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Protein

Sodium/potassium/calcium exchanger 3

Gene

Slc24a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-425561. Sodium/Calcium exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 3
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3
Gene namesi
Name:Slc24a3
Synonyms:Nckx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2137513. Slc24a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 106ExtracellularSequence analysisAdd BLAST63
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 151CytoplasmicSequence analysisAdd BLAST24
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 181ExtracellularSequence analysis9
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 209CytoplasmicSequence analysis7
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 234ExtracellularSequence analysis4
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 486CytoplasmicSequence analysisAdd BLAST231
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 512ExtracellularSequence analysis5
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 551CytoplasmicSequence analysisAdd BLAST18
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21
Topological domaini573 – 582ExtracellularSequence analysis10
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 617CytoplasmicSequence analysisAdd BLAST14
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Topological domaini639 – 645ExtracellularSequence analysis7

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000001937144 – 645Sodium/potassium/calcium exchanger 3Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Modified residuei307PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99PD7.
PaxDbiQ99PD7.
PRIDEiQ99PD7.

PTM databases

iPTMnetiQ99PD7.
PhosphoSitePlusiQ99PD7.

Expressioni

Tissue specificityi

Abundant in the brain. Highest levels found in selected thalamic nuclei, hippocampal CA1 neurons and in layer IV of the cerebral cortex. Expressed in dental tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000063873.
ExpressionAtlasiQ99PD7. baseline and differential.
GenevisibleiQ99PD7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079897.

Structurei

3D structure databases

ProteinModelPortaliQ99PD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 188Alpha-1Add BLAST41
Repeati520 – 551Alpha-2Add BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi424 – 430Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ99PD7.
OMAiLGCGCLF.
OrthoDBiEOG091G0M5C.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPGDQDCA RRRSRRRRRD LLLSQLCFLA SVALLLWSLS SLREQKELDL
60 70 80 90 100
MDLIGEDRKW MVGRKLMQVN DTLTSEDAGL QSSKNCTEPA LHEFPRDIFS
110 120 130 140 150
NEDRRQGAVV LHVLCAMYMF YALAIVCDDF FVPSLEKICE RLHLSEDVAG
160 170 180 190 200
ATFMAAGSSA PELFTSVIGV FITKGDVGVG TIVGSAVFNI LCIIGVCGLF
210 220 230 240 250
AGQVVALSSW CLLRDSIYYT LSVVALIVFI YDEKVSWWES LVLVLMYLIY
260 270 280 290 300
IVIMKYNACI HQCFERRTKG AGNMVNGLAN NAEIDDSSNC DATVVLLKKA
310 320 330 340 350
NFHRKASVIM VDELLSAYPH QLSFSEAGLR IMITSHFPPK TRLSMASRML
360 370 380 390 400
INERQRLINS RAYTNGESEV AIKIPIKHTV ENGTGPSSAP DRGVNGTRRD
410 420 430 440 450
DIVAETDNET ENENEDNENN ENDEEEEEDE DDDEGPYTPF DPPSGKLETV
460 470 480 490 500
KWAFTWPLSF VLYFTVPNCN KPHWEKWFMV TFASSTLWIA AFSYMMVWMV
510 520 530 540 550
TIIGYTLGIP DVIMGITFLA AGTSVPDCMA SLIVARQGMG DMAVSNSIGS
560 570 580 590 600
NVFDILIGLG LPWALQTLAV DYGSYIRLNS RGLIYSVGLL LASVFVTVFG
610 620 630 640
VHLNKWQLDK KLGCGCLFLY GVFLCFSIMT EFNVFTFVNL PMCGD
Length:645
Mass (Da):71,942
Last modified:July 27, 2011 - v3
Checksum:iFA57D33BA1D14B84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422N → S in AAG60049 (PubMed:11294880).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314821 mRNA. Translation: AAG60049.1.
AF314822 Genomic DNA. Translation: AAG60050.1.
AL772192
, AL808117, AL824715, AL831783 Genomic DNA. Translation: CAM15824.1.
AL831783
, AL772192, AL808117, AL824715 Genomic DNA. Translation: CAM17347.1.
AL808117
, AL772192, AL824715, AL831783 Genomic DNA. Translation: CAM18366.1.
AL824715
, AL772192, AL808117, AL831783 Genomic DNA. Translation: CAM27508.1.
BC005742 mRNA. Translation: AAH05742.1.
UniGeneiMm.217171.

Genome annotation databases

EnsembliENSMUST00000110007; ENSMUSP00000105634; ENSMUSG00000063873.
UCSCiuc008mrq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314821 mRNA. Translation: AAG60049.1.
AF314822 Genomic DNA. Translation: AAG60050.1.
AL772192
, AL808117, AL824715, AL831783 Genomic DNA. Translation: CAM15824.1.
AL831783
, AL772192, AL808117, AL824715 Genomic DNA. Translation: CAM17347.1.
AL808117
, AL772192, AL824715, AL831783 Genomic DNA. Translation: CAM18366.1.
AL824715
, AL772192, AL808117, AL831783 Genomic DNA. Translation: CAM27508.1.
BC005742 mRNA. Translation: AAH05742.1.
UniGeneiMm.217171.

3D structure databases

ProteinModelPortaliQ99PD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079897.

PTM databases

iPTMnetiQ99PD7.
PhosphoSitePlusiQ99PD7.

Proteomic databases

MaxQBiQ99PD7.
PaxDbiQ99PD7.
PRIDEiQ99PD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110007; ENSMUSP00000105634; ENSMUSG00000063873.
UCSCiuc008mrq.1. mouse.

Organism-specific databases

MGIiMGI:2137513. Slc24a3.

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ99PD7.
OMAiLGCGCLF.
OrthoDBiEOG091G0M5C.
TreeFamiTF318759.

Enzyme and pathway databases

ReactomeiR-MMU-425561. Sodium/Calcium exchangers.

Miscellaneous databases

ChiTaRSiSlc24a3. mouse.
PROiQ99PD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063873.
ExpressionAtlasiQ99PD7. baseline and differential.
GenevisibleiQ99PD7. MM.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX3_MOUSE
AccessioniPrimary (citable) accession number: Q99PD7
Secondary accession number(s): B1AWL7, Q99JR2, Q99PD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.