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Q99P87

- RETN_MOUSE

UniProt

Q99P87 - RETN_MOUSE

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Protein

Resistin

Gene

Retn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

GO - Biological processi

  1. aging Source: Ensembl
  2. fat cell differentiation Source: Ensembl
  3. negative regulation of feeding behavior Source: Ensembl
  4. positive regulation of collagen metabolic process Source: Ensembl
  5. positive regulation of progesterone secretion Source: Ensembl
  6. positive regulation of smooth muscle cell migration Source: Ensembl
  7. positive regulation of smooth muscle cell proliferation Source: Ensembl
  8. positive regulation of synaptic transmission Source: Ensembl
  9. response to insulin Source: Ensembl
  10. response to mechanical stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name:
ADSF
Adipose-specific cysteine-rich secreted protein A12-alpha
Cysteine-rich secreted protein FIZZ3
Gene namesi
Name:Retn
Synonyms:Fizz3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1888506. Retn.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 11494ResistinPRO_0000030342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 – 26Interchain1 Publication
Disulfide bondi55 ↔ 1081 Publication
Disulfide bondi67 ↔ 1071 Publication
Disulfide bondi76 ↔ 931 Publication
Disulfide bondi78 ↔ 951 Publication
Disulfide bondi82 ↔ 971 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ99P87.
PaxDbiQ99P87.
PRIDEiQ99P87.

Expressioni

Tissue specificityi

Expressed in white but not brown adipose tissue in a variety of organs.

Gene expression databases

BgeeiQ99P87.
CleanExiMM_RETN.
ExpressionAtlasiQ99P87. baseline and differential.
GenevestigatoriQ99P87.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 4821
Beta strandi51 – 6616
Beta strandi72 – 798
Beta strandi85 – 884
Turni89 – 913
Beta strandi92 – 954
Beta strandi101 – 11212

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RFXX-ray2.00A/B/C21-114[»]
1RGXX-ray1.79A/B/C1-114[»]
ProteinModelPortaliQ99P87.
SMRiQ99P87. Positions 21-114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99P87.

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46608.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ99P87.
KOiK13438.
OMAiCQCARID.
OrthoDBiEOG7CVQ14.
PhylomeDBiQ99P87.
TreeFamiTF337024.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN
60 70 80 90 100
IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI
110
DWTAARCCKL QVAS
Length:114
Mass (Da):12,492
Last modified:June 1, 2001 - v1
Checksum:iD44930E51D3F22C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323080 mRNA. Translation: AAG59823.1.
AF290870 mRNA. Translation: AAK83102.1.
BC051196 mRNA. Translation: AAH51196.1.
CCDSiCCDS22068.1.
RefSeqiNP_001191888.1. NM_001204959.1.
NP_075360.1. NM_022984.4.
XP_006508909.1. XM_006508846.1.
UniGeneiMm.1181.

Genome annotation databases

EnsembliENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.
GeneIDi57264.
KEGGimmu:57264.
UCSCiuc009ksg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323080 mRNA. Translation: AAG59823.1 .
AF290870 mRNA. Translation: AAK83102.1 .
BC051196 mRNA. Translation: AAH51196.1 .
CCDSi CCDS22068.1.
RefSeqi NP_001191888.1. NM_001204959.1.
NP_075360.1. NM_022984.4.
XP_006508909.1. XM_006508846.1.
UniGenei Mm.1181.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1RFX X-ray 2.00 A/B/C 21-114 [» ]
1RGX X-ray 1.79 A/B/C 1-114 [» ]
ProteinModelPortali Q99P87.
SMRi Q99P87. Positions 21-114.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q99P87.
PaxDbi Q99P87.
PRIDEi Q99P87.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012849 ; ENSMUSP00000012849 ; ENSMUSG00000012705 .
ENSMUST00000169234 ; ENSMUSP00000133024 ; ENSMUSG00000012705 .
GeneIDi 57264.
KEGGi mmu:57264.
UCSCi uc009ksg.2. mouse.

Organism-specific databases

CTDi 56729.
MGIi MGI:1888506. Retn.

Phylogenomic databases

eggNOGi NOG46608.
GeneTreei ENSGT00390000016177.
HOGENOMi HOG000137607.
HOVERGENi HBG018297.
InParanoidi Q99P87.
KOi K13438.
OMAi CQCARID.
OrthoDBi EOG7CVQ14.
PhylomeDBi Q99P87.
TreeFami TF337024.

Miscellaneous databases

EvolutionaryTracei Q99P87.
NextBioi 313591.
PROi Q99P87.
SOURCEi Search...

Gene expression databases

Bgeei Q99P87.
CleanExi MM_RETN.
ExpressionAtlasi Q99P87. baseline and differential.
Genevestigatori Q99P87.

Family and domain databases

InterProi IPR009714. Resistin.
[Graphical view ]
PANTHERi PTHR21101. PTHR21101. 1 hit.
Pfami PF06954. Resistin. 1 hit.
[Graphical view ]
SUPFAMi SSF111423. SSF111423. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
  2. "Identification of a novel adipose-specific cysteine-rich secreted protein."
    Rajala M.W., Scherer P.E.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "Dimerization of resistin and resistin-like molecules is determined by a single cysteine."
    Banerjee R.R., Lazar M.A.
    J. Biol. Chem. 276:25970-25973(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  5. "Disulfide-dependent multimeric assembly of resistin family hormones."
    Patel S.D., Rajala M.W., Rossetti L., Scherer P.E., Shapiro L.
    Science 304:1154-1158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-114, DISULFIDE BONDS.

Entry informationi

Entry nameiRETN_MOUSE
AccessioniPrimary (citable) accession number: Q99P87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3