Q99PD2 (RN138_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase RNF138
EC=6.3.2.-

Alternative name(s):
RING finger protein 138

Gene names

Name:	Rnf138
ORF Names:	RSD-4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with NLK (via C-terminus) By similarity.
Domain	The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.
Post-translational modification	Auto-ubiquitinated By similarity.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Ubl conjugation pathway Wnt signaling pathway
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Ligase
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	ligase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	E3 ubiquitin-protein ligase RNF138		PRO_0000261609
Regions
	Zinc finger	18 – 58	41	RING-type

Sequences

	Sequence		Length	Mass (Da)
	Q99PD2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 8C3A06E4EB24CFDB	FASTA	209	24,072
	10 20 30 40 50 60 MSEELSADTS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES GIHCPLCRGS 70 80 90 100 110 120 VTRRERACPE RAIDLENIMR RVSGSCRCCS KKIKFYRMRH HYKSCKKYQD EYGVSSVIPN 130 140 150 160 170 180 VKISQDSVRS SNRSETSASD NTETYQEDTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH 190 200 LFQIVPVNLQ LDEETQYQTA VEESFQVNM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A rat testis-specific gene including a RING finger domain homolog to HSD-4." Wang L., Gou D., Zhang X. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF315468 mRNA. Translation: AAK11282.1. BC061821 mRNA. Translation: AAH61821.1.
IPI	IPI00200841.
RefSeq	NP_446040.1. NM_053588.2.
UniGene	Rn.6814.
3D structure databases
HSSP	HSSP built from PDB template 1JM7 based on UniProtKB P38398.
ProteinModelPortal	Q99PD2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	94196.
KEGG	rno:94196.
Organism-specific databases
CTD	51444.
RGD	621485. Rnf138.
Phylogenomic databases
HOVERGEN	HBG074331.
KO	K10668.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Genevestigator	Q99PD2.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR015880. Znf_C2H2-like. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
SMART	SM00184. RING. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	617854.

Entry information

Entry name

RN138_RAT

Accession

Primary (citable) accession number: Q99PD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program