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Protein

UBX domain-containing protein 6

Gene

Ubxn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.By similarity

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 6Curated
Alternative name(s):
UBX domain-containing protein 11 Publication
Gene namesi
Name:Ubxn6Imported
Synonyms:Ubxd11 Publication, Ubxdc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913780. Ubxn6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110261 – 442UBX domain-containing protein 6Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99PL6.
PeptideAtlasiQ99PL6.
PRIDEiQ99PL6.

PTM databases

iPTMnetiQ99PL6.
PhosphoSitePlusiQ99PL6.

Expressioni

Tissue specificityi

Widely expressed (at protein level). Highest expression in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000019578.
ExpressionAtlasiQ99PL6. baseline and differential.
GenevisibleiQ99PL6. MM.

Interactioni

Subunit structurei

Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus); the interaction is direct. Forms a ternary complex with CAV1 and VCP. Interacts with SYVN1. Interacts with HERPUD1. Interacts with VCPKMT. May interact with DERL1. Interacts with PLAA, VCP and YOD1; may form a complex involved in macroautophagy. Interacts with LMAN1.By similarity

Protein-protein interaction databases

BioGridi211538. 1 interactor.
IntActiQ99PL6. 1 interactor.
MINTiMINT-4139401.
STRINGi10090.ENSMUSP00000019722.

Structurei

3D structure databases

ProteinModelPortaliQ99PL6.
SMRiQ99PL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 244PUBSequence analysisAdd BLAST70
Domaini332 – 408UBXPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 10Mediates interaction with LMAN1By similarity10
Regioni51 – 63VCP/p97-interacting motif (VIM)By similarityAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 61Poly-Ala7

Domaini

The UBX domain lacks key residues critical for VCP binding.By similarity

Phylogenomic databases

eggNOGiKOG2699. Eukaryota.
ENOG410XQQK. LUCA.
GeneTreeiENSGT00900000141106.
HOVERGENiHBG061370.
InParanoidiQ99PL6.
KOiK14011.
OMAiNLAFNEC.
OrthoDBiEOG091G0EB3.
PhylomeDBiQ99PL6.
TreeFamiTF314617.

Family and domain databases

InterProiView protein in InterPro
IPR036339. PUB-like_dom.
IPR018997. PUB_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
PfamiView protein in Pfam
PF09409. PUB. 1 hit.
PF00789. UBX. 1 hit.
SMARTiView protein in SMART
SM00580. PUG. 1 hit.
SUPFAMiSSF143503. SSF143503. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50033. UBX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99PL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFFQEIKA DIKFKSAGPG QKLTDSAGEK TTKGKSPQLA LRQPRQGPTD
60 70 80 90 100
EAQMAAAAAL ARLEQKQPRA RGPTSQDSIR NQVRKELQAE ATSSNNPGAP
110 120 130 140 150
GTNSVPEPKE EISPHLAVPG VFFICPLTGV TLRRDQRDAH IKQAILSHFS
160 170 180 190 200
TDPVAASIMK IHTFNRDRDR VKLGVDTIAK YLDNIHLHPE EEKYQKIKLQ
210 220 230 240 250
NKVFQERINC LEGSHEFFEA IGFKKVTLPV PDQEGQEEFY VLGEDARAQP
260 270 280 290 300
QNLARHKQQL LDAEPVRATL DRQLRVFRPS ALASHFELPS DFFSLTAEEV
310 320 330 340 350
KREQRLRTEA VERLSSLRTK AMREKEEQRE LRKYTYALVR VRLPDGCLLQ
360 370 380 390 400
GTFYAREKLS ALFRFVREAL QNDWLPFELR ASGGQKLEEN EALALNECGL
410 420 430 440
VPSALLTFSW DASVLEDIRA AGAEPAKSVL RPELLAAIEQ LS
Length:442
Mass (Da):49,796
Last modified:June 1, 2001 - v1
Checksum:i9240DB2870F25B11
GO
Isoform 2 (identifier: Q99PL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:389
Mass (Da):43,995
Checksum:i44713ABCDEED8586
GO

Sequence cautioni

Q99PL6: The sequence BAB26082 differs from that shown. Reason: Frameshift at position 435.Curated
Q99PL6: The sequence BAC38512 differs from that shown. Reason: Frameshift at position 394.Curated
Q99PL6: The sequence BAE36284 differs from that shown. Reason: Frameshift at position 390.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151T → S in BAC38512 (PubMed:16141072).Curated1
Sequence conflicti400L → V in BAB26082 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0074541 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272895 mRNA. Translation: AAK13259.1.
AK009117 mRNA. Translation: BAB26082.1. Frameshift.
AK082510 mRNA. Translation: BAC38512.1. Frameshift.
AK148170 mRNA. Translation: BAE28390.1.
AK161273 mRNA. Translation: BAE36284.1. Frameshift.
CH466559 Genomic DNA. Translation: EDL23709.1.
CT009719 Genomic DNA. Translation: CAX15602.1.
BC016412 mRNA. Translation: AAH16412.1.
BC049963 mRNA. Translation: AAH49963.1.
CCDSiCCDS28893.1. [Q99PL6-1]
RefSeqiNP_077752.1. NM_024432.2. [Q99PL6-1]
XP_006524859.1. XM_006524796.2. [Q99PL6-2]
XP_017173099.1. XM_017317610.1. [Q99PL6-1]
UniGeneiMm.28000.

Genome annotation databases

EnsembliENSMUST00000019722; ENSMUSP00000019722; ENSMUSG00000019578. [Q99PL6-1]
GeneIDi66530.
KEGGimmu:66530.
UCSCiuc008dat.2. mouse. [Q99PL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBXN6_MOUSE
AccessioniPrimary (citable) accession number: Q99PL6
Secondary accession number(s): B8JJA5
, Q3TTP1, Q3UG19, Q8C4D6, Q91W79, Q9D7L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot