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Q99PF5

- FUBP2_RAT

UniProt

Q99PF5 - FUBP2_RAT

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Protein
Far upstream element-binding protein 2
Gene
Khsrp, Fubp2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs By similarity. Binds to the dendritic targeting element and may play a role in mRNA trafficking.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. mRNA 3'-UTR binding Source: RGD
  3. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. mRNA processing Source: UniProtKB-KW
  3. mRNA transport Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Far upstream element-binding protein 2
Short name:
FUSE-binding protein 2
Alternative name(s):
KH type-splicing regulatory protein
Short name:
KSRP
MAP2 RNA trans-acting protein 1
Short name:
MARTA1
Gene namesi
Name:Khsrp
Synonyms:Fubp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621828. Khsrp.

Subcellular locationi

Nucleus. Cytoplasm
Note: A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. dendrite Source: RGD
  3. neuronal cell body Source: RGD
  4. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 721720Far upstream element-binding protein 2
PRO_0000050138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei88 – 881N6-acetyllysine By similarity
Modified residuei101 – 1011Phosphothreonine By similarity
Modified residuei182 – 1821Phosphoserine By similarity
Modified residuei185 – 1851Phosphoserine By similarity
Modified residuei194 – 1941Phosphoserine By similarity
Modified residuei275 – 2751Phosphoserine By similarity
Modified residuei481 – 4811Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ99PF5.

2D gel databases

REPRODUCTION-2DPAGEQ99PF5.

PTM databases

PhosphoSiteiQ99PF5.

Expressioni

Gene expression databases

GenevestigatoriQ99PF5.

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ99PF5.
SMRiQ99PF5. Positions 131-219, 222-306, 325-504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 20965KH 1
Add
BLAST
Domaini234 – 30067KH 2
Add
BLAST
Domaini323 – 38765KH 3
Add
BLAST
Domaini425 – 49268KH 4
Add
BLAST
Repeati572 – 583121
Add
BLAST
Repeati618 – 629122
Add
BLAST
Repeati644 – 655123
Add
BLAST
Repeati674 – 685124
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni572 – 6851144 X 12 AA imperfect repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 6862Gly/Pro-rich
Add
BLAST
Compositional biasi69 – 498430Gly-rich
Add
BLAST
Compositional biasi499 – 613115Ala/Gly/Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the KHSRP family.
Contains 4 KH domains.

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000625.
KOiK13210.
PhylomeDBiQ99PF5.

Family and domain databases

Gene3Di3.30.1370.10. 4 hits.
InterProiIPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view]
SMARTiSM00322. KH. 4 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 4 hits.
PROSITEiPS50084. KH_TYPE_1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PF5-1 [UniParc]FASTAAdd to Basket

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MSDYSTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP    50
GGGGASGGPS QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN 100
TPDFGFGGQK RQLEDGDQPD SKKLASQGDS IGSQLGPIHP PPRTSMTEEY 150
RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ ISPDSGGLPE RSVSLTGAPE 200
SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM IPAGKAGLVI 250
GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV 300
MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ 350
NDAGVRIQFK QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG 400
PPGAPGMPPG GRGRGRGQGN WGPPGGEMTF SIPTHKCGLV IGRGGENVKA 450
INQQTGAFVE ISRQLPPNGD PNFKLFVIRG SPQQIDHAKQ LIEEKIEGPL 500
CPVGPGPGGP GPAGPMGPFH PGPFNQGPPG APPHAGGPPP HQYPPQGWGN 550
TYPEWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA 600
APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE 650
EYYKKQAQVA TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ 700
PPSTQQGQQQ ATEANGYELH L 721
Length:721
Mass (Da):74,226
Last modified:June 1, 2001 - v1
Checksum:i482C7A765C60EE4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF308818 mRNA. Translation: AAG59811.1.
RefSeqiNP_598286.1. NM_133602.1.
UniGeneiRn.92643.

Genome annotation databases

GeneIDi171137.
KEGGirno:171137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF308818 mRNA. Translation: AAG59811.1 .
RefSeqi NP_598286.1. NM_133602.1.
UniGenei Rn.92643.

3D structure databases

ProteinModelPortali Q99PF5.
SMRi Q99PF5. Positions 131-219, 222-306, 325-504.
ModBasei Search...

PTM databases

PhosphoSitei Q99PF5.

2D gel databases

REPRODUCTION-2DPAGE Q99PF5.

Proteomic databases

PRIDEi Q99PF5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171137.
KEGGi rno:171137.

Organism-specific databases

CTDi 8570.
RGDi 621828. Khsrp.

Phylogenomic databases

HOVERGENi HBG000625.
KOi K13210.
PhylomeDBi Q99PF5.

Miscellaneous databases

NextBioi 621918.
PROi Q99PF5.

Gene expression databases

Genevestigatori Q99PF5.

Family and domain databases

Gene3Di 3.30.1370.10. 4 hits.
InterProi IPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view ]
SMARTi SM00322. KH. 4 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 4 hits.
PROSITEi PS50084. KH_TYPE_1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs."
    Rehbein M., Wege K., Buck F., Schweizer M., Richter D., Kindler S.
    J. Neurochem. 82:1039-1046(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 73-87; 89-108 AND 475-486, SUBCELLULAR LOCATION, FUNCTION.
    Tissue: Brain.

Entry informationi

Entry nameiFUBP2_RAT
AccessioniPrimary (citable) accession number: Q99PF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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