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Protein

Resistin

Gene

Retn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name:
ADSF
Adipose-specific cysteine-rich secreted protein A12-alpha
Cysteine-rich secreted protein FIZZ3
Gene namesi
Name:Retn
Synonyms:Fizz3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1888506 Retn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003034221 – 114ResistinAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26Interchain1 Publication
Disulfide bondi55 ↔ 1081 Publication
Disulfide bondi67 ↔ 1071 Publication
Disulfide bondi76 ↔ 931 Publication
Disulfide bondi78 ↔ 951 Publication
Disulfide bondi82 ↔ 971 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ99P87
PaxDbiQ99P87
PeptideAtlasiQ99P87
PRIDEiQ99P87

Expressioni

Tissue specificityi

Expressed in white but not brown adipose tissue in a variety of organs.1 Publication

Gene expression databases

BgeeiENSMUSG00000012705
CleanExiMM_RETN
ExpressionAtlasiQ99P87 baseline and differential
GenevisibleiQ99P87 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ99P87
STRINGi10090.ENSMUSP00000012849

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 48Combined sources21
Beta strandi51 – 66Combined sources16
Beta strandi72 – 79Combined sources8
Beta strandi85 – 88Combined sources4
Turni89 – 91Combined sources3
Beta strandi92 – 95Combined sources4
Beta strandi101 – 112Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RFXX-ray2.00A/B/C21-114[»]
1RGXX-ray1.79A/B/C1-114[»]
ProteinModelPortaliQ99P87
SMRiQ99P87
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99P87

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J40Z Eukaryota
ENOG410ZE8R LUCA
GeneTreeiENSGT00390000016177
HOGENOMiHOG000137607
HOVERGENiHBG018297
InParanoidiQ99P87
KOiK13438
OMAiLECQSVT
OrthoDBiEOG091G112J
PhylomeDBiQ99P87
TreeFamiTF337024

Family and domain databases

CDDicd16333 RELM, 1 hit
Gene3Di3.30.1660.20, 1 hit
InterProiView protein in InterPro
IPR009714 Resistin
IPR036262 Resistin-like_sf
PANTHERiPTHR21101 PTHR21101, 1 hit
PfamiView protein in Pfam
PF06954 Resistin, 1 hit
SUPFAMiSSF111423 SSF111423, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN
60 70 80 90 100
IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI
110
DWTAARCCKL QVAS
Length:114
Mass (Da):12,492
Last modified:June 1, 2001 - v1
Checksum:iD44930E51D3F22C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323080 mRNA Translation: AAG59823.1
AF290870 mRNA Translation: AAK83102.1
BC051196 mRNA Translation: AAH51196.1
CCDSiCCDS22068.1
RefSeqiNP_001191888.1, NM_001204959.1
NP_075360.1, NM_022984.4
UniGeneiMm.1181

Genome annotation databases

EnsembliENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705
ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705
GeneIDi57264
KEGGimmu:57264
UCSCiuc009ksg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRETN_MOUSE
AccessioniPrimary (citable) accession number: Q99P87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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