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Protein

Histone deacetylase 7

Gene

Hdac7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3.By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: UniProtKB
  • B cell differentiation Source: UniProtKB
  • cellular response to mechanical stimulus Source: RGD
  • chromatin modification Source: UniProtKB
  • chromatin organization Source: UniProtKB
  • histone deacetylation Source: GOC
  • inflammatory response Source: UniProtKB
  • negative regulation of neuron death Source: RGD
  • negative regulation of striated muscle tissue development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nervous system development Source: UniProtKB
  • neuron apoptotic process Source: RGD
  • neuron differentiation Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 7 (EC:3.5.1.98)
Short name:
HD7
Alternative name(s):
Histone deacetylase 7A
Short name:
HD7a
Gene namesi
Name:Hdac7
Synonyms:Hdac7a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619982. Hdac7.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • histone deacetylase complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›238›238Histone deacetylase 7PRO_0000114707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei164 – 1641Phosphoserine; by MARK2, MARK3 and PKD/PRKD1By similarity
Modified residuei190 – 1901Phosphoserine; by PKD/PRKD2By similarity

Post-translational modificationi

May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-164 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-164 is a prerequisite for phosphorylation at Ser-190 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99P96.

Interactioni

Subunit structurei

Interacts with KAT5 and EDNRA. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KDM5B. Interacts with ZMYND15. Interacts with PML. Interacts with FOXP3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011322.

Family & Domainsi

Domaini

The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
InParanoidiQ99P96.

Family and domain databases

InterProiIPR000286. His_deacetylse.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q99P96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TPGSQPQPMD LRVGQRPTVE PPPEPALLTL QHPQRLHRHL FLAGLQQQQR
60 70 80 90 100
SAEPMRLSMD PPLPELQGGQ QEQELRQLLN KDKSKRSAVA SSVVKQKLAE
110 120 130 140 150
VILKKQQAAL ERTVHPSSPS IPYRTLEPLD TEGAARSVLS SFLPPVPSLP
160 170 180 190 200
TEPPEHFPLR KTVSEPNLKL RYKPKKSLER RKNPLLRKES APPSLRRRPA
210 220 230
ETLGDSSPSS SSTPASGCSS PNDSEHGPNP ALGSEADG
Length:238
Mass (Da):26,101
Last modified:June 1, 2001 - v1
Checksum:iB8869B96FBD040C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei238 – 2381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321135 mRNA. Translation: AAK11188.1.
UniGeneiRn.203327.

Genome annotation databases

UCSCiRGD:619982. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321135 mRNA. Translation: AAK11188.1.
UniGeneiRn.203327.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011322.

Chemistry

ChEMBLiCHEMBL2095943.

Proteomic databases

PaxDbiQ99P96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619982. rat.

Organism-specific databases

RGDi619982. Hdac7.

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
InParanoidiQ99P96.

Family and domain databases

InterProiIPR000286. His_deacetylse.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Expression pattern of rat histone deacetylases."
    Wilquet V., Chavez M., Korbers R., Geerts A.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Testis.

Entry informationi

Entry nameiHDAC7_RAT
AccessioniPrimary (citable) accession number: Q99P96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.