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Q99PG4

- RGS18_MOUSE

UniProt

Q99PG4 - RGS18_MOUSE

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Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

GO - Molecular functioni

  1. GTPase activator activity Source: MGI

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. positive regulation of GTPase activity Source: GOC
  3. regulation of G-protein coupled receptor protein signaling pathway Source: MGI
  4. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:Rgs18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1927498. Rgs18.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Regulator of G-protein signaling 18PRO_0000204228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ99PG4.

PTM databases

PhosphoSiteiQ99PG4.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart.

Gene expression databases

BgeeiQ99PG4.
CleanExiMM_RGS18.
ExpressionAtlasiQ99PG4. baseline and differential.
GenevestigatoriQ99PG4.

Interactioni

Protein-protein interaction databases

BioGridi211040. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99PG4.
SMRiQ99PG4. Positions 75-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 202117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278594.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ99PG4.
KOiK16449.
OMAiLDFHTKE.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ99PG4.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL
60 70 80 90 100
LLQRPDFHGE TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF
110 120 130 140 150
TRFLKTEFSE ENIEFWVACE DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE
160 170 180 190 200
VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV YQLMEHDSYK RFLKSETYLH
210 220 230
LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL
Length:235
Mass (Da):27,610
Last modified:June 1, 2001 - v1
Checksum:i6433435AC1CBCFD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302685 mRNA. Translation: AAG53657.1.
AB042807 mRNA. Translation: BAB60723.1.
CCDSiCCDS15350.1.
RefSeqiNP_075019.1. NM_022881.4.
UniGeneiMm.253927.

Genome annotation databases

EnsembliENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
GeneIDi64214.
KEGGimmu:64214.
UCSCiuc007cxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302685 mRNA. Translation: AAG53657.1 .
AB042807 mRNA. Translation: BAB60723.1 .
CCDSi CCDS15350.1.
RefSeqi NP_075019.1. NM_022881.4.
UniGenei Mm.253927.

3D structure databases

ProteinModelPortali Q99PG4.
SMRi Q99PG4. Positions 75-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211040. 2 interactions.

PTM databases

PhosphoSitei Q99PG4.

Proteomic databases

PRIDEi Q99PG4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027603 ; ENSMUSP00000027603 ; ENSMUSG00000026357 .
GeneIDi 64214.
KEGGi mmu:64214.
UCSCi uc007cxl.1. mouse.

Organism-specific databases

CTDi 64407.
MGIi MGI:1927498. Rgs18.

Phylogenomic databases

eggNOGi NOG278594.
GeneTreei ENSGT00760000118903.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi Q99PG4.
KOi K16449.
OMAi LDFHTKE.
OrthoDBi EOG7VHSZ5.
PhylomeDBi Q99PG4.
TreeFami TF315837.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi Rgs18. mouse.
NextBioi 319964.
PROi Q99PG4.
SOURCEi Search...

Gene expression databases

Bgeei Q99PG4.
CleanExi MM_RGS18.
ExpressionAtlasi Q99PG4. baseline and differential.
Genevestigatori Q99PG4.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells."
    Park I.K., Klug C.A., Li K., Jerabek L., Li L., Nanamori M., Neubig R.R., Hood L., Weissman I.L., Clarke M.F.
    J. Biol. Chem. 276:915-923(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BA.
  2. "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes."
    Nagata Y., Oda M., Nakata H., Shozaki Y., Kozasa T., Todokoro K.
    Blood 97:3051-3060(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BDF1.

Entry informationi

Entry nameiRGS18_MOUSE
AccessioniPrimary (citable) accession number: Q99PG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3