Q99P96HDAC7_RATHistone deacetylase 7HD73.5.1.98Histone deacetylase 7AHD7aHdac7Hdac7aRattus norvegicusRatEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattusExpression pattern of rat histone deacetylases.NUCLEOTIDE SEQUENCE [MRNA]Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]Interacts with KAT5 and EDNRA. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KDM5B. Interacts with ZMYND15. Interacts with PML. Interacts with FOXP3. Interacts with RARA (By similarity).NucleusCytoplasmIn the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation (By similarity).The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-164 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-164 is a prerequisite for phosphorylation at Ser-190 (By similarity).Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor.Belongs to the histone deacetylase family. HD type 2 subfamily.Chromatin regulatorCytoplasmHydrolaseNucleusPhosphoproteinReference proteomeRepeatRepressorTranscriptionTranscription regulationTPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPLPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEADG
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