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Q99PG2

- OGFR_MOUSE

UniProt

Q99PG2 - OGFR_MOUSE

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Protein

Opioid growth factor receptor

Gene

Ogfr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid growth factor receptor
Short name:
OGFr
Alternative name(s):
Zeta-type opioid receptor
Gene namesi
Name:Ogfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1919325. Ogfr.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: The OGF/OGFR complex is probably translocated to the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. membrane Source: InterPro
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Opioid growth factor receptorPRO_0000058031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei403 – 4031PhosphoserineBy similarity
Modified residuei452 – 4521PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99PG2.
PaxDbiQ99PG2.
PRIDEiQ99PG2.

PTM databases

PhosphoSiteiQ99PG2.

Expressioni

Tissue specificityi

Expressed in all tissues examined, including brain, heart, lung, liver, kidney and skeletal muscle.

Gene expression databases

BgeeiQ99PG2.
CleanExiMM_OGFR.
GenevestigatoriQ99PG2.

Interactioni

Protein-protein interaction databases

IntActiQ99PG2. 1 interaction.
MINTiMINT-4105826.

Structurei

3D structure databases

ProteinModelPortaliQ99PG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati467 – 47591
Repeati476 – 48492
Repeati485 – 49393
Repeati494 – 50294
Repeati503 – 51195
Repeati512 – 52096
Repeati521 – 52997
Repeati530 – 53898
Repeati539 – 54799
Repeati548 – 556910
Repeati557 – 565911
Repeati566 – 574912
Repeati575 – 583913
Repeati584 – 592914

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni467 – 59212614 X approximate tandem repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi257 – 28630Bipartite nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG28316.
GeneTreeiENSGT00390000018730.
HOGENOMiHOG000231272.
HOVERGENiHBG024736.
InParanoidiQ99PG2.
OMAiNWRSHNN.
OrthoDBiEOG7RV9G9.
PhylomeDBiQ99PG2.
TreeFamiTF331377.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
[Graphical view]
PfamiPF04664. OGFr_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99PG2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM
60 70 80 90 100
TRYRNWRAMQ DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI
110 120 130 140 150
EDILQNWKDN YDLLEENHSY IQWLFPLREP GVNWHAKPLT LKEVEAFKSS
160 170 180 190 200
KEVRERLVRA YELMLGFYGI QLEDRNTGAV CRAQNFQPRF HNLNSHSHNN
210 220 230 240 250
LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR QSALDYFLFA
260 270 280 290 300
VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA
310 320 330 340 350
DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD
360 370 380 390 400
GDQRHEAKSP SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC
410 420 430 440 450
ALSPTSQEPR EAEQPCLVAR VANEVRKRRK VEEGAEGDGV ASNTQVQASA
460 470 480 490 500
LSPTPSECPE SQKDGNGPED PKSQVGPEDP KSQVGPEDPK SQVGPEDPKS
510 520 530 540 550
QVGPEDPKGQ VEPEDPKGQV GPEDPKGQVG PEDPKGQVGP EDPKSQVGPE
560 570 580 590 600
DPKSQVEPED PKSQVEPEDP KSQVEPEDPK SQVGPEDPQS QVGPEQAASK
610 620 630
SLGEDPDSDT TGTSMSESEE LARIEASVEP PKP
Length:633
Mass (Da):70,679
Last modified:June 1, 2001 - v1
Checksum:i0B18933C0A0C891F
GO
Isoform 2 (identifier: Q99PG2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-512: Missing.
     563-589: Missing.

Note: No experimental confirmation available.

Show »
Length:597
Mass (Da):66,741
Checksum:iEA7005742DA2AE72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191E → D in AAH03875. (PubMed:15489334)Curated
Sequence conflicti317 – 3182GR → SW in AAH03875. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei504 – 5129Missing in isoform 2. 1 PublicationVSP_004061
Alternative sequencei563 – 58927Missing in isoform 2. 1 PublicationVSP_004062Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303894 mRNA. Translation: AAK01353.1.
AL669926 Genomic DNA. Translation: CAM26816.1.
BC003875 mRNA. Translation: AAH03875.1.
CCDSiCCDS17179.1. [Q99PG2-1]
RefSeqiNP_113550.3. NM_031373.3. [Q99PG2-1]
UniGeneiMm.250418.

Genome annotation databases

EnsembliENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401. [Q99PG2-1]
GeneIDi72075.
KEGGimmu:72075.
UCSCiuc008ojj.2. mouse. [Q99PG2-1]
uc008ojk.2. mouse. [Q99PG2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303894 mRNA. Translation: AAK01353.1 .
AL669926 Genomic DNA. Translation: CAM26816.1 .
BC003875 mRNA. Translation: AAH03875.1 .
CCDSi CCDS17179.1. [Q99PG2-1 ]
RefSeqi NP_113550.3. NM_031373.3. [Q99PG2-1 ]
UniGenei Mm.250418.

3D structure databases

ProteinModelPortali Q99PG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99PG2. 1 interaction.
MINTi MINT-4105826.

PTM databases

PhosphoSitei Q99PG2.

Proteomic databases

MaxQBi Q99PG2.
PaxDbi Q99PG2.
PRIDEi Q99PG2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029087 ; ENSMUSP00000029087 ; ENSMUSG00000049401 . [Q99PG2-1 ]
GeneIDi 72075.
KEGGi mmu:72075.
UCSCi uc008ojj.2. mouse. [Q99PG2-1 ]
uc008ojk.2. mouse. [Q99PG2-2 ]

Organism-specific databases

CTDi 11054.
MGIi MGI:1919325. Ogfr.

Phylogenomic databases

eggNOGi NOG28316.
GeneTreei ENSGT00390000018730.
HOGENOMi HOG000231272.
HOVERGENi HBG024736.
InParanoidi Q99PG2.
OMAi NWRSHNN.
OrthoDBi EOG7RV9G9.
PhylomeDBi Q99PG2.
TreeFami TF331377.

Miscellaneous databases

NextBioi 335368.
PROi Q99PG2.
SOURCEi Search...

Gene expression databases

Bgeei Q99PG2.
CleanExi MM_OGFR.
Genevestigatori Q99PG2.

Family and domain databases

InterProi IPR006757. OGF_rcpt.
[Graphical view ]
Pfami PF04664. OGFr_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse."
    Zagon I.S., Verderame M.F., Zimmer W.E., McLaughlin P.J.
    Brain Res. Mol. Brain Res. 84:106-114(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiOGFR_MOUSE
AccessioniPrimary (citable) accession number: Q99PG2
Secondary accession number(s): A2ACT6, Q99L33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3