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Q99PG4

- RGS18_MOUSE

UniProt

Q99PG4 - RGS18_MOUSE

Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

    GO - Molecular functioni

    1. GTPase activator activity Source: MGI

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. positive regulation of GTPase activity Source: GOC
    3. regulation of G-protein coupled receptor protein signaling pathway Source: MGI
    4. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 18
    Short name:
    RGS18
    Gene namesi
    Name:Rgs18
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1927498. Rgs18.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Regulator of G-protein signaling 18PRO_0000204228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ99PG4.

    PTM databases

    PhosphoSiteiQ99PG4.

    Expressioni

    Tissue specificityi

    Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart.

    Gene expression databases

    ArrayExpressiQ99PG4.
    BgeeiQ99PG4.
    CleanExiMM_RGS18.
    GenevestigatoriQ99PG4.

    Interactioni

    Protein-protein interaction databases

    BioGridi211040. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PG4.
    SMRiQ99PG4. Positions 75-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 202117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278594.
    GeneTreeiENSGT00750000117382.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiQ99PG4.
    KOiK16449.
    OMAiLDFHTKE.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiQ99PG4.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99PG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL    50
    LLQRPDFHGE TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF 100
    TRFLKTEFSE ENIEFWVACE DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE 150
    VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV YQLMEHDSYK RFLKSETYLH 200
    LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL 235
    Length:235
    Mass (Da):27,610
    Last modified:June 1, 2001 - v1
    Checksum:i6433435AC1CBCFD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302685 mRNA. Translation: AAG53657.1.
    AB042807 mRNA. Translation: BAB60723.1.
    CCDSiCCDS15350.1.
    RefSeqiNP_075019.1. NM_022881.4.
    UniGeneiMm.253927.

    Genome annotation databases

    EnsembliENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
    GeneIDi64214.
    KEGGimmu:64214.
    UCSCiuc007cxl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302685 mRNA. Translation: AAG53657.1 .
    AB042807 mRNA. Translation: BAB60723.1 .
    CCDSi CCDS15350.1.
    RefSeqi NP_075019.1. NM_022881.4.
    UniGenei Mm.253927.

    3D structure databases

    ProteinModelPortali Q99PG4.
    SMRi Q99PG4. Positions 75-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211040. 2 interactions.

    PTM databases

    PhosphoSitei Q99PG4.

    Proteomic databases

    PRIDEi Q99PG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027603 ; ENSMUSP00000027603 ; ENSMUSG00000026357 .
    GeneIDi 64214.
    KEGGi mmu:64214.
    UCSCi uc007cxl.1. mouse.

    Organism-specific databases

    CTDi 64407.
    MGIi MGI:1927498. Rgs18.

    Phylogenomic databases

    eggNOGi NOG278594.
    GeneTreei ENSGT00750000117382.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi Q99PG4.
    KOi K16449.
    OMAi LDFHTKE.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi Q99PG4.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi RGS18. mouse.
    NextBioi 319964.
    PROi Q99PG4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99PG4.
    Bgeei Q99PG4.
    CleanExi MM_RGS18.
    Genevestigatori Q99PG4.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells."
      Park I.K., Klug C.A., Li K., Jerabek L., Li L., Nanamori M., Neubig R.R., Hood L., Weissman I.L., Clarke M.F.
      J. Biol. Chem. 276:915-923(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BA.
    2. "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes."
      Nagata Y., Oda M., Nakata H., Shozaki Y., Kozasa T., Todokoro K.
      Blood 97:3051-3060(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BDF1.

    Entry informationi

    Entry nameiRGS18_MOUSE
    AccessioniPrimary (citable) accession number: Q99PG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3