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Protein

Ankyrin repeat family A protein 2

Gene

Ankra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.

GO - Molecular functioni

  • histone deacetylase binding Source: MGI
  • low-density lipoprotein particle binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat family A protein 2
Alternative name(s):
RFXANK-like protein 2
Gene namesi
Name:Ankra2
Synonyms:Ankra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915808. Ankra2.

Subcellular locationi

  • Cytoplasmcytoskeleton 1 Publication
  • Membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: MGI
  • membrane Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Ankyrin repeat family A protein 2PRO_0000066896Add
BLAST

Proteomic databases

PaxDbiQ99PE2.
PRIDEiQ99PE2.

PTM databases

PhosphoSiteiQ99PE2.

Expressioni

Gene expression databases

BgeeiQ99PE2.
CleanExiMM_ANKRA2.
ExpressionAtlasiQ99PE2. baseline and differential.
GenevisibleiQ99PE2. MM.

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of LRP2/megalin, HDAC4, HDAC5, and HDAC9, all these interactions occur via the recognition of a PxLPxI/L motif. Interacts with AHRR. Interacts with NEK6 (By similarity).By similarity

GO - Molecular functioni

  • histone deacetylase binding Source: MGI

Protein-protein interaction databases

BioGridi212926. 2 interactions.
MINTiMINT-4998003.
STRINGi10090.ENSMUSP00000022164.

Structurei

3D structure databases

ProteinModelPortaliQ99PE2.
SMRiQ99PE2. Positions 87-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati147 – 17933ANK 1Add
BLAST
Repeati180 – 21233ANK 2Add
BLAST
Repeati213 – 24533ANK 3Add
BLAST
Repeati246 – 27833ANK 4Add
BLAST
Repeati279 – 31234ANK 5Add
BLAST

Domaini

The three central ANK repeats mediate binding to the PxLPxI/L motif of interactors.By similarity

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0502. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00820000127028.
HOGENOMiHOG000033969.
HOVERGENiHBG017718.
InParanoidiQ99PE2.
PhylomeDBiQ99PE2.
TreeFamiTF333112.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99PE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSANLDIG AQLIVEECPS SYISGMPDIK LEHQLDPNPD EGAAQGVAMG
60 70 80 90 100
MKFILPNRFD MNVCSRFVKS LNEEDSKNIQ DQVNSDLEVA SVLFKAECNI
110 120 130 140 150
HTSPSPGIQV RHVYTPSTTK HFSPIKQSTT LTNKHRGNEV STTPLLANSL
160 170 180 190 200
SAHQLAAQGE MLYLATRIEQ ENVINHTDEE GFTPLMWAAA HGQIAVVEFL
210 220 230 240 250
LQNGADPQLL GKGRESALSL ACSKGYTDIV KMLLDCGVDV NEYDWNGGTP
260 270 280 290 300
LLYAVHGNHV KCVKMLLENG ADPTIETDSG YNSMDLAVAL GYRGVQQAIE
310
SHLLKLLQNI RE
Length:312
Mass (Da):34,063
Last modified:June 1, 2001 - v1
Checksum:i3B52B1415B7A5AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314031 mRNA. Translation: AAK01620.1.
CCDSiCCDS26713.1.
RefSeqiNP_075961.1. NM_023472.2.
UniGeneiMm.209642.
Mm.491346.

Genome annotation databases

EnsembliENSMUST00000022164; ENSMUSP00000022164; ENSMUSG00000021661.
GeneIDi68558.
KEGGimmu:68558.
UCSCiuc007ror.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314031 mRNA. Translation: AAK01620.1.
CCDSiCCDS26713.1.
RefSeqiNP_075961.1. NM_023472.2.
UniGeneiMm.209642.
Mm.491346.

3D structure databases

ProteinModelPortaliQ99PE2.
SMRiQ99PE2. Positions 87-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212926. 2 interactions.
MINTiMINT-4998003.
STRINGi10090.ENSMUSP00000022164.

PTM databases

PhosphoSiteiQ99PE2.

Proteomic databases

PaxDbiQ99PE2.
PRIDEiQ99PE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022164; ENSMUSP00000022164; ENSMUSG00000021661.
GeneIDi68558.
KEGGimmu:68558.
UCSCiuc007ror.2. mouse.

Organism-specific databases

CTDi57763.
MGIiMGI:1915808. Ankra2.

Phylogenomic databases

eggNOGiKOG0502. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00820000127028.
HOGENOMiHOG000033969.
HOVERGENiHBG017718.
InParanoidiQ99PE2.
PhylomeDBiQ99PE2.
TreeFamiTF333112.

Miscellaneous databases

NextBioi327450.
PROiQ99PE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99PE2.
CleanExiMM_ANKRA2.
ExpressionAtlasiQ99PE2. baseline and differential.
GenevisibleiQ99PE2. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin."
    Rader K., Orlando R.A., Lou X., Farquhar M.G.
    J. Am. Soc. Nephrol. 11:2167-2178(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH LRP2, SUBCELLULAR LOCATION.
  2. "Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5."
    Oshima M., Mimura J., Yamamoto M., Fujii-Kuriyama Y.
    Biochem. Biophys. Res. Commun. 364:276-282(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AHRR.

Entry informationi

Entry nameiANRA2_MOUSE
AccessioniPrimary (citable) accession number: Q99PE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.