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Protein

Resistin

Gene

Retn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name:
ADSF
Adipose-specific cysteine-rich secreted protein A12-alpha
Cysteine-rich secreted protein FIZZ3
Gene namesi
Name:Retn
Synonyms:Fizz3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1888506. Retn.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003034221 – 114ResistinAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26Interchain1 Publication
Disulfide bondi55 ↔ 1081 Publication
Disulfide bondi67 ↔ 1071 Publication
Disulfide bondi76 ↔ 931 Publication
Disulfide bondi78 ↔ 951 Publication
Disulfide bondi82 ↔ 971 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ99P87.
PaxDbiQ99P87.
PeptideAtlasiQ99P87.
PRIDEiQ99P87.

Expressioni

Tissue specificityi

Expressed in white but not brown adipose tissue in a variety of organs.

Gene expression databases

BgeeiENSMUSG00000012705.
CleanExiMM_RETN.
ExpressionAtlasiQ99P87. baseline and differential.
GenevisibleiQ99P87. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012849.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 48Combined sources21
Beta strandi51 – 66Combined sources16
Beta strandi72 – 79Combined sources8
Beta strandi85 – 88Combined sources4
Turni89 – 91Combined sources3
Beta strandi92 – 95Combined sources4
Beta strandi101 – 112Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RFXX-ray2.00A/B/C21-114[»]
1RGXX-ray1.79A/B/C1-114[»]
ProteinModelPortaliQ99P87.
SMRiQ99P87.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99P87.

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J40Z. Eukaryota.
ENOG410ZE8R. LUCA.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ99P87.
KOiK13438.
OMAiSCTCGSA.
OrthoDBiEOG091G112J.
PhylomeDBiQ99P87.
TreeFamiTF337024.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN
60 70 80 90 100
IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI
110
DWTAARCCKL QVAS
Length:114
Mass (Da):12,492
Last modified:June 1, 2001 - v1
Checksum:iD44930E51D3F22C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323080 mRNA. Translation: AAG59823.1.
AF290870 mRNA. Translation: AAK83102.1.
BC051196 mRNA. Translation: AAH51196.1.
CCDSiCCDS22068.1.
RefSeqiNP_001191888.1. NM_001204959.1.
NP_075360.1. NM_022984.4.
UniGeneiMm.1181.

Genome annotation databases

EnsembliENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.
GeneIDi57264.
KEGGimmu:57264.
UCSCiuc009ksg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323080 mRNA. Translation: AAG59823.1.
AF290870 mRNA. Translation: AAK83102.1.
BC051196 mRNA. Translation: AAH51196.1.
CCDSiCCDS22068.1.
RefSeqiNP_001191888.1. NM_001204959.1.
NP_075360.1. NM_022984.4.
UniGeneiMm.1181.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RFXX-ray2.00A/B/C21-114[»]
1RGXX-ray1.79A/B/C1-114[»]
ProteinModelPortaliQ99P87.
SMRiQ99P87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012849.

Proteomic databases

MaxQBiQ99P87.
PaxDbiQ99P87.
PeptideAtlasiQ99P87.
PRIDEiQ99P87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.
GeneIDi57264.
KEGGimmu:57264.
UCSCiuc009ksg.2. mouse.

Organism-specific databases

CTDi56729.
MGIiMGI:1888506. Retn.

Phylogenomic databases

eggNOGiENOG410J40Z. Eukaryota.
ENOG410ZE8R. LUCA.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ99P87.
KOiK13438.
OMAiSCTCGSA.
OrthoDBiEOG091G112J.
PhylomeDBiQ99P87.
TreeFamiTF337024.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiQ99P87.
PROiQ99P87.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012705.
CleanExiMM_RETN.
ExpressionAtlasiQ99P87. baseline and differential.
GenevisibleiQ99P87. MM.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRETN_MOUSE
AccessioniPrimary (citable) accession number: Q99P87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.