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Q99PD2

- RN138_RAT

UniProt

Q99PD2 - RN138_RAT

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Protein

E3 ubiquitin-protein ligase RNF138

Gene
Rnf138, RSD-4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5841RING-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
  2. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF138 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 138
Gene namesi
Name:Rnf138
ORF Names:RSD-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621485. Rnf138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 209208E3 ubiquitin-protein ligase RNF138PRO_0000261609Add
BLAST

Post-translational modificationi

Auto-ubiquitinated By similarity.

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

GenevestigatoriQ99PD2.

Interactioni

Subunit structurei

Interacts with NLK (via C-terminus) By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ99PD2.

Family & Domainsi

Domaini

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5841RING-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG074331.
KOiK10668.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PD2-1 [UniParc]FASTAAdd to Basket

« Hide

MSEELSADTS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES    50
GIHCPLCRGS VTRRERACPE RAIDLENIMR RVSGSCRCCS KKIKFYRMRH 100
HYKSCKKYQD EYGVSSVIPN VKISQDSVRS SNRSETSASD NTETYQEDTS 150
SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH LFQIVPVNLQ LDEETQYQTA 200
VEESFQVNM 209
Length:209
Mass (Da):24,072
Last modified:June 1, 2001 - v1
Checksum:i8C3A06E4EB24CFDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF315468 mRNA. Translation: AAK11282.1.
BC061821 mRNA. Translation: AAH61821.1.
RefSeqiNP_446040.1. NM_053588.2.
UniGeneiRn.6814.

Genome annotation databases

GeneIDi94196.
KEGGirno:94196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF315468 mRNA. Translation: AAK11282.1 .
BC061821 mRNA. Translation: AAH61821.1 .
RefSeqi NP_446040.1. NM_053588.2.
UniGenei Rn.6814.

3D structure databases

ProteinModelPortali Q99PD2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 94196.
KEGGi rno:94196.

Organism-specific databases

CTDi 51444.
RGDi 621485. Rnf138.

Phylogenomic databases

HOVERGENi HBG074331.
KOi K10668.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 617854.
PROi Q99PD2.

Gene expression databases

Genevestigatori Q99PD2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A rat testis-specific gene including a RING finger domain homolog to HSD-4."
    Wang L., Gou D., Zhang X.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiRN138_RAT
AccessioniPrimary (citable) accession number: Q99PD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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