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Protein

Reticulon-4 receptor

Gene

Rtn4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for RTN4, OMG and MAG. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system (PubMed:22923615). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development.Curated3 Publications

GO - Molecular functioni

  • neuregulin receptor activity Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

  • axonogenesis Source: MGI
  • cytokine-mediated signaling pathway Source: GO_Central
  • negative regulation of axon extension Source: UniProtKB
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • neuronal signal transduction Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-193634. Axonal growth inhibition (RHOA activation).

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor
Alternative name(s):
Nogo receptor
Short name:
NgR
Nogo-66 receptor
Gene namesi
Name:Rtn4r
Synonyms:Nogor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2136886. Rtn4r.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • axonal growth cone Source: UniProtKB
  • cell surface Source: MGI
  • cytoplasm Source: GO_Central
  • endoplasmic reticulum Source: MGI
  • extracellular exosome Source: MGI
  • growth cone Source: MGI
  • integral component of plasma membrane Source: UniProtKB
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002225727 – 447Reticulon-4 receptorAdd BLAST421
PropeptideiPRO_0000022258448 – 473Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 33By similarity
Disulfide bondi31 ↔ 43By similarity
Glycosylationi82N-linked (GlcNAc...)By similarity1
Glycosylationi179N-linked (GlcNAc...)By similarity1
Disulfide bondi264 ↔ 287By similarity
Disulfide bondi266 ↔ 309By similarity
Lipidationi447GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ99PI8.
PeptideAtlasiQ99PI8.
PRIDEiQ99PI8.

Expressioni

Tissue specificityi

Detected in brain, dorsal root ganglion and heart.2 Publications

Gene expression databases

BgeeiENSMUSG00000043811.
CleanExiMM_RTN4R.
GenevisibleiQ99PI8. MM.

Interactioni

Subunit structurei

Homomultimer (By similarity). Interacts with LINGO1 and NGFR (PubMed:22923615). Interacts with KIAA0319L (By similarity). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (PubMed:22923615).By similarity1 Publication

Protein-protein interaction databases

BioGridi211123. 1 interactor.
MINTiMINT-188355.
STRINGi10090.ENSMUSP00000062924.

Structurei

3D structure databases

ProteinModelPortaliQ99PI8.
SMRiQ99PI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 57LRRNTAdd BLAST31
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 128LRR 3Add BLAST23
Repeati131 – 152LRR 4Add BLAST22
Repeati155 – 176LRR 5Add BLAST22
Repeati179 – 200LRR 6Add BLAST22
Repeati203 – 224LRR 7Add BLAST22
Repeati227 – 248LRR 8Add BLAST22
Domaini260 – 311LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ99PI8.
KOiK16659.
OMAiNDNPWVC.
OrthoDBiEOG091G08II.
PhylomeDBiQ99PI8.
TreeFamiTF330080.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRASSGGSR LLAWVLWLQA WRVATPCPGA CVCYNEPKVT TSCPQQGLQA
60 70 80 90 100
VPTGIPASSQ RIFLHGNRIS HVPAASFQSC RNLTILWLHS NALARIDAAA
110 120 130 140 150
FTGLTLLEQL DLSDNAQLHV VDPTTFHGLG HLHTLHLDRC GLRELGPGLF
160 170 180 190 200
RGLAALQYLY LQDNNLQALP DNTFRDLGNL THLFLHGNRI PSVPEHAFRG
210 220 230 240 250
LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM LPAEVLMPLR
260 270 280 290 300
SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLADRDLKR
310 320 330 340 350
LAASDLEGCA VASGPFRPIQ TSQLTDEELL SLPKCCQPDA ADKASVLEPG
360 370 380 390 400
RPASAGNALK GRVPPGDTPP GNGSGPRHIN DSPFGTLPSS AEPPLTALRP
410 420 430 440 450
GGSEPPGLPT TGPRRRPGCS RKNRTRSHCR LGQAGSGASG TGDAEGSGAL
460 470
PALACSLAPL GLALVLWTVL GPC
Length:473
Mass (Da):50,987
Last modified:June 1, 2001 - v1
Checksum:i14C5270EBF557E7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283462 mRNA. Translation: AAG53611.1.
BC052317 mRNA. Translation: AAH52317.2.
BC058381 mRNA. Translation: AAH58381.1.
CCDSiCCDS37279.1.
RefSeqiNP_075358.1. NM_022982.2.
UniGeneiMm.40149.

Genome annotation databases

EnsembliENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
GeneIDi65079.
KEGGimmu:65079.
UCSCiuc007ymv.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283462 mRNA. Translation: AAG53611.1.
BC052317 mRNA. Translation: AAH52317.2.
BC058381 mRNA. Translation: AAH58381.1.
CCDSiCCDS37279.1.
RefSeqiNP_075358.1. NM_022982.2.
UniGeneiMm.40149.

3D structure databases

ProteinModelPortaliQ99PI8.
SMRiQ99PI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211123. 1 interactor.
MINTiMINT-188355.
STRINGi10090.ENSMUSP00000062924.

Proteomic databases

PaxDbiQ99PI8.
PeptideAtlasiQ99PI8.
PRIDEiQ99PI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
GeneIDi65079.
KEGGimmu:65079.
UCSCiuc007ymv.1. mouse.

Organism-specific databases

CTDi65078.
MGIiMGI:2136886. Rtn4r.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ99PI8.
KOiK16659.
OMAiNDNPWVC.
OrthoDBiEOG091G08II.
PhylomeDBiQ99PI8.
TreeFamiTF330080.

Enzyme and pathway databases

ReactomeiR-MMU-193634. Axonal growth inhibition (RHOA activation).

Miscellaneous databases

PROiQ99PI8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043811.
CleanExiMM_RTN4R.
GenevisibleiQ99PI8. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTN4R_MOUSE
AccessioniPrimary (citable) accession number: Q99PI8
Secondary accession number(s): Q80WQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.