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Q99PI8

- RTN4R_MOUSE

UniProt

Q99PI8 - RTN4R_MOUSE

Protein

Reticulon-4 receptor

Gene

Rtn4r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system By similarity. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development.By similarity2 Publications

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. axonogenesis Source: MGI

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_203657. Axonal growth inhibition (RHOA activation).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulon-4 receptor
    Alternative name(s):
    Nogo receptor
    Short name:
    NgR
    Nogo-66 receptor
    Gene namesi
    Name:Rtn4r
    Synonyms:Nogor
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2136886. Rtn4r.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: Ensembl
    3. endoplasmic reticulum Source: Ensembl
    4. growth cone Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 447421Reticulon-4 receptorPRO_0000022257Add
    BLAST
    Propeptidei448 – 47326Removed in mature formSequence AnalysisPRO_0000022258Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 33By similarity
    Disulfide bondi31 ↔ 43By similarity
    Glycosylationi82 – 821N-linked (GlcNAc...)By similarity
    Glycosylationi179 – 1791N-linked (GlcNAc...)By similarity
    Disulfide bondi264 ↔ 287By similarity
    Disulfide bondi266 ↔ 309By similarity
    Lipidationi447 – 4471GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ99PI8.
    PRIDEiQ99PI8.

    Expressioni

    Gene expression databases

    BgeeiQ99PI8.
    CleanExiMM_RTN4R.
    GenevestigatoriQ99PI8.

    Interactioni

    Subunit structurei

    Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L.By similarity

    Protein-protein interaction databases

    BioGridi211123. 1 interaction.
    MINTiMINT-188355.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PI8.
    SMRiQ99PI8. Positions 27-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 5731LRRNTAdd
    BLAST
    Repeati58 – 7922LRR 1Add
    BLAST
    Repeati82 – 10322LRR 2Add
    BLAST
    Repeati106 – 12823LRR 3Add
    BLAST
    Repeati131 – 15222LRR 4Add
    BLAST
    Repeati155 – 17622LRR 5Add
    BLAST
    Repeati179 – 20022LRR 6Add
    BLAST
    Repeati203 – 22422LRR 7Add
    BLAST
    Repeati227 – 24822LRR 8Add
    BLAST
    Domaini260 – 31152LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nogo receptor family.Curated
    Contains 8 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00750000117338.
    HOGENOMiHOG000116109.
    HOVERGENiHBG063707.
    InParanoidiQ99PI8.
    KOiK16659.
    OMAiNDNPWVC.
    OrthoDBiEOG7CZK5N.
    PhylomeDBiQ99PI8.
    TreeFamiTF330080.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99PI8-1 [UniParc]FASTAAdd to Basket

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    MKRASSGGSR LLAWVLWLQA WRVATPCPGA CVCYNEPKVT TSCPQQGLQA    50
    VPTGIPASSQ RIFLHGNRIS HVPAASFQSC RNLTILWLHS NALARIDAAA 100
    FTGLTLLEQL DLSDNAQLHV VDPTTFHGLG HLHTLHLDRC GLRELGPGLF 150
    RGLAALQYLY LQDNNLQALP DNTFRDLGNL THLFLHGNRI PSVPEHAFRG 200
    LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM LPAEVLMPLR 250
    SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLADRDLKR 300
    LAASDLEGCA VASGPFRPIQ TSQLTDEELL SLPKCCQPDA ADKASVLEPG 350
    RPASAGNALK GRVPPGDTPP GNGSGPRHIN DSPFGTLPSS AEPPLTALRP 400
    GGSEPPGLPT TGPRRRPGCS RKNRTRSHCR LGQAGSGASG TGDAEGSGAL 450
    PALACSLAPL GLALVLWTVL GPC 473
    Length:473
    Mass (Da):50,987
    Last modified:June 1, 2001 - v1
    Checksum:i14C5270EBF557E7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF283462 mRNA. Translation: AAG53611.1.
    BC052317 mRNA. Translation: AAH52317.2.
    BC058381 mRNA. Translation: AAH58381.1.
    CCDSiCCDS37279.1.
    RefSeqiNP_075358.1. NM_022982.2.
    UniGeneiMm.40149.

    Genome annotation databases

    EnsembliENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
    GeneIDi65079.
    KEGGimmu:65079.
    UCSCiuc007ymv.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF283462 mRNA. Translation: AAG53611.1 .
    BC052317 mRNA. Translation: AAH52317.2 .
    BC058381 mRNA. Translation: AAH58381.1 .
    CCDSi CCDS37279.1.
    RefSeqi NP_075358.1. NM_022982.2.
    UniGenei Mm.40149.

    3D structure databases

    ProteinModelPortali Q99PI8.
    SMRi Q99PI8. Positions 27-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211123. 1 interaction.
    MINTi MINT-188355.

    Proteomic databases

    PaxDbi Q99PI8.
    PRIDEi Q99PI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059589 ; ENSMUSP00000062924 ; ENSMUSG00000043811 .
    GeneIDi 65079.
    KEGGi mmu:65079.
    UCSCi uc007ymv.1. mouse.

    Organism-specific databases

    CTDi 65078.
    MGIi MGI:2136886. Rtn4r.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00750000117338.
    HOGENOMi HOG000116109.
    HOVERGENi HBG063707.
    InParanoidi Q99PI8.
    KOi K16659.
    OMAi NDNPWVC.
    OrthoDBi EOG7CZK5N.
    PhylomeDBi Q99PI8.
    TreeFami TF330080.

    Enzyme and pathway databases

    Reactomei REACT_203657. Axonal growth inhibition (RHOA activation).

    Miscellaneous databases

    NextBioi 320259.
    PROi Q99PI8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99PI8.
    CleanExi MM_RTN4R.
    Genevestigatori Q99PI8.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration."
      Fournier A.E., GrandPre T., Strittmatter S.M.
      Nature 409:341-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: Swiss Webster.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Colon.
    3. "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration."
      Ng C.E.L., Tang B.L.
      J. Neurosci. Res. 67:559-565(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    4. "Nogo-a regulates neural precursor migration in the embryonic mouse cortex."
      Mathis C., Schroeter A., Thallmair M., Schwab M.E.
      Cereb. Cortex 20:2380-2390(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRTN4R_MOUSE
    AccessioniPrimary (citable) accession number: Q99PI8
    Secondary accession number(s): Q80WQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3