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Q99PF5 (FUBP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Far upstream element-binding protein 2

Short name=FUSE-binding protein 2
Alternative name(s):
KH type-splicing regulatory protein
Short name=KSRP
MAP2 RNA trans-acting protein 1
Short name=MARTA1
Gene names
Name:Khsrp
Synonyms:Fubp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length721 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs By similarity. Binds to the dendritic targeting element and may play a role in mRNA trafficking. Ref.1

Subunit structure

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN By similarity.

Subcellular location

Nucleus. Cytoplasm. Note: A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. Ref.1

Sequence similarities

Belongs to the KHSRP family.

Contains 4 KH domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 721720Far upstream element-binding protein 2
PRO_0000050138

Regions

Domain145 – 20965KH 1
Domain234 – 30067KH 2
Domain323 – 38765KH 3
Domain425 – 49268KH 4
Repeat572 – 583121
Repeat618 – 629122
Repeat644 – 655123
Repeat674 – 685124
Region572 – 6851144 X 12 AA imperfect repeats
Compositional bias7 – 6862Gly/Pro-rich
Compositional bias69 – 498430Gly-rich
Compositional bias499 – 613115Ala/Gly/Pro-rich

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue881N6-acetyllysine By similarity
Modified residue1011Phosphothreonine By similarity
Modified residue1821Phosphoserine By similarity
Modified residue1851Phosphoserine By similarity
Modified residue1941Phosphoserine By similarity
Modified residue2751Phosphoserine By similarity
Modified residue4811Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99PF5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 482C7A765C60EE4A

FASTA72174,226
        10         20         30         40         50         60 
MSDYSTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP GGGGASGGPS 

        70         80         90        100        110        120 
QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN TPDFGFGGQK RQLEDGDQPD 

       130        140        150        160        170        180 
SKKLASQGDS IGSQLGPIHP PPRTSMTEEY RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ 

       190        200        210        220        230        240 
ISPDSGGLPE RSVSLTGAPE SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM 

       250        260        270        280        290        300 
IPAGKAGLVI GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV 

       310        320        330        340        350        360 
MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ NDAGVRIQFK 

       370        380        390        400        410        420 
QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG PPGAPGMPPG GRGRGRGQGN 

       430        440        450        460        470        480 
WGPPGGEMTF SIPTHKCGLV IGRGGENVKA INQQTGAFVE ISRQLPPNGD PNFKLFVIRG 

       490        500        510        520        530        540 
SPQQIDHAKQ LIEEKIEGPL CPVGPGPGGP GPAGPMGPFH PGPFNQGPPG APPHAGGPPP 

       550        560        570        580        590        600 
HQYPPQGWGN TYPEWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA 

       610        620        630        640        650        660 
APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE EYYKKQAQVA 

       670        680        690        700        710        720 
TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ PPSTQQGQQQ ATEANGYELH 


L 

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References

[1]"Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs."
Rehbein M., Wege K., Buck F., Schweizer M., Richter D., Kindler S.
J. Neurochem. 82:1039-1046(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 73-87; 89-108 AND 475-486, SUBCELLULAR LOCATION, FUNCTION.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF308818 mRNA. Translation: AAG59811.1.
RefSeqNP_598286.1. NM_133602.1.
UniGeneRn.92643.

3D structure databases

ProteinModelPortalQ99PF5.
SMRQ99PF5. Positions 131-219, 222-306, 325-504.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ99PF5.

2D gel databases

REPRODUCTION-2DPAGEQ99PF5.

Proteomic databases

PRIDEQ99PF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171137.
KEGGrno:171137.

Organism-specific databases

CTD8570.
RGD621828. Khsrp.

Phylogenomic databases

HOVERGENHBG000625.
KOK13210.
PhylomeDBQ99PF5.

Gene expression databases

GenevestigatorQ99PF5.

Family and domain databases

Gene3D3.30.1370.10. 4 hits.
InterProIPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamPF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view]
SMARTSM00322. KH. 4 hits.
[Graphical view]
SUPFAMSSF54791. SSF54791. 4 hits.
PROSITEPS50084. KH_TYPE_1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio621918.
PROQ99PF5.

Entry information

Entry nameFUBP2_RAT
AccessionPrimary (citable) accession number: Q99PF5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families