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Protein

Opioid growth factor receptor

Gene

Ogfr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid growth factor receptor
Short name:
OGFr
Alternative name(s):
Zeta-type opioid receptor
Gene namesi
Name:Ogfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919325. Ogfr.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: The OGF/OGFR complex is probably translocated to the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580311 – 633Opioid growth factor receptorAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei327PhosphoserineCombined sources1
Modified residuei340PhosphoserineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei601PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99PG2.
PaxDbiQ99PG2.
PeptideAtlasiQ99PG2.
PRIDEiQ99PG2.

PTM databases

iPTMnetiQ99PG2.
PhosphoSitePlusiQ99PG2.

Expressioni

Tissue specificityi

Expressed in all tissues examined, including brain, heart, lung, liver, kidney and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000049401.
CleanExiMM_OGFR.
GenevisibleiQ99PG2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99PG2. 1 interactor.
MINTiMINT-4105826.
STRINGi10090.ENSMUSP00000029087.

Structurei

3D structure databases

ProteinModelPortaliQ99PG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati467 – 47519
Repeati476 – 48429
Repeati485 – 49339
Repeati494 – 50249
Repeati503 – 51159
Repeati512 – 52069
Repeati521 – 52979
Repeati530 – 53889
Repeati539 – 54799
Repeati548 – 556109
Repeati557 – 565119
Repeati566 – 574129
Repeati575 – 583139
Repeati584 – 592149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni467 – 59214 X approximate tandem repeatsAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi257 – 286Bipartite nuclear localization signalSequence analysisAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH5X. Eukaryota.
ENOG4111XCW. LUCA.
GeneTreeiENSGT00390000018730.
HOGENOMiHOG000231272.
HOVERGENiHBG024736.
InParanoidiQ99PG2.
OMAiEDPKSQV.
OrthoDBiEOG091G04CN.
PhylomeDBiQ99PG2.
TreeFamiTF331377.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
[Graphical view]
PfamiPF04664. OGFr_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99PG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM
60 70 80 90 100
TRYRNWRAMQ DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI
110 120 130 140 150
EDILQNWKDN YDLLEENHSY IQWLFPLREP GVNWHAKPLT LKEVEAFKSS
160 170 180 190 200
KEVRERLVRA YELMLGFYGI QLEDRNTGAV CRAQNFQPRF HNLNSHSHNN
210 220 230 240 250
LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR QSALDYFLFA
260 270 280 290 300
VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA
310 320 330 340 350
DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD
360 370 380 390 400
GDQRHEAKSP SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC
410 420 430 440 450
ALSPTSQEPR EAEQPCLVAR VANEVRKRRK VEEGAEGDGV ASNTQVQASA
460 470 480 490 500
LSPTPSECPE SQKDGNGPED PKSQVGPEDP KSQVGPEDPK SQVGPEDPKS
510 520 530 540 550
QVGPEDPKGQ VEPEDPKGQV GPEDPKGQVG PEDPKGQVGP EDPKSQVGPE
560 570 580 590 600
DPKSQVEPED PKSQVEPEDP KSQVEPEDPK SQVGPEDPQS QVGPEQAASK
610 620 630
SLGEDPDSDT TGTSMSESEE LARIEASVEP PKP
Length:633
Mass (Da):70,679
Last modified:June 1, 2001 - v1
Checksum:i0B18933C0A0C891F
GO
Isoform 2 (identifier: Q99PG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-512: Missing.
     563-589: Missing.

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):66,741
Checksum:iEA7005742DA2AE72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19E → D in AAH03875 (PubMed:15489334).Curated1
Sequence conflicti317 – 318GR → SW in AAH03875 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004061504 – 512Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_004062563 – 589Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303894 mRNA. Translation: AAK01353.1.
AL669926 Genomic DNA. Translation: CAM26816.1.
BC003875 mRNA. Translation: AAH03875.1.
CCDSiCCDS17179.1. [Q99PG2-1]
RefSeqiNP_113550.3. NM_031373.3. [Q99PG2-1]
UniGeneiMm.250418.

Genome annotation databases

EnsembliENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401. [Q99PG2-1]
GeneIDi72075.
KEGGimmu:72075.
UCSCiuc008ojj.2. mouse. [Q99PG2-1]
uc008ojk.2. mouse. [Q99PG2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303894 mRNA. Translation: AAK01353.1.
AL669926 Genomic DNA. Translation: CAM26816.1.
BC003875 mRNA. Translation: AAH03875.1.
CCDSiCCDS17179.1. [Q99PG2-1]
RefSeqiNP_113550.3. NM_031373.3. [Q99PG2-1]
UniGeneiMm.250418.

3D structure databases

ProteinModelPortaliQ99PG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99PG2. 1 interactor.
MINTiMINT-4105826.
STRINGi10090.ENSMUSP00000029087.

PTM databases

iPTMnetiQ99PG2.
PhosphoSitePlusiQ99PG2.

Proteomic databases

EPDiQ99PG2.
PaxDbiQ99PG2.
PeptideAtlasiQ99PG2.
PRIDEiQ99PG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401. [Q99PG2-1]
GeneIDi72075.
KEGGimmu:72075.
UCSCiuc008ojj.2. mouse. [Q99PG2-1]
uc008ojk.2. mouse. [Q99PG2-2]

Organism-specific databases

CTDi11054.
MGIiMGI:1919325. Ogfr.

Phylogenomic databases

eggNOGiENOG410IH5X. Eukaryota.
ENOG4111XCW. LUCA.
GeneTreeiENSGT00390000018730.
HOGENOMiHOG000231272.
HOVERGENiHBG024736.
InParanoidiQ99PG2.
OMAiEDPKSQV.
OrthoDBiEOG091G04CN.
PhylomeDBiQ99PG2.
TreeFamiTF331377.

Miscellaneous databases

PROiQ99PG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049401.
CleanExiMM_OGFR.
GenevisibleiQ99PG2. MM.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
[Graphical view]
PfamiPF04664. OGFr_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOGFR_MOUSE
AccessioniPrimary (citable) accession number: Q99PG2
Secondary accession number(s): A2ACT6, Q99L33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.