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Protein

E3 ubiquitin-protein ligase RNF138

Gene

Rnf138

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (By similarity).By similarity

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5841RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF138 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 138
Gene namesi
Name:Rnf138
ORF Names:RSD-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621485. Rnf138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 209208E3 ubiquitin-protein ligase RNF138PRO_0000261609Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

GenevisibleiQ99PD2. RN.

Interactioni

Subunit structurei

Interacts with NLK (via C-terminus).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99PD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5841RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG074331.
InParanoidiQ99PD2.
KOiK10668.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99PD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEELSADTS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES
60 70 80 90 100
GIHCPLCRGS VTRRERACPE RAIDLENIMR RVSGSCRCCS KKIKFYRMRH
110 120 130 140 150
HYKSCKKYQD EYGVSSVIPN VKISQDSVRS SNRSETSASD NTETYQEDTS
160 170 180 190 200
SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH LFQIVPVNLQ LDEETQYQTA

VEESFQVNM
Length:209
Mass (Da):24,072
Last modified:June 1, 2001 - v1
Checksum:i8C3A06E4EB24CFDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315468 mRNA. Translation: AAK11282.1.
BC061821 mRNA. Translation: AAH61821.1.
RefSeqiNP_446040.1. NM_053588.2.
UniGeneiRn.6814.

Genome annotation databases

GeneIDi94196.
KEGGirno:94196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315468 mRNA. Translation: AAK11282.1.
BC061821 mRNA. Translation: AAH61821.1.
RefSeqiNP_446040.1. NM_053588.2.
UniGeneiRn.6814.

3D structure databases

ProteinModelPortaliQ99PD2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi94196.
KEGGirno:94196.

Organism-specific databases

CTDi51444.
RGDi621485. Rnf138.

Phylogenomic databases

HOVERGENiHBG074331.
InParanoidiQ99PD2.
KOiK10668.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi617854.
PROiQ99PD2.

Gene expression databases

GenevisibleiQ99PD2. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A rat testis-specific gene including a RING finger domain homolog to HSD-4."
    Wang L., Gou D., Zhang X.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiRN138_RAT
AccessioniPrimary (citable) accession number: Q99PD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.