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Q99PE9

- ARL4D_MOUSE

UniProt

Q99PE9 - ARL4D_MOUSE

Protein

ADP-ribosylation factor-like protein 4D

Gene

Arl4d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi28 – 358GTPBy similarity
    Nucleotide bindingi76 – 805GTPBy similarity
    Nucleotide bindingi135 – 1384GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-like protein 4D
    Alternative name(s):
    ADP-ribosylation factor-like protein 4L
    ADP-ribosylation factor-like protein 5
    Gene namesi
    Name:Arl4d
    Synonyms:Arf4l, Arl5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1933155. Arl4d.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cell membrane 1 Publication. Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleolus Source: UniProtKB-SubCell
    3. nucleus Source: MGI
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 201200ADP-ribosylation factor-like protein 4DPRO_0000207465Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PRIDEiQ99PE9.

    PTM databases

    PhosphoSiteiQ99PE9.

    Expressioni

    Gene expression databases

    CleanExiMM_ARL4D.
    GenevestigatoriQ99PE9.

    Interactioni

    Subunit structurei

    Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-1340386.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99PE9.
    SMRiQ99PE9. Positions 22-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117434.
    HOGENOMiHOG000163691.
    HOVERGENiHBG002073.
    InParanoidiQ99PE9.
    KOiK07945.
    OMAiAIRTITP.
    OrthoDBiEOG7H793N.
    TreeFamiTF105464.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00177. ARF. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99PE9-1 [UniParc]FASTAAdd to Basket

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    MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV    50
    PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV 100
    VDSAETERLE EARMELHRIS KASDNQGVPV LVLANKQDQP GALSAAEVEK 150
    RLAVRELAAA TLTHVQGCSA VDGLGLQPGL EHLYEMILKR KKAPRSSKKR 200
    R 201
    Length:201
    Mass (Da):22,270
    Last modified:October 3, 2012 - v2
    Checksum:iA6462A22B3AD451A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71E → D in AAG53667. (PubMed:12414990)Curated
    Sequence conflicti106 – 1061T → I in AAG53667. (PubMed:12414990)Curated
    Sequence conflicti113 – 1142RM → KV in AAG53667. (PubMed:12414990)Curated
    Sequence conflicti167 – 1671G → A in AAG53667. (PubMed:12414990)Curated
    Sequence conflicti178 – 1781P → Q in AAG53667. (PubMed:12414990)Curated
    Sequence conflicti182 – 1821H → R in AAG53667. (PubMed:12414990)Curated
    Sequence conflicti196 – 1961S → G in AAG53667. (PubMed:12414990)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312686 mRNA. Translation: AAG53667.1.
    AK004126 mRNA. Translation: BAB23183.1.
    AK013320 mRNA. Translation: BAB28789.1.
    AL590994 Genomic DNA. Translation: CAM22640.1.
    CH466558 Genomic DNA. Translation: EDL34064.1.
    BC016113 mRNA. Translation: AAH16113.1.
    CCDSiCCDS36336.1.
    RefSeqiNP_079680.1. NM_025404.3.
    UniGeneiMm.266840.

    Genome annotation databases

    EnsembliENSMUST00000039388; ENSMUSP00000035918; ENSMUSG00000034936.
    GeneIDi80981.
    KEGGimmu:80981.
    UCSCiuc007lpq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312686 mRNA. Translation: AAG53667.1 .
    AK004126 mRNA. Translation: BAB23183.1 .
    AK013320 mRNA. Translation: BAB28789.1 .
    AL590994 Genomic DNA. Translation: CAM22640.1 .
    CH466558 Genomic DNA. Translation: EDL34064.1 .
    BC016113 mRNA. Translation: AAH16113.1 .
    CCDSi CCDS36336.1.
    RefSeqi NP_079680.1. NM_025404.3.
    UniGenei Mm.266840.

    3D structure databases

    ProteinModelPortali Q99PE9.
    SMRi Q99PE9. Positions 22-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1340386.

    PTM databases

    PhosphoSitei Q99PE9.

    Proteomic databases

    PRIDEi Q99PE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039388 ; ENSMUSP00000035918 ; ENSMUSG00000034936 .
    GeneIDi 80981.
    KEGGi mmu:80981.
    UCSCi uc007lpq.2. mouse.

    Organism-specific databases

    CTDi 379.
    MGIi MGI:1933155. Arl4d.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117434.
    HOGENOMi HOG000163691.
    HOVERGENi HBG002073.
    InParanoidi Q99PE9.
    KOi K07945.
    OMAi AIRTITP.
    OrthoDBi EOG7H793N.
    TreeFami TF105464.

    Miscellaneous databases

    NextBioi 350314.
    PROi Q99PE9.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ARL4D.
    Genevestigatori Q99PE9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00177. ARF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1."
      Lin C.-Y., Li C.-C., Huang P.-H., Lee F.-J.S.
      J. Cell Sci. 115:4433-4445(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Strain: BALB/c.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiARL4D_MOUSE
    AccessioniPrimary (citable) accession number: Q99PE9
    Secondary accession number(s): Q9CQB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3