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Q99P87

- RETN_MOUSE

UniProt

Q99P87 - RETN_MOUSE

Protein

Resistin

Gene

Retn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

    GO - Biological processi

    1. aging Source: Ensembl
    2. fat cell differentiation Source: Ensembl
    3. negative regulation of feeding behavior Source: Ensembl
    4. positive regulation of collagen metabolic process Source: Ensembl
    5. positive regulation of progesterone secretion Source: Ensembl
    6. positive regulation of smooth muscle cell migration Source: Ensembl
    7. positive regulation of smooth muscle cell proliferation Source: Ensembl
    8. positive regulation of synaptic transmission Source: Ensembl
    9. response to insulin Source: Ensembl
    10. response to mechanical stimulus Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Resistin
    Alternative name(s):
    Adipose tissue-specific secretory factor
    Short name:
    ADSF
    Adipose-specific cysteine-rich secreted protein A12-alpha
    Cysteine-rich secreted protein FIZZ3
    Gene namesi
    Name:Retn
    Synonyms:Fizz3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1888506. Retn.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: MGI
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Diabetes mellitus, Obesity

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 11494ResistinPRO_0000030342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 – 26Interchain1 Publication
    Disulfide bondi55 ↔ 1081 Publication
    Disulfide bondi67 ↔ 1071 Publication
    Disulfide bondi76 ↔ 931 Publication
    Disulfide bondi78 ↔ 951 Publication
    Disulfide bondi82 ↔ 971 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ99P87.
    PaxDbiQ99P87.
    PRIDEiQ99P87.

    Expressioni

    Tissue specificityi

    Expressed in white but not brown adipose tissue in a variety of organs.

    Gene expression databases

    ArrayExpressiQ99P87.
    BgeeiQ99P87.
    CleanExiMM_RETN.
    GenevestigatoriQ99P87.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.2 Publications

    Structurei

    Secondary structure

    1
    114
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi28 – 4821
    Beta strandi51 – 6616
    Beta strandi72 – 798
    Beta strandi85 – 884
    Turni89 – 913
    Beta strandi92 – 954
    Beta strandi101 – 11212

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RFXX-ray2.00A/B/C21-114[»]
    1RGXX-ray1.79A/B/C1-114[»]
    ProteinModelPortaliQ99P87.
    SMRiQ99P87. Positions 21-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99P87.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the resistin/FIZZ family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46608.
    GeneTreeiENSGT00390000016177.
    HOGENOMiHOG000137607.
    HOVERGENiHBG018297.
    InParanoidiQ99P87.
    KOiK13438.
    OMAiCQCARID.
    OrthoDBiEOG7CVQ14.
    PhylomeDBiQ99P87.
    TreeFamiTF337024.

    Family and domain databases

    InterProiIPR009714. Resistin.
    [Graphical view]
    PANTHERiPTHR21101. PTHR21101. 1 hit.
    PfamiPF06954. Resistin. 1 hit.
    [Graphical view]
    SUPFAMiSSF111423. SSF111423. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99P87-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN    50
    IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI 100
    DWTAARCCKL QVAS 114
    Length:114
    Mass (Da):12,492
    Last modified:June 1, 2001 - v1
    Checksum:iD44930E51D3F22C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323080 mRNA. Translation: AAG59823.1.
    AF290870 mRNA. Translation: AAK83102.1.
    BC051196 mRNA. Translation: AAH51196.1.
    CCDSiCCDS22068.1.
    RefSeqiNP_001191888.1. NM_001204959.1.
    NP_075360.1. NM_022984.4.
    XP_006508909.1. XM_006508846.1.
    UniGeneiMm.1181.

    Genome annotation databases

    EnsembliENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
    ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.
    GeneIDi57264.
    KEGGimmu:57264.
    UCSCiuc009ksg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323080 mRNA. Translation: AAG59823.1 .
    AF290870 mRNA. Translation: AAK83102.1 .
    BC051196 mRNA. Translation: AAH51196.1 .
    CCDSi CCDS22068.1.
    RefSeqi NP_001191888.1. NM_001204959.1.
    NP_075360.1. NM_022984.4.
    XP_006508909.1. XM_006508846.1.
    UniGenei Mm.1181.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RFX X-ray 2.00 A/B/C 21-114 [» ]
    1RGX X-ray 1.79 A/B/C 1-114 [» ]
    ProteinModelPortali Q99P87.
    SMRi Q99P87. Positions 21-114.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q99P87.
    PaxDbi Q99P87.
    PRIDEi Q99P87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000012849 ; ENSMUSP00000012849 ; ENSMUSG00000012705 .
    ENSMUST00000169234 ; ENSMUSP00000133024 ; ENSMUSG00000012705 .
    GeneIDi 57264.
    KEGGi mmu:57264.
    UCSCi uc009ksg.2. mouse.

    Organism-specific databases

    CTDi 56729.
    MGIi MGI:1888506. Retn.

    Phylogenomic databases

    eggNOGi NOG46608.
    GeneTreei ENSGT00390000016177.
    HOGENOMi HOG000137607.
    HOVERGENi HBG018297.
    InParanoidi Q99P87.
    KOi K13438.
    OMAi CQCARID.
    OrthoDBi EOG7CVQ14.
    PhylomeDBi Q99P87.
    TreeFami TF337024.

    Miscellaneous databases

    EvolutionaryTracei Q99P87.
    NextBioi 313591.
    PROi Q99P87.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99P87.
    Bgeei Q99P87.
    CleanExi MM_RETN.
    Genevestigatori Q99P87.

    Family and domain databases

    InterProi IPR009714. Resistin.
    [Graphical view ]
    PANTHERi PTHR21101. PTHR21101. 1 hit.
    Pfami PF06954. Resistin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111423. SSF111423. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    2. "Identification of a novel adipose-specific cysteine-rich secreted protein."
      Rajala M.W., Scherer P.E.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "Dimerization of resistin and resistin-like molecules is determined by a single cysteine."
      Banerjee R.R., Lazar M.A.
      J. Biol. Chem. 276:25970-25973(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    5. "Disulfide-dependent multimeric assembly of resistin family hormones."
      Patel S.D., Rajala M.W., Rossetti L., Scherer P.E., Shapiro L.
      Science 304:1154-1158(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-114, DISULFIDE BONDS.

    Entry informationi

    Entry nameiRETN_MOUSE
    AccessioniPrimary (citable) accession number: Q99P87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3