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Protein

Resistin-like beta

Gene

Retnlb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable hormone.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin-like beta
Alternative name(s):
Cysteine-rich secreted protein A12-beta
Cysteine-rich secreted protein FIZZ2
RELMbeta
Gene namesi
Name:Retnlb
Synonyms:Fizz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1888505. Retnlb.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 10582Resistin-like betaPRO_0000030346Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 – 25Interchain1 Publication
Disulfide bondi49 ↔ 102By similarity
Disulfide bondi61 ↔ 101By similarity
Disulfide bondi70 ↔ 87By similarity
Disulfide bondi72 ↔ 89By similarity
Disulfide bondi76 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ99P86.
PRIDEiQ99P86.

Expressioni

Tissue specificityi

Expressed only in the gastrointestinal tract, particularly the colon.

Gene expression databases

BgeeiENSMUSG00000022650.
CleanExiMM_RETNLB.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023328.

Structurei

Secondary structure

1
105
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 357Combined sources
Turni36 – 383Combined sources
Beta strandi46 – 6015Combined sources
Beta strandi66 – 727Combined sources
Helixi73 – 753Combined sources
Beta strandi79 – 824Combined sources
Turni83 – 853Combined sources
Beta strandi86 – 894Combined sources
Beta strandi91 – 933Combined sources
Beta strandi96 – 10510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RH7X-ray3.11A/B/C/D/E/F25-105[»]
ProteinModelPortaliQ99P86.
SMRiQ99P86. Positions 25-105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99P86.

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J40Z. Eukaryota.
ENOG410ZE8R. LUCA.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ99P86.
PhylomeDBiQ99P86.
TreeFamiTF337024.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99P86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTLCFLFI LVSLFPLIVP GNAQCSFESL VDQRIKEALS RQEPKTISCT
60 70 80 90 100
SVTSSGRLAS CPAGMVVTGC ACGYGCGSWD IRNGNTCHCQ CSVMDWASAR

CCRMA
Length:105
Mass (Da):11,278
Last modified:June 1, 2001 - v1
Checksum:i2F5FFDA5A28B7141
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151F → L in BAB32036 (PubMed:16141072).Curated
Sequence conflicti105 – 1051A → V in AAK83103 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323083 mRNA. Translation: AAG59826.1.
AF290871 mRNA. Translation: AAK83103.1.
AK020240 mRNA. Translation: BAB32036.1.
BC022650 mRNA. Translation: AAH22650.1.
CCDSiCCDS28210.1.
RefSeqiNP_076370.3. NM_023881.4.
UniGeneiMm.21123.

Genome annotation databases

GeneIDi57263.
KEGGimmu:57263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323083 mRNA. Translation: AAG59826.1.
AF290871 mRNA. Translation: AAK83103.1.
AK020240 mRNA. Translation: BAB32036.1.
BC022650 mRNA. Translation: AAH22650.1.
CCDSiCCDS28210.1.
RefSeqiNP_076370.3. NM_023881.4.
UniGeneiMm.21123.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RH7X-ray3.11A/B/C/D/E/F25-105[»]
ProteinModelPortaliQ99P86.
SMRiQ99P86. Positions 25-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023328.

Proteomic databases

PaxDbiQ99P86.
PRIDEiQ99P86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi57263.
KEGGimmu:57263.

Organism-specific databases

CTDi84666.
MGIiMGI:1888505. Retnlb.

Phylogenomic databases

eggNOGiENOG410J40Z. Eukaryota.
ENOG410ZE8R. LUCA.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ99P86.
PhylomeDBiQ99P86.
TreeFamiTF337024.

Miscellaneous databases

EvolutionaryTraceiQ99P86.
PROiQ99P86.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022650.
CleanExiMM_RETNLB.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRETNB_MOUSE
AccessioniPrimary (citable) accession number: Q99P86
Secondary accession number(s): Q9D286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.