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Q99P91

- GPNMB_MOUSE

UniProt

Q99P91 - GPNMB_MOUSE

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Protein

Transmembrane glycoprotein NMB

Gene
Gpnmb, Dchil, Hgfin, Nmb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could be a melanogenic enzyme By similarity.

GO - Molecular functioni

  1. heparin binding Source: MGI
  2. integrin binding Source: MGI

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell adhesion Source: MGI
  3. osteoblast differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane glycoprotein NMB
Alternative name(s):
DC-HIL
Dendritic cell-associated transmembrane protein
Osteoactivin
Gene namesi
Name:Gpnmb
Synonyms:Dchil, Hgfin, Nmb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1934765. Gpnmb.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Endomembrane system; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome By similarity
Note: Vesicular, endosomal like structures.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 502480Extracellular Reviewed predictionAdd
BLAST
Transmembranei503 – 52321Helical; Reviewed predictionAdd
BLAST
Topological domaini524 – 57451Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: MGI
  2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  3. endomembrane system Source: UniProtKB-SubCell
  4. integral component of plasma membrane Source: MGI
  5. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Involvement in diseasei

May promote bone metastatic phenotype when overexpressed in breast cancer cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 574552Transmembrane glycoprotein NMBPRO_0000024710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi275 – 2751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi463 – 4631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi471 – 4711N-linked (GlcNAc...) Reviewed prediction
Modified residuei546 – 5461Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99P91.
PRIDEiQ99P91.

PTM databases

PhosphoSiteiQ99P91.

Expressioni

Tissue specificityi

In early development, mRNA is detected at high levels in the outer layer of the retina. Later in development expression gets restricted to the retinal pigment epithelium and iris. Overexpressed in mammary cancer cells possessing a strong bone metastatic phenotype.1 Publication

Gene expression databases

ArrayExpressiQ99P91.
BgeeiQ99P91.
CleanExiMM_GPNMB.
MM_NMB.
GenevestigatoriQ99P91.

Interactioni

Protein-protein interaction databases

IntActiQ99P91. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99P91.
SMRiQ99P91. Positions 258-320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini250 – 33889PKDAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi558 – 5603Cell attachment site Reviewed prediction

Sequence similaritiesi

Belongs to the PMEL/NMB family.
Contains 1 PKD domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40272.
GeneTreeiENSGT00530000063573.
HOGENOMiHOG000252941.
HOVERGENiHBG051797.
InParanoidiQ3U3R9.
OMAiHTYVLNG.
OrthoDBiEOG7GXPB9.
TreeFamiTF334865.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
[Graphical view]
SMARTiSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P91-1 [UniParc]FASTAAdd to Basket

« Hide

MESLCGVLGF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE HNQLRGWSSD    50
ENEWDEHLYP VWRRGDGRWK DSWEGGRVQA VLTSDSPALV GSNITFVVNL 100
VFPRCQKEDA NGNIVYEKNC RNDLGLTSDL HVYNWTAGAD DGDWEDGTSR 150
SQHLRFPDRR PFPRPHGWKK WSFVYVFHTL GQYFQKLGRC SARVSINTVN 200
LTAGPQVMEV TVFRRYGRAY IPISKVKDVY VITDQIPVFV TMSQKNDRNL 250
SDEIFLRDLP IVFDVLIHDP SHFLNDSAIS YKWNFGDNTG LFVSNNHTLN 300
HTYVLNGTFN LNLTVQTAVP GPCPPPSPST PPPPSTPPSP PPSPLPTLST 350
PSPSLMPTGY KSMELSDISN ENCRINRYGY FRATITIVEG ILEVSIMQIA 400
DVPMPTPQPA NSLMDFTVTC KGATPMEACT IISDPTCQIA QNRVCSPVAV 450
DGLCLLSVRR AFNGSGTYCV NFTLGDDASL ALTSTLISIP GKDPDSPLRA 500
VNGVLISIGC LAVLVTMVTI LLYKKHKAYK PIGNCPRNTV KGKGLSVLLS 550
HAKAPFFRGD QEKDPLLQDK PRTL 574
Length:574
Mass (Da):63,676
Last modified:July 27, 2011 - v2
Checksum:iB6AE99DD5DB7C6D0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361D → N in AAK14240. 1 Publication
Sequence conflicti36 – 361D → N in BAC32074. 1 Publication
Sequence conflicti36 – 361D → N in AAH26375. 1 Publication
Sequence conflicti333 – 3331P → S in CAB65272. 1 Publication
Sequence conflicti339 – 3413SPP → LPS in CAB65272. 1 Publication
Sequence conflicti498 – 4981L → M in BAC32074. 1 Publication
Sequence conflicti541 – 5411K → E in BAC32074. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322054 mRNA. Translation: AAK14240.1.
AJ251685 mRNA. Translation: CAB65272.1.
AK044764 mRNA. Translation: BAC32074.1.
AK076347 mRNA. Translation: BAC36306.1.
AK150739 mRNA. Translation: BAE29813.1.
AK154617 mRNA. Translation: BAE32716.1.
AK170506 mRNA. Translation: BAE41844.1.
AK171441 mRNA. Translation: BAE42454.1.
AK171465 mRNA. Translation: BAE42471.1.
AK171474 mRNA. Translation: BAE42479.1.
AK171517 mRNA. Translation: BAE42501.1.
BC026375 mRNA. Translation: AAH26375.1.
CCDSiCCDS20122.1.
RefSeqiNP_444340.3. NM_053110.4.
UniGeneiMm.302602.

Genome annotation databases

EnsembliENSMUST00000031840; ENSMUSP00000031840; ENSMUSG00000029816.
GeneIDi93695.
KEGGimmu:93695.
UCSCiuc012elo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322054 mRNA. Translation: AAK14240.1 .
AJ251685 mRNA. Translation: CAB65272.1 .
AK044764 mRNA. Translation: BAC32074.1 .
AK076347 mRNA. Translation: BAC36306.1 .
AK150739 mRNA. Translation: BAE29813.1 .
AK154617 mRNA. Translation: BAE32716.1 .
AK170506 mRNA. Translation: BAE41844.1 .
AK171441 mRNA. Translation: BAE42454.1 .
AK171465 mRNA. Translation: BAE42471.1 .
AK171474 mRNA. Translation: BAE42479.1 .
AK171517 mRNA. Translation: BAE42501.1 .
BC026375 mRNA. Translation: AAH26375.1 .
CCDSi CCDS20122.1.
RefSeqi NP_444340.3. NM_053110.4.
UniGenei Mm.302602.

3D structure databases

ProteinModelPortali Q99P91.
SMRi Q99P91. Positions 258-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99P91. 1 interaction.

PTM databases

PhosphoSitei Q99P91.

Proteomic databases

MaxQBi Q99P91.
PRIDEi Q99P91.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031840 ; ENSMUSP00000031840 ; ENSMUSG00000029816 .
GeneIDi 93695.
KEGGi mmu:93695.
UCSCi uc012elo.1. mouse.

Organism-specific databases

CTDi 10457.
MGIi MGI:1934765. Gpnmb.

Phylogenomic databases

eggNOGi NOG40272.
GeneTreei ENSGT00530000063573.
HOGENOMi HOG000252941.
HOVERGENi HBG051797.
InParanoidi Q3U3R9.
OMAi HTYVLNG.
OrthoDBi EOG7GXPB9.
TreeFami TF334865.

Miscellaneous databases

ChiTaRSi GPNMB. mouse.
NextBioi 351449.
PROi Q99P91.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99P91.
Bgeei Q99P91.
CleanExi MM_GPNMB.
MM_NMB.
Genevestigatori Q99P91.

Family and domain databases

Gene3Di 2.60.40.670. 1 hit.
InterProi IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view ]
Pfami PF00801. PKD. 1 hit.
[Graphical view ]
SMARTi SM00089. PKD. 1 hit.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 1 hit.
PROSITEi PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans."
    Shikano S., Bonkobara M., Zukas P.K., Ariizumi K.
    J. Biol. Chem. 276:8125-8134(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "mRNA expression of the murine glycoprotein (transmembrane) nmb (Gpnmb) gene is linked to the developing retinal pigment epithelium and iris."
    Bachner D., Schroder D., Gross G.
    Gene Expr. Patterns 1:159-165(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Retina and Skin.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  5. Cited for: DISEASE.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPNMB_MOUSE
AccessioniPrimary (citable) accession number: Q99P91
Secondary accession number(s): Q3U3R9
, Q8BVV9, Q8BXL4, Q9QXA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi