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Q99PF5

- FUBP2_RAT

UniProt

Q99PF5 - FUBP2_RAT

Protein

Far upstream element-binding protein 2

Gene

Khsrp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs By similarity. Binds to the dendritic targeting element and may play a role in mRNA trafficking.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. mRNA 3'-UTR binding Source: RGD
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. mRNA transport Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. RNA splicing Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Far upstream element-binding protein 2
    Short name:
    FUSE-binding protein 2
    Alternative name(s):
    KH type-splicing regulatory protein
    Short name:
    KSRP
    MAP2 RNA trans-acting protein 1
    Short name:
    MARTA1
    Gene namesi
    Name:Khsrp
    Synonyms:Fubp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621828. Khsrp.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. dendrite Source: RGD
    3. neuronal cell body Source: RGD
    4. nucleus Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 721720Far upstream element-binding protein 2PRO_0000050138Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei88 – 881N6-acetyllysineBy similarity
    Modified residuei101 – 1011PhosphothreonineBy similarity
    Modified residuei182 – 1821PhosphoserineBy similarity
    Modified residuei185 – 1851PhosphoserineBy similarity
    Modified residuei194 – 1941PhosphoserineBy similarity
    Modified residuei275 – 2751PhosphoserineBy similarity
    Modified residuei481 – 4811PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ99PF5.

    2D gel databases

    REPRODUCTION-2DPAGEQ99PF5.

    PTM databases

    PhosphoSiteiQ99PF5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99PF5.

    Interactioni

    Subunit structurei

    Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PF5.
    SMRiQ99PF5. Positions 131-219, 222-306, 325-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 20965KH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini234 – 30067KH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini323 – 38765KH 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 49268KH 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati572 – 583121Add
    BLAST
    Repeati618 – 629122Add
    BLAST
    Repeati644 – 655123Add
    BLAST
    Repeati674 – 685124Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni572 – 6851144 X 12 AA imperfect repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 6862Gly/Pro-richAdd
    BLAST
    Compositional biasi69 – 498430Gly-richAdd
    BLAST
    Compositional biasi499 – 613115Ala/Gly/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KHSRP family.Curated
    Contains 4 KH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG000625.
    KOiK13210.
    PhylomeDBiQ99PF5.

    Family and domain databases

    Gene3Di3.30.1370.10. 4 hits.
    InterProiIPR015096. DUF1897.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF09005. DUF1897. 2 hits.
    PF00013. KH_1. 4 hits.
    [Graphical view]
    SMARTiSM00322. KH. 4 hits.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 4 hits.
    PROSITEiPS50084. KH_TYPE_1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99PF5-1 [UniParc]FASTAAdd to Basket

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    MSDYSTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP    50
    GGGGASGGPS QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN 100
    TPDFGFGGQK RQLEDGDQPD SKKLASQGDS IGSQLGPIHP PPRTSMTEEY 150
    RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ ISPDSGGLPE RSVSLTGAPE 200
    SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM IPAGKAGLVI 250
    GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV 300
    MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ 350
    NDAGVRIQFK QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG 400
    PPGAPGMPPG GRGRGRGQGN WGPPGGEMTF SIPTHKCGLV IGRGGENVKA 450
    INQQTGAFVE ISRQLPPNGD PNFKLFVIRG SPQQIDHAKQ LIEEKIEGPL 500
    CPVGPGPGGP GPAGPMGPFH PGPFNQGPPG APPHAGGPPP HQYPPQGWGN 550
    TYPEWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA 600
    APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE 650
    EYYKKQAQVA TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ 700
    PPSTQQGQQQ ATEANGYELH L 721
    Length:721
    Mass (Da):74,226
    Last modified:June 1, 2001 - v1
    Checksum:i482C7A765C60EE4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF308818 mRNA. Translation: AAG59811.1.
    RefSeqiNP_598286.1. NM_133602.1.
    UniGeneiRn.92643.

    Genome annotation databases

    GeneIDi171137.
    KEGGirno:171137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF308818 mRNA. Translation: AAG59811.1 .
    RefSeqi NP_598286.1. NM_133602.1.
    UniGenei Rn.92643.

    3D structure databases

    ProteinModelPortali Q99PF5.
    SMRi Q99PF5. Positions 131-219, 222-306, 325-504.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q99PF5.

    2D gel databases

    REPRODUCTION-2DPAGE Q99PF5.

    Proteomic databases

    PRIDEi Q99PF5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 171137.
    KEGGi rno:171137.

    Organism-specific databases

    CTDi 8570.
    RGDi 621828. Khsrp.

    Phylogenomic databases

    HOVERGENi HBG000625.
    KOi K13210.
    PhylomeDBi Q99PF5.

    Miscellaneous databases

    NextBioi 621918.
    PROi Q99PF5.

    Gene expression databases

    Genevestigatori Q99PF5.

    Family and domain databases

    Gene3Di 3.30.1370.10. 4 hits.
    InterProi IPR015096. DUF1897.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF09005. DUF1897. 2 hits.
    PF00013. KH_1. 4 hits.
    [Graphical view ]
    SMARTi SM00322. KH. 4 hits.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 4 hits.
    PROSITEi PS50084. KH_TYPE_1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs."
      Rehbein M., Wege K., Buck F., Schweizer M., Richter D., Kindler S.
      J. Neurochem. 82:1039-1046(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 73-87; 89-108 AND 475-486, SUBCELLULAR LOCATION, FUNCTION.
      Tissue: Brain.

    Entry informationi

    Entry nameiFUBP2_RAT
    AccessioniPrimary (citable) accession number: Q99PF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3