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Q99PI8 (RTN4R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-4 receptor
Alternative name(s):
Nogo receptor
Short name=NgR
Nogo-66 receptor
Gene names
Name:Rtn4r
Synonyms:Nogor
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system By similarity. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development. Ref.1 Ref.4

Subunit structure

Homomultimer By similarity. Interacts with LINGO1 By similarity. Interacts with KIAA0319L By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Sequence similarities

Belongs to the Nogo receptor family.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 447421Reticulon-4 receptor
PRO_0000022257
Propeptide448 – 47326Removed in mature form Potential
PRO_0000022258

Regions

Domain27 – 5731LRRNT
Repeat58 – 7922LRR 1
Repeat82 – 10322LRR 2
Repeat106 – 12823LRR 3
Repeat131 – 15222LRR 4
Repeat155 – 17622LRR 5
Repeat179 – 20022LRR 6
Repeat203 – 22422LRR 7
Repeat227 – 24822LRR 8
Domain260 – 31152LRRCT

Amino acid modifications

Lipidation4471GPI-anchor amidated serine Potential
Glycosylation821N-linked (GlcNAc...) By similarity
Glycosylation1791N-linked (GlcNAc...) By similarity
Disulfide bond27 ↔ 33 By similarity
Disulfide bond31 ↔ 43 By similarity
Disulfide bond264 ↔ 287 By similarity
Disulfide bond266 ↔ 309 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99PI8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 14C5270EBF557E7C

FASTA47350,987
        10         20         30         40         50         60 
MKRASSGGSR LLAWVLWLQA WRVATPCPGA CVCYNEPKVT TSCPQQGLQA VPTGIPASSQ 

        70         80         90        100        110        120 
RIFLHGNRIS HVPAASFQSC RNLTILWLHS NALARIDAAA FTGLTLLEQL DLSDNAQLHV 

       130        140        150        160        170        180 
VDPTTFHGLG HLHTLHLDRC GLRELGPGLF RGLAALQYLY LQDNNLQALP DNTFRDLGNL 

       190        200        210        220        230        240 
THLFLHGNRI PSVPEHAFRG LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM 

       250        260        270        280        290        300 
LPAEVLMPLR SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLADRDLKR 

       310        320        330        340        350        360 
LAASDLEGCA VASGPFRPIQ TSQLTDEELL SLPKCCQPDA ADKASVLEPG RPASAGNALK 

       370        380        390        400        410        420 
GRVPPGDTPP GNGSGPRHIN DSPFGTLPSS AEPPLTALRP GGSEPPGLPT TGPRRRPGCS 

       430        440        450        460        470 
RKNRTRSHCR LGQAGSGASG TGDAEGSGAL PALACSLAPL GLALVLWTVL GPC 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration."
Fournier A.E., GrandPre T., Strittmatter S.M.
Nature 409:341-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: Swiss Webster.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Colon.
[3]"Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration."
Ng C.E.L., Tang B.L.
J. Neurosci. Res. 67:559-565(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[4]"Nogo-a regulates neural precursor migration in the embryonic mouse cortex."
Mathis C., Schroeter A., Thallmair M., Schwab M.E.
Cereb. Cortex 20:2380-2390(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF283462 mRNA. Translation: AAG53611.1.
BC052317 mRNA. Translation: AAH52317.2.
BC058381 mRNA. Translation: AAH58381.1.
CCDSCCDS37279.1.
RefSeqNP_075358.1. NM_022982.2.
UniGeneMm.40149.

3D structure databases

ProteinModelPortalQ99PI8.
SMRQ99PI8. Positions 27-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211123. 1 interaction.
MINTMINT-188355.

Proteomic databases

PaxDbQ99PI8.
PRIDEQ99PI8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059589; ENSMUSP00000062924; ENSMUSG00000043811.
GeneID65079.
KEGGmmu:65079.
UCSCuc007ymv.1. mouse.

Organism-specific databases

CTD65078.
MGIMGI:2136886. Rtn4r.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00750000117338.
HOGENOMHOG000116109.
HOVERGENHBG063707.
InParanoidQ99PI8.
KOK16659.
OMANDNPWVC.
OrthoDBEOG7CZK5N.
PhylomeDBQ99PI8.
TreeFamTF330080.

Gene expression databases

BgeeQ99PI8.
CleanExMM_RTN4R.
GenevestigatorQ99PI8.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio320259.
PROQ99PI8.
SOURCESearch...

Entry information

Entry nameRTN4R_MOUSE
AccessionPrimary (citable) accession number: Q99PI8
Secondary accession number(s): Q80WQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot