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Q99PF3

- Q99PF3_RAT

UniProt

Q99PF3 - Q99PF3_RAT

Protein
Submitted name:

APEX

Gene

Apex1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. damaged DNA binding Source: Ensembl
    3. DNA-(apurinic or apyrimidinic site) lyase activity Source: Ensembl
    4. DNA binding Source: UniProtKB
    5. metal ion binding Source: UniProtKB
    6. oxidoreductase activity Source: UniProtKB
    7. phosphoric diester hydrolase activity Source: Ensembl
    8. site-specific endodeoxyribonuclease activity, specific for altered base Source: Ensembl
    9. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. cell redox homeostasis Source: Ensembl
    2. DNA demethylation Source: Ensembl
    3. DNA repair Source: InterPro
    4. positive regulation of DNA repair Source: Ensembl
    5. regulation of mRNA stability Source: Ensembl
    6. regulation of RNA biosynthetic process Source: GOC

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    APEXImported
    Gene namesi
    Name:Apex1Imported
    Synonyms:ApexImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2126. Apex1.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. nuclear speck Source: Ensembl
    3. nucleolus Source: Ensembl
    4. nucleus Source: UniProtKB
    5. perinuclear region of cytoplasm Source: UniProtKB

    PTM / Processingi

    Proteomic databases

    PRIDEiQ99PF3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99PF3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99PF3. 1 interaction.
    MINTiMINT-4613115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG050531.
    InParanoidiQ99PF3.

    Family and domain databases

    Gene3Di3.60.10.10. 2 hits.
    InterProiIPR004808. AP_endonuc_1.
    IPR020847. AP_endonuclease_F1_BS.
    IPR020848. AP_endonuclease_F1_CS.
    IPR005135. Endo/exonuclease/phosphatase.
    [Graphical view]
    PANTHERiPTHR22748. PTHR22748. 1 hit.
    PfamiPF03372. Exo_endo_phos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 1 hit.
    TIGRFAMsiTIGR00633. xth. 2 hits.
    PROSITEiPS00726. AP_NUCLEASE_F1_1. 1 hit.
    PS00727. AP_NUCLEASE_F1_2. 1 hit.
    PS00728. AP_NUCLEASE_F1_3. 1 hit.
    PS51435. AP_NUCLEASE_F1_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99PF3-1 [UniParc]FASTAAdd to Basket

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    KRAAAEDGEE PKSEPETKKS KGAAKKTEKE AAGEGPVLYE DPPDQKTSAS    50
    GKSATLKICS WNVDGLRAWI KKKGLDWVKE EAPDILCLQE TKCSENKLPA 100
    ELQELPGLTH QYWSAPSDKE GYSGVGLLSR QCPLKVSYGI AYVPNAGRGL 150
    VRLEYRQRWD EAFRKFLKDL ASRKPLVLCG DLNVAHEEID LRNPKGNKKN 200
    AGFTPQERQG FGEMLQAVPL ADSFRHLYPN TAYAYTFWTY MMNARSKNVG 250
    WRLDYFLLSH SLLPALCDSK IRSKALGSDH CPITLYLAL 289
    Length:289
    Mass (Da):32,353
    Last modified:June 1, 2001 - v1
    Checksum:i67E82454D062CE51
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311054 mRNA. Translation: AAG49922.1.
    UniGeneiRn.5949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311054 mRNA. Translation: AAG49922.1 .
    UniGenei Rn.5949.

    3D structure databases

    ProteinModelPortali Q99PF3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99PF3. 1 interaction.
    MINTi MINT-4613115.

    Proteomic databases

    PRIDEi Q99PF3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2126. Apex1.

    Phylogenomic databases

    HOVERGENi HBG050531.
    InParanoidi Q99PF3.

    Gene expression databases

    Genevestigatori Q99PF3.

    Family and domain databases

    Gene3Di 3.60.10.10. 2 hits.
    InterProi IPR004808. AP_endonuc_1.
    IPR020847. AP_endonuclease_F1_BS.
    IPR020848. AP_endonuclease_F1_CS.
    IPR005135. Endo/exonuclease/phosphatase.
    [Graphical view ]
    PANTHERi PTHR22748. PTHR22748. 1 hit.
    Pfami PF03372. Exo_endo_phos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 1 hit.
    TIGRFAMsi TIGR00633. xth. 2 hits.
    PROSITEi PS00726. AP_NUCLEASE_F1_1. 1 hit.
    PS00727. AP_NUCLEASE_F1_2. 1 hit.
    PS00728. AP_NUCLEASE_F1_3. 1 hit.
    PS51435. AP_NUCLEASE_F1_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Xie Z.H., Liu C.Z., He Y.H., Wang A.M., Ma C.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NorwayImported.

    Entry informationi

    Entry nameiQ99PF3_RAT
    AccessioniPrimary (citable) accession number: Q99PF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)