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Protein

Pre-mRNA-splicing factor SYF1

Gene

Xab2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.By similarity

GO - Biological processi

  • blastocyst development Source: RGD
  • cerebral cortex development Source: RGD
  • generation of catalytic spliceosome for first transesterification step Source: GO_Central
  • mRNA splicing, via spliceosome Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB
  • transcription-coupled nucleotide-excision repair Source: UniProtKB

Keywordsi

Biological processDNA damage, DNA repair, mRNA processing, mRNA splicing, Transcription

Enzyme and pathway databases

ReactomeiR-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SYF1
Alternative name(s):
Adapter protein ATH-551 Publication
XPA-binding protein 2
Gene namesi
Name:Xab2
Synonyms:Ath551 Publication, Syf1
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621217 Xab2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064161 – 855Pre-mRNA-splicing factor SYF1Add BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei420N6-acetyllysineBy similarity1
Modified residuei851PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99PK0
PRIDEiQ99PK0

PTM databases

iPTMnetiQ99PK0
PhosphoSitePlusiQ99PK0

Expressioni

Gene expression databases

BgeeiENSRNOG00000000988
GenevisibleiQ99PK0 RN

Interactioni

Subunit structurei

Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001309

Structurei

3D structure databases

ProteinModelPortaliQ99PK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 47HAT 1CuratedAdd BLAST33
Repeati48 – 80HAT 2CuratedAdd BLAST33
Repeati90 – 122HAT 3CuratedAdd BLAST33
Repeati124 – 158HAT 4CuratedAdd BLAST35
Repeati160 – 192HAT 5CuratedAdd BLAST33
Repeati198 – 230HAT 6Add BLAST33
Repeati235 – 268HAT 7Add BLAST34
Repeati270 – 305HAT 8Add BLAST36
Repeati369 – 407HAT 9Add BLAST39
Repeati498 – 530HAT 10Add BLAST33
Repeati532 – 566HAT 11Add BLAST35
Repeati571 – 605HAT 12Add BLAST35
Repeati643 – 677HAT 13Add BLAST35
Repeati679 – 713HAT 14Add BLAST35

Sequence similaritiesi

Belongs to the crooked-neck family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2047 Eukaryota
ENOG410XPD9 LUCA
GeneTreeiENSGT00550000075140
HOGENOMiHOG000176133
HOVERGENiHBG024066
InParanoidiQ99PK0
KOiK12867
OMAiAVKIWRR
OrthoDBiEOG091G01UP
PhylomeDBiQ99PK0
TreeFamiTF300866

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 10 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 4 hits

Sequencei

Sequence statusi: Complete.

Q99PK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMARVPRP ERPDLVFEEE DLPYEEEIMR NQFSVKCWLR YIEFKQGAPK
60 70 80 90 100
PRLNQLYERA LKLLPCSYKL WYRYLKARRA QVKHRCVTDP AYEDVNNCHE
110 120 130 140 150
RAFVFMHKMP RLWLDYCQFL MDQGRVTHTR RTFDRALRAL PITQHSRIWP
160 170 180 190 200
LYLRFLRSHP LPETAVRGYR RFLKLSPESA EEYIEYLKSS DRLDEAAQRL
210 220 230 240 250
ATVVNDERFV SKAGKSNYQL WHELCDLISQ NPDKVQSLNV DAIIRGGLTR
260 270 280 290 300
FTDQLGKLWC SLADYYIRSG HFEKARDVYE EAIRTVMTVR DFTQVFDSYA
310 320 330 340 350
QFEESMIAAK METASELGRE EEDDVDLELR LARFEQLISR RPLLLNSVLL
360 370 380 390 400
RQNPHHVHEW HKRVALHQGR PREIINTYTE AVQTVDPFKA TGKPHTLWVA
410 420 430 440 450
FAKFYEDNGQ LDDARVILEK ATKVNFKQVD DLASVWCQCG ELELRHENYD
460 470 480 490 500
EALKLLRKAT ALPARRAEYF DGSEPVQNRV YKSLKVWSML ADLEESLGTF
510 520 530 540 550
QSTKAVYDRI LDLRIATPQI VINYAMFLEE HKYFEESFKA YERGISLFKW
560 570 580 590 600
PNVSDIWSTY LTKFISRYGG RKLERARDLF EQALDGCPPK YAKTLYLLYA
610 620 630 640 650
QLEEEWGLAR HAMAVYDRAT RAVEPAQQYD MFNIYIKRAA EIYGVTHTRG
660 670 680 690 700
IYQKAIEVLS DEHAREMCLR FADMECKLGE IDRARAIYSF CSQICDPRTT
710 720 730 740 750
GAFWQTWKDF EVRHGNEDTI REMLRIRRSV QATYNTQVNF MASQMLKVSG
760 770 780 790 800
SATGTVSDLA PGQSGMDDMK LLEQRAEQLA AEAERDQPPR AQSKIFFVRS
810 820 830 840 850
DASREELAEL AQQANPEEIQ LGEDEDEDEM DLEPNEVRLE QQSVPAAVFG

SLKED
Length:855
Mass (Da):99,998
Last modified:June 1, 2001 - v1
Checksum:i35D18C33F66121A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277899 mRNA Translation: AAG53885.1
BC081723 mRNA Translation: AAH81723.1
RefSeqiNP_620809.1, NM_139109.2
UniGeneiRn.24921

Genome annotation databases

EnsembliENSRNOT00000001309; ENSRNOP00000001309; ENSRNOG00000000988
GeneIDi245976
KEGGirno:245976
UCSCiRGD:621217 rat

Similar proteinsi

Entry informationi

Entry nameiSYF1_RAT
AccessioniPrimary (citable) accession number: Q99PK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health