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Protein

Neurotrimin

Gene

Ntm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrimin
Gene namesi
Name:Ntm
Synonyms:Hnt, Nt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2446259. Ntm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 321288NeurotriminPRO_0000015112Add
BLAST
Propeptidei322 – 34423Removed in mature formSequence analysisPRO_0000015113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 201PROSITE-ProRule annotation
Disulfide bondi243 ↔ 295PROSITE-ProRule annotation
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence analysis
Lipidationi321 – 3211GPI-anchor amidated asparagine; alternateSequence analysis
Glycosylationi321 – 3211N-linked (GlcNAc...); alternateSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ99PJ0.
PaxDbiQ99PJ0.
PeptideAtlasiQ99PJ0.
PRIDEiQ99PJ0.

PTM databases

iPTMnetiQ99PJ0.
PhosphoSiteiQ99PJ0.

Expressioni

Gene expression databases

BgeeiQ99PJ0.
CleanExiMM_HNT.
ExpressionAtlasiQ99PJ0. baseline and differential.
GenevisibleiQ99PJ0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99PJ0. 3 interactions.
MINTiMINT-1177225.
STRINGi10090.ENSMUSP00000074578.

Structurei

3D structure databases

ProteinModelPortaliQ99PJ0.
SMRiQ99PJ0. Positions 44-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12688Ig-like C2-type 1Add
BLAST
Domaini136 – 21883Ig-like C2-type 2Add
BLAST
Domaini222 – 30988Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJF. Eukaryota.
ENOG4111SM8. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ99PJ0.
OMAiASMILYE.
PhylomeDBiQ99PJ0.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI
110 120 130 140 150
EIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVSPKIVE ISSDISINEG
160 170 180 190 200
NNISLTCIAT GRPEPTVTWR HISPKAVGFV SEDEYLEIQG ITREQSGEYE
210 220 230 240 250
CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT LQCEASAVPS
260 270 280 290 300
AEFQWFKDDK RLVEGKKGVK VENRPFLSKL TFFNVSEHDY GNYTCVASNK
310 320 330 340
LGHTNASIML FGPGAVSEVN NGTSRRAGCI WLLPLLVLHL LLKF
Length:344
Mass (Da):37,984
Last modified:December 13, 2002 - v2
Checksum:iC885BBA52C148554
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751L → P in AAK00276 (Ref. 1) Curated
Sequence conflicti92 – 921S → G in AAK00276 (Ref. 1) Curated
Sequence conflicti119 – 1191T → I in AAK00276 (Ref. 1) Curated
Sequence conflicti187 – 1871E → Q in AAK00276 (Ref. 1) Curated
Sequence conflicti213 – 2131R → P in AAK00276 (Ref. 1) Curated
Sequence conflicti225 – 2251I → F in AAK00276 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282980 mRNA. Translation: AAK00276.1.
BC023307 mRNA. Translation: AAH23307.1.
UniGeneiMm.283138.

Genome annotation databases

EnsembliENSMUST00000115237; ENSMUSP00000110892; ENSMUSG00000059974.
UCSCiuc009oqt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282980 mRNA. Translation: AAK00276.1.
BC023307 mRNA. Translation: AAH23307.1.
UniGeneiMm.283138.

3D structure databases

ProteinModelPortaliQ99PJ0.
SMRiQ99PJ0. Positions 44-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99PJ0. 3 interactions.
MINTiMINT-1177225.
STRINGi10090.ENSMUSP00000074578.

PTM databases

iPTMnetiQ99PJ0.
PhosphoSiteiQ99PJ0.

Proteomic databases

MaxQBiQ99PJ0.
PaxDbiQ99PJ0.
PeptideAtlasiQ99PJ0.
PRIDEiQ99PJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115237; ENSMUSP00000110892; ENSMUSG00000059974.
UCSCiuc009oqt.1. mouse.

Organism-specific databases

MGIiMGI:2446259. Ntm.

Phylogenomic databases

eggNOGiENOG410IQJF. Eukaryota.
ENOG4111SM8. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ99PJ0.
OMAiASMILYE.
PhylomeDBiQ99PJ0.

Miscellaneous databases

ChiTaRSiNtm. mouse.
PROiQ99PJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ99PJ0.
CleanExiMM_HNT.
ExpressionAtlasiQ99PJ0. baseline and differential.
GenevisibleiQ99PJ0. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of mouse neurotrimin gene in the developing nervous system."
    Kim T.H., Choi S.C., Kim J., Jeon J.W., Kim K.D., Lee S.H.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNTRI_MOUSE
AccessioniPrimary (citable) accession number: Q99PJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 13, 2002
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.