Q99PG2 (OGFR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Opioid growth factor receptor
Short name=OGFr

Alternative name(s):
Zeta-type opioid receptor

Gene names

Name:

Ogfr

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	633 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: The OGF/OGFR complex is probably translocated to the nucleus.
Tissue specificity	Expressed in all tissues examined, including brain, heart, lung, liver, kidney and skeletal muscle.
Sequence similarities	Belongs to the opioid growth factor receptor family.

Ontologies

Keywords
Biological process	Growth regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Molecular function	Receptor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99PG2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99PG2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     504-512: Missing.
     563-589: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 633	633	Opioid growth factor receptor		PRO_0000058031
Regions
	Repeat	467 – 475	9	1
	Repeat	476 – 484	9	2
	Repeat	485 – 493	9	3
	Repeat	494 – 502	9	4
	Repeat	503 – 511	9	5
	Repeat	512 – 520	9	6
	Repeat	521 – 529	9	7
	Repeat	530 – 538	9	8
	Repeat	539 – 547	9	9
	Repeat	548 – 556	9	10
	Repeat	557 – 565	9	11
	Repeat	566 – 574	9	12
	Repeat	575 – 583	9	13
	Repeat	584 – 592	9	14
	Region	467 – 592	126	14 X approximate tandem repeats
	Motif	257 – 286	30	Bipartite nuclear localization signal Potential
Amino acid modifications
	Modified residue	337	1	Phosphoserine By similarity
	Modified residue	361	1	Phosphoserine By similarity
	Modified residue	403	1	Phosphoserine By similarity
	Modified residue	452	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	504 – 512	9	Missing in isoform 2.		VSP_004061
	Alternative sequence	563 – 589	27	Missing in isoform 2.		VSP_004062
Experimental info
	Sequence conflict	19	1	E → D in AAH03875. Ref.3
	Sequence conflict	317 – 318	2	GR → SW in AAH03875. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0B18933C0A0C891F	FASTA	633	70,679
	10 20 30 40 50 60 MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM TRYRNWRAMQ 70 80 90 100 110 120 DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI EDILQNWKDN YDLLEENHSY 130 140 150 160 170 180 IQWLFPLREP GVNWHAKPLT LKEVEAFKSS KEVRERLVRA YELMLGFYGI QLEDRNTGAV 190 200 210 220 230 240 CRAQNFQPRF HNLNSHSHNN LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR 250 260 270 280 290 300 QSALDYFLFA VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA 310 320 330 340 350 360 DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD GDQRHEAKSP 370 380 390 400 410 420 SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC ALSPTSQEPR EAEQPCLVAR 430 440 450 460 470 480 VANEVRKRRK VEEGAEGDGV ASNTQVQASA LSPTPSECPE SQKDGNGPED PKSQVGPEDP 490 500 510 520 530 540 KSQVGPEDPK SQVGPEDPKS QVGPEDPKGQ VEPEDPKGQV GPEDPKGQVG PEDPKGQVGP 550 560 570 580 590 600 EDPKSQVGPE DPKSQVEPED PKSQVEPEDP KSQVEPEDPK SQVGPEDPQS QVGPEQAASK 610 620 630 SLGEDPDSDT TGTSMSESEE LARIEASVEP PKP
	Isoform 2 [UniParc]. Checksum: EA7005742DA2AE72	FASTA	597	66,741
	10 20 30 40 50 60 MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM TRYRNWRAMQ 70 80 90 100 110 120 DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI EDILQNWKDN YDLLEENHSY 130 140 150 160 170 180 IQWLFPLREP GVNWHAKPLT LKEVEAFKSS KEVRERLVRA YELMLGFYGI QLEDRNTGAV 190 200 210 220 230 240 CRAQNFQPRF HNLNSHSHNN LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR 250 260 270 280 290 300 QSALDYFLFA VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA 310 320 330 340 350 360 DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD GDQRHEAKSP 370 380 390 400 410 420 SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC ALSPTSQEPR EAEQPCLVAR 430 440 450 460 470 480 VANEVRKRRK VEEGAEGDGV ASNTQVQASA LSPTPSECPE SQKDGNGPED PKSQVGPEDP 490 500 510 520 530 540 KSQVGPEDPK SQVGPEDPKS QVGPEDPKGQ VGPEDPKGQV GPEDPKGQVG PEDPKSQVGP 550 560 570 580 590 EDPKSQVEPE DPKSQVGPEQ AASKSLGEDP DSDTTGTSMS ESEELARIEA SVEPPKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse." Zagon I.S., Verderame M.F., Zimmer W.E., McLaughlin P.J. Brain Res. Mol. Brain Res. 84:106-114(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303894 mRNA. Translation: AAK01353.1. AL669926 Genomic DNA. Translation: CAM26816.1. BC003875 mRNA. Translation: AAH03875.1.
IPI	IPI00121018. IPI00230639.
RefSeq	NP_113550.3. NM_031373.3.
UniGene	Mm.250418.
3D structure databases
ProteinModelPortal	Q99PG2.
ModBase	Search...
PTM databases
PhosphoSite	Q99PG2.
Proteomic databases
PaxDb	Q99PG2.
PRIDE	Q99PG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401.
GeneID	72075.
KEGG	mmu:72075.
UCSC	uc008ojj.2. mouse. uc008ojk.2. mouse.
Organism-specific databases
CTD	11054.
MGI	MGI:1919325. Ogfr.
Phylogenomic databases
eggNOG	NOG28316.
GeneTree	ENSGT00390000018730.
HOGENOM	HOG000231272.
HOVERGEN	HBG024736.
InParanoid	A2ACT6.
OMA	NWRSHNN.
OrthoDB	EOG4FBHTH.
Gene expression databases
Bgee	Q99PG2.
CleanEx	MM_OGFR.
Genevestigator	Q99PG2.
GermOnline	ENSMUSG00000049401. Mus musculus.
Family and domain databases
InterPro	IPR006757. OGF_rcpt. [Graphical view]
Pfam	PF04664. OGFr_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	335368.
SOURCE	Search...

Entry information

Entry name

OGFR_MOUSE

Accession

Primary (citable) accession number: Q99PG2
Secondary accession number(s): A2ACT6, Q99L33

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program