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Protein

Ribosome-binding protein 1

Gene

Rrbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-binding protein 1
Alternative name(s):
Ribosome receptor protein
Short name:
RRp
Short name:
mRRp
Gene namesi
Name:Rrbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1932395. Rrbp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7LumenalSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 1605CytoplasmicSequence analysisAdd BLAST1577

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974421 – 1605Ribosome-binding protein 1Add BLAST1605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei786PhosphoserineBy similarity1
Modified residuei818PhosphoserineBy similarity1
Cross-linki823Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei1135N6-acetyllysineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1178PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99PL5.
PaxDbiQ99PL5.
PeptideAtlasiQ99PL5.
PRIDEiQ99PL5.

PTM databases

iPTMnetiQ99PL5.
PhosphoSitePlusiQ99PL5.
SwissPalmiQ99PL5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000027422.
CleanExiMM_RRBP1.
ExpressionAtlasiQ99PL5. baseline and differential.
GenevisibleiQ99PL5. MM.

Interactioni

Protein-protein interaction databases

BioGridi219905. 219 interactors.
IntActiQ99PL5. 226 interactors.
MINTiMINT-1867743.
STRINGi10090.ENSMUSP00000016072.

Structurei

3D structure databases

ProteinModelPortaliQ99PL5.
SMRiQ99PL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati196 – 205110
Repeati206 – 215210
Repeati216 – 225310
Repeati226 – 235410
Repeati236 – 245510
Repeati246 – 255610
Repeati256 – 265710
Repeati266 – 275810
Repeati276 – 285910
Repeati286 – 2951010
Repeati296 – 3051110
Repeati306 – 3151210
Repeati316 – 3251310
Repeati326 – 3351410
Repeati336 – 3451510
Repeati346 – 3551610
Repeati356 – 3651710
Repeati366 – 3751810
Repeati376 – 3851910
Repeati386 – 3952010
Repeati396 – 4052110
Repeati406 – 4152210
Repeati416 – 4252310
Repeati426 – 4352410
Repeati436 – 4452510
Repeati446 – 4552610
Repeati456 – 4652710
Repeati466 – 4752810
Repeati476 – 4852910
Repeati486 – 4953010
Repeati496 – 5053110
Repeati506 – 5153210
Repeati516 – 5253310
Repeati527 – 5363410
Repeati537 – 5463510
Repeati547 – 5563610
Repeati557 – 5663710
Repeati567 – 5763810
Repeati577 – 5863910
Repeati587 – 5964010
Repeati597 – 6064110
Repeati607 – 6164210
Repeati617 – 6264310
Repeati628 – 6374410
Repeati638 – 6474510
Repeati648 – 6574610
Repeati658 – 6674710
Repeati668 – 6774810
Repeati678 – 6874910
Repeati688 – 6975010
Repeati698 – 7075110
Repeati708 – 7175210
Repeati718 – 7275310
Repeati729 – 7385410
Repeati739 – 7485510
Repeati749 – 7585610
Repeati759 – 7685710
Repeati769 – 7785810
Repeati779 – 7885910
Repeati789 – 7986010
Repeati799 – 8086110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 80861 X 10 AA tandem repeats of [NSQ]-[NKQVGA]-[GSAQKRT]-[ASGDTK]-[KGTQSAV]-[KGAED]-[EQVGIPTDMA]-[EGVAS]-[AGVPETNS]-[AQNGPTVS]Add BLAST613

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFNK. Eukaryota.
ENOG410XY8H. LUCA.
GeneTreeiENSGT00530000063895.
HOVERGENiHBG061483.
InParanoidiQ99PL5.
KOiK14000.
PhylomeDBiQ99PL5.

Family and domain databases

InterProiIPR007794. Rib_rcpt_KP.
[Graphical view]
PfamiPF05104. Rib_recp_KP_reg. 1 hit.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 3 (identifier: Q99PL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA
60 70 80 90 100
KTHHQKGEKK KKEKTVEKKG KTKKKEEKPN GKIPEHDLDP NVTIILKEPV
110 120 130 140 150
RVSAVAVAPT SVHSSVGHTP IATVPAMPQE KLASSPKDRK KKEKKVAKVE
160 170 180 190 200
PAVSSIVNSI QVLASKSAIL EATPKEVPMV AVPPVGSKAS SPATSSQGKK
210 220 230 240 250
GQGAQNQAKK GEGAQNQGKK GEGAQNQAKK GEGAQNQAKK GEGAQNQGKK
260 270 280 290 300
GEGAQNQAKK GEGGQNQAKK GEGAQNQGKK GEGAQNQGKK GEGAQNQAKK
310 320 330 340 350
GEGAQNQAKK GEGAQNQGKK GEGAQNQSKK GEGAQNQAKK GEGGQNQAKK
360 370 380 390 400
GEGAQNQAKK GEGAQNQAKK GEGVQNQAKK GVEGAQNQGK KGEANQNQAK
410 420 430 440 450
KGEGGQNQTK KGEGPQNQGK KGEAAQKQDK KIEGAQNQGK KPEGTSNQGK
460 470 480 490 500
KGEGAQNQGK KGEGAQNQSK KGEGAQNQAK KGEGGQNQAK KGEGAQNQAK
510 520 530 540 550
KGEGAQNQAK KGEGVQNQAK KGVEGAQNQG KKGEANQNQA KKGEGGQNQT
560 570 580 590 600
KKGEGPQNQG KKGEAAQKQD KKIEGAQNQG KKPEGTSNQG KKGEGAQNQG
610 620 630 640 650
KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG
660 670 680 690 700
KKGEGAQNQG KKGEGPQNQA KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG
710 720 730 740 750
KKAEGVQSQS KKGEGTQNQG KKGDGNPNQG KKGEGASNQN RKTDTVANQG
760 770 780 790 800
TKQEGVSNQV KKSEGSPNQG KKAEGAPNQG KKKDGSPSQA KKVDAAANQG
810 820 830 840 850
KKSEMAPAQG QKASMVQSQE APKQDAPAKK KSGSRKKGEP GPPDCDGPLF
860 870 880 890 900
LPYKTLVSTV GSMVFSEGEA QRLIEILSEK TGVIQDTWHK ATQKGDPVAI
910 920 930 940 950
LKRQLQEKEK LLATEQEDAA VAKSKLRELN KEMASEKAKA AAGEAKVKKQ
960 970 980 990 1000
LVAREQEIAA VQARMQASYR DHVKEVQQLQ GKIRTLQEQL ENGPNTQLAR
1010 1020 1030 1040 1050
LQQENSILRD ALNQATSQVE SKQNTELAKL RQELSKVNKE LVEKSEASRQ
1060 1070 1080 1090 1100
EEQQRKALEA KAATFEKQVL QLQASHKESE EALQKRLEEV TRELCRAQTS
1110 1120 1130 1140 1150
HANLRADAEK AQEQQQRVAE LHSKLQSSEV EVKSKCEELS SLHGQLKEAR
1160 1170 1180 1190 1200
AENSQLTERI RSIEALLEAG QAQDTQASHA EANQQQTRLK ELESQVSCLE
1210 1220 1230 1240 1250
KETSELKEAM EQQKGKNNDL REKNWKAMEA LALAERACEE KLRSLTQAKE
1260 1270 1280 1290 1300
ESEKQLHLAE AQTKETLLAL LPGLSISAHQ NYAEWLQEFK EKGSELLKKP
1310 1320 1330 1340 1350
PTLEPSMDIV LKLREAEETQ NSLQAECDQY RTILAETEGM LKDLQKSVEE
1360 1370 1380 1390 1400
EERVWKAKVG AAEEELHKSR VTVKHLEDIV EKLKGELESS DQVREHTSHL
1410 1420 1430 1440 1450
EAELEKHMAA ASAECQNYAK EVAGLRQLLL ESQSQLDEAK SEAQKQSDEL
1460 1470 1480 1490 1500
ALVRQQLSDM RSHVEDGDVA GSPAVPPAEQ DPMKLKTQLE RTEATLEAEQ
1510 1520 1530 1540 1550
TRRQKLTAEF EEAQRTACRI QEELEKLRAA GPLESSGKEE ITQLKERLEK
1560 1570 1580 1590 1600
EKRLTSDLGR AAIKLQELLK TTQEQLTKEK DTVKKLQEQL GKAEDGSSSK

EGTSV
Note: No experimental confirmation available.
Length:1,605
Mass (Da):172,879
Last modified:March 1, 2002 - v2
Checksum:i0BE08088BF10C665
GO
Isoform RRp61 (identifier: Q99PL5-2) [UniParc]FASTAAdd to basket
Also known as: p180

The sequence of this isoform differs from the canonical sequence as follows:
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:842
Mass (Da):86,953
Checksum:iDAD1C053D4904BAC
GO
Isoform RRp47 (identifier: Q99PL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-449: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:701
Mass (Da):72,468
Checksum:i63D57896FC079133
GO
Isoform RRp41 (identifier: Q99PL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-666: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:641
Mass (Da):66,454
Checksum:i0509DA8AF7772544
GO
Isoform RRp16.8 (identifier: Q99PL5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-626: Missing.
     717-738: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:398
Mass (Da):41,731
Checksum:i4C72BD0F051EC91F
GO
Isoform RRp15a (identifier: Q99PL5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-730: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:380
Mass (Da):39,877
Checksum:i212A3D6A950A28BA
GO
Isoform RRp15b (identifier: Q99PL5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-666: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:380
Mass (Da):39,908
Checksum:i3599ED50A5A46A28
GO
Isoform RRp10 (identifier: Q99PL5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-720: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:330
Mass (Da):34,843
Checksum:i0F543600AD81F64F
GO
Isoform RRp5.4 (identifier: Q99PL5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-766: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:284
Mass (Da):30,074
Checksum:i52547E6ED669C411
GO
Isoform RRp2 (identifier: Q99PL5-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     196-787: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:250
Mass (Da):26,672
Checksum:i8F29ACC4CEC3502A
GO
Isoform RRp1.8 (identifier: Q99PL5-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-789: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:229
Mass (Da):24,693
Checksum:i4B3A6F26525DD903
GO
Isoform RRp0 (identifier: Q99PL5-12) [UniParc]FASTAAdd to basket
Also known as: ES130

The sequence of this isoform differs from the canonical sequence as follows:
     177-809: Missing.
     841-842: GP → VC
     843-1605: Missing.

Show »
Length:209
Mass (Da):22,667
Checksum:i1885DB27662C7343
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti670A → G in AAK11965 (PubMed:11167022).Curated1
Sequence conflicti700G → S in AAK11967 (PubMed:11167022).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003952177 – 809Missing in isoform RRp0. 1 PublicationAdd BLAST633
Alternative sequenceiVSP_003951177 – 789Missing in isoform RRp1.8. 1 PublicationAdd BLAST613
Alternative sequenceiVSP_003953196 – 787Missing in isoform RRp2. 1 PublicationAdd BLAST592
Alternative sequenceiVSP_003955205 – 666Missing in isoform RRp15b. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_003954205 – 626Missing in isoform RRp16.8. 1 PublicationAdd BLAST422
Alternative sequenceiVSP_003957209 – 766Missing in isoform RRp5.4. 1 PublicationAdd BLAST558
Alternative sequenceiVSP_003956209 – 720Missing in isoform RRp10. 1 PublicationAdd BLAST512
Alternative sequenceiVSP_003958269 – 730Missing in isoform RRp15a. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_003959309 – 449Missing in isoform RRp47. 2 PublicationsAdd BLAST141
Alternative sequenceiVSP_003961466 – 666Missing in isoform RRp41. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_003962717 – 738Missing in isoform RRp16.8. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_003963841 – 842GP → VC in isoform RRp61, isoform RRp1.8, isoform RRp0, isoform RRp2, isoform RRp16.8, isoform RRp15b, isoform RRp10, isoform RRp5.4, isoform RRp15a, isoform RRp47 and isoform RRp41. 2 Publications2
Alternative sequenceiVSP_003964843 – 1605Missing in isoform RRp61, isoform RRp1.8, isoform RRp0, isoform RRp2, isoform RRp16.8, isoform RRp15b, isoform RRp10, isoform RRp5.4, isoform RRp15a, isoform RRp47 and isoform RRp41. 2 PublicationsAdd BLAST763

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273683 mRNA. Translation: AAK11963.1.
AF273684 mRNA. Translation: AAK11964.1.
AF273685 mRNA. Translation: AAK11965.1.
AF273686 mRNA. Translation: AAK11966.1.
AF273687 mRNA. Translation: AAK11967.1.
AF273688 mRNA. Translation: AAK11968.1.
AF273689 mRNA. Translation: AAK11969.1.
AF273690 mRNA. Translation: AAK11970.1.
AF273691 mRNA. Translation: AAK11971.1.
AF273692 mRNA. Translation: AAK11972.1.
AF273693 mRNA. Translation: AAK11973.1.
AL929550 Genomic DNA. Translation: CAM26891.1.
BC031452 mRNA. Translation: AAH31452.1.
AK019964 mRNA. Translation: BAB31939.1.
CCDSiCCDS38253.1. [Q99PL5-3]
RefSeqiNP_077243.2. NM_024281.2.
NP_598329.1. NM_133626.2. [Q99PL5-3]
UniGeneiMm.13705.

Genome annotation databases

EnsembliENSMUST00000037875; ENSMUSP00000040560; ENSMUSG00000027422. [Q99PL5-3]
GeneIDi81910.
KEGGimmu:81910.
UCSCiuc008mqk.1. mouse. [Q99PL5-3]
uc008mql.1. mouse. [Q99PL5-12]
uc008mqm.1. mouse. [Q99PL5-11]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273683 mRNA. Translation: AAK11963.1.
AF273684 mRNA. Translation: AAK11964.1.
AF273685 mRNA. Translation: AAK11965.1.
AF273686 mRNA. Translation: AAK11966.1.
AF273687 mRNA. Translation: AAK11967.1.
AF273688 mRNA. Translation: AAK11968.1.
AF273689 mRNA. Translation: AAK11969.1.
AF273690 mRNA. Translation: AAK11970.1.
AF273691 mRNA. Translation: AAK11971.1.
AF273692 mRNA. Translation: AAK11972.1.
AF273693 mRNA. Translation: AAK11973.1.
AL929550 Genomic DNA. Translation: CAM26891.1.
BC031452 mRNA. Translation: AAH31452.1.
AK019964 mRNA. Translation: BAB31939.1.
CCDSiCCDS38253.1. [Q99PL5-3]
RefSeqiNP_077243.2. NM_024281.2.
NP_598329.1. NM_133626.2. [Q99PL5-3]
UniGeneiMm.13705.

3D structure databases

ProteinModelPortaliQ99PL5.
SMRiQ99PL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219905. 219 interactors.
IntActiQ99PL5. 226 interactors.
MINTiMINT-1867743.
STRINGi10090.ENSMUSP00000016072.

PTM databases

iPTMnetiQ99PL5.
PhosphoSitePlusiQ99PL5.
SwissPalmiQ99PL5.

Proteomic databases

EPDiQ99PL5.
PaxDbiQ99PL5.
PeptideAtlasiQ99PL5.
PRIDEiQ99PL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037875; ENSMUSP00000040560; ENSMUSG00000027422. [Q99PL5-3]
GeneIDi81910.
KEGGimmu:81910.
UCSCiuc008mqk.1. mouse. [Q99PL5-3]
uc008mql.1. mouse. [Q99PL5-12]
uc008mqm.1. mouse. [Q99PL5-11]

Organism-specific databases

CTDi6238.
MGIiMGI:1932395. Rrbp1.

Phylogenomic databases

eggNOGiENOG410IFNK. Eukaryota.
ENOG410XY8H. LUCA.
GeneTreeiENSGT00530000063895.
HOVERGENiHBG061483.
InParanoidiQ99PL5.
KOiK14000.
PhylomeDBiQ99PL5.

Miscellaneous databases

ChiTaRSiRrbp1. mouse.
PROiQ99PL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027422.
CleanExiMM_RRBP1.
ExpressionAtlasiQ99PL5. baseline and differential.
GenevisibleiQ99PL5. MM.

Family and domain databases

InterProiIPR007794. Rib_rcpt_KP.
[Graphical view]
PfamiPF05104. Rib_recp_KP_reg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRBP1_MOUSE
AccessioniPrimary (citable) accession number: Q99PL5
Secondary accession number(s): A2AVJ8
, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.