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Q99PG4 (RGS18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 18

Short name=RGS18
Gene names
Name:Rgs18
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Regulator of G-protein signaling 18
PRO_0000204228

Regions

Domain86 – 202117RGS

Amino acid modifications

Modified residue491Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99PG4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6433435AC1CBCFD8

FASTA23527,610
        10         20         30         40         50         60 
MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL LLQRPDFHGE 

        70         80         90        100        110        120 
TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF TRFLKTEFSE ENIEFWVACE 

       130        140        150        160        170        180 
DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV 

       190        200        210        220        230 
YQLMEHDSYK RFLKSETYLH LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL 

« Hide

References

[1]"Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells."
Park I.K., Klug C.A., Li K., Jerabek L., Li L., Nanamori M., Neubig R.R., Hood L., Weissman I.L., Clarke M.F.
J. Biol. Chem. 276:915-923(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BA.
[2]"A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes."
Nagata Y., Oda M., Nakata H., Shozaki Y., Kozasa T., Todokoro K.
Blood 97:3051-3060(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BDF1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF302685 mRNA. Translation: AAG53657.1.
AB042807 mRNA. Translation: BAB60723.1.
CCDSCCDS15350.1.
RefSeqNP_075019.1. NM_022881.4.
UniGeneMm.253927.

3D structure databases

ProteinModelPortalQ99PG4.
SMRQ99PG4. Positions 75-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211040. 2 interactions.

PTM databases

PhosphoSiteQ99PG4.

Proteomic databases

PRIDEQ99PG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
GeneID64214.
KEGGmmu:64214.
UCSCuc007cxl.1. mouse.

Organism-specific databases

CTD64407.
MGIMGI:1927498. Rgs18.

Phylogenomic databases

eggNOGNOG278594.
GeneTreeENSGT00750000117382.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidQ99PG4.
KOK16449.
OMALDFHTKE.
OrthoDBEOG7VHSZ5.
PhylomeDBQ99PG4.
TreeFamTF315837.

Gene expression databases

ArrayExpressQ99PG4.
BgeeQ99PG4.
CleanExMM_RGS18.
GenevestigatorQ99PG4.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRGS18. mouse.
NextBio319964.
PROQ99PG4.
SOURCESearch...

Entry information

Entry nameRGS18_MOUSE
AccessionPrimary (citable) accession number: Q99PG4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot