Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 689

Gene

Znf689

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 17123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 48226C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Alternative name(s):
Transcription factor HIT-39
Gene namesi
Name:Znf689
Synonyms:Hit39, Zfp689
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628696. Zfp689.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Zinc finger protein 689PRO_0000234010Add
BLAST

Proteomic databases

PaxDbiQ99PJ7.
PRIDEiQ99PJ7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029821.
ExpressionAtlasiQ99PJ7. baseline and differential.
GenevisibleiQ99PJ7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024969.

Structurei

3D structure databases

ProteinModelPortaliQ99PJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 17123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 48226C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ99PJ7.
KOiK09228.
PhylomeDBiQ99PJ7.
TreeFamiTF336948.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSAPLLE QAPGEVGPTR RRGRRPRALK FADVAVYFSS EEWGRLRPAQ
60 70 80 90 100
RTLYRDVMRE TYGLLGALGC AGPKPALITW LERNTDDWEP AALDPQEYRR
110 120 130 140 150
WVTFQRKTRT RQKNEEKEVF PPKDVPRKGK RGRKPSKPRL IARQTSGGPI
160 170 180 190 200
CPDCGCTFPD LPALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECSRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCCPN THNGSPRPLI GGPNQRSSAL
Length:500
Mass (Da):57,282
Last modified:June 1, 2001 - v1
Checksum:i7F4D21648E6DE026
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277902 mRNA. Translation: AAG53888.1.
RefSeqiNP_775452.1. NM_173330.1.
UniGeneiRn.205819.

Genome annotation databases

EnsembliENSRNOT00000024969; ENSRNOP00000024969; ENSRNOG00000018877.
GeneIDi286996.
KEGGirno:286996.
UCSCiRGD:628696. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277902 mRNA. Translation: AAG53888.1.
RefSeqiNP_775452.1. NM_173330.1.
UniGeneiRn.205819.

3D structure databases

ProteinModelPortaliQ99PJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024969.

Proteomic databases

PaxDbiQ99PJ7.
PRIDEiQ99PJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024969; ENSRNOP00000024969; ENSRNOG00000018877.
GeneIDi286996.
KEGGirno:286996.
UCSCiRGD:628696. rat.

Organism-specific databases

CTDi71131.
RGDi628696. Zfp689.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ99PJ7.
KOiK09228.
PhylomeDBiQ99PJ7.
TreeFamiTF336948.

Miscellaneous databases

PROiQ99PJ7.

Gene expression databases

BgeeiENSRNOG00000029821.
ExpressionAtlasiQ99PJ7. baseline and differential.
GenevisibleiQ99PJ7. RN.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN689_RAT
AccessioniPrimary (citable) accession number: Q99PJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.