Q99PI8 (RTN4R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reticulon-4 receptor

Alternative name(s):
Nogo receptor
Short name=NgR
Nogo-66 receptor

Gene names

Name:	Rtn4r
Synonyms:	Nogor

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system By similarity. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development. Ref.1 Ref.4
Subunit structure	Homomultimer By similarity. Interacts with LINGO1 By similarity. Interacts with KIAA0319L By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Sequence similarities	Belongs to the Nogo receptor family. Contains 8 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Leucine-rich repeat Repeat Signal
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from direct assay Ref.1. Source: MGI
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara plasma membrane Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 447	421	Reticulon-4 receptor		PRO_0000022257
	Propeptide	448 – 473	26	Removed in mature form Potential		PRO_0000022258
Regions
	Domain	27 – 57	31	LRRNT
	Repeat	58 – 79	22	LRR 1
	Repeat	82 – 103	22	LRR 2
	Repeat	106 – 128	23	LRR 3
	Repeat	131 – 152	22	LRR 4
	Repeat	155 – 176	22	LRR 5
	Repeat	179 – 200	22	LRR 6
	Repeat	203 – 224	22	LRR 7
	Repeat	227 – 248	22	LRR 8
	Domain	260 – 311	52	LRRCT
Amino acid modifications
	Lipidation	447	1	GPI-anchor amidated serine Potential
	Glycosylation	82	1	N-linked (GlcNAc...) By similarity
	Glycosylation	179	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	27 ↔ 33		By similarity
	Disulfide bond	31 ↔ 43		By similarity
	Disulfide bond	264 ↔ 287		By similarity
	Disulfide bond	266 ↔ 309		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99PI8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 14C5270EBF557E7C	FASTA	473	50,987
	10 20 30 40 50 60 MKRASSGGSR LLAWVLWLQA WRVATPCPGA CVCYNEPKVT TSCPQQGLQA VPTGIPASSQ 70 80 90 100 110 120 RIFLHGNRIS HVPAASFQSC RNLTILWLHS NALARIDAAA FTGLTLLEQL DLSDNAQLHV 130 140 150 160 170 180 VDPTTFHGLG HLHTLHLDRC GLRELGPGLF RGLAALQYLY LQDNNLQALP DNTFRDLGNL 190 200 210 220 230 240 THLFLHGNRI PSVPEHAFRG LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM 250 260 270 280 290 300 LPAEVLMPLR SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLADRDLKR 310 320 330 340 350 360 LAASDLEGCA VASGPFRPIQ TSQLTDEELL SLPKCCQPDA ADKASVLEPG RPASAGNALK 370 380 390 400 410 420 GRVPPGDTPP GNGSGPRHIN DSPFGTLPSS AEPPLTALRP GGSEPPGLPT TGPRRRPGCS 430 440 450 460 470 RKNRTRSHCR LGQAGSGASG TGDAEGSGAL PALACSLAPL GLALVLWTVL GPC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration." Fournier A.E., GrandPre T., Strittmatter S.M. Nature 409:341-346(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: Swiss Webster.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Colon.
[3]	"Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration." Ng C.E.L., Tang B.L. J. Neurosci. Res. 67:559-565(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[4]	"Nogo-a regulates neural precursor migration in the embryonic mouse cortex." Mathis C., Schroeter A., Thallmair M., Schwab M.E. Cereb. Cortex 20:2380-2390(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF283462 mRNA. Translation: AAG53611.1. BC052317 mRNA. Translation: AAH52317.2. BC058381 mRNA. Translation: AAH58381.1.
IPI	IPI00121067.
RefSeq	NP_075358.1. NM_022982.2.
UniGene	Mm.40149.
3D structure databases
ProteinModelPortal	Q99PI8.
SMR	Q99PI8. Positions 27-309.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-188355.
Proteomic databases
PaxDb	Q99PI8.
PRIDE	Q99PI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
GeneID	65079.
KEGG	mmu:65079.
UCSC	uc007ymv.1. mouse.
Organism-specific databases
CTD	65078.
MGI	MGI:2136886. Rtn4r.
Phylogenomic databases
eggNOG	COG4886.
GeneTree	ENSGT00690000101803.
HOGENOM	HOG000116109.
HOVERGEN	HBG063707.
InParanoid	Q99PI8.
KO	K16659.
OMA	PLWAWLQ.
OrthoDB	EOG4MGS7M.
Gene expression databases
Bgee	Q99PI8.
CleanEx	MM_RTN4R.
Genevestigator	Q99PI8.
GermOnline	ENSMUSG00000043811. Mus musculus.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
SMART	SM00369. LRR_TYP. 3 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 8 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	320259.
SOURCE	Search...

Entry information

Entry name

RTN4R_MOUSE

Accession

Primary (citable) accession number: Q99PI8
Secondary accession number(s): Q80WQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program