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Protein

Reticulon-4 receptor

Gene

Rtn4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity). Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development.By similarity2 Publications

GO - Biological processi

  • axonogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_336835. Axonal growth inhibition (RHOA activation).

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor
Alternative name(s):
Nogo receptor
Short name:
NgR
Nogo-66 receptor
Gene namesi
Name:Rtn4r
Synonyms:Nogor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2136886. Rtn4r.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • cell surface Source: MGI
  • endoplasmic reticulum Source: MGI
  • extracellular exosome Source: MGI
  • growth cone Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 447421Reticulon-4 receptorPRO_0000022257Add
BLAST
Propeptidei448 – 47326Removed in mature formSequence AnalysisPRO_0000022258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 33By similarity
Disulfide bondi31 ↔ 43By similarity
Glycosylationi82 – 821N-linked (GlcNAc...)By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)By similarity
Disulfide bondi264 ↔ 287By similarity
Disulfide bondi266 ↔ 309By similarity
Lipidationi447 – 4471GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ99PI8.
PaxDbiQ99PI8.
PRIDEiQ99PI8.

Expressioni

Gene expression databases

BgeeiQ99PI8.
CleanExiMM_RTN4R.
GenevestigatoriQ99PI8.

Interactioni

Subunit structurei

Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L.By similarity

Protein-protein interaction databases

BioGridi211123. 1 interaction.
MINTiMINT-188355.

Structurei

3D structure databases

ProteinModelPortaliQ99PI8.
SMRiQ99PI8. Positions 27-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 5731LRRNTAdd
BLAST
Repeati58 – 7922LRR 1Add
BLAST
Repeati82 – 10322LRR 2Add
BLAST
Repeati106 – 12823LRR 3Add
BLAST
Repeati131 – 15222LRR 4Add
BLAST
Repeati155 – 17622LRR 5Add
BLAST
Repeati179 – 20022LRR 6Add
BLAST
Repeati203 – 22422LRR 7Add
BLAST
Repeati227 – 24822LRR 8Add
BLAST
Domaini260 – 31152LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00790000122991.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ99PI8.
KOiK16659.
OMAiNDNPWVC.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ99PI8.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRASSGGSR LLAWVLWLQA WRVATPCPGA CVCYNEPKVT TSCPQQGLQA
60 70 80 90 100
VPTGIPASSQ RIFLHGNRIS HVPAASFQSC RNLTILWLHS NALARIDAAA
110 120 130 140 150
FTGLTLLEQL DLSDNAQLHV VDPTTFHGLG HLHTLHLDRC GLRELGPGLF
160 170 180 190 200
RGLAALQYLY LQDNNLQALP DNTFRDLGNL THLFLHGNRI PSVPEHAFRG
210 220 230 240 250
LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM LPAEVLMPLR
260 270 280 290 300
SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLADRDLKR
310 320 330 340 350
LAASDLEGCA VASGPFRPIQ TSQLTDEELL SLPKCCQPDA ADKASVLEPG
360 370 380 390 400
RPASAGNALK GRVPPGDTPP GNGSGPRHIN DSPFGTLPSS AEPPLTALRP
410 420 430 440 450
GGSEPPGLPT TGPRRRPGCS RKNRTRSHCR LGQAGSGASG TGDAEGSGAL
460 470
PALACSLAPL GLALVLWTVL GPC
Length:473
Mass (Da):50,987
Last modified:June 1, 2001 - v1
Checksum:i14C5270EBF557E7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283462 mRNA. Translation: AAG53611.1.
BC052317 mRNA. Translation: AAH52317.2.
BC058381 mRNA. Translation: AAH58381.1.
CCDSiCCDS37279.1.
RefSeqiNP_075358.1. NM_022982.2.
UniGeneiMm.40149.

Genome annotation databases

EnsembliENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
GeneIDi65079.
KEGGimmu:65079.
UCSCiuc007ymv.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283462 mRNA. Translation: AAG53611.1.
BC052317 mRNA. Translation: AAH52317.2.
BC058381 mRNA. Translation: AAH58381.1.
CCDSiCCDS37279.1.
RefSeqiNP_075358.1. NM_022982.2.
UniGeneiMm.40149.

3D structure databases

ProteinModelPortaliQ99PI8.
SMRiQ99PI8. Positions 27-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211123. 1 interaction.
MINTiMINT-188355.

Proteomic databases

MaxQBiQ99PI8.
PaxDbiQ99PI8.
PRIDEiQ99PI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
GeneIDi65079.
KEGGimmu:65079.
UCSCiuc007ymv.1. mouse.

Organism-specific databases

CTDi65078.
MGIiMGI:2136886. Rtn4r.

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00790000122991.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ99PI8.
KOiK16659.
OMAiNDNPWVC.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ99PI8.
TreeFamiTF330080.

Enzyme and pathway databases

ReactomeiREACT_336835. Axonal growth inhibition (RHOA activation).

Miscellaneous databases

NextBioi320259.
PROiQ99PI8.
SOURCEiSearch...

Gene expression databases

BgeeiQ99PI8.
CleanExiMM_RTN4R.
GenevestigatoriQ99PI8.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration."
    Fournier A.E., GrandPre T., Strittmatter S.M.
    Nature 409:341-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Swiss Webster.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Colon.
  3. "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration."
    Ng C.E.L., Tang B.L.
    J. Neurosci. Res. 67:559-565(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "Nogo-a regulates neural precursor migration in the embryonic mouse cortex."
    Mathis C., Schroeter A., Thallmair M., Schwab M.E.
    Cereb. Cortex 20:2380-2390(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRTN4R_MOUSE
AccessioniPrimary (citable) accession number: Q99PI8
Secondary accession number(s): Q80WQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2001
Last modified: May 27, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.