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Protein

Nuclear pore complex protein Nup155

Gene

Nup155

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • atrial cardiac muscle cell action potential Source: MGI
  • mRNA export from nucleus Source: MGI
  • nuclear envelope organization Source: MGI
  • protein import into nucleus Source: MGI
  • protein localization to nuclear inner membrane Source: GO_Central
  • transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery Source: GO_Central

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup155
Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155
Gene namesi
Name:Nup155
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2181182 Nup155

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Disruption phenotypei

Homozygous null mice die before embryonic day 8.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048451 – 1391Nuclear pore complex protein Nup155Add BLAST1391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi526O-linked (GlcNAc) serineBy similarity1
Modified residuei1057PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).By similarity
Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99P88
MaxQBiQ99P88
PaxDbiQ99P88
PRIDEiQ99P88

PTM databases

CarbonylDBiQ99P88
iPTMnetiQ99P88
PhosphoSitePlusiQ99P88
SwissPalmiQ99P88

Expressioni

Gene expression databases

BgeeiENSMUSG00000022142
CleanExiMM_NUP155
GenevisibleiQ99P88 MM

Interactioni

Subunit structurei

Interacts with GLE1 and NUP35/NUP53. Able to form a heterotrimer with GLE1 and NUPL2 in vitro (By similarity). Forms a complex with NUP35, NUP93, NUP205 and lamin B (By similarity).By similarity

Protein-protein interaction databases

BioGridi228424, 26 interactors
IntActiQ99P88, 24 interactors
MINTiQ99P88
STRINGi10090.ENSMUSP00000128819

Structurei

3D structure databases

ProteinModelPortaliQ99P88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi585 – 655Pro-richAdd BLAST71

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1900 Eukaryota
COG5308 LUCA
GeneTreeiENSGT00390000016532
HOVERGENiHBG052680
InParanoidiQ99P88
KOiK14312
OMAiTRYVENP
OrthoDBiEOG091G00T9
PhylomeDBiQ99P88
TreeFamiTF105951

Family and domain databases

InterProiView protein in InterPro
IPR007187 Nucleoporin_Nup133/Nup155_C
IPR014908 Nucleoporin_Nup133/Nup155_N
IPR004870 Nucleoporin_Nup155
PANTHERiPTHR10350 PTHR10350, 1 hit
PfamiView protein in Pfam
PF03177 Nucleoporin_C, 1 hit
PF08801 Nucleoporin_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q99P88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVLGSMMV ASTSAAASLQ EALENAGRLI DRQLQEDRMY PDLSELLMVS
60 70 80 90 100
APNSPTVSGM SDMDYPLQGP GLLSVPSLPE ISTIRRVPLP PELVEQFGHM
110 120 130 140 150
QCNCMMGVFP PISRAWLTID SDIFMWNYED GGDLAYFDGL SETILAVGLV
160 170 180 190 200
KPKAGIFQPH VRHLLVLATP VDIVILGLSY ANVQTGSGIL NDSMCGGMQL
210 220 230 240 250
LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY QAEAGWFSQR
260 270 280 290 300
CRKINHSKSS LSFLVPSLLQ FTFSEDDPIV QIEIDNSRNI LYTRSEKGVI
310 320 330 340 350
QVYDLGHDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIES
360 370 380 390 400
SESLDCQLLA VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS
410 420 430 440 450
TVEKPSKVHK ALYSKGILLM TASENEDNDI LWCVNHDTFP FQKPMMETQM
460 470 480 490 500
TTRVDGHSWA LSAIDELKVD KIITPLNKDH IPITDSPVVV QQHMLPPKKF
510 520 530 540 550
VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK LHQEDQACAT
560 570 580 590 600
CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPATLPT PSNVGPILGS
610 620 630 640 650
PMYSSSPVPS GSPYPNPSSL GTPSHGAQPP TMSTPMCAVG SPAMQAASMS
660 670 680 690 700
GLTGPEIVYS GKHNGICIYF SRIMGNIWDA SLVVERVFKS SNREITAIES
710 720 730 740 750
SVPVQLLESV LQELKGLQEF LDRNSQFSGG PLGNPNTTAR VQQRLVGFMR
760 770 780 790 800
PENGNTQQMQ QELQRKFQEA QLSEKISLQA IQQLVRKSYQ ALALWKLLCE
810 820 830 840 850
HQFSVIVGEL QKEFQEQLKI TTFKDLVIRD KEVTGALIAS LINCYIRDNA
860 870 880 890 900
AVDGISLHLQ DTCPLLYSTD DAVCSKANEL LQRSRQVQSK TERERMLRES
910 920 930 940 950
LKEYQKISNQ VDLPSVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY
960 970 980 990 1000
KHGEPEEDVV GLQTFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG
1010 1020 1030 1040 1050
PPVLSSDPNM LSNEEAGHHF EQMLKLAQRS KDELFSIALY NWLIQADLAD
1060 1070 1080 1090 1100
KLLQIASPFL EPHLVRMARV DQNRVRYMDL LWRYYEKNRS FSSAARVLSK
1110 1120 1130 1140 1150
LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF LHELEEKMEV
1160 1170 1180 1190 1200
ARIQLQIQET LQRQYSHHSS VQDAISQLDS ELMDITKLYG EFADPFKLAE
1210 1220 1230 1240 1250
CKLAVIHCAG YSDPILVHTL WQDIIEKELN DSVALSSSDR MHALSLKLVL
1260 1270 1280 1290 1300
LGKIYAGTPR FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL
1310 1320 1330 1340 1350
EVYDQLFKSR DPFWNRVKSP LHLLDCIHVL LTRYVENPSL VLNCERRRFT
1360 1370 1380 1390
NLCLDAVCGY LVELQSMSSS VAVQAITGNF KSLQAKLERL H
Length:1,391
Mass (Da):155,118
Last modified:June 1, 2001 - v1
Checksum:iA8F9BE2E25653F32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322375 mRNA Translation: AAK11317.1
CCDSiCCDS37034.1
RefSeqiNP_573490.3, NM_133227.3
UniGeneiMm.295168

Genome annotation databases

EnsembliENSMUST00000163765; ENSMUSP00000128819; ENSMUSG00000022142
GeneIDi170762
KEGGimmu:170762
UCSCiuc007vei.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNU155_MOUSE
AccessioniPrimary (citable) accession number: Q99P88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health