000041683; ENSMUSG00000038496.
ENSMUST00000164473; ENSMUSP00000126646; ENSMUSG00000038496.
GeneIDi80721.
KEGGimmu:80721.
UCSCiuc007bsi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271634 mRNA. Translation: AAG53880.1.
BC109154 mRNA. Translation: AAI09155.1.
BC109155 mRNA. Translation: AAI09156.1.
CCDSiCCDS15101.1.
RefSeqiNP_085033.2. NM_030556.2.
XP_006496642.1. XM_006496579.3.
XP_006496643.1. XM_006496580.3.
XP_011237017.1. XM_011238715.2.
XP_011237018.1. XM_011238716.2.
UniGeneiMm.261542.

3D structure databases

ProteinModelPortaliQ99PL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041683.

PTM databases

iPTMnetiQ99PL8.
PhosphoSitePlusiQ99PL8.

Proteomic databases

PaxDbiQ99PL8.
PRIDEiQ99PL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045560; ENSMUSP00000041683; ENSMUSG00000038496.
ENSMUST00000164473; ENSMUSP00000126646; ENSMUSG00000038496.
GeneIDi80721.
KEGGimmu:80721.
UCSCiuc007bsi.2. mouse.

Organism-specific databases

CTDi80704.
MGIiMGI:1931307. Slc19a3.

Phylogenomic databases

eggNOGiKOG3810. Eukaryota.
ENOG410XT34. LUCA.
GeneTreeiENSGT00510000046382.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiQ99PL8.
KOiK14610.
OMAiMYIIYST.
OrthoDBiEOG091G0BSJ.
PhylomeDBiQ99PL8.
TreeFamiTF313684.

Enzyme and pathway databases

ReactomeiR-MMU-196819. Vitamin B1 (thiamin) metabolism.

Miscellaneous databases

PROiQ99PL8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038496.
GenevisibleiQ99PL8. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002666. Folate_carrier.
IPR020846. MFS_dom.
IPR028337. ThTr-2.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500795. Thiamine_transporter_2. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00806. rfc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS19A3_MOUSE
AccessioniPrimary (citable) accession number: Q99PL8
Secondary accession number(s): Q32MF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.