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Q99PD2 (RN138_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase RNF138

EC=6.3.2.-
Alternative name(s):
RING finger protein 138
Gene names
Name:Rnf138
ORF Names:RSD-4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with NLK (via C-terminus) By similarity.

Domain

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.

Post-translational modification

Auto-ubiquitinated By similarity.

Sequence similarities

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processUbl conjugation pathway
Wnt signaling pathway
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 209208E3 ubiquitin-protein ligase RNF138
PRO_0000261609

Regions

Zinc finger18 – 5841RING-type

Sequences

Sequence LengthMass (Da)Tools
Q99PD2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 8C3A06E4EB24CFDB

FASTA20924,072
        10         20         30         40         50         60 
MSEELSADTS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES GIHCPLCRGS 

        70         80         90        100        110        120 
VTRRERACPE RAIDLENIMR RVSGSCRCCS KKIKFYRMRH HYKSCKKYQD EYGVSSVIPN 

       130        140        150        160        170        180 
VKISQDSVRS SNRSETSASD NTETYQEDTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH 

       190        200 
LFQIVPVNLQ LDEETQYQTA VEESFQVNM 

« Hide

References

« Hide 'large scale' references
[1]"A rat testis-specific gene including a RING finger domain homolog to HSD-4."
Wang L., Gou D., Zhang X.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF315468 mRNA. Translation: AAK11282.1.
BC061821 mRNA. Translation: AAH61821.1.
RefSeqNP_446040.1. NM_053588.2.
UniGeneRn.6814.

3D structure databases

ProteinModelPortalQ99PD2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID94196.
KEGGrno:94196.

Organism-specific databases

CTD51444.
RGD621485. Rnf138.

Phylogenomic databases

HOVERGENHBG074331.
KOK10668.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorQ99PD2.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR015880. Znf_C2H2-like.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617854.
PROQ99PD2.

Entry information

Entry nameRN138_RAT
AccessionPrimary (citable) accession number: Q99PD2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways