Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-binding cassette sub-family G member 5

Gene

Abcg5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cholesterol efflux Source: GO_Central
  • cholesterol homeostasis Source: Ensembl
  • cholesterol transport Source: RGD
  • excretion Source: Ensembl
  • negative regulation of intestinal cholesterol absorption Source: Ensembl
  • negative regulation of intestinal phytosterol absorption Source: Ensembl
  • regulation of intestinal cholesterol absorption Source: RGD
  • response to drug Source: RGD
  • response to ionizing radiation Source: RGD
  • response to nutrient Source: RGD
  • sterol transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1369062. ABC transporters in lipid homeostasis.
R-RNO-265473. Trafficking of dietary sterols.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 5
Alternative name(s):
Sterolin-1
Gene namesi
Name:Abcg5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620298. Abcg5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 385CytoplasmicSequence analysisAdd BLAST385
Transmembranei386 – 406Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini407 – 422ExtracellularSequence analysisAdd BLAST16
Transmembranei423 – 443Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini444 – 463CytoplasmicSequence analysisAdd BLAST20
Transmembranei464 – 484Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini485 – 504ExtracellularSequence analysisAdd BLAST20
Transmembranei505 – 525Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini526 – 529CytoplasmicSequence analysis4
Transmembranei530 – 550Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini551 – 624ExtracellularSequence analysisAdd BLAST74
Transmembranei625 – 645Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini646 – 652CytoplasmicSequence analysis7

GO - Cellular componenti

  • apical plasma membrane Source: GO_Central
  • ATP-binding cassette (ABC) transporter complex Source: RGD
  • receptor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933951 – 652ATP-binding cassette sub-family G member 5Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi585N-linked (GlcNAc...)Sequence analysis1
Glycosylationi592N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99PE7.
PRIDEiQ99PE7.

Expressioni

Tissue specificityi

Expressed only in liver and intestine.1 Publication

Gene expression databases

BgeeiENSRNOG00000005250.
GenevisibleiQ99PE7. RN.

Interactioni

Subunit structurei

May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007174.

Structurei

3D structure databases

ProteinModelPortaliQ99PE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 294ABC transporterPROSITE-ProRule annotationAdd BLAST256
Domaini389 – 646ABC transmembrane type-2Add BLAST258

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000033763.
HOVERGENiHBG050443.
InParanoidiQ99PE7.
KOiK05683.
OMAiCELRRDQ.
OrthoDBiEOG091G0FOJ.
PhylomeDBiQ99PE7.
TreeFamiTF105212.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELPFLSPE GARGPHNNRG SQSSLEEGSV TGSEARHSLG VLNVSFSVSN
60 70 80 90 100
RVGPWWNIKS CQQKWDRKIL KDVSLYIESG QTMCILGSSG SGKTTLLDAI
110 120 130 140 150
SGRLRRTGTL EGEVFVNGCE LRRDQFQDCV SYLLQSDVFL SSLTVRETLR
160 170 180 190 200
YTAMLALRSS SADFYDKKVE AVLTELSLSH VADQMIGNYN FGGISSGERR
210 220 230 240 250
RVSIAAQLLQ DPKVMMLDEP TTGLDCMTAN HIVLLLVELA RRNRIVIVTI
260 270 280 290 300
HQPRSELFHH FDKIAILTYG ELVFCGTPEE MLGFFNNCGY PCPEHSNPFD
310 320 330 340 350
FYMDLTSVDT QSREREIETY KRVQMLESAF RQSDICHKIL ENIERTRHLK
360 370 380 390 400
TLPMVPFKTK NPPGMFCKLG VLLRRVTRNL MRNKQVVIMR LVQNLIMGLF
410 420 430 440 450
LIFYLLRVQN NMLKGAVQDR VGLLYQLVGA TPYTGMLNAV NLFPMLRAVS
460 470 480 490 500
DQESQDGLYQ KWQMLLAYVL HALPFSIVAT VIFSSVCYWT LGLYPEVARF
510 520 530 540 550
GYFSAALLAP HLIGEFLTLV LLGMVQNPNI VNSIVALLSI SGLLIGSGFI
560 570 580 590 600
RNIEEMPIPL KILGYFTFQK YCCEILVVNE FYGLNFTCGG SNTSVPNNPM
610 620 630 640 650
CSMTQGIQFI EKTCPGATSR FTTNFLILYS FIPTLVILGM VVFKVRDYLI

SR
Length:652
Mass (Da):73,372
Last modified:August 15, 2003 - v3
Checksum:i49FEF7372269299D
GO

Polymorphismi

The polymorphism at position 583 is found in strains SHR, SHRSP and Wistar Kyoto which are both hypertensive and sitosterolemic. Strains which are hypertensive but not sitosterolemic do not contain a polymorphism at this position.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti583G → C in strain: SHR, SHRSP and Wistar Kyoto. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312714 mRNA. Translation: AAG53098.3.
AY145899 Genomic DNA. Translation: AAN64275.1.
RefSeqiNP_446206.2. NM_053754.2.
UniGeneiRn.74258.

Genome annotation databases

EnsembliENSRNOT00000007174; ENSRNOP00000007174; ENSRNOG00000005250.
GeneIDi114628.
KEGGirno:114628.
UCSCiRGD:620298. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312714 mRNA. Translation: AAG53098.3.
AY145899 Genomic DNA. Translation: AAN64275.1.
RefSeqiNP_446206.2. NM_053754.2.
UniGeneiRn.74258.

3D structure databases

ProteinModelPortaliQ99PE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007174.

Proteomic databases

PaxDbiQ99PE7.
PRIDEiQ99PE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007174; ENSRNOP00000007174; ENSRNOG00000005250.
GeneIDi114628.
KEGGirno:114628.
UCSCiRGD:620298. rat.

Organism-specific databases

CTDi64240.
RGDi620298. Abcg5.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000033763.
HOVERGENiHBG050443.
InParanoidiQ99PE7.
KOiK05683.
OMAiCELRRDQ.
OrthoDBiEOG091G0FOJ.
PhylomeDBiQ99PE7.
TreeFamiTF105212.

Enzyme and pathway databases

ReactomeiR-RNO-1369062. ABC transporters in lipid homeostasis.
R-RNO-265473. Trafficking of dietary sterols.

Miscellaneous databases

PROiQ99PE7.

Gene expression databases

BgeeiENSRNOG00000005250.
GenevisibleiQ99PE7. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCG5_RAT
AccessioniPrimary (citable) accession number: Q99PE7
Secondary accession number(s): Q8CIQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: August 15, 2003
Last modified: November 30, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.