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Q99P87 (RETN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name=ADSF
Adipose-specific cysteine-rich secreted protein A12-alpha
Cysteine-rich secreted protein FIZZ3
Gene names
Name:Retn
Synonyms:Fizz3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

Subunit structure

Homodimer; disulfide-linked. Ref.4 Ref.5

Subcellular location

Secreted.

Tissue specificity

Expressed in white but not brown adipose tissue in a variety of organs.

Sequence similarities

Belongs to the resistin/FIZZ family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 11494Resistin
PRO_0000030342

Amino acid modifications

Disulfide bond26Interchain Probable
Disulfide bond55 ↔ 108 Ref.5
Disulfide bond67 ↔ 107 Ref.5
Disulfide bond76 ↔ 93 Ref.5
Disulfide bond78 ↔ 95 Ref.5
Disulfide bond82 ↔ 97 Ref.5

Secondary structure

............. 114
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q99P87 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D44930E51D3F22C8

FASTA11412,492
        10         20         30         40         50         60 
MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN IGLNCWTVSS 

        70         80         90        100        110 
RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI DWTAARCCKL QVAS 

« Hide

References

« Hide 'large scale' references
[1]"The hormone resistin links obesity to diabetes."
Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., Lazar M.A.
Nature 409:307-312(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
[2]"Identification of a novel adipose-specific cysteine-rich secreted protein."
Rajala M.W., Scherer P.E.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[4]"Dimerization of resistin and resistin-like molecules is determined by a single cysteine."
Banerjee R.R., Lazar M.A.
J. Biol. Chem. 276:25970-25973(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[5]"Disulfide-dependent multimeric assembly of resistin family hormones."
Patel S.D., Rajala M.W., Rossetti L., Scherer P.E., Shapiro L.
Science 304:1154-1158(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-114, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF323080 mRNA. Translation: AAG59823.1.
AF290870 mRNA. Translation: AAK83102.1.
BC051196 mRNA. Translation: AAH51196.1.
RefSeqNP_001191888.1. NM_001204959.1.
NP_075360.1. NM_022984.4.
XP_006508909.1. XM_006508846.1.
UniGeneMm.1181.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RFXX-ray2.00A/B/C21-114[»]
1RGXX-ray1.79A/B/C1-114[»]
ProteinModelPortalQ99P87.
SMRQ99P87. Positions 21-114.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ99P87.
PRIDEQ99P87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.
GeneID57264.
KEGGmmu:57264.
UCSCuc009ksg.2. mouse.

Organism-specific databases

CTD56729.
MGIMGI:1888506. Retn.

Phylogenomic databases

eggNOGNOG46608.
GeneTreeENSGT00390000016177.
HOGENOMHOG000137607.
HOVERGENHBG018297.
InParanoidQ99P87.
KOK13438.
OMACQSVTSR.
OrthoDBEOG7CVQ14.
PhylomeDBQ99P87.
TreeFamTF337024.

Gene expression databases

ArrayExpressQ99P87.
BgeeQ99P87.
CleanExMM_RETN.
GenevestigatorQ99P87.

Family and domain databases

InterProIPR009714. Resistin.
[Graphical view]
PANTHERPTHR21101. PTHR21101. 1 hit.
PfamPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMSSF111423. SSF111423. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ99P87.
NextBio313591.
PROQ99P87.
SOURCESearch...

Entry information

Entry nameRETN_MOUSE
AccessionPrimary (citable) accession number: Q99P87
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot