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Q99PE9

- ARL4D_MOUSE

UniProt

Q99PE9 - ARL4D_MOUSE

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Protein

ADP-ribosylation factor-like protein 4D

Gene

Arl4d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4D
Alternative name(s):
ADP-ribosylation factor-like protein 4L
ADP-ribosylation factor-like protein 5
Gene namesi
Name:Arl4d
Synonyms:Arf4l, Arl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1933155. Arl4d.

Subcellular locationi

Nucleusnucleolus By similarity. Cell membrane 1 Publication. Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: MGI
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedSequence Analysis
Chaini2 – 201200ADP-ribosylation factor-like protein 4DPRO_0000207465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence Analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiQ99PE9.

PTM databases

PhosphoSiteiQ99PE9.

Expressioni

Gene expression databases

CleanExiMM_ARL4D.
GenevestigatoriQ99PE9.

Interactioni

Subunit structurei

Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-1340386.

Structurei

3D structure databases

ProteinModelPortaliQ99PE9.
SMRiQ99PE9. Positions 22-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118835.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ99PE9.
KOiK07945.
OMAiAIRTITP.
OrthoDBiEOG7H793N.
TreeFamiTF105464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV
60 70 80 90 100
PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV
110 120 130 140 150
VDSAETERLE EARMELHRIS KASDNQGVPV LVLANKQDQP GALSAAEVEK
160 170 180 190 200
RLAVRELAAA TLTHVQGCSA VDGLGLQPGL EHLYEMILKR KKAPRSSKKR

R
Length:201
Mass (Da):22,270
Last modified:October 3, 2012 - v2
Checksum:iA6462A22B3AD451A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71E → D in AAG53667. (PubMed:12414990)Curated
Sequence conflicti106 – 1061T → I in AAG53667. (PubMed:12414990)Curated
Sequence conflicti113 – 1142RM → KV in AAG53667. (PubMed:12414990)Curated
Sequence conflicti167 – 1671G → A in AAG53667. (PubMed:12414990)Curated
Sequence conflicti178 – 1781P → Q in AAG53667. (PubMed:12414990)Curated
Sequence conflicti182 – 1821H → R in AAG53667. (PubMed:12414990)Curated
Sequence conflicti196 – 1961S → G in AAG53667. (PubMed:12414990)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312686 mRNA. Translation: AAG53667.1.
AK004126 mRNA. Translation: BAB23183.1.
AK013320 mRNA. Translation: BAB28789.1.
AL590994 Genomic DNA. Translation: CAM22640.1.
CH466558 Genomic DNA. Translation: EDL34064.1.
BC016113 mRNA. Translation: AAH16113.1.
CCDSiCCDS36336.1.
RefSeqiNP_079680.1. NM_025404.3.
UniGeneiMm.266840.

Genome annotation databases

EnsembliENSMUST00000039388; ENSMUSP00000035918; ENSMUSG00000034936.
GeneIDi80981.
KEGGimmu:80981.
UCSCiuc007lpq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312686 mRNA. Translation: AAG53667.1 .
AK004126 mRNA. Translation: BAB23183.1 .
AK013320 mRNA. Translation: BAB28789.1 .
AL590994 Genomic DNA. Translation: CAM22640.1 .
CH466558 Genomic DNA. Translation: EDL34064.1 .
BC016113 mRNA. Translation: AAH16113.1 .
CCDSi CCDS36336.1.
RefSeqi NP_079680.1. NM_025404.3.
UniGenei Mm.266840.

3D structure databases

ProteinModelPortali Q99PE9.
SMRi Q99PE9. Positions 22-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1340386.

PTM databases

PhosphoSitei Q99PE9.

Proteomic databases

PRIDEi Q99PE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039388 ; ENSMUSP00000035918 ; ENSMUSG00000034936 .
GeneIDi 80981.
KEGGi mmu:80981.
UCSCi uc007lpq.2. mouse.

Organism-specific databases

CTDi 379.
MGIi MGI:1933155. Arl4d.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118835.
HOGENOMi HOG000163691.
HOVERGENi HBG002073.
InParanoidi Q99PE9.
KOi K07945.
OMAi AIRTITP.
OrthoDBi EOG7H793N.
TreeFami TF105464.

Miscellaneous databases

NextBioi 350314.
PROi Q99PE9.
SOURCEi Search...

Gene expression databases

CleanExi MM_ARL4D.
Genevestigatori Q99PE9.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00328. SAR1GTPBP.
SMARTi SM00177. ARF. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1."
    Lin C.-Y., Li C.-C., Huang P.-H., Lee F.-J.S.
    J. Cell Sci. 115:4433-4445(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiARL4D_MOUSE
AccessioniPrimary (citable) accession number: Q99PE9
Secondary accession number(s): Q9CQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3