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Q99PF3

- Q99PF3_RAT

UniProt

Q99PF3 - Q99PF3_RAT

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Protein
Submitted name: APEX
Gene
Apex1, Apex
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. DNA-(apurinic or apyrimidinic site) lyase activity Source: Ensembl
  3. chromatin DNA binding Source: Ensembl
  4. damaged DNA binding Source: Ensembl
  5. metal ion binding Source: UniProtKB
  6. oxidoreductase activity Source: UniProtKB
  7. phosphoric diester hydrolase activity Source: Ensembl
  8. site-specific endodeoxyribonuclease activity, specific for altered base Source: Ensembl
  9. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. DNA demethylation Source: Ensembl
  2. DNA repair Source: InterPro
  3. cell redox homeostasis Source: Ensembl
  4. positive regulation of DNA repair Source: Ensembl
  5. regulation of RNA biosynthetic process Source: GOC
  6. regulation of mRNA stability Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
APEXImported
Gene namesi
Name:Apex1Imported
Synonyms:ApexImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2126. Apex1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. nuclear speck Source: Ensembl
  3. nucleolus Source: Ensembl
  4. nucleus Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ99PF3.

Expressioni

Gene expression databases

GenevestigatoriQ99PF3.

Interactioni

Protein-protein interaction databases

IntActiQ99PF3. 1 interaction.
MINTiMINT-4613115.

Structurei

3D structure databases

ProteinModelPortaliQ99PF3.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG050531.
InParanoidiQ99PF3.

Family and domain databases

Gene3Di3.60.10.10. 2 hits.
InterProiIPR004808. AP_endonuc_1.
IPR020847. AP_endonuclease_F1_BS.
IPR020848. AP_endonuclease_F1_CS.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR22748. PTHR22748. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
TIGRFAMsiTIGR00633. xth. 2 hits.
PROSITEiPS00726. AP_NUCLEASE_F1_1. 1 hit.
PS00727. AP_NUCLEASE_F1_2. 1 hit.
PS00728. AP_NUCLEASE_F1_3. 1 hit.
PS51435. AP_NUCLEASE_F1_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99PF3-1 [UniParc]FASTAAdd to Basket

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KRAAAEDGEE PKSEPETKKS KGAAKKTEKE AAGEGPVLYE DPPDQKTSAS    50
GKSATLKICS WNVDGLRAWI KKKGLDWVKE EAPDILCLQE TKCSENKLPA 100
ELQELPGLTH QYWSAPSDKE GYSGVGLLSR QCPLKVSYGI AYVPNAGRGL 150
VRLEYRQRWD EAFRKFLKDL ASRKPLVLCG DLNVAHEEID LRNPKGNKKN 200
AGFTPQERQG FGEMLQAVPL ADSFRHLYPN TAYAYTFWTY MMNARSKNVG 250
WRLDYFLLSH SLLPALCDSK IRSKALGSDH CPITLYLAL 289
Length:289
Mass (Da):32,353
Last modified:June 1, 2001 - v1
Checksum:i67E82454D062CE51
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311054 mRNA. Translation: AAG49922.1.
UniGeneiRn.5949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311054 mRNA. Translation: AAG49922.1 .
UniGenei Rn.5949.

3D structure databases

ProteinModelPortali Q99PF3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99PF3. 1 interaction.
MINTi MINT-4613115.

Proteomic databases

PRIDEi Q99PF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2126. Apex1.

Phylogenomic databases

HOVERGENi HBG050531.
InParanoidi Q99PF3.

Gene expression databases

Genevestigatori Q99PF3.

Family and domain databases

Gene3Di 3.60.10.10. 2 hits.
InterProi IPR004808. AP_endonuc_1.
IPR020847. AP_endonuclease_F1_BS.
IPR020848. AP_endonuclease_F1_CS.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view ]
PANTHERi PTHR22748. PTHR22748. 1 hit.
Pfami PF03372. Exo_endo_phos. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 1 hit.
TIGRFAMsi TIGR00633. xth. 2 hits.
PROSITEi PS00726. AP_NUCLEASE_F1_1. 1 hit.
PS00727. AP_NUCLEASE_F1_2. 1 hit.
PS00728. AP_NUCLEASE_F1_3. 1 hit.
PS51435. AP_NUCLEASE_F1_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Xie Z.H., Liu C.Z., He Y.H., Wang A.M., Ma C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NorwayImported.

Entry informationi

Entry nameiQ99PF3_RAT
AccessioniPrimary (citable) accession number: Q99PF3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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