Q99P87 (RETN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Resistin

Alternative name(s):
Adipose tissue-specific secretory factor
Short name=ADSF
Adipose-specific cysteine-rich secreted protein A12-alpha
Cysteine-rich secreted protein FIZZ3

Gene names

Name:	Retn
Synonyms:	Fizz3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Subunit structure	Homodimer; disulfide-linked. Ref.4 Ref.5
Subcellular location	Secreted.
Tissue specificity	Expressed in white but not brown adipose tissue in a variety of organs.
Sequence similarities	Belongs to the resistin/FIZZ family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Diabetes mellitus Obesity
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	fat cell differentiation Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from direct assay PubMed 17693256. Source: MGI nucleus Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Chain

21 – 114

94

Resistin

PRO_0000030342

Amino acid modifications

Disulfide bond

26

Interchain Probable

Disulfide bond

55 ↔ 108

Ref.5

Disulfide bond

67 ↔ 107

Ref.5

Disulfide bond

76 ↔ 93

Ref.5

Disulfide bond

78 ↔ 95

Ref.5

Disulfide bond

82 ↔ 97

Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

114

Helix Strand Turn

Details...

Helix

28 – 48

21

Beta strand

51 – 66

16

Beta strand

72 – 79

8

Beta strand

85 – 88

4

Turn

89 – 91

3

Beta strand

92 – 95

4

Beta strand

101 – 112

12

Sequences

	Sequence		Length	Mass (Da)
	Q99P87 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D44930E51D3F22C8	FASTA	114	12,492
	10 20 30 40 50 60 MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN IGLNCWTVSS 70 80 90 100 110 RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI DWTAARCCKL QVAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The hormone resistin links obesity to diabetes." Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., Lazar M.A. Nature 409:307-312(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
[2]	"Identification of a novel adipose-specific cysteine-rich secreted protein." Rajala M.W., Scherer P.E. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[4]	"Dimerization of resistin and resistin-like molecules is determined by a single cysteine." Banerjee R.R., Lazar M.A. J. Biol. Chem. 276:25970-25973(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[5]	"Disulfide-dependent multimeric assembly of resistin family hormones." Patel S.D., Rajala M.W., Rossetti L., Scherer P.E., Shapiro L. Science 304:1154-1158(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-114, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF323080 mRNA. Translation: AAG59823.1.
AF290870 mRNA. Translation: AAK83102.1.
BC051196 mRNA. Translation: AAH51196.1.

IPI

IPI00120465.

RefSeq

NP_001191888.1. NM_001204959.1.
NP_075360.1. NM_022984.4.

UniGene

Mm.1181.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RFX	X-ray	2.00	A/B/C	21-114	[»]
1RGX	X-ray	1.79	A/B/C	1-114	[»]

ProteinModelPortal

Q99P87.

SMR

Q99P87. Positions 21-114.

ModBase

Search...

Proteomic databases

PaxDb

Q99P87.

PRIDE

Q99P87.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.

GeneID

57264.

KEGG

mmu:57264.

UCSC

uc009ksg.2. mouse.

Organism-specific databases

CTD

56729.

MGI

MGI:1888506. Retn.

Phylogenomic databases

eggNOG

NOG46608.

GeneTree

ENSGT00390000016177.

HOGENOM

HOG000137607.

HOVERGEN

HBG018297.

InParanoid

Q99P87.

KO

K13438.

OMA

CQSVTSR.

OrthoDB

EOG45TCPP.

Gene expression databases

ArrayExpress

Q99P87.

Bgee

Q99P87.

CleanEx

MM_RETN.

Genevestigator

Q99P87.

GermOnline

ENSMUSG00000012705. Mus musculus.

Family and domain databases

InterPro

IPR009714. Resistin.
[Graphical view]

PANTHER

PTHR21101. PTHR21101. 1 hit.

Pfam

PF06954. Resistin. 1 hit.
[Graphical view]

SUPFAM

SSF111423. Resistin. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q99P87.

NextBio

313591.

SOURCE

Search...

Entry information

Entry name

RETN_MOUSE

Accession

Primary (citable) accession number: Q99P87

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program