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Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of GTPase activity Source: GOC
  • regulation of G-protein coupled receptor protein signaling pathway Source: MGI
  • termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:Rgs18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1927498. Rgs18.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Regulator of G-protein signaling 18PRO_0000204228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99PG4.
PRIDEiQ99PG4.

PTM databases

PhosphoSiteiQ99PG4.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart.

Gene expression databases

BgeeiQ99PG4.
CleanExiMM_RGS18.
ExpressionAtlasiQ99PG4. baseline and differential.
GenevisibleiQ99PG4. MM.

Interactioni

Protein-protein interaction databases

BioGridi211040. 2 interactions.
STRINGi10090.ENSMUSP00000027603.

Structurei

3D structure databases

ProteinModelPortaliQ99PG4.
SMRiQ99PG4. Positions 75-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 202117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278594.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ99PG4.
KOiK16449.
OMAiLDFHTKE.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ99PG4.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL
60 70 80 90 100
LLQRPDFHGE TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF
110 120 130 140 150
TRFLKTEFSE ENIEFWVACE DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE
160 170 180 190 200
VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV YQLMEHDSYK RFLKSETYLH
210 220 230
LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL
Length:235
Mass (Da):27,610
Last modified:June 1, 2001 - v1
Checksum:i6433435AC1CBCFD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302685 mRNA. Translation: AAG53657.1.
AB042807 mRNA. Translation: BAB60723.1.
CCDSiCCDS15350.1.
RefSeqiNP_075019.1. NM_022881.4.
UniGeneiMm.253927.

Genome annotation databases

EnsembliENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
GeneIDi64214.
KEGGimmu:64214.
UCSCiuc007cxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302685 mRNA. Translation: AAG53657.1.
AB042807 mRNA. Translation: BAB60723.1.
CCDSiCCDS15350.1.
RefSeqiNP_075019.1. NM_022881.4.
UniGeneiMm.253927.

3D structure databases

ProteinModelPortaliQ99PG4.
SMRiQ99PG4. Positions 75-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211040. 2 interactions.
STRINGi10090.ENSMUSP00000027603.

PTM databases

PhosphoSiteiQ99PG4.

Proteomic databases

MaxQBiQ99PG4.
PRIDEiQ99PG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
GeneIDi64214.
KEGGimmu:64214.
UCSCiuc007cxl.1. mouse.

Organism-specific databases

CTDi64407.
MGIiMGI:1927498. Rgs18.

Phylogenomic databases

eggNOGiNOG278594.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ99PG4.
KOiK16449.
OMAiLDFHTKE.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ99PG4.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiRgs18. mouse.
NextBioi319964.
PROiQ99PG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ99PG4.
CleanExiMM_RGS18.
ExpressionAtlasiQ99PG4. baseline and differential.
GenevisibleiQ99PG4. MM.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells."
    Park I.K., Klug C.A., Li K., Jerabek L., Li L., Nanamori M., Neubig R.R., Hood L., Weissman I.L., Clarke M.F.
    J. Biol. Chem. 276:915-923(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BA.
  2. "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes."
    Nagata Y., Oda M., Nakata H., Shozaki Y., Kozasa T., Todokoro K.
    Blood 97:3051-3060(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BDF1.

Entry informationi

Entry nameiRGS18_MOUSE
AccessioniPrimary (citable) accession number: Q99PG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.