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Protein

Zinc finger protein 689

Gene

Znf689

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 482C2H2-type 12PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Alternative name(s):
Transcription factor HIT-39
Gene namesi
Name:Znf689
Synonyms:Hit39, Zfp689
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628696 Zfp689

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340101 – 500Zinc finger protein 689Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ99PJ7
PRIDEiQ99PJ7

Expressioni

Gene expression databases

BgeeiENSRNOG00000018877
ExpressionAtlasiQ99PJ7 baseline and differential
GenevisibleiQ99PJ7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024969

Structurei

3D structure databases

ProteinModelPortaliQ99PJ7
SMRiQ99PJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 482C2H2-type 12PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144036
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ99PJ7
KOiK09228
PhylomeDBiQ99PJ7
TreeFamiTF336948

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q99PJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSAPLLE QAPGEVGPTR RRGRRPRALK FADVAVYFSS EEWGRLRPAQ
60 70 80 90 100
RTLYRDVMRE TYGLLGALGC AGPKPALITW LERNTDDWEP AALDPQEYRR
110 120 130 140 150
WVTFQRKTRT RQKNEEKEVF PPKDVPRKGK RGRKPSKPRL IARQTSGGPI
160 170 180 190 200
CPDCGCTFPD LPALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECSRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCCPN THNGSPRPLI GGPNQRSSAL
Length:500
Mass (Da):57,282
Last modified:June 1, 2001 - v1
Checksum:i7F4D21648E6DE026
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277902 mRNA Translation: AAG53888.1
RefSeqiNP_775452.1, NM_173330.1
UniGeneiRn.205819

Genome annotation databases

EnsembliENSRNOT00000024969; ENSRNOP00000024969; ENSRNOG00000018877
GeneIDi286996
KEGGirno:286996
UCSCiRGD:628696 rat

Similar proteinsi

Entry informationi

Entry nameiZN689_RAT
AccessioniPrimary (citable) accession number: Q99PJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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