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Protein

Neurotrimin

Gene

Ntm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrimin
Gene namesi
Name:Ntm
Synonyms:Hnt, Nt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2446259. Ntm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001511234 – 321NeurotriminAdd BLAST288
PropeptideiPRO_0000015113322 – 344Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi157 ↔ 201PROSITE-ProRule annotation
Disulfide bondi243 ↔ 295PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Lipidationi321GPI-anchor amidated asparagine; alternateSequence analysis1
Glycosylationi321N-linked (GlcNAc...); alternateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ99PJ0.
PaxDbiQ99PJ0.
PeptideAtlasiQ99PJ0.
PRIDEiQ99PJ0.

PTM databases

iPTMnetiQ99PJ0.
PhosphoSitePlusiQ99PJ0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059974.
CleanExiMM_HNT.
ExpressionAtlasiQ99PJ0. baseline and differential.
GenevisibleiQ99PJ0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99PJ0. 3 interactors.
MINTiMINT-1177225.
STRINGi10090.ENSMUSP00000074578.

Structurei

3D structure databases

ProteinModelPortaliQ99PJ0.
SMRiQ99PJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 218Ig-like C2-type 2Add BLAST83
Domaini222 – 309Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJF. Eukaryota.
ENOG4111SM8. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ99PJ0.
OMAiASMILYE.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ99PJ0.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI
110 120 130 140 150
EIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVSPKIVE ISSDISINEG
160 170 180 190 200
NNISLTCIAT GRPEPTVTWR HISPKAVGFV SEDEYLEIQG ITREQSGEYE
210 220 230 240 250
CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT LQCEASAVPS
260 270 280 290 300
AEFQWFKDDK RLVEGKKGVK VENRPFLSKL TFFNVSEHDY GNYTCVASNK
310 320 330 340
LGHTNASIML FGPGAVSEVN NGTSRRAGCI WLLPLLVLHL LLKF
Length:344
Mass (Da):37,984
Last modified:December 13, 2002 - v2
Checksum:iC885BBA52C148554
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75L → P in AAK00276 (Ref. 1) Curated1
Sequence conflicti92S → G in AAK00276 (Ref. 1) Curated1
Sequence conflicti119T → I in AAK00276 (Ref. 1) Curated1
Sequence conflicti187E → Q in AAK00276 (Ref. 1) Curated1
Sequence conflicti213R → P in AAK00276 (Ref. 1) Curated1
Sequence conflicti225I → F in AAK00276 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282980 mRNA. Translation: AAK00276.1.
BC023307 mRNA. Translation: AAH23307.1.
UniGeneiMm.283138.

Genome annotation databases

EnsembliENSMUST00000115237; ENSMUSP00000110892; ENSMUSG00000059974.
UCSCiuc009oqt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282980 mRNA. Translation: AAK00276.1.
BC023307 mRNA. Translation: AAH23307.1.
UniGeneiMm.283138.

3D structure databases

ProteinModelPortaliQ99PJ0.
SMRiQ99PJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99PJ0. 3 interactors.
MINTiMINT-1177225.
STRINGi10090.ENSMUSP00000074578.

PTM databases

iPTMnetiQ99PJ0.
PhosphoSitePlusiQ99PJ0.

Proteomic databases

MaxQBiQ99PJ0.
PaxDbiQ99PJ0.
PeptideAtlasiQ99PJ0.
PRIDEiQ99PJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115237; ENSMUSP00000110892; ENSMUSG00000059974.
UCSCiuc009oqt.1. mouse.

Organism-specific databases

MGIiMGI:2446259. Ntm.

Phylogenomic databases

eggNOGiENOG410IQJF. Eukaryota.
ENOG4111SM8. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ99PJ0.
OMAiASMILYE.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ99PJ0.

Miscellaneous databases

ChiTaRSiNtm. mouse.
PROiQ99PJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059974.
CleanExiMM_HNT.
ExpressionAtlasiQ99PJ0. baseline and differential.
GenevisibleiQ99PJ0. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTRI_MOUSE
AccessioniPrimary (citable) accession number: Q99PJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 13, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.