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Q99PG2 (OGFR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Opioid growth factor receptor

Short name=OGFr
Alternative name(s):
Zeta-type opioid receptor
Gene names
Name:Ogfr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: The OGF/OGFR complex is probably translocated to the nucleus.

Tissue specificity

Expressed in all tissues examined, including brain, heart, lung, liver, kidney and skeletal muscle.

Sequence similarities

Belongs to the opioid growth factor receptor family.

Ontologies

Keywords
   Biological processGrowth regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   Molecular functionReceptor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of growth

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99PG2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99PG2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     504-512: Missing.
     563-589: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633Opioid growth factor receptor
PRO_0000058031

Regions

Repeat467 – 47591
Repeat476 – 48492
Repeat485 – 49393
Repeat494 – 50294
Repeat503 – 51195
Repeat512 – 52096
Repeat521 – 52997
Repeat530 – 53898
Repeat539 – 54799
Repeat548 – 556910
Repeat557 – 565911
Repeat566 – 574912
Repeat575 – 583913
Repeat584 – 592914
Region467 – 59212614 X approximate tandem repeats
Motif257 – 28630Bipartite nuclear localization signal Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue3611Phosphoserine By similarity
Modified residue4031Phosphoserine By similarity
Modified residue4521Phosphoserine By similarity

Natural variations

Alternative sequence504 – 5129Missing in isoform 2.
VSP_004061
Alternative sequence563 – 58927Missing in isoform 2.
VSP_004062

Experimental info

Sequence conflict191E → D in AAH03875. Ref.3
Sequence conflict317 – 3182GR → SW in AAH03875. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0B18933C0A0C891F

FASTA63370,679
        10         20         30         40         50         60 
MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM TRYRNWRAMQ 

        70         80         90        100        110        120 
DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI EDILQNWKDN YDLLEENHSY 

       130        140        150        160        170        180 
IQWLFPLREP GVNWHAKPLT LKEVEAFKSS KEVRERLVRA YELMLGFYGI QLEDRNTGAV 

       190        200        210        220        230        240 
CRAQNFQPRF HNLNSHSHNN LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR 

       250        260        270        280        290        300 
QSALDYFLFA VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA 

       310        320        330        340        350        360 
DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD GDQRHEAKSP 

       370        380        390        400        410        420 
SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC ALSPTSQEPR EAEQPCLVAR 

       430        440        450        460        470        480 
VANEVRKRRK VEEGAEGDGV ASNTQVQASA LSPTPSECPE SQKDGNGPED PKSQVGPEDP 

       490        500        510        520        530        540 
KSQVGPEDPK SQVGPEDPKS QVGPEDPKGQ VEPEDPKGQV GPEDPKGQVG PEDPKGQVGP 

       550        560        570        580        590        600 
EDPKSQVGPE DPKSQVEPED PKSQVEPEDP KSQVEPEDPK SQVGPEDPQS QVGPEQAASK 

       610        620        630 
SLGEDPDSDT TGTSMSESEE LARIEASVEP PKP 

« Hide

Isoform 2 [UniParc].

Checksum: EA7005742DA2AE72
Show »

FASTA59766,741

References

« Hide 'large scale' references
[1]"Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse."
Zagon I.S., Verderame M.F., Zimmer W.E., McLaughlin P.J.
Brain Res. Mol. Brain Res. 84:106-114(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303894 mRNA. Translation: AAK01353.1.
AL669926 Genomic DNA. Translation: CAM26816.1.
BC003875 mRNA. Translation: AAH03875.1.
RefSeqNP_113550.3. NM_031373.3.
UniGeneMm.250418.

3D structure databases

ProteinModelPortalQ99PG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ99PG2. 1 interaction.
MINTMINT-4105826.

PTM databases

PhosphoSiteQ99PG2.

Proteomic databases

PaxDbQ99PG2.
PRIDEQ99PG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401. [Q99PG2-1]
GeneID72075.
KEGGmmu:72075.
UCSCuc008ojj.2. mouse. [Q99PG2-1]
uc008ojk.2. mouse. [Q99PG2-2]

Organism-specific databases

CTD11054.
MGIMGI:1919325. Ogfr.

Phylogenomic databases

eggNOGNOG28316.
GeneTreeENSGT00390000018730.
HOGENOMHOG000231272.
HOVERGENHBG024736.
InParanoidA2ACT6.
OMANWRSHNN.
OrthoDBEOG7RV9G9.
PhylomeDBQ99PG2.
TreeFamTF331377.

Gene expression databases

BgeeQ99PG2.
CleanExMM_OGFR.
GenevestigatorQ99PG2.

Family and domain databases

InterProIPR006757. OGF_rcpt.
[Graphical view]
PfamPF04664. OGFr_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335368.
PROQ99PG2.
SOURCESearch...

Entry information

Entry nameOGFR_MOUSE
AccessionPrimary (citable) accession number: Q99PG2
Secondary accession number(s): A2ACT6, Q99L33
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot