Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99PG2

- OGFR_MOUSE

UniProt

Q99PG2 - OGFR_MOUSE

Protein

Opioid growth factor receptor

Gene

Ogfr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation By similarity.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. regulation of growth Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Opioid growth factor receptor
    Short name:
    OGFr
    Alternative name(s):
    Zeta-type opioid receptor
    Gene namesi
    Name:Ogfr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1919325. Ogfr.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: The OGF/OGFR complex is probably translocated to the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: InterPro
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 633633Opioid growth factor receptorPRO_0000058031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei361 – 3611PhosphoserineBy similarity
    Modified residuei403 – 4031PhosphoserineBy similarity
    Modified residuei452 – 4521PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ99PG2.
    PRIDEiQ99PG2.

    PTM databases

    PhosphoSiteiQ99PG2.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined, including brain, heart, lung, liver, kidney and skeletal muscle.

    Gene expression databases

    BgeeiQ99PG2.
    CleanExiMM_OGFR.
    GenevestigatoriQ99PG2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99PG2. 1 interaction.
    MINTiMINT-4105826.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PG2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati467 – 47591
    Repeati476 – 48492
    Repeati485 – 49393
    Repeati494 – 50294
    Repeati503 – 51195
    Repeati512 – 52096
    Repeati521 – 52997
    Repeati530 – 53898
    Repeati539 – 54799
    Repeati548 – 556910
    Repeati557 – 565911
    Repeati566 – 574912
    Repeati575 – 583913
    Repeati584 – 592914

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni467 – 59212614 X approximate tandem repeatsAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi257 – 28630Bipartite nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG28316.
    GeneTreeiENSGT00390000018730.
    HOGENOMiHOG000231272.
    HOVERGENiHBG024736.
    InParanoidiA2ACT6.
    OMAiNWRSHNN.
    OrthoDBiEOG7RV9G9.
    PhylomeDBiQ99PG2.
    TreeFamiTF331377.

    Family and domain databases

    InterProiIPR006757. OGF_rcpt.
    [Graphical view]
    PfamiPF04664. OGFr_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99PG2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM    50
    TRYRNWRAMQ DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI 100
    EDILQNWKDN YDLLEENHSY IQWLFPLREP GVNWHAKPLT LKEVEAFKSS 150
    KEVRERLVRA YELMLGFYGI QLEDRNTGAV CRAQNFQPRF HNLNSHSHNN 200
    LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR QSALDYFLFA 250
    VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA 300
    DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD 350
    GDQRHEAKSP SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC 400
    ALSPTSQEPR EAEQPCLVAR VANEVRKRRK VEEGAEGDGV ASNTQVQASA 450
    LSPTPSECPE SQKDGNGPED PKSQVGPEDP KSQVGPEDPK SQVGPEDPKS 500
    QVGPEDPKGQ VEPEDPKGQV GPEDPKGQVG PEDPKGQVGP EDPKSQVGPE 550
    DPKSQVEPED PKSQVEPEDP KSQVEPEDPK SQVGPEDPQS QVGPEQAASK 600
    SLGEDPDSDT TGTSMSESEE LARIEASVEP PKP 633
    Length:633
    Mass (Da):70,679
    Last modified:June 1, 2001 - v1
    Checksum:i0B18933C0A0C891F
    GO
    Isoform 2 (identifier: Q99PG2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         504-512: Missing.
         563-589: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:597
    Mass (Da):66,741
    Checksum:iEA7005742DA2AE72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191E → D in AAH03875. (PubMed:15489334)Curated
    Sequence conflicti317 – 3182GR → SW in AAH03875. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei504 – 5129Missing in isoform 2. 1 PublicationVSP_004061
    Alternative sequencei563 – 58927Missing in isoform 2. 1 PublicationVSP_004062Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303894 mRNA. Translation: AAK01353.1.
    AL669926 Genomic DNA. Translation: CAM26816.1.
    BC003875 mRNA. Translation: AAH03875.1.
    CCDSiCCDS17179.1. [Q99PG2-1]
    RefSeqiNP_113550.3. NM_031373.3. [Q99PG2-1]
    UniGeneiMm.250418.

    Genome annotation databases

    EnsembliENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401. [Q99PG2-1]
    GeneIDi72075.
    KEGGimmu:72075.
    UCSCiuc008ojj.2. mouse. [Q99PG2-1]
    uc008ojk.2. mouse. [Q99PG2-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303894 mRNA. Translation: AAK01353.1 .
    AL669926 Genomic DNA. Translation: CAM26816.1 .
    BC003875 mRNA. Translation: AAH03875.1 .
    CCDSi CCDS17179.1. [Q99PG2-1 ]
    RefSeqi NP_113550.3. NM_031373.3. [Q99PG2-1 ]
    UniGenei Mm.250418.

    3D structure databases

    ProteinModelPortali Q99PG2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99PG2. 1 interaction.
    MINTi MINT-4105826.

    PTM databases

    PhosphoSitei Q99PG2.

    Proteomic databases

    PaxDbi Q99PG2.
    PRIDEi Q99PG2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029087 ; ENSMUSP00000029087 ; ENSMUSG00000049401 . [Q99PG2-1 ]
    GeneIDi 72075.
    KEGGi mmu:72075.
    UCSCi uc008ojj.2. mouse. [Q99PG2-1 ]
    uc008ojk.2. mouse. [Q99PG2-2 ]

    Organism-specific databases

    CTDi 11054.
    MGIi MGI:1919325. Ogfr.

    Phylogenomic databases

    eggNOGi NOG28316.
    GeneTreei ENSGT00390000018730.
    HOGENOMi HOG000231272.
    HOVERGENi HBG024736.
    InParanoidi A2ACT6.
    OMAi NWRSHNN.
    OrthoDBi EOG7RV9G9.
    PhylomeDBi Q99PG2.
    TreeFami TF331377.

    Miscellaneous databases

    NextBioi 335368.
    PROi Q99PG2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99PG2.
    CleanExi MM_OGFR.
    Genevestigatori Q99PG2.

    Family and domain databases

    InterProi IPR006757. OGF_rcpt.
    [Graphical view ]
    Pfami PF04664. OGFr_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse."
      Zagon I.S., Verderame M.F., Zimmer W.E., McLaughlin P.J.
      Brain Res. Mol. Brain Res. 84:106-114(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiOGFR_MOUSE
    AccessioniPrimary (citable) accession number: Q99PG2
    Secondary accession number(s): A2ACT6, Q99L33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3