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Protein

Cadherin-23

Gene

Cdh23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.1 Publication

GO - Molecular functioni

GO - Biological processi

  • auditory receptor cell differentiation Source: MGI
  • auditory receptor cell stereocilium organization Source: MGI
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • calcium ion transport Source: MGI
  • cell adhesion Source: MGI
  • equilibrioception Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • inner ear development Source: MGI
  • inner ear morphogenesis Source: MGI
  • inner ear receptor stereocilium organization Source: MGI
  • locomotory behavior Source: MGI
  • photoreceptor cell maintenance Source: MGI
  • post-embryonic animal organ morphogenesis Source: MGI
  • regulation of cytosolic calcium ion concentration Source: MGI
  • sensory perception of light stimulus Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hearing

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-23
Alternative name(s):
Otocadherin
Gene namesi
Name:Cdh23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1890219. Cdh23.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 3064ExtracellularSequence analysisAdd BLAST3041
Transmembranei3065 – 3085HelicalSequence analysisAdd BLAST21
Topological domaini3086 – 3354CytoplasmicSequence analysisAdd BLAST269

GO - Cellular componenti

  • centrosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • kinocilium Source: MGI
  • photoreceptor inner segment Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
  • stereocilium Source: HGNC
  • stereocilium tip Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26N → I: Strongly reduced affinity for PCDH15. 1 Publication1
Mutagenesisi27R → I: Strongly reduced affinity for PCDH15. 1 Publication1
Mutagenesisi168L → G: Strongly reduced interaction with PCDH15. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000382524 – 3354Cadherin-23Add BLAST3331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi466N-linked (GlcNAc...)Sequence analysis1
Glycosylationi472N-linked (GlcNAc...)Sequence analysis1
Glycosylationi602N-linked (GlcNAc...)Sequence analysis1
Glycosylationi694N-linked (GlcNAc...)Sequence analysis1
Glycosylationi765N-linked (GlcNAc...)Sequence analysis1
Glycosylationi810N-linked (GlcNAc...)Sequence analysis1
Glycosylationi827N-linked (GlcNAc...)Sequence analysis1
Glycosylationi941N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1001N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1018N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1315N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1473N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1651N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1667N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1818N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1857N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1889N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1902N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2014N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2050N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2263N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2357N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2369N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2578N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2616N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2749N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2808N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2877N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2896N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2941N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2981N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99PF4.
PRIDEiQ99PF4.

PTM databases

iPTMnetiQ99PF4.
PhosphoSitePlusiQ99PF4.

Expressioni

Tissue specificityi

In adult animals relatively high levels of expression are found in testis, skeletal muscle, heart, eye and thymus, and lower expression in kidney, lung and brain. Found in the sensory hair cells of the inner ear.1 Publication

Gene expression databases

BgeeiENSMUSG00000012819.
ExpressionAtlasiQ99PF4. baseline and differential.
GenevisibleiQ99PF4. MM.

Interactioni

Subunit structurei

Interacts with USH1C and USH1G (By similarity). antiparallel heterodimer with PCDH15.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ush1cQ9ES64-32EBI-7419021,EBI-7418919

Protein-protein interaction databases

BioGridi204475. 1 interactor.
DIPiDIP-42152N.
IntActiQ99PF4. 1 interactor.
MINTiMINT-1895823.
STRINGi10090.ENSMUSP00000101104.

Structurei

Secondary structure

13354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 36Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi51 – 54Combined sources4
Beta strandi66 – 71Combined sources6
Helixi72 – 77Combined sources6
Beta strandi78 – 80Combined sources3
Turni82 – 84Combined sources3
Beta strandi86 – 91Combined sources6
Turni95 – 97Combined sources3
Beta strandi100 – 108Combined sources9
Beta strandi113 – 123Combined sources11
Beta strandi131 – 134Combined sources4
Beta strandi136 – 142Combined sources7
Beta strandi150 – 153Combined sources4
Helixi162 – 165Combined sources4
Beta strandi167 – 173Combined sources7
Beta strandi176 – 180Combined sources5
Turni182 – 184Combined sources3
Beta strandi186 – 189Combined sources4
Turni195 – 197Combined sources3
Beta strandi199 – 209Combined sources11
Beta strandi212 – 214Combined sources3
Beta strandi217 – 227Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WBXX-ray1.50A24-124[»]
2WCPX-ray1.98A24-228[»]
2WD0X-ray2.74A/C24-228[»]
2WHVX-ray2.36A24-228[»]
3MVSX-ray1.10A24-233[»]
4APXX-ray1.65A24-228[»]
4AQ8X-ray2.63A/B24-228[»]
4AQAX-ray1.96A24-228[»]
4AQEX-ray2.27A24-228[»]
4AXWX-ray2.23A24-228[»]
4XXWX-ray2.26C/D24-228[»]
ProteinModelPortaliQ99PF4.
SMRiQ99PF4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99PF4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini133 – 236Cadherin 2PROSITE-ProRule annotationAdd BLAST104
Domaini237 – 348Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini349 – 460Cadherin 4PROSITE-ProRule annotationAdd BLAST112
Domaini461 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST101
Domaini562 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST110
Domaini672 – 784Cadherin 7PROSITE-ProRule annotationAdd BLAST113
Domaini779 – 890Cadherin 8PROSITE-ProRule annotationAdd BLAST112
Domaini891 – 995Cadherin 9PROSITE-ProRule annotationAdd BLAST105
Domaini996 – 1102Cadherin 10PROSITE-ProRule annotationAdd BLAST107
Domaini1103 – 1208Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1210 – 1313Cadherin 12PROSITE-ProRule annotationAdd BLAST104
Domaini1314 – 1418Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1420 – 1527Cadherin 14PROSITE-ProRule annotationAdd BLAST108
Domaini1529 – 1634Cadherin 15PROSITE-ProRule annotationAdd BLAST106
Domaini1635 – 1744Cadherin 16PROSITE-ProRule annotationAdd BLAST110
Domaini1745 – 1851Cadherin 17PROSITE-ProRule annotationAdd BLAST107
Domaini1852 – 1959Cadherin 18PROSITE-ProRule annotationAdd BLAST108
Domaini1960 – 2069Cadherin 19PROSITE-ProRule annotationAdd BLAST110
Domaini2070 – 2174Cadherin 20PROSITE-ProRule annotationAdd BLAST105
Domaini2175 – 2293Cadherin 21PROSITE-ProRule annotationAdd BLAST119
Domaini2297 – 2402Cadherin 22PROSITE-ProRule annotationAdd BLAST106
Domaini2403 – 2509Cadherin 23PROSITE-ProRule annotationAdd BLAST107
Domaini2510 – 2611Cadherin 24PROSITE-ProRule annotationAdd BLAST102
Domaini2614 – 2722Cadherin 25PROSITE-ProRule annotationAdd BLAST109
Domaini2729 – 2846Cadherin 26PROSITE-ProRule annotationAdd BLAST118
Domaini2847 – 2975Cadherin 27PROSITE-ProRule annotationAdd BLAST129

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15.1 Publication

Sequence similaritiesi

Contains 27 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000139588.
HOVERGENiHBG050768.
InParanoidiQ99PF4.
KOiK06813.
OMAiEDMTFRM.
OrthoDBiEOG091G074O.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.40.60. 27 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR033030. CDH23.
[Graphical view]
PANTHERiPTHR24027:SF277. PTHR24027:SF277. 5 hits.
PfamiPF00028. Cadherin. 25 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 26 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 27 hits.
PROSITEiPS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99PF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRYSLVTCYA VLWLLMLVPG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS
60 70 80 90 100
SVTQLLARDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE
110 120 130 140 150
FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP
160 170 180 190 200
IFIVNATDPD LGAGGSVLYS FQPPSPFFAI DSARGIVTVI QELDYEVTQA
210 220 230 240 250
YQLTVNATDQ DKTRPLSTLA NLAIIITDMQ DMDPIFINLP YSTNIYEHSP
260 270 280 290 300
PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD
310 320 330 340 350
RENPLYSHGF ILTVKGTELN DDRTPSDATV TTTFNILVID INDNAPEFNS
360 370 380 390 400
SEYSVAITEL AQVGFALPLF IQVVDKDEDL GLNSMFEVYL VGNNSHHFII
410 420 430 440 450
SPTSVQGKAD IRIRVAIPLD YETVDRYDFD LFANESVPDH VGYAKVKITL
460 470 480 490 500
INENDNRPIF SQPLYNVSLY ENITVGTSVL TVLATDNDVG TFGEVNYFFS
510 520 530 540 550
DDPDRFSLDK DTGLIMLIAR LDYELIQRFT LTVIARDGGG EETTGRVRIN
560 570 580 590 600
VLDVNDNVPT FQKDAYVGAL RENEPSVTQL VRLRATDEDS PPNNLITYSI
610 620 630 640 650
VNASAFGSYF DISIYEGYGV ISVSRPLDYE QIPNGLIYLT VMAKDAGNPP
660 670 680 690 700
LYSTVPVTIE VFDENDNPPT FSKPAYFVSV LENIMAGATV LFLNATDLDR
710 720 730 740 750
SREYGQESII YSLEGSSQFR INARSGEITT TSLLDRETKS EYILIVRAVD
760 770 780 790 800
GGVGHNQKTG IATVNVTLLD INDNHPTWKD APYYINLVEM TPPDSDVTTV
810 820 830 840 850
VAVDPDLGEN GTLVYSIHPP NKFYSLNSTT GKIRTTHVML DRENPDPVEA
860 870 880 890 900
ELMRKIIVSV TDCGRPPLKA TSSATVFVNL LDLNDNDPTF RNLPFVAEIL
910 920 930 940 950
EGTPAGVSVY QVVAIDLDEG LNGLVSYRMQ VGMPRMDFVI NSTSGVVTTT
960 970 980 990 1000
AELDRERIAE YQLRVVASDA GTPTKSSTST LTVRVLDVND ETPTFFPAVY
1010 1020 1030 1040 1050
NVSVSEDVPR EFRVVWLNCT DNDVGLNAEL SYFITAGNVD GKFSVGYRDA
1060 1070 1080 1090 1100
VVRTVVGLDR ETTAAYTLVL EAIDNGPVGK RRTGTATVFV TVLDVNDNRP
1110 1120 1130 1140 1150
IFLQSSYEAS VPEDIPEGHS IVQLKATDAD EGEFGRVWYR ILHGNHGNNF
1160 1170 1180 1190 1200
RIHVGSGLLM RGPRPLDRER NSSHVLMVEA YNHDLGPMRS SVRVIVYVED
1210 1220 1230 1240 1250
VNDEAPVFTQ QQYNRLGLRE TAGIGTSVIV VRATDKDTGD GGLVNYRILS
1260 1270 1280 1290 1300
GAEGKFEIDE STGLIVTVDY LDYETKTSYL MNVSATDGAP PFNQGFCSVY
1310 1320 1330 1340 1350
VTLLNELDEA VQFSNASYEA VIMENLALGT EIVRVQAYSI DNLNQITYRF
1360 1370 1380 1390 1400
DAYTSAQAKA LFKIDAITGV ITVKGLVDRE KGDFYTLTVV ADDGGPKVDS
1410 1420 1430 1440 1450
TVKVYITVLD ENDNSPRFDF TSDSAISVPE DCPVGQRVAT VKARDPDAGS
1460 1470 1480 1490 1500
NGQVVFSLAS GNIAGAFEII TSNDSIGEVF VAKPLDREEL DHYILKVVAS
1510 1520 1530 1540 1550
DRGTPPRKKD HILQVTILDV NDNPPVIESP FGYNVSVNEN VGGGTSVVQV
1560 1570 1580 1590 1600
RATDRDIGIN SVLSYYITEG NEDMTFRMDR ISGEIATRPA PPDRERQNFY
1610 1620 1630 1640 1650
HLVVTVEDEG TPTLSATTHV YVTIVDENDN APVFQQPHYE VVLDEGPDTI
1660 1670 1680 1690 1700
NTSLITVQAL DLDEGPNGTV TYAIVAGNII NTFRINKHTG VITAAKELDY
1710 1720 1730 1740 1750
EISHGRYTLI VTATDQCPIL SHRLTSTTTV LVNVNDINDN VPTFPRDYEG
1760 1770 1780 1790 1800
PFDVTEGQPG PRVWTFLAHD RDSGPNGQVE YSVVDGDPLG EFVISPVEGV
1810 1820 1830 1840 1850
LRVRKDVELD RETIAFYNLT ICARDRGVPP LSSTMLVGIR VLDINDNDPV
1860 1870 1880 1890 1900
LLNLPMNVTI SENSPVSSFV AHVLASDADS GCNALLTFNI TAGNRERAFF
1910 1920 1930 1940 1950
INATTGIVTV NRPLDRERIP EYRLTVSVKD NPENPRIARK DFDLLLVSLA
1960 1970 1980 1990 2000
DENDNHPLFT EGTYQAEVME NSPAGTPLTV LNGPILALDA DEDVYAVVTY
2010 2020 2030 2040 2050
QLLGTHSDLF VIDNSTGVVT VRSGIIIDRE AFSPPFLELL LLAEDIGQLN
2060 2070 2080 2090 2100
GTAHLFITIL DDNDNWPTFS PPTYTVHLLE NCPPGFSVLQ VTATDEDSGL
2110 2120 2130 2140 2150
NGELVYRIEA GAQDRFLIHP VTGVIRVGNA TIDREEQESY RLTVVATDRG
2160 2170 2180 2190 2200
TVPLSGTAIV TILIDDINDS RPEFLNPIQT VSVLESAEPG TIIANVTAID
2210 2220 2230 2240 2250
LDLNPKLEYH IISIVAKDDT DRLVPDQEDA FAVNINTGSV MVKSPLNREL
2260 2270 2280 2290 2300
VATYEVTLSV IDNASDLPEH SVSVPNAKLT VNILDVNDNT PQFKPFGITY
2310 2320 2330 2340 2350
YTERVLEGAT PGTTLIAVAA VDPDKGLNGL ITYTLLDLTP PGYVQLEDSS
2360 2370 2380 2390 2400
AGKVIANRTV DYEEVHWLNF TVRASDNGSP PRAAEIPVYL EIVDINDNNP
2410 2420 2430 2440 2450
IFDQPSYQEA VFEDIAVGTV ILRVTATDAD SGNFALIEYS LVDGEGKFAI
2460 2470 2480 2490 2500
NPNTGDISVL SSLDREKKDH YILTALAKDN PGDVASNRRE NSVQVVIRVL
2510 2520 2530 2540 2550
DVNDCRPQFS KPQFSTSVYE NEPAGTSVIT MLATDQDEGS NSQLTYSLEG
2560 2570 2580 2590 2600
PGMEAFSVDM DSGLVTTQRP LQSYERFNLT VVATDGGEPP LWGTTMLLVE
2610 2620 2630 2640 2650
VIDVNDNRPV FVRPPNGTIL HIKEEIPLRS NVYEVYATDN DEGLNGAVRY
2660 2670 2680 2690 2700
SFLKTTGNRD WEYFTIDPIS GLIQTAQRLD REKQAVYSLI LVASDLGQPV
2710 2720 2730 2740 2750
PYETMQPLQV ALEDIDDNEP LFVRPPKGSP QYQLLTVPEH SPRGTLVGNV
2760 2770 2780 2790 2800
TGAVDADEGP NAIVYYFIAA GDEDKNFHLQ PDGRLLVLRD LDRETEATFS
2810 2820 2830 2840 2850
FIVKASSNRS WTPPRGPSPA LDLLTDLTLQ EVRVVLEDIN DQPPRFTKAE
2860 2870 2880 2890 2900
YTAGVATDAK VGSELIQVLA LDADIGNNSL VFYGILAIHY FRALANDSED
2910 2920 2930 2940 2950
VGQVFTMGSV DGILRTFDLF MAYSPGYFVV DIVARDLAGH NDTAIIGIYI
2960 2970 2980 2990 3000
LRDDQRVKIV INEIPDRVRG FEEEFIRLLS NITGAIVNTD DVQFHVDMKG
3010 3020 3030 3040 3050
RVNFAQTELL IHVVNRDTNR ILDVDRVIQM IDENKEQLRN LFRNYNVLDV
3060 3070 3080 3090 3100
QPAISVQLPD DMSALQMAII VLAILLFLAA MLFVLMNWYY RTIHKRKLKA
3110 3120 3130 3140 3150
IVAGSAGNRG FIDIMDMPNT NKYSFDGSNP VWLDPFCRNL ELAAQAEHED
3160 3170 3180 3190 3200
DLPENLSEIA DLWNSPTRTH GTFGREPAAV KPDDDRYLRA AIQEYDNIAK
3210 3220 3230 3240 3250
LGQIIREGPI KGSLLKVVLE DYLRLKKLFA QRMVQKASSC HSSISELIHT
3260 3270 3280 3290 3300
DLEEEPGDHS PGQGSLRFRH KPPMELKGQD GIHMVHGSTG TLLATDLNSL
3310 3320 3330 3340 3350
PEDDQKGLDR SLETLTASEA TAFERNARTE SAKSTPLHKL RDVIMESPLE

ITEL
Length:3,354
Mass (Da):369,623
Last modified:July 27, 2011 - v2
Checksum:i6ADFABF6A5001DC0
GO
Isoform 2 (identifier: Q99PF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3212-3246: Missing.

Show »
Length:3,319
Mass (Da):365,675
Checksum:i9ECA04DF22B1943F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94D → G in AAK07670 (PubMed:11386759).Curated1
Sequence conflicti142 – 143PE → TQ in AAK07670 (PubMed:11386759).Curated2
Sequence conflicti248 – 251HSPP → QLTVNAT in AAK07670 (PubMed:11386759).Curated4
Sequence conflicti379D → N in AAG52817 (PubMed:11138008).Curated1
Sequence conflicti379D → N in AAK07670 (PubMed:11386759).Curated1
Sequence conflicti3128S → A in AAG52817 (PubMed:11138008).Curated1
Sequence conflicti3128S → A in AAK07670 (PubMed:11386759).Curated1
Sequence conflicti3262G → S in AAG52817 (PubMed:11138008).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti5L → P in strain: CAST/Ei. 1 Publication1
Natural varianti229M → V in strain: CAST/Ei. 1 Publication1
Natural varianti891R → K in strain: CAST/Ei. 1 Publication1
Natural varianti1137V → I in strain: CAST/Ei. 1 Publication1
Natural varianti1236K → R in strain: CAST/Ei. 1 Publication1
Natural varianti2025I → V in strain: CAST/Ei. 1 Publication1
Natural varianti2026I → V in strain: CAST/Ei. 1 Publication1
Natural varianti2217K → T in strain: CAST/Ei. 1 Publication1
Natural varianti2222R → H in strain: CAST/Ei. 1 Publication1
Natural varianti2270H → R in strain: CAST/Ei. 1 Publication1
Natural varianti2617G → A in strain: CAST/Ei. 1 Publication1
Natural varianti2718 – 2720Missing in waltzer. 1 Publication3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0006483212 – 3246Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308939 mRNA. Translation: AAG52817.1.
AY026062 mRNA. Translation: AAK07670.1.
AK016365 mRNA. No translation available.
AC079082 Genomic DNA. No translation available.
AC079818 Genomic DNA. No translation available.
AC079819 Genomic DNA. No translation available.
AC153517 Genomic DNA. No translation available.
RefSeqiNP_075859.2. NM_023370.3.
UniGeneiMm.440327.

Genome annotation databases

EnsembliENSMUST00000105461; ENSMUSP00000101101; ENSMUSG00000012819. [Q99PF4-1]
ENSMUST00000105463; ENSMUSP00000101103; ENSMUSG00000012819. [Q99PF4-2]
GeneIDi22295.
KEGGimmu:22295.
UCSCiuc033fpl.1. mouse. [Q99PF4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308939 mRNA. Translation: AAG52817.1.
AY026062 mRNA. Translation: AAK07670.1.
AK016365 mRNA. No translation available.
AC079082 Genomic DNA. No translation available.
AC079818 Genomic DNA. No translation available.
AC079819 Genomic DNA. No translation available.
AC153517 Genomic DNA. No translation available.
RefSeqiNP_075859.2. NM_023370.3.
UniGeneiMm.440327.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WBXX-ray1.50A24-124[»]
2WCPX-ray1.98A24-228[»]
2WD0X-ray2.74A/C24-228[»]
2WHVX-ray2.36A24-228[»]
3MVSX-ray1.10A24-233[»]
4APXX-ray1.65A24-228[»]
4AQ8X-ray2.63A/B24-228[»]
4AQAX-ray1.96A24-228[»]
4AQEX-ray2.27A24-228[»]
4AXWX-ray2.23A24-228[»]
4XXWX-ray2.26C/D24-228[»]
ProteinModelPortaliQ99PF4.
SMRiQ99PF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204475. 1 interactor.
DIPiDIP-42152N.
IntActiQ99PF4. 1 interactor.
MINTiMINT-1895823.
STRINGi10090.ENSMUSP00000101104.

PTM databases

iPTMnetiQ99PF4.
PhosphoSitePlusiQ99PF4.

Proteomic databases

PaxDbiQ99PF4.
PRIDEiQ99PF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105461; ENSMUSP00000101101; ENSMUSG00000012819. [Q99PF4-1]
ENSMUST00000105463; ENSMUSP00000101103; ENSMUSG00000012819. [Q99PF4-2]
GeneIDi22295.
KEGGimmu:22295.
UCSCiuc033fpl.1. mouse. [Q99PF4-1]

Organism-specific databases

CTDi64072.
MGIiMGI:1890219. Cdh23.

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000139588.
HOVERGENiHBG050768.
InParanoidiQ99PF4.
KOiK06813.
OMAiEDMTFRM.
OrthoDBiEOG091G074O.
TreeFamiTF316403.

Miscellaneous databases

EvolutionaryTraceiQ99PF4.
PROiQ99PF4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012819.
ExpressionAtlasiQ99PF4. baseline and differential.
GenevisibleiQ99PF4. MM.

Family and domain databases

Gene3Di2.60.40.60. 27 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR033030. CDH23.
[Graphical view]
PANTHERiPTHR24027:SF277. PTHR24027:SF277. 5 hits.
PfamiPF00028. Cadherin. 25 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 26 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 27 hits.
PROSITEiPS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD23_MOUSE
AccessioniPrimary (citable) accession number: Q99PF4
Secondary accession number(s): E9QP63, Q99NH1, Q9D4N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.